检索结果-南通市图书馆

Chinese Science Bulletin 2006年第8期51卷 977-986页

作者： YUE Wenze xu Jianhua WU Jiawei xu lihua College of Southeast Land Management Zhejiang University Hangzhou 310029 China Department of Geography East China Normal University Shanghai 200062 China Zhejiang Forest University Lin'an 311300 China

It is very important to integrate remote sensing with urban geography that the spectral mix- ture analysis technique is applied to urban land cover evolvement and its eco-environmental effect. Urban land cover is mainly composed of complicated artifi- cial materials, which is the key factor to limit the de- velopment of the spectral mixture analysis technique. There are two main aspects in which the technique of spectral mixture analysis is applied to urban geog- raphy: one is to calculate vegetation fraction; the other is to build quantitative model of the urban im- pervious surface obtained from the combination be- tween high albedo fraction and low albedo fraction. The technique of spectral mixture analysis is firstly applied to study urban renewal pattern, scale and mode which happened in Shanghai City from 1997 to 2000.

关键词：遥感分布类型城市更新上海线性光谱分析

Effect of Daiqin phlegm-expelling pill on development of inflammation in rats with chronic obstructive pulmonary disease induced by lipopolysaccharide and smoke

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2019年第1期39卷 59-64页

作者： Li Lei xu lihua Wu Xinping Dong Jie Department of Respiration Affiliated Hospital of Nanjing University of Traditional Chinese MedicineNanjing 210029China Department of Respiration The First People's Hospital of LianyungangLianyungang 222000China Department of Laboratory Affiliated Hospital of Nanjing University of Traditional Chinese MedicineNanjing 210029China

OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary disease(COPD) induced by lipopolysaccharide(LPS) and smoke, and to identity the possible underlying ***: Sixty male rats were divided into 6 groups(healthy control group, untreated group,Daiqin phlegm-expelling pill low, middle and high dose, and ambroxol hydrochloride tablet group).COPD was established in SD rats by sootiness and tracheal instillation with LPS. The rats were treated with Daiqin phlegm-expelling pill at the indicated doses for 28 d, the inflammatory cells in bronchoalveolar lavage fluid(BALF), the concentration of tumor necrosis factor-α(TNF-α), interleukin(IL)-8 and IL-6 in blood and the inflammation in lung were ***: The number of inflammatory cells in the BALF and TNF-ficantly redα, IL-8 and IL-6 level in plasma were signiuced in rats with COPD when treated with Daiqin phlegm-expelling pill or ambroxol hydrochloride tablet, compared with those without any treatment. The Daiqin phlegm-expelling pill treated rats with COPD had a attenuated inflammation in lung tissue, compared with the untreated ***: Daiqin phlegm-expelling pill can significantly restrain the airway inflammation in rats with LPS-smoke induced COPD.

关键词： Pulmonary disease,chronic obstructive Daiqin phlegm-expelling pill Tumor necrosis factoralpha Inflammation

Kinetics mechanism of microwave sintering in ceramic materials

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2009年第9期52卷 2727-2731页

作者： HAO HongShun xu lihua HUANG Yong ZHANG XiaoMeng XIE ZhiPeng Department of Inorganic Non-metallic Materials University of Science and Technology BeijingBeijing 100083China Department of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Based on the traditional sintering model incorporating the characteristic of microwave sintering, the ionic conductance diffusion mechanism in microwave sintering was studied. A flat-ball model was presented to describe the kinetics process in microwave sintering, and was applied to the sintering process of TZP and ZrO2-Al2O3 ceramics. The results indicate that the shrinkage rate of materials in microwave sintering is proportional to t2/3 and r-4/3, respectively, where t is the sintering time and r is the particle radius. Whereas, the shrinkage rate of materials in conventional sintering is proportional to sintering time t2/5. Our model suggests that microwave sintering is faster than conventional sintering, which shows a good agreement with the experimental observation in sintering process of TZP and ZrO2-Al2O3.

关键词： microwave sintering ionic conductance kinetics sintering mechanism

A multi-functional nanoplatform for efficacy tumor theranostic applications

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2017年第3期12卷 235-249页

作者： Jinjin Shi Hongling Zhang Zhaoyang Chen lihua xu Zhenzhong Zhang School of Pharmaceutical Sciences Zhengzhou University

