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Frontiers of Mechanical Engineering 2022年第3期17卷 281-301页

作者： wenchao xu Dengfeng WANG State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun130022China

The multi-material assembled light alloy wheel presents an effective lightweight solution for new energy vehicles,but its riveting connection remains a *** address this problem,this paper proposed the explicit riveting-implicit springback-implicit fatigue/explicit impact sequence coupling simulation analysis method,analyzed the fatigue and impact performance of the punching riveting connected magnesium/aluminum alloy(Mg/Al)assembled wheel,and constructed some major evaluation *** accuracy of the proposed simulation method was verified by conducting physical experiments of single and cross lap *** punching riveting process parameters of the assembled wheel joints were defined as design variables,and the fatigue and impact performance of the assembled wheel was defined as the optimization *** connection-performance integration multi-objective optimization design of the assembled wheel considering riveting residual stress was designed via Taguchi experiment,grey relational analysis,analytic hierarchy process,principal component analysis,and entropy weighting *** optimization results of the three weighting methods were compared,and the optimal combination of design variables was *** fatigue and impact performance of the Mg/Al assembled wheel were effectively improved after optimization.

关键词： magnesium/aluminum assembled wheel riveting residual stress fatigue analysis impact analysis multi-objective optimization

Druse Calcite Crystals Formed by Mesoproterozoic Paleo-Earthquake Activity in the Northern Margin of the North China Craton

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Journal of Earth Science 2024年第2期35卷 514-524页

作者： Yueshuang Du Zhiguang Zhou Guosheng Wang Chen Wu wenchao xu School of Earth Sciences and Resources China University of GeosciencesBeijing100083China Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau Researchand Center for Excellence in Tibetan Plateau Earth SciencesChinese Academy of SciencesBeijing100101China No.1 Institute of Geological and Mineral Resources Survey Henan Bureau of Geo-Exploration&Mineral DevelopmentLuoyang471000China

The Meso-neoproterozoic Bayan Obo rift is located along the northern margin of the North China Craton,and was associated with the break-up of the Columbia *** rift evolution,syn-sedimentary deformation occurred due to tectonic activity and *** events are recorded in the Jianshan Formation of the Bayan Obo Group,Inner Mongolia,as soft sediment deformation structures in the central Bayan Obo *** calcite crystals and collapse breccias in the Jianshan Formation may provide information on the rift *** druse calcite crystals are idiomorphic-columnar in shape and associated with graphite,pyrite,and quartz.δ^(13)C values of the graphite are−20‰,indicative of biogenic deoxygenation and formation in *** druse calcite crystals are inorganic in origin and formed in water at a temperature of 55℃,based on calciteδ^(13)C andδ^(18)O *** calcite grew in paleo-caves containing fault breccias,with heat derived from *** such,the druse calcite crystals are important evidence for seismic *** collapse breccias(i.e.,fault breccias)and other indicators of slip show that displacement occurred from NE to SW,which is different from the paleocurrent direction in the Jianshan *** thickness of the collapse breccia is∼200 m,which represents the height of the fault *** strike of the fault scarp was NE-SW,based on the distribution of the collapse *** Bayan Obo and Yanliao rifts experienced rapid NW-SE extension,and developed similar deformation structures at ca.1.6 Ga related to break-up of the Columbia supercontinent.

关键词： North China Craton druse calcite crystals paleo-earthquake activity collapse breccia Bayan Obo rift Proterozoic

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

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Genes & Diseases 2024年第1期11卷 19-22页

作者： Zhenhai Li wenchao xu Feng Chen Jun Zhang Wei-Guo Zhu Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhenGuangdong 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D Center International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay Laboratory Shenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical Engineering Shenzhen University School of MedicineShenzhenGuangdong 518055China

Etoposide is widely used for cancer chemotherapy in the ***,long-term etoposide treatment can lead to adverse effects or drug *** improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer ***,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway.

关键词： etoposide damage cancer

Multi-objective Collaborative Optimization for the Lightweight Design of an Electric Bus Body Frame

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Automotive Innovation 2020年第3期3卷 250-259页

作者： Dengfeng Wang Chong Xie Yuchang Liu wenchao xu Qi Chen State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchunChina FAW-Volkswagen Automotive Co Ltd ChangchunChina

To analyze the rollover safety,finite element models were established for the electric bus body frame,rollover simulation platform,living space,and bus *** strength and stiffness of the body frame were calculated under four typical work-ing conditions considering the main low-order elastic modal *** results indicate that the initial body frame of the electric bus satisfies the required structural strength,stiffness,modes,and rollover safety,and it has great potential for lightweight *** and structural contribution analyses were performed to determine the design variables for lightweight optimization of the body frame,and a mathematical model was established for multi-objective collaborative optimization design of the electric ***,the radial basis function neural network was used to approximate the optimiza-tion ***,the accuracy of the approximate model was verified,and the non-dominated sorting genetic algorithm II was employed to determine solutions for the lightweight *** with the initial model,the mass of the optimized model is reduced by 240 kg(9.0%)without any changes in the materials of the body frame.

关键词： Electric bus Body frame Lightweight optimization Structural contribution analysis Multi-objective collaborative optimization

Internet of Vehicles in Big Data Era

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 19-35页

作者： wenchao xu Haibo Zhou Nan Cheng Feng Lyu Weisen Shi Jiayin Chen xuemin (Sherman) Shen Department of Electrical and Computer Engineering University of Waterloo Waterloo Ontario N2L 3G1 Canada School of Electronic Science and Engineering Nanjing University Nanjing China Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China IEEE

As the rapid development of automotive telematics,modern vehicles are expected to be connected through heterogeneous radio access technologies and are able to exchange massive information with their surrounding environment. By significantly expanding the network scale and conducting both real-time and long-term information processing, the traditional Vehicular AdHoc Networks(VANETs) are evolving to the Internet of Vehicles(Io V), which promises efficient and intelligent prospect for the future transportation system. On the other hand, vehicles are not only consuming but also generating a huge amount and enormous types of data, which is referred to as Big Data. In this article, we first investigate the relationship between Io V and big data in vehicular environment, mainly on how Io V supports the transmission, storage, computing of the big data, and how Io V benefits from big data in terms of Io V characterization,performance evaluation and big data assisted communication protocol design. We then investigate the application of Io V big data in autonomous vehicles. Finally, the emerging issues of the big data enabled Io V are discussed.

关键词： Autonomous vehicles big data big data applications data communication IoV vehicular networks

Nucleoside deaminases: the key players in base editing toolkit

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Biophysics Reports 2023年第6期9卷 325-337页

作者： Jiangchao Xiang wenchao xu Jing Wu Yaxin Luo Bei Yang Jia Chen Gene Editing Center School of Life Science and Technology Shanghai Tech University Shanghai Institute for Advanced Immunochemical Studies Shanghai Tech University Shanghai Clinical Research and Trial Center

The development of nucleoside deaminase-containing base editors realized targeted single base change with high efficiency and precision. Such nucleoside deaminases include adenosine and cytidine deaminases, which can catalyze adenosine-to-inosine(A-to-I) and cytidine-to-uridine(C-to-U) conversion respectively. These nucleoside deaminases are under the spotlight because of their vast application potential in gene editing. Recent advances in the engineering of current nucleoside deaminases and the discovery of new nucleoside deaminases greatly broaden the application scope and improve the editing specificity of base editors. In this review, we cover current knowledge about the deaminases used in base editors, including their key structural features, working mechanisms, optimization, and evolution.

关键词： Nucleoside deaminase Base editors

Future Performance Prediction of Research Infrastructure Based on Past Performance

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Journal of Donghua University(English Edition) 2018年第4期35卷 336-338页

作者： WU Di PENG Rui SUN Dongbai xu wenchao QIAO Lili Shool of Management Xi＇an Jiao tong UniversityXi＇an 710049China Donlinks School of Economics ＆Management University of Science ＆ Technology BeijingBeijing 100083China National Center for Materials Service Safety University of Science ＆ Technology BeijingBeijing 100083China

Research infrastructure is crucial for development of research,and thus the evaluation of its performance is ***,existing researches mostly focus on its past observations,lacking of a prediction for future. In this paper, procedures are proposed to predict the distribution for the number of papers published in a certain future year. The publication reliability,which is defined as the probability that the number of published papers in the future year is bigger than a pre-specified number,is evaluated. Illustrative examples are proposed to show the applications of the model.

关键词： research infrastructure performance prediction reliability

Performability of Research Infrastructure Comsidering Costs and Values for Different Outputs

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Journal of Donghua University(English Edition) 2018年第4期35卷 333-335页

作者： SUN Dongbai xu wenchao QIAO Lili PENG Rui WU Di National Center for Materials Service Safety University of Science ＆ Technology BeijingBeijing 100083China Donlinks School of Economics ＆ Management University of Science ＆ Technology BeijingBeijing 100083China Shool of Management Xi＇an Jiaotong UniversityXi＇an 710049China

The research infrastructure is very crucial for the development of some fundamental research. However,it is costly to buy,install and operate the infrastructure. This paper analyzes the costs and benefits of research infrastructure using a concept termed as investment reliability. Both the costs and the outputs are represented by a cash flow diagram,and the investment reliability is modeled. Different types of outputs are taken into concern in the model formulation. Illustrative examples are proposed to show how to apply the model.

关键词： research infrastructure benefit cost output reliability

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镁铝合金车轮胶栓复合连接稳健性优化设计

汽车工程 2020年第4期42卷 545-551页

作者：王登峰许文超吉林大学汽车仿真与控制国家重点实验室长春130022

提出了车轮胶栓复合连接的多目标确定性与稳健性优化设计方法。首先,建立镁铝合金组装式车轮螺栓连接有限元模型,对其进行弯曲疲劳寿命仿真,对比疲劳试验结果,验证了车轮仿真模型的准确性。随后,建立结构胶弹塑性本构模型,通过试验得到... 详细信息

提出了车轮胶栓复合连接的多目标确定性与稳健性优化设计方法。首先,建立镁铝合金组装式车轮螺栓连接有限元模型,对其进行弯曲疲劳寿命仿真,对比疲劳试验结果,验证了车轮仿真模型的准确性。随后,建立结构胶弹塑性本构模型,通过试验得到其应力应变曲线和剪切强度。最后,选取胶层厚度与种类、螺栓预紧力和螺栓孔直径为设计变量,建立车轮栓胶复合连接参数化仿真模型,以车轮连接螺栓疲劳寿命、结构胶最大拉伸和最大剪切应力为优化目标,借助ISIGHT优化平台,分别采用第二代非劣排序遗传算法(NSGA-Ⅱ)和微存档遗传算法(AMGA)对车轮胶栓连接结构进行了多目标确定性和6σ稳健性优化设计。稳健性优化后车轮连接的可靠性得到进一步提升。

关键词：组装式车轮胶栓复合连接疲劳分析多目标优化稳健性优化

Synthesis,crystal structures,electrochemical and spectroscopic properties of ruthenium(Ⅱ) complexes containing diamino-1,3,5-triazine derivatives

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Science China Chemistry 2010年第10期53卷 2099-2105页

作者： CHEN Yu, xu wenchao, KOU JunFeng, WEI xuHui, YU BoLe, CHAO Hui & JI LiangNian MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China 1. MOE Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 China

Three Ru(Ⅱ) complexes [Ru(bpy)2(1-IQTNH)](ClO4)2 (1), [Ru(bpy)2(2-QTNH)](ClO4)2 (2) and [Ru(bpy)2(3-IQTNH)](ClO4)2 (3) (bpy = 2,2′-bipyridine, 1-IQTNH = 6-(isoquinolin-1-yl)-1,3,5-triazine-2,4-diamine, 2-QTNH = 6-(quinolin-2-yl)-1,3,5-triazine-2,4-diamine, 3-IQTNH = 6-(isoquinolin-3-yl)-1,3,5-triazine-2,4-diamine) have been synthesized and characterized by elemental analysis, 1H NMR spectroscopy, electrospray ionization mass spectrometry and X-ray crystallography. The electrochemical and spectroscopic properties of the complexes differ from those of [Ru(bpy)3]2+ owing to the structural differences between the ligands and their complexes.

关键词： ruthenium(Ⅱ) complex diamino-1 3 5-triazine crystal structures electrochemistry spectroscopy