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仪器仪表学报 2018年第10期39卷 18-26页

作者：常玉清许弟伍李昊恩麻茹雪赵旭光东北大学信息科学与工程学院沈阳110819 东南大学电子科学与工程学院南京210096

针对定性信息与定量信息共存的湿法冶金过程中金泥品位无法在线测量的问题,提出了定性信息与定量信息共同驱动的软测量建模方法。通过深入的过程分析,选取了用于建立湿法冶金过程金泥品位软测量模型的辅助变量;针对过程中的多专家信息,... 详细信息

针对定性信息与定量信息共存的湿法冶金过程中金泥品位无法在线测量的问题,提出了定性信息与定量信息共同驱动的软测量建模方法。通过深入的过程分析,选取了用于建立湿法冶金过程金泥品位软测量模型的辅助变量;针对过程中的多专家信息,提出采用D-S证据理论进行信息融合,降低定性信息的不确定性,避免专家误信息对软测量模型的影响;针对径向基函数神经网络（RBF）无法处理定性信息的问题,提出采用云模型实现定性信息的定量化,在实现定量转换的同时,最大限度保留原有不确定信息的随机性与模糊性。仿真分析验证了所提出的金泥品位软测量方法的有效性。

关键词：湿法冶金金泥品位 D-S证据理论云模型软测量

The development of molecular and nano actinide decorporation agents

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Chinese Chemical Letters 2022年第7期33卷 3395-3404页

作者： Xiaomei Wang Cen Shi Jingwen Guan Yemeng Chen Yigong xu Juan diwu Shuao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

Internal contamination of actinides has led to significant health hazards to the public and workers in the context of nuclear power plant accidents,uranium ore mining,and reprocessing of the used *** effective sequestering agent that is able to remove accidentally incorporated actinides in vivo with low toxicity is always in urgent *** molecular decorporation ligands have been the most widely researched agents for the past few decades,while preliminary studies of functionalized nanoparticles have shown their clear advantages in metal binding selectivity,toxicity,and oxidative stress ***,the state-of-the-art of those two types of decorporation agents is presented with special attention being paid on the correlation between the solution and solid-state chemistry of those agents with actinides and the corresponding decorporation efficacies.

关键词： Actinides Chelator Binding selectivity Coordination mode Decorporation efficiency

非能动压水堆核电站1E级压力和差压变送器国产化研究

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自动化与仪器仪表 2022年第10期 278-281页

作者：岳红旭喻立川欧卫兵金跃明许第伍文怿恺三门核电有限公司浙江台州317112 重庆川仪自动化股份有限公司重庆401121

压水堆核电站内部环境严酷复杂,为了保证核电站安全稳定运行,需要对其内部工艺介质的压力、差压、流量和液位等进行全天候不间断测量。但这些介质往往是在具有辐射和高温等恶劣环境下,普通压力和差压仪表无法保证在核辐射等环境下长期... 详细信息

压水堆核电站内部环境严酷复杂,为了保证核电站安全稳定运行,需要对其内部工艺介质的压力、差压、流量和液位等进行全天候不间断测量。但这些介质往往是在具有辐射和高温等恶劣环境下,普通压力和差压仪表无法保证在核辐射等环境下长期稳定运行。依托实际研发项目,根据非能动压水堆核电站的参数要求,研发了具有在核电站严重事故下可运行的1E级压力和差压变送器。对样机进行了精度、绝缘耐压、EMC、响应时间、辐照老化等摸底测试。该设备可以用于非能动压水堆核电站一回路工艺介质压力和差压等参数的测量,并满足严重事故可运行要求。

关键词：核电站 1E级压力和差压变送器核辐射严重事故

Improving in vivo Uranyl Removal Efficacy of a Nano-Metal Organic Framework by Interior Functionalization with 3-Hydroxy-2-pyridinone

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Chinese Journal of Chemistry 2022年第17期40卷 2054-2060页

作者： Mengping Chen Lang Lang Lei Chen Xiaomei Wang Cen Shi Qiwen Sun Yigong xu Juan diwu Shuao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhouJiangsu215123 China

The environmental contamination of uranium will occur in scenarios such as nuclear accidents and leakage from nuclear waste storage sites,which eventually leads to the internal uranium exposure of people,causing consequential injuries of renal failure,osteosarcoma,*** development of uranyl specific chelating agents that could sequester uranium in vivo is in urgent need and is important for the safe and efficient development of nuclear *** organic frameworks(MOFs)already serve as efficient uranium depletion materials in solutions of a wide range of pH and ionic strength for nuclear fuel recycling,uranium extraction from seawater,as well as environmental ***,a chromium-based nano-metal organic framework(nano-MOF)functionalized interiorly with 3,2-HOPO ligands,MIL-101-HOPO,is rationally *** vitro adsorption experiments show that MIL-101-HOPO exhibits high adsorption selectivity and fast adsorption kinetics for *** results of in vivo uranyl decorporation assays reveal that MIL-101-HOPO with the decoration of HOPO ligands on the interior wall exhibits significantly increased uranyl removal ratio in kidneys comparing to the pristine nMOFs,and is more effective than the clinically used ZnNa_(3)-*** those results corroborate the interior functionalization of MOFs as an efficient strategy to develop promising uranyl decorporation agents.

关键词： Metal-organic frameworks Uranium 3,2-HOPO Adsorption Sequestration

～4.1 Ga xenocrystal zircon from Ordovician volcanic rocks in western part of North Qinling Orogenic Belt

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Chinese Science Bulletin 2007年第21期52卷 3002-3010页

作者： WANG HongLiang CHEN Liang SUN Yong LIU XiaoMing xu xueYi CHEN JuanLu ZHANG Hong diwu ChunRong State Key Laboratory of Continental Dynamics Northwest University Xi'an 710069 China Xi'an Institute of Geology and Mineral Resource Xi'an 710054 China

High-precision U-Pb dating by in situ LA-ICP-MS yields an age of 4079±5 Ma for a xenocrystal zircon from Ordovician volcanics of the Caotangou Group in western part of the North Qinling Orogenic Belt. As a result, the North Qinling Orogenic Belt becomes one of a few localities in the world that contain Hadean age records (4276±6 Ma and 4404±8 Ma detrital zircons from Jack Hill of the Yilgarn craton, 4016 Ma Acasta gneisses of the Wopmay Orogeny and Burang quartzite with detrital zircon of 4103 Ma in Tibet). It is also the first report of the Hadean age in Phanerozoic volcanics. The finding of the 4.1 Ga xenocrystal zircon provides not only the geochronological record of the oldest crustal materials in China, but also the condition for further search for rocks forming in the region during the early time of the Earth’s evolution. Thirty-six zircon U-Pb dates from the Ordovician volcanic rocks are subgrouped into seven generations that represent different tectono-magmatic events in the North Qinling Orogenic Belt. Among them, two periods of 0.9-1.5 Ga and 0.4-0.5 Ga are consistent with Mesoproterozoic and Early Paleozoic orogenies, respectively.

关键词：火山石造山地带锆石地质学

Fracture Effectiveness and its Influence on Gas Productivity in Ultra-deep Tight Sandstone Reservoirs of the Keshen Gas Field,Tarim Basin

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Acta Geologica Sinica(English Edition) 2024年第6期98卷 1557-1573页

作者： xu Xiaotong ZENG Lianbo DONG Shaoqun diwu Pengxiang LI Haiming LIU Jianzhong HAN Gaosong xu Hui JI Chunqiu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China College of Geoscience China University of Petroleum(Beijing)Beijing 102249China College of Science China University of Petroleum(Beijing)Beijing 102249China Tarim Oilfield Company PetroChinaKorlaXinjiang 841000China SINOPEC Northwest Oil Field Company Urumqi 830011China Shenzhen Branch of CNOOC Ltd. Shenzhen 518000China

Fracture effectiveness plays a key role in gas productivity of ultra-deep tight sandstone reservoirs,Kuqa depression,Tarim *** on cores,thin sections,well logging,well testing and production data,the study evaluated fracture effectiveness and illustrated its impacts on gas ***-angle and vertical shear fractures are the most important *** of effective fractures shows great *** effectiveness is influenced by tectonism,diagenesis and in-situ *** fractures or fractures in close to gypsum rock are easier to be *** filled fractures can be reopened under late *** improves local fracture *** spanning fracture surfaces protect fracture effectiveness from late *** filled with calcite can be activated by *** fractures parallel to maximum horizontal principal compressive stress direction show larger *** can decrease the effective normal stress to maintain fracture *** exploitation,decline in pore pressure reduces fracture *** density,aperture,and strike of effective fractures influence gas *** fractures greatly enhance matrix ***,more abundant and larger aperture fractures are always corresponded to higher ***,effective fractures also facilitate late water invasion,especially,both mutually *** water invasion leads to rapidly declines in productivity.

关键词： tectonic fracture fracture effectiveness gas productivity ultra-deep tight sandstone Kuqa depression

Application of a supervised machine learning algorithm in bone evaluation using ultrasonic backscatter signal

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Chinese Journal of Acoustics 2020年第3期39卷 399-410页

作者： diwu Qiangqiang LIU Chengcheng LI Ying LI Boyi xu Feng TA Dean Department of Electronic Engineering Fudan UniversityShanghai 200433 Academy for Engineering and Technology Fudan UniversityShanghai 200433

Improving the diagnosis accuracy is essential for the clinical application of osteoporosis evaluation using ultrasonic backscatter *** vitro ultrasonic backscatter signals were measured on bone specimens and backscatter parameters were *** the measured backscatter parameters,the involved cancellous bone specimens were evaluated and classified using support vector machine and adaptive boosting *** showed that the accuracy of classification was 80.00%-82.86% and the specificity of osteoporosis diagnosis was significant(specificity>92.3%).The supervised machine learning method using ultrasonic backscatter in bone evaluation is effective in the diagnosis of *** performance of the proposed machine-learning method is superior to the traditional bone evaluation using quantitative backscatter *** study may contribute to the application of ultrasonic backscatter in the diagnosis of osteoporosis in vivo.

关键词： diagnosis specificity osteoporosis

Neuroprotective effects of tectoridin on H2O2-induced damage in PC12 cells and an amyloid-infused rat model of Alzheimer's disease

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Neuroprotective effects of tectoridin on H2O2-induced damage...

Study of the decorporation efficacy and toxicity of tetradentate 3-hydroxy- 2-pyridinone ligands at the cellular level

中国解剖学会2021年年会

作者： Zhou Yuan Liu Qi Chao xu Wu Tao Wang Nan diwu Yongchang Zhang Qi Department of Anatomy Basic Medical CollegeShaanxi University of Chinese Medicine Shaanxi Key Laboratory of Chinese Medicine Encephalopathy Discipline Innovation Team 1st Clinical Medical School Acupuncture and Tuina School Department of Biochemistry Basic Medical College

Tectoridin,the main active ingredient in Belamcandachinensis (L.) Redoute,has been found to possess profound anti-inflammatory and antioxidant ***,the neuroprotective effects of tectoridin on Alzheimer’s disease remain *** our study,treatment with 400μmol/L HO on PC12 was employed to establish the oxidative stress cellular damage model in *** found that different concentrations of tectoridin could substantially promote the cell survival and elevate the SOD and CAT activities,raise the GSH *** addition,tectoridin treatment up-regulated Bcl-2,and down-regulated Bax,caspase-3 and caspase-9.

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Radiation Medicine and Protection 2020年第4期1卷 159-165页

作者： Xiaomei Wang Cen Shi Manni Gao Ying xu Yang Jiao Jianmei Wan Jianping Cao Zhifang Chai Juan diwu State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123China Beijing Nuclear Industry Hospital-Fangshan Campus Beijing102413China

Objective:A series of experiments were carried out to study the comparative decorporation efficacy and toxicity of three tetradentate hydroxypyridinone ligands(3LI-1-Cm-3,2-HOPO,5LIO-1-Cm-3,2-HOPO,and 7LIO-1-Cm-3,2-HOPO)with the variation of the linker length and the ***:Three ligands were obtained from a 4-step synthesis via the amidation of HOPO unit and different *** titrations were carried out to evaluate the formation constants of their corresponding uranyl ***-8 and colony formation assays were used to compare the cytotoxicity of the three ligands and uranyl using renal proximal tubular epithelial(NRK-52E)*** vitro uranium removal assays were performed to assess decorporation efficiencies of those ligands by co-incubating uranium and chelators with NRK-52E cells for 48 ***:Among the three ligands,5LIO-1-Cm-3,2-HOPO exhibits the highest uranyl affinity(logβ110?18.6(7))in comparison to the other two ligands(logβ110?14.9(2)for 3LI-1-Cm-3,2-HOPO and logβ110?16.7(1)for 7LIO-1-Cm-3,2-HOPO).The results of CCK-8 tests and colony formation assays further elucidate that 5LIO-1-Cm-3,2-HOPO and 7LIO-1-Cm-3,2-HOPO both show a similar level of cytotoxicity compared with ZnNa3-DTPA at relatively low ligand *** contrast,in the 3LI-1-Cm-3,2-HOPO treated group,the cell viability decreased markedly with the increase of the ligand concentrations,and the colony formation capability of NRK-52E cells was ***,the comparative decorporation efficacy of the three ligands was obtained from in vitro uranium removal assays,suggesting that these ligands could significantly inhibit the cellular uptake and prompt the cellular release of uranium from NRK-52E cells by the level of 81.9%,91.8%,and 87.1%,***:Our current results demonstrate that the linker/backbone species would significantly affect the decorporation efficacy and toxicity of the tetradentate 3-hydroxy-2-pyridinone ligands

关键词： Uranium Hydroxypyridinone Decorporation efficacy Cytotoxicity Metal complexation