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Skeletal interoception in osteoarthritis

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Bone Research 2024年第2期12卷 241-254页

作者： Dinglong Yang Jiawen xu Ke xu Peng xu Department of Joint Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054China Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengdu 610041China

The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the *** its various forms,skeletal interoception specifically regulates the metabolic homeostasis of ***(OA)is a complex joint disorder involving cartilage,subchondral bone,and *** subchondral bone undergoes continuous remodeling to adapt to dynamic joint *** findings highlight that skeletal interoception mediated by aberrant mechanical loads contributes to pathological remodeling of the subchondral bone,resulting in subchondral bone sclerosis in *** skeletal interoception is also a potential mechanism for chronic synovial inflammation in *** this review,we offer a general overview of interoception,specifically skeletal interoception,subchondral bone microenviroment and the aberrant subchondral *** also discuss the role of skeletal interoception in abnormal subchondral bone remodeling and synovial inflammation in OA,as well as the potential prospects and challenges in exploring novel OA therapies that target skeletal interoception.

关键词： homeostasis inflammation releasing

Malware Evasion Attacks Against IoT and Other Devices: An Empirical Study

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Tsinghua Science and Technology 2024年第1期29卷 127-142页

作者： Yan xu Deqiang Li Qianmu Li Shouhuai xu School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Computer Science University of Colorado Colorado SpringsColorado SpringsCO 80918USA

The Internet of Things(loT)has grown rapidly due to artificial intelligence driven edge *** enabling many new functions,edge computing devices expand the vulnerability surface and have become the target of malware ***,attackers have used advanced techniques to evade defenses by transforming their malware into functionality-preserving *** systematically analyze such evasion attacks and conduct a large-scale empirical study in this paper to evaluate their impact on *** specifically,we focus on two forms of evasion attacks:obfuscation and adversarial *** the best of our knowledge,this paper is the first to investigate and contrast the two families of evasion attacks *** apply 10 obfuscation attacks and 9 adversarial attacks to 2870 malware *** obtained findings are as follows.(1)Commercial Off-The-Shelf(COTS)malware detectors are vulnerable to evasion attacks.(2)Adversarial attacks affect COTS malware detectors slightly more effectively than obfuscated malware examples.(3)Code similarity detection approaches can be affected by obfuscated examples and are barely affected by adversarial attacks.(4)These attacks can preserve the functionality of original malware examples.

关键词： Android malware obfuscation adversarial examples

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小型潮流水轮机叶片对称翼型的流动特性分析

水力发电学报 2010年第2期29卷 239-243页

作者：罗先武王鑫许洪元余伟平吴振宇清华大学水沙科学与水利水电工程国家重点实验室北京100084 浙江清华长三角研究院浙江省嘉兴314050 浙江水泵总厂有限公司浙江省临海317000

本文对一种适合于小型立轴潮流水轮机的THI翼型进行了流体动力特性和翼型外围的流动分析。经计算可知,该翼型在保持与机翼NACA633-0018相近的升力特性的同时,阻力系数稍微增大;从THI翼型全流体动力特性可知随攻角变化,流体力的变化异常... 详细信息

本文对一种适合于小型立轴潮流水轮机的THI翼型进行了流体动力特性和翼型外围的流动分析。经计算可知,该翼型在保持与机翼NACA633-0018相近的升力特性的同时,阻力系数稍微增大;从THI翼型全流体动力特性可知随攻角变化,流体力的变化异常剧烈,翼型的最大升力系数达到1.5、最大阻力系数1.1、最大升阻比28;除攻角0°附近之外的大部分攻角范围内,翼型外围的流动结构复杂,不仅出现回流,而且存在强烈的流动分离。这样的分离流动既影响翼型的升阻力特性,也可能引发流体振动。研究结果可为小型立轴潮流水轮机转轮的水力设计提供重要的参考。

关键词：水力机械潮流水轮机对称翼型流动分离

1-[2-(N,N-二甲氨)乙基]-5-巯基-1H-四氮唑的制备与表征

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化学通报 2000年第8期63卷 36-37页

作者：祝一锋单尚胥洪原石明孝浙江工业大学化工学院杭州310032 浙江大学应用化学研究所杭州310027

本文在制得2-氯乙胺盐酸盐[2]的基础上、加成、脂化，最后以叠氮钠为1,3-偶极体，通过一个类似1,3-偶极环加成反应成功合成了目标产物，用该法合成杂环四氮唑类化合物的方法及标题化合物的谱学性质国内未见报道。

关键词：偶极环加成表征杂环四氮唑头孢替安脂

Preface for the Special Issue on“Safety and Intelligent Maintenance of Offshore Structures”

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China Ocean Engineering 2024年第2期38卷 181-182页

作者： xu Wan-hai State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China

The ocean serves as a vital carrier for human resource development and economic growth and contains rich mineral resources such as oil,natural gas,polymetallic nodules,cobalt-rich ferromanganese crusts,polymetallic sulfides,and rare earth ***,the ocean has wealthy reserves of wind,wave,tidal,and solar energy,making it an essential strategic space for sustainable future ***,offshore structures are complex.

关键词： ocean offshore tidal

Spreadable Magnetic Soft Robots with On-Demand Hardening

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Research 2024年第3期2023卷 487-498页

作者： Zichen xu Yuanhe Chen Qingsong xu Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina.

Magnetically actuated mobile robots demonstrate attractive advantages in various medical applications due to their wireless and programmable executions with tiny sizes. Confronted with complex application scenarios, however, it requires more flexible and adaptive deployment and utilization methods to fully exploit the functionalities brought by magnetic robots. Herein, we report a design and utilization strategy of magnetic soft robots using a mixture of magnetic particles and non-Newtonian fluidic soft materials to produce programmable, hardened, adhesive, reconfigurable soft robots. For deployment, their ultrasoft structure and adhesion enable them to be spread on various surfaces, achieving magnetic actuation empowerment. The reported technology can potentially improve the functionality of robotic end-effectors and functional surfaces. Experimental results demonstrate that the proposed robots could help to grasp and actuate objects 300 times heavier than their weight. Furthermore, it is the first time we have enhanced the stiffness of mechanical structures for these soft materials by on-demand programmable hardening, enabling the robots to maximize force outputs. These findings offer a promising path to understanding, designing, and leveraging magnetic robots for more powerful applications.

关键词： execution attractive enable

Quantifying the strength of magnetic fields using baryon electric charge correlation

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Nuclear Science and Techniques 2024年第8期35卷 5-8页

作者： xu‑Guang Huang Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics National Natural Science Foundation of China and Fudan UniversityShanghai 200438China

Although heavy-ion collisions generate strong magnetic fields,their direct measurement is a challenging task.A new observable,the baryon electric charge correlation,was recently found to be sensitive to the magnetic field strength and thus could be used as a magnetometer for heavy-ion ***,this observable may shed light on the equation of state and phase structure of quantum chromodynamics(QCD)under magnetic *** and understanding the phase structure of quantum chromodynamics(QCD)is important in contemporary physics[1].

关键词： charge observable magnetic

基于模型预测控制的新型电力系统光储电站调频控制策略

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电力建设 2022年第11期43卷 99-107页

作者：赵晶晶张宇杜明朱炯达许宏源上海电力大学电气工程学院上海市200090

光伏渗透率的不断提高降低了新型电力系统的转动惯量,给系统频率稳定性带来了新的挑战,储能出力灵活且迅速,将储能与光伏结合构成光储电站参与电网调频能够提高新型电力系统频率稳定性。光储电站参与系统调频的有功出力受到光照强度、... 详细信息

光伏渗透率的不断提高降低了新型电力系统的转动惯量,给系统频率稳定性带来了新的挑战,储能出力灵活且迅速,将储能与光伏结合构成光储电站参与电网调频能够提高新型电力系统频率稳定性。光储电站参与系统调频的有功出力受到光照强度、储能荷电系数等多因素的影响,然而现有的与光储电站调频控制有关的研究大多对这些多约束的处理能力较差。在此背景下,提出一种基于模型预测控制的新型电力系统光储电站调频控制策略。该控制策略以最小化系统频率偏差与频率变化率之和为目标,计及光储电站有功出力及总发电量约束,优化光储电站有功出力,并通过控制光储电站有功输出参与系统频率调节。最后,通过仿真算例说明了所提方法相比传统控制策略调频效果更优,能够在考虑多约束的情况下快速精准确定光储电站出力,提高系统频率稳定性。

关键词：新型电力系统光储电站模型预测控制调频

Surface Polarization Effects on Collapse Transition of Polyelectrolyte Brushes

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Chinese Journal of Polymer Science 2024年第9期42卷 1313-1320,I0006页

作者： Xiao-Fei xu State Key Laboratory of Chemical Engineering and School of Chemical Engineering East China University of Science and TechnologyShanghai200237China

Polyelectrolyte brushes(PEBs)are commonly used to modify surface that have attracted great research *** dielectric permittivity of the grafted surface is typically significantly different from that of solution,which results in surface polarization(SP)effect with a jump of electric *** is thus important to study how SP alters the PEB’s structure and *** this work,the SP effects on PEB structure was studied using a statistical thermodynamic *** free energy functional to describe SP effect was constructed by using the image-charge ***,the electrostatic potential was solved from a modified Poisson-Boltzmann equation taking the ion solvation effect into *** the absence of SP,the thickness of PEB exhibited a continuous collapse transition when decreasing the solvent *** the presence of SP,the collapse became a jump-like *** energy analysis showed that the long-range Coulombic interaction dominated the transition because of the enhanced counterion condensation in the presence of *** theory provides an effective tool to study SP effect on PEBs,and the results explain the underlying physics in PEB collapse transition.

关键词： Surface polarization Polyelectrolyte brush Image charge Ion solvation Polyelectrolyte collapse transition