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Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating SIRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao Hong LIU Yu Mei SHAN Hui TAN Jin Feng ZHOU Jian SONG Yuan Jin LI Si Qi LIU Chen xu Dong qun YU Li LI Wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of SIRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and SIRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,SIRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the SIRT1-PGC-1α *** SAL can activate SIRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis SIRT1-PGC-1α

全球气温趋势和近期中国气候灾害的成因分析和展望

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气象科学 2010年第5期30卷 582-590页

作者：徐群江苏省气象科学研究所南京210008

全球气温演变趋势和近期中国气候灾害有一定的联系;分析表明:1998年以来全球气温基本稳定仅有小幅波动,并未呈现如IPCC(2007)所预言的那样快速升温,而2005年以来太阳活动的异常状况可能标志它今后的长期减弱趋势;因此本文首先归纳太阳... 详细信息

全球气温演变趋势和近期中国气候灾害有一定的联系;分析表明:1998年以来全球气温基本稳定仅有小幅波动,并未呈现如IPCC(2007)所预言的那样快速升温,而2005年以来太阳活动的异常状况可能标志它今后的长期减弱趋势;因此本文首先归纳太阳活动影响气候研究的最新进展,发现其对气候的影响绝非限于大气顶上太阳总幅照(TSI)的微小变化,而会通过平流层臭氧对更大变幅的紫外辐射的的吸收,加热作用触发平流层-对流层的大气环流变化,结合热带-副热带海洋混合层对太阳输入能量的积累,TSI 0.1%的变化会在地球气候系统中产生放大效应,这突出表现在东太平洋热带-副热带海域海-气作用的响应,ENSO位相相应变化及北极/北大西洋涛动指数的响应,大量的观测研究结果支持上述论点;近年来太阳活动低值期北半球冬季中高纬和中国均遭受异常冷害侵袭即是明证,初步揭示出以夏季东太平洋副高强度指数首先反映的地球气候系统对太阳活动响应的一系列气候过程;对今后10 a全球气温趋势也作了初步展望。

关键词：气温气候灾害日地关系机理太阳活动异常减弱成因分析与展望

Efficacy of hepatic arterial infusion chemotherapy and its combination strategies for advanced hepatocellular carcinoma:A network meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3672-3686页

作者： Shun-An Zhou Qing-Mei Zhou Lei Wu Zhi-Hong Chen Fan Wu Zhen-Rong Chen Lian-qun xu Bi-LingGan Hao-Sheng Jin Ning Shi Department of General Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Geriatrics Ganzhou Hospital-Nanfang HospitalSouthern Medical UniversityGanzhou 341000Jiangxi ProvinceChina Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000Guangdong ProvinceChina Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

BACKGROUND With the rapid progress of systematic therapy for hepatocellular carcinoma(HCC),therapeutic strategies combining hepatic arterial infusion chemotherapy(HAIC)with systematic therapy arised increasing ***,there have been no systematic review comparing HAIC and its combination strategies in the first-line treatment for advanced *** To investigate the efficacy and safety of HAIC and its combination therapies for advanced *** A network meta-analysis was performed by including 9 randomized controlled trails and 35 cohort studies to carry out our *** outcomes of interest comprised overall survival(OS),progression-free survival(PFS),tumor response and adverse *** ratios(HR)and odds ratios(OR)with a 95% confidence interval(CI)were calculated and agents were ranked based on their ranking *** HAIC outperformed Sorafenib(HR=0.55,95%CI:0.42-0.72;HR=0.51,95%CI:0.33-0.78;OR=2.86,95%CI:1.37-5.98;OR=5.45,95%CI:3.57-8.30;OR=7.15,95%CI:4.06-12.58;OR=2.89,95%CI:1.99-4.19;OR=0.48,95%CI:0.25-0.92,respectively)and transarterial chemoembolization(TACE)(HR=0.50,95%CI:0.33-0.75;HR=0.62,95%CI:0.39-0.98;OR=3.08,95%CI:1.36-6.98;OR=2.07,95%CI:1.54-2.80;OR=3.16,95%CI:1.71-5.85;OR=2.67,95%CI:1.59-4.50;OR=0.16,95%CI:0.05-0.54,respectively)in terms of efficacy and ***+lenvatinib+ablation,HAIC+ablation,HAIC+anti-programmed cell death 1(PD-1),and HAIC+radiotherapy had the higher likelihood of providing better OS and PFS outcomes compared to HAIC ***+TACE+S-1,HAIC+lenvatinib,HAIC+PD-1,HAIC+TACE,and HAIC+sorafenib had the higher likelihood of providing better partial response and objective response rate outcomes compared to ***+PD-1,HAIC+TACE+S-1 and HAIC+TACE had the higher likelihood of providing better complete response and disease control rate outcomes compared to HAIC *** HAIC proved more effective and safer than sorafenib and ***,combined with other interventions,HAIC showed imp

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Network meta-analysis Interventional therapy Systemic treatment

近红外反射光谱研究光透明剂渗透特性对胃组织光学透明的影响

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中国激光 2005年第5期32卷 717-722页

作者：徐向群吴柳浙江理工大学生命科学学院浙江杭州310018 北京交通大学物理系北京100044

为了解高渗溶液渗透特性对生物组织的光学透明进程的影响,探索光透明剂的安全有效浓度,用近红外反射光谱和相干光断层成像(OCT)研究了两种光透明剂丙三醇(甘油)和二甲亚砜(DMSO)以及二者的混合溶液[体积分数为80%的甘油水溶液,50%的DMS... 详细信息

为了解高渗溶液渗透特性对生物组织的光学透明进程的影响,探索光透明剂的安全有效浓度,用近红外反射光谱和相干光断层成像(OCT)研究了两种光透明剂丙三醇(甘油)和二甲亚砜(DMSO)以及二者的混合溶液[体积分数为80%的甘油水溶液,50%的DMSO水溶液,50%的甘油+20%的DMSO水溶液(GD1)和50%的甘油+30%的DMSO水溶液(GD2)]对胃黏膜组织的光学透明作用。结果表明,这四种溶液都能显著增强近红外光在胃黏膜组织中的穿透能力,光学透明的能力由低到高依次为体积分数为50%的DMSO,80%的甘油,GD1和GD2。发现生物组织光透明进程的快慢和效果与光透明剂的渗透所导致的组织的失水速率和程度成正比。

关键词：医用光学和生物技术光透明近红外反射光谱相干光断层成像生物组织

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近四十年季度天气趋势预报研究与实践的进展

气象科学 2000年第3期20卷 302-308页

作者：徐群江苏省气象科学研究所南京210008

本文总结了作者近 4 0年在季度天气趋势预报研究与实践的历程和主要进展。六十年代提出并利用中高纬和低纬前期大气环流特征与夏季江淮流域旱涝趋势的隔季遥联制作预报 ,80年代初进一步考虑外在因子影响改进为“前期物理成因综合相似法... 详细信息

本文总结了作者近 4 0年在季度天气趋势预报研究与实践的历程和主要进展。六十年代提出并利用中高纬和低纬前期大气环流特征与夏季江淮流域旱涝趋势的隔季遥联制作预报 ,80年代初进一步考虑外在因子影响改进为“前期物理成因综合相似法”:1968～ 87这 2 0年长江中下游夏季旱涝趋势预报取得较好成绩。随后的预报实践表明 ,因全球气候异常增长 ,预报难度有所增大。1995年开始建立一种短期气候系统多变因子的物理—统计预报方法 ,近 4年 ( 1996～ 1999)我国中东部地区夏季旱涝趋势预报和用历史资料的 5年事后预报 ( hindcasts)共 10 3例的高技巧评分 ( 0 .4 8～ 0 .59)表明 ,该方法具有相当推广价值。

关键词：季度预报天气趋势预报长期预报

Measurement Uncertainty Assessment for Determination of Allura Red in Puffed Food by HPLC

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Current Medical Science 2018年第2期38卷 324-328页

作者： Ying CHEN Yun ZHAO Hua-Ming WANG Qing WANG Xi CHEN Dong-qun xu Tao LI Feng YU Xiao-yong WANG Jia-fa LIU Institute of Health Inspection and Testing Hubei Provincial Center for Disease Control and Prevention Wuhan 430079 China Department of Obsterics Maternal and Child Health Hospital of Hubei Province Wuhan 430070 China Institute for Environmental Health and Related Product Safety Chinese Center for Disease Control and Prevention Beijing100021 China Public Hospital Administration of Hubei Province Health And Family Planning Commission of Hubei Province Wuhan430079 China

This study aimed to assess the measurement uncertainty of a new method for determination of allura redin food by high performance liquid chromatography （HPLC）. The uncertainty of mathematical model of allura red is based on Europe for Analytical Chemistry（EURACHEM） guidelines. The sources and components of uncertainty were calculated, including recovery, working solution, sample mass, final volume, response of standard solution, response of sample solution. The expanded uncertainty was 0.0024 （k=2）. Uncertainty of working solution was the most significant factor contributing to the total uncertainty, accounting for 86.2%. The uncertainty of volume accounted for the minimum at 0.025%. The developed method is simple and accurate, which can be used for the determination of allura redin puffed samples.

关键词： uncertainty assessment allura red high performance liquid chromatography

丁基苯酞对脂多糖活化的小胶质细胞炎症介质释放的影响

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上海交通大学学报（医学版） 2016年第12期36卷 1719-1722页

作者：支楠徐群上海交通大学医学院附属仁济医院神经内科上海200127

目的·观察丁基苯酞(NBP)对脂多糖(LPS)激活后的小胶质细胞炎症介质释放的影响。方法·原代培养大鼠脑皮质小胶质细胞和神经元,将接种后的小胶质细胞分为5组,即空白对照组、LPS激活组、溶剂+LPS组、0.01 mmol/L NBP+LPS组以及0.1 mmol/L... 详细信息

目的·观察丁基苯酞(NBP)对脂多糖(LPS)激活后的小胶质细胞炎症介质释放的影响。方法·原代培养大鼠脑皮质小胶质细胞和神经元,将接种后的小胶质细胞分为5组,即空白对照组、LPS激活组、溶剂+LPS组、0.01 mmol/L NBP+LPS组以及0.1 mmol/L NBP+LPS组。在LPS作用前2 h用NBP对小胶质细胞进行预处理,经LPS刺激24 h后在倒置显微镜下观察小胶质细胞形态;同时用酶联免疫吸附测定(ELISA)法检测各组小胶质细胞释放的炎症因子肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)及白介素-10(IL-10)含量;用硝酸还原法检测一氧化碳(NO)含量;经四甲基偶氮唑盐(MTT)法检测经各组作用后的神经元存活率。结果·NBP预处理后的小胶质细胞经LPS刺激后仍呈激活形态,NBP不影响激活的小胶质细胞释放炎症因子TNF-α、IL-1β以及IL-10,但可抑制其释放炎症介质NO,提高神经元存活率,并呈现剂量依赖性。结论·NBP可减轻小胶质细胞经LPS活化后的神经炎症反应,并具有剂量依赖性的神经保护作用。

关键词：丁基苯酞小胶质细胞炎症

Separation of Intact Monoclonal Antibody Sialylation Isoforms by pH Gradient Ion Exchange Chromatography

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Determination of Carbendazim in Orange Juice by On-line SPE- HPLC

第十届全国生物医药色谱及相关技术学术交流会

作者： Dai Zhenyu xu qun Lina Liang Jeffrey Rohrer Chromatography and Mass Spectrometry Division Thermo Fisher Scientific

Glycosylated proteins,including erythropoietins,monoclonal antibodies,various hormones,constitute major approved therapeutic biological *** acid is important to cell recognition and migration and critical to circulation half life of the protein as exampled by therapeutic protein rh *** monitoring protein glycosylation,including sialylation,is important for both glycoprotein characterization and quality control *** oligosaccharide profiling（both fluorescently labeled and unlabeled）requires releasing the glycan from the protein and thus is time and labor *** electrophoresis,currently available technique for intact protein sialylation profiling,may not provide enough *** an analysis method with both convenience and higher resolution is needed for protein sialylation monitoring.

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Determination of Carbendazim in Orange Juice by On-line SPE-...