Nanomaterials with multiple functions have become more and more popular in the domain of cancer research. MoS2 has a great potential in photothermal therapy, X-ray/CT imaging and drug delivery. In this study, a water soluble MoS2 nanosystem(MoS2-PEG) was synthesized and explored in drug delivery, photothermal therapy(PTT) and X-ray ***(DOX) was loaded onto MoS2-PEG with a high drug loading efficiency(~69%)and obtained a multifunctional drug delivery system(MoS2-PEG/DOX). As the drug delivery, MoS2-PEG/DOX could efficiently cross the cell membranes, and escape from the endosome via NIR light irradiation, lead to more apoptosis in MCF-7 cells, and afford higher antitumor efficacy without obvious toxic effects to normal organs owing to its prolonged blood circulation and 11.6-fold higher DTX uptake of tumor than DOX. Besides, MoS2-PEG/DOX not only served as a drug delivery system, but also as a powerful PTT agent for thermal ablation of tumor and a strong X-ray contrast agent for tumor diagnosis. In the in vitro and in vivo studies, MoS2-PEG/DOX exhibited excellent tumor-targeting efficacy, outstanding synergistic anti-cancer effect of photothermal and chemotherapy and X-ray imaging property,demonstrating that MoS2-PEG/DOX had a great potential for simultaneous diagnosis and photothermal-chemotherapy in cancer treatment.

关键词： Multifunctional drug delivery Endosome escape Tumor-targeting Bio-imaging Theranostic

Convenient Synthesis of 1-Thiohydroxypyrene by Newman-Kwart Rearrangement

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2015年第2期31卷 224-227页

作者： ZHANG Ran xu lihua CHEN Hui QIN Zhihong ZHAO Yu Ni Zhonghai School of Chemical Engineering and Technology China University of Mining and Technology Xuzhou 221116 P. R. China

l-Thiohydroxypyrene（l） and its two intermediates, l-pyrenyl-O-thiocarbamate（2） and l-pyrenyl-S-thiocarbamate（3）, were synthesized using l-hydroxypyrene as the starting material. The key synthetic step is New- manoKwart rearrangement. The results indicate that the Newman-Kwart rearrangement is more effective in suitable solvent than conventional method based on pure organic compound. The structures of compounds 1-3 were characterized by FTIR, NMR, CJC-MS and elementary analysis. The crystal structures of two new compounds（2 and 3） were determined by single crystal X-ray diffraction analysis. The whole synthetic process is simple, mild and with high yield.

关键词： Newman-Kwart rearrangement l-Thiohydroxypyrene Crystal structure

Nonlinear Finite Element Analysis of Steel Fiber Reinforced Concrete Deep Beams

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2008年第2期13卷 201-206页

作者： xu lihua CHI Yin SU Jie XIA Dongtao School of Civil Engineering Wuhan University Wuhan430072Hubei China School of Civil Engineering Hubei University of Technology Wuhan 430064 Hubei China

By the nonlinear finite element analysis （FEA） method, the mechanical properties of the steel fiber reinforced concrete （SFRC） deep beams were discussed in terms of the crack load and ultimate bearing capacity. In the simulation process, the ANSYS parametric design language （APDL） was used to set up the finite element model; the model of bond stress-slip relationship between steel bar and concrete was established. The nonlinear FEA results and test results demonstrated that the steel fiber can not only significantly improve the cracking load and ultimate bearing capacity of the concrete but also repress the development of the cracks. Meanwhile, good agreement was found between the experimental data and FEA results, if the unit type, the parameter model and the failure criterion are selected reasonably.

关键词： steel fiber reinforced concrete deep beam nonlinear finite element bond stress-slip relationship

Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第5期11卷 1329-1340页

作者： Airong Li Chenglin Liang lihua xu Yiyang Wang Wei Liu Kaixiang Zhang Junjie Liu Jinjin Shi Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases School of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive ***,the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor *** by the crucial function of iron ions in 5-ALA transformation and DNA repair,a liposomal nanomedicine(MFLs@5-ALA/DFO)with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA,which was prepared by co-encapsulating 5-ALA and DFO(deferoxamine,a special iron chelator)into the membrane fusion liposomes(MFLs).MFLs@5-ALA/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO ***@5-ALA/DFO could efficiently reduce iron ion,thus blocking the biotransformation of photosensitive protoporphyrin IX(Pp IX)to heme,realizing significant accumulation of ***,the activity of DNA repair enzyme was also inhibited with the reduction of iron ion,resulting in the aggravated DNA damage in tumor *** findings showed MFLs@5-ALA/DFO had potential to be applied for enhanced PDT of 5-ALA.

关键词： 5-Aminolevulinic acid Biotransformation interference Iron ion regulation DNA repair inhibition ALKBH2 Membrane fusion liposomes Photodynamic therapy Drug delivery

Role of selenoprotein M knockdown in the melatonin antagonism of nickel-induced apoptosis and endoplasmic reticulum stress in mouse heart

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 406-417页

作者： Xintong ZHANG Xiaoxue GAI lihua xu Wenxue MA Qiaohan LIU Bendong SHI Cheng FANG Jingzeng CAI Ziwei ZHANG College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Suihua Agricultural and Rural Bureau Suihua 152000China College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China4.Key Laboratory of the Provincial EducationDepartment of Heilongjiang for Common Animal Disease Prevention and TreatmentNortheast Agricultural UniversityHarbin 150030China

The aim of this study was to investigate the role of selenoprotein M(SelM)in endoplasmic reticulum stress and apoptosis in nickel-exposed mouse hearts and to explore the detoxifying effects of *** 21 d after intraperitoneal injection of nickel chloride(NiCl_(2))and/or melatonin into male wild-type(WT)and SelM knockout(KO)C57BL/6J mice,NiCl_(2)was found to induce changes in the microstructure and ultrastructure of the hearts of both WT and SelM KO mice,which were caused by oxidative stress,endoplasmic reticulum stress,and apoptosis,as evidenced by decreases in malondialdehyde(MDA)content and total antioxidant capacity(T-AOC)*** in the messenger RNA(mRNA)and protein expression of genes related to endoplasmic reticulum stress(activating transcription factor 4(ATF4),inositol-requiring protein 1(IRE1),c-Jun N-terminal kinase(JNK),and C/EBP homologous protein(CHOP))and apoptosis(B-cell lymphoma-2(Bcl-2),Bcl-2-associated X protein(Bax),Caspase-3,Caspase-9,and Caspase-12)were also ***,the observed damage was worse in SelM KO ***,melatonin alleviated the heart injury caused by NiCl_(2)in WT mice but could not exert a good protective effect in the heart of SelM KO ***,the findings suggested that the antioxidant capacity of SelM,as well as its modulation of endoplasmic reticulum stress and apoptosis,plays important roles in nickel-induced heart injury.

关键词： Selenoprotein M(SelM) Nickel chloride(NiCl_(2)) Melatonin Apoptosis Mouse heart

Impact of Land Use Change on Vegetation Carbon Storage During Rapid Urbanization:A Case Study of Hangzhou,China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Geographical Science 2021年第2期31卷 209-222页

作者： WANG Zhi xu lihua SHI Yijun MA Qiwei WU Yaqi LU Zhangwei MAO Liwei PANG Enqi ZHANG Qi School of Environmental and Resource Sciences Zhejiang A&F UniversityHangzhou 311300China School of Landscape Architecture Zhejiang A&F UniversityHangzhou 311300China Hangzhou Planning&Design Academy Hangzhou 310012China

Land use changes have significant impacts on the carbon balance in an urban *** there is rapid development in urbanizing regions,land use changes have a dramatic effect on vegetation carbon storage(VCS).This study investigates the impact of land use change on VCS in a period of rapid urbanization in Hangzhou,*** results show that:1)from 2000 to 2015,land use in Hangzhou underwent huge changes,mainly reflected in decrease in cropland and wetland and the increased *** than 34.58%of the land was transformed,and the land use changes are primarily characterized by a significant decrease in cropland due to the occupation by settlement.2)over the 15 years,changes in land use led to a decrease of 3.93×10^(5) t of VCS in the urban *** large-scale transformation of cropland and wetland,which have a comparatively high carbon density,into land for settlement exerted a negative impact on VCS.3)The central city,which with the Circle-E/I/O mode,had the lowest comprehensive land use dynamic degree,leading to moderate land use change and an increase in VCS;Yuhang and Xiaoshan,which with Multicore-E/O/I mode and Fan-E/O/I modes,had a higher comprehensive land use dynamic degree,drastic changes in land use,and a decrease in *** study proposes a reliable method of estimating changes in VCS,clarifies the relationship between land use change and VCS during rapid urbanization,and provides recommendations for sustainable urban development.

关键词： land use change vegetation carbon storage(VCS) urbanization GAIN-LOSS method Hangzhou,China

Spatial sight analysis of Hangzhou Xiaoyingzhou based on tourists’landscape preference

在线全文

学校读者我要写书评

暂无评论

Frontiers of Architectural Research 2023年第6期12卷 1157-1170页

作者： Yiying Chen Qiwei Ma lihua xu Yijun Shi Zhangwei Lu Yaqi Wu Mao Feng College of Landscape Architecture and Architecture Zhejiang Agriculture and Forestry UniversityHangzhou 310000China

Tourist preferences are important for the high-quality planning and design of recreation *** famous scenic locale of West Lake in Hangzhou,China,is used as an example in this *** on multi-source data(e.g.,online comments,and tourist photographs),we used content analysis,kernel density estimation,and image semantic segmentation technology to determine the spatial distribution of tourists’landscape *** analyzed these spatial sight characteristics from the viewpoint,sight distance,and *** results show that tourists’landscape preferences are mainly concentrated on landscape architecture for *** viewpoints of these preferences are concentrated in the north-south embankmentdfar beyond that of the east-west *** preferences also show a spatial sequence in terms of sight distance,and the best visual effect is the open platform at the north and south islands of *** the perspective of vision,the degree of spatial openness in the tourists’landscape preferences is proportional to the distance of vision;the two factors have a convergent *** discussion of the characteristics of tourists’landscape preference and space sight creation in Xiaoyingzhou provides a reference for the quality improvement of island recreation space.

关键词： Landscape preference Photo content analysis Landscape Xiaoyingzhou Line of sight analysis