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Au/Ag_(2)S dimeric nanostructures for highly specific plasmonic sensing of mercury(Ⅱ)

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Chinese Chemical Letters 2023年第3期34卷 142-147页

作者： Xinyi Liang xu du Ao Liu Zhixiong Cai Jingwen Li Maosheng Zhang Qingxiang Wang Jingbin Zeng College of Chemistry and Chemical Engineering and State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)Qingdao 266580China College of Chemistry and Environment Fujian Provincial Key Laboratory of Modern Analytical Science and Separation TechnologyMinnan Normal UniversityZhangzhou 363000China

Although many plasmonic nanosenosrs have been established for the detection of mercury(Ⅱ)(Hg^(2+)),few of them is feasible for analyzing natural samples with very complex matrices because of insufficient method *** address this challenge,we propose an epitaxial and lattice-mismatch approach to the synthesis of a unique Au/Ag_(2)S dimeric nanostructure,which consists of an Au segment with excellent plasmonic characteristics,and a highly stable Ag_(2)S portion with minimum solubility product (K_(sp)(Ag_(2)S)=6.3×10^(-50)).The detection relies on the chemical conversion of Ag_(2)S to HgS when reacting with Hg^(2+),resulting in a red shift in the absorption band of the connecting Au *** concurrent color changes of the solution from gray purple to dark green and finally to navy correlate well with Hg^(2+)concentration,thus enables UV-vis quantitation and a naked-eye readout of the Hg^(2+)*** method exhibits superior selectivity towards Hg^(2+) over other interfering ions tested because Hg^(2+) is the only ion that can react with Ag_(2)S to form HgS with even smaller solubility product (K_(sp)(HgS)=4×10^(-53)).The detection limit of this method is 1.21μmol/L,calculated by the signal-to-noise of *** practicability of the method was verified by analyzing the Hg^(2+)in sewage water samples without sample pretreatment with satisfactory recoveries (93.1%-102.8%) and relative standard deviations (1.38%-2.89%).We believe this method holds great potential for on-the-spot detection of Hg^(2+) in environmental water samples with complex matrices.

关键词： Au/Ag_(2)S dimeric nanoparticles Mercury ion Colorimetric detection High selectivity

Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1268-1280页

作者： xu-xu He Bang du Tao Wu Hao Shen Department of Surgery Fudan University Affiliated Zhongshan Hospital(Qingpu Branch)Shanghai 201700China Department of Surgery Anhui Provincial Red Cross Society HospitalHefei 230031Anhui ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Immunotherapy for advanced gastric cancer has attracted widespread attention in recent ***,the adverse reactions of immunotherapy and its relationship with patient prognosis still need further *** order to determine the association between adverse reaction factors and prognosis,the aim of this study was to conduct a systematic prognostic *** comprehensively evaluating the clinical data of patients with advanced gastric cancer treated by immunotherapy,a nomogram model will be established to predict the survival status of patients more *** To explore the characteristics and predictors of immune-related adverse reactions(irAEs)in advanced gastric cancer patients receiving immunotherapy with programmed death protein-1(PD-1)inhibitors and to analyze the correlation between irAEs and patient *** A total of 140 patients with advanced gastric cancer who were treated with PD-1 inhibitors in our hospital from June 2021 to October 2023 were *** were divided into the irAEs group and the non-irAEs group according to whether or not irAEs *** features,manifestations,and prognosis of irAEs in the two groups were collected and analyzed.A multivariate logistic regression model was used to analyze the related factors affecting the occurrence of irAEs,and the prediction model of irAEs was *** receiver operating characteristic(ROC)curve was used to evaluate the ability of different indicators to predict irAEs.A Kaplan-Meier survival curve was used to analyze the correlation between irAEs and *** Cox proportional risk model was used to analyze the related factors affecting the prognosis of *** A total of 132 patients were followed up,of whom 63(47.7%)developed *** looked at the two groups’clinical features and found that the two groups were statistically different in age≥65 years,Ki-67 index,white blood cell count,neutrophil count,and regulatory T cell(Treg)count

关键词： Advanced gastric cancer Prognostic analysis Immunotherapