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Postoperative Elevations of Neutrophil-to-lymphocyte and Platelet-to- lymphocyte Ratios Predict Postoperative Pulmonary Complications in Non-small Cell Lung Cancer Patients: A Retrospective Cohort Study

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Current Medical Science 2020年第2期40卷 339-347页

作者： Yan WANG xu hut Meng-chan SU Yan wen WANG Guo-wei CHEI Deparment of Thoracic Surgery West China HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China

The neutrophil-to-lymphocyte ratio(NLR)and the platelet-to-lymphocyte ratio(PLR)are found to increase in patients who develop postoperative complications(PCs).The aim of the present study was to explore the association of the perioperative changes of NLR(ANLR)and PLR(OPLR)with PCs in non-small cell lung cancer(NSCLC).Clinical data of 509 patients,who were diagnosed with NSCLC and underwent thoracoscopic radical resection between January 1,2014 and July 31,2016 at the Department of Thoracic Surgery,West China Hospital,were *** were divided into PC and non-PC groups,and clinical characteristics including ANLR and APLR were compared between *** optimal cut-off values of ONLR and APLR were determined by receiver operating characteristics(ROC)curves and patients were assigned to high ANLR/APLR and low ONLR/OPLR groups in terms of the cut-off *** characteristics and the incidence of different PCs were compared between the dichotomized *** and multivariate logistic regression analyses were performed to identify the independent risk factors for *** results showed that the ANLR and APLR in the PC group were significantly higher than those in the non-PC group(P6.6 or 0PLR>49 were more likely to experience postoperative pulmonary complications(PPCs)(P6.6(OR:2.453,95%CI:1.2244.914,P-0.011)and APLR>49(OR:2.231,95%CI:1.182-4.212,P-0.013)were predictive of *** conclusion,the ONLR and APLR may act as novel predictors for PPCs in NSCLC patients undergoing thoracoscopic radical lung resection,and patients with ONLR>6.6 or APLR>49 should be treated more actively to prevent or reduce PPCs.

关键词： neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio non-small cell lung cancer postoperative pulmonary complication

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以PPARγ2为靶点的传统中药细胞学筛选方法的建立和应用

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基础医学与临床 2017年第5期37卷 619-624页

作者：王欣徐剑朱惠娟李乃适王林杰阳洪波龚凤英潘慧河北北方学院河北张家口075000 中国医学科学院中国协和医学院北京协和医院内分泌科卫计委内分泌重点实验室协和转化医学中心北京100730 首都医科大学附属北京天坛医院内分泌科北京100050

目的构建含人PPARγ2基因启动子的荧光素酶表达质粒,通过建立稳定转染该质粒的细胞系,建立传统中药细胞学筛选方法。方法首先以p GL3-Basic-Luc和p GL3-Enhancer-Luc为载体构建含不同长度人PPARγ2基因启动子序列的荧光素酶表达质粒。... 详细信息

目的构建含人PPARγ2基因启动子的荧光素酶表达质粒,通过建立稳定转染该质粒的细胞系,建立传统中药细胞学筛选方法。方法首先以p GL3-Basic-Luc和p GL3-Enhancer-Luc为载体构建含不同长度人PPARγ2基因启动子序列的荧光素酶表达质粒。脂质体转染,建立稳定转染上述质粒的3T3-L1细胞系。选取红花和茜草等28种可能具有减肥作用的中药制备成中药水溶性提取物(ECMH),观察不同浓度ECMH对3T3-L1细胞中荧光素酶表达的影响。结果 p GL3-Enhancer-PPARγ2 625 bp-Luc质粒稳定转染的细胞荧光素酶表达最高,是本底的200倍左右。故采用此细胞系进行传统中药筛选,红花ECMH在10、100和1 000μg/m L时均可使3T3-L1细胞中荧光素酶的表达明显增加,分别为对照组的1.63倍、1.90倍和2.30倍(P<0.05)。在10~1 000μg/m L荷叶、茜草ECMH也均能促进3T3-L1细胞中荧光素酶的表达,在浓度为1 000μg/m L时荷叶和茜草对3T3-L1细胞中荧光素酶的表达作用最强,分别为对照组的2.03倍(P<0.01)和2.00倍(P<0.01)。结论成功构建p GL3-Enhancer-PPARγ2625 bp-Luc质粒,并建立稳定转染的3T3-L1细胞系。红花、荷叶和茜草的ECMH能明显促进3T3-L1细胞中人PPARγ2基因启动子的活性,它们可能成为未来潜在的减肥药物。

关键词：过氧化物酶体增生物激活受体γ2 中药水溶性提取物质粒构建稳定转染 3T3-L1前脂肪细胞

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Synthesis of Chiral 3-Acylcamphors

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Chinese Chemical Letters 1999年第5期10卷 347-348页

作者： Zheng Ning LI Zhi Xiu xu Zhuo ZHENG hut Lin CHEN(Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, Dalian 116023) Chinese Acad Sci Dalian Inst Chem Phys Dalian 116023 Peoples R China

3-Acylcamphors were synthesized in moderate yields by the condensation of camphor with esters using sodium hydride as a base.

关键词： camphor acylation 3-acylcamphor synthesis

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BIOTRANSFORMATION　OF　2α，5α，10β，14β－TETRA－ACETOXY－4（20），11－TAXADIENE　BY　THE　FUNGIJS　CUNNINGHAMELLA　ECHINULATA

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Chinese Chemical Letters 1996年第6期7卷 543-544页

作者： Shang hut HU xu Fang TIAN Wei Hua ZHU and Qi Cheng FANG(Institute of Materia Medica, Chinese Academy or Medical Sciencesand Peking Union Medical College, Beijing 1000050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050

?5α,10β,14β-Tetra-acctoxy-4(20).11-taxadicne (1) could be regioselectively transfonnedinto 6α 10β-dihydroxy-2α,5α,14β-triacetoxy-4(20). 11- taxadiene (2) by Cunninghamella echinnlata infair yield. 6βM.10β-Dihydroxy-2α,5α,14β-triacet 11-taxadienc (3). 10β-hydroxy-2α,5α,14β-triacetoxy-4(20).11-taxadiene (4), 10 β-hyboxy-4β,20-epoxy -2α,5α,14β-triacetoxy- tax - 11- ene (5)asminor prpducts were also isolated

关键词： TETRA OF FUNGIJS THE CUNNINGHAMELLA ECHINULATA BY ACETOXY BIOTRANSFORMATION

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Microbial Transformation of Taxoids and Synthesis of Taxoids with an Oxetane Ring

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Chinese Chemical Letters 1998年第1期9卷 39-43页

作者： Shang hut HU xu Fang TIAN Wen Yi HE Man KONG Di An SUN Qi Cheng FANG(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050) Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

Microbial trdrisformation of taxoids was inveStigared: taxoid 2 was transformed into 1β and 14β hydroxylated derivahves 3 and 4, unnatural taxoid 6 was transformed into 1β-hydroxy derivative 7 and 11(15-1) abeotaxa... 详细信息

关键词： Taxoid abeotaxane oxetane ring chemoenzymatic method

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太阳能集热砖热吸收性能的分析

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沈阳建筑大学学报（自然科学版） 1994年第1期18卷 21-24页

作者：李宝骏赵德华徐辉马乔矢

首先分析太阳能集热砖对太阳直射辐射、漫射辐射和反射辐射的吸收性能；然后根据测试数据绘出太阳能集热砖组成的集热墙的温度曲线，通过理论和实测证明太阳能集热砖的高吸热性能．

关键词：太阳能太阳辐射强度黑体集热砖直射辐射特隆伯墙

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Ultrafast Optical Kerr Effect of ConjugatedSilver Phenylacetylide Complex Oligomer

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Chinese Chemical Letters 1999年第9期10卷 793-794页

作者： Yi Hui xu Li LIN Jia Gang LUO Boon K. TEO Zong Ju XIA Ying Hua ZOU hut Ying CHEN (1Department of Chemistry. University of Hinois at Chicago. Chicago. IL 60680. USA2Department of Physics. Mesoscopic Physics Laboratory. Peking University,Beijing 1008713 Univ Illinois Dept Chem Chicago IL 60680 USA Beijing Univ Dept Phys Mesoscop Phys Lab Beijing 100871 Peoples R China Beijing Univ Dept Chem Inst Polymer Sci Beijing 100871 Peoples R China

Silver phenylacetylide oligomer was found to exhibit prominent third-order nonlinear optical property, with susceptibility chi((3)) of 2.4x10(-14) esu (10(-4) mol/L in 1:1 dimethyl sulfoxide/CHCl3 mixed solution) and second-order hyperpolarizability gamma of 5.18x10(-32) esu via heterodyned ultrafast optical Kerr effect measurement. It existed mainly as 1:1 complex oligomers and polymers as characterized by mass spectroscopy and elemental analysis etc.

关键词： silver phenylacetylide conjugated complex optical Kerr effect

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Efficient implementation of the Barnes-hut octree algorithm for Monte Carlo simulations of charged systems

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Science China Mathematics 2014年第7期57卷 1331-1340页

作者： GAN ZeCheng xu ZhenLi Department of Mathematics Institute of Natural Sciencesand MoE Key Lab of Scientific and Engineering ComputingShanghai Jiao Tong University

Computer simulation with Monte Carlo is an important tool to investigate the function and equilibrium properties of many biological and soft matter materials solvable in *** appropriate treatment of long-range electrostatic interaction is essential for these charged systems,but remains a challenging problem for large-scale *** develop an efficient Barnes-hut treecode algorithm for electrostatic evaluation in Monte Carlo simulations of Coulomb many-body *** algorithm is based on a divide-and-conquer strategy and fast update of the octree data structure in each trial move through a local adjustment *** test the accuracy of the tree algorithm,and use it to perform computer simulations of electric double layer near a spherical *** is shown that the computational cost of the Monte Carlo method with treecode acceleration scales as log N in each *** a typical system with ten thousand particles,by using the new algorithm,the speed has been improved by two orders of magnitude from the direct summation.

关键词： electrostatics Monte Carlo fast algorithms octree colloidal interfaces

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Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery

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Nano Research 2021年第11期14卷 4264-4273页

作者： Zhongyin Chen Tao Liao Lihui Wan Ying Kuang Chang Liu Junlin Duan Xiangyu xu Ziqiang xu Bingbing Jiang Cao Li Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and MinistryHubei Key Laboratory of Polymer MaterialsHubei UniversityWuhan430062China Glyn O.Philips Hydrocolloid Research Centre at hut Hubei University of TechnologyWuhan430068China

Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue.

关键词： charge-reversal hollow mesoporous silica nanoparticles near-infrared emissive carbon dots dual-stimuli responsive

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Orbital evolution of a planet with tidal dissipation in a restricted three-body system

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Research in Astronomy and Astrophysics 2019年第9期19卷 79-96页

作者： Wen-Lei Wang xue-Qing xu Xin-Hao Liao Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai200030China Key Laboratory of Planetary Sciences Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai200030China University of Chinese Academy of Sciences Beijing100049China

The angle between planetary spin and the normal direction of an orbital plane is supposed to reveal a range of information about the associated planetary formation and evolution. Since the orbit’s eccentricity and inclination oscillate periodically in a hierarchical triple body and tidal friction makes the spin parallel to the normal orientation of the orbital plane with a short timescale in an isolated binary system, we focus on the comprehensive effect of third body perturbation and tidal mechanism on the angle. Firstly, we extend the hut tidal model(1981) to the general spatial case, adopting the equilibrium tide and weak friction hypothesis with constant delay time, which is suitable for arbitrary eccentricity and any angle ? between the planetary spin and normal orientation of the orbital plane. Furthermore, under the constraint of angular momentum conservation, the equations of orbital and ratational motion are given. Secondly, considering the coupled effects of tidal dissipation and third body perturbation, and adopting the quadrupole approximation as the third body perturbation effect, a comprehensive model is established by this work. Finally, we find that the ultimate evolution depends on the timescales of the third body and tidal friction. When the timescale of the third body is much shorter than that of tidal friction, the angle ? will oscillate for a long time,even over the whole evolution;when the timescale of the third body is observably larger than that of the tidal friction, the system may enter stable states, with the angle ? decaying to zero ultimately, and some cases may have a stable inclination beyond the critical value of Lidov-Kozai resonance. In addition, these dynamical evolutions depend on the initial values of the orbital elements and may aid in understanding the characteristics of the orbits of exoplanets.

关键词： astrometry and celestial mechanics:celestial mechanics planet-star interactions planets and satellites:dynamical evolution and stability

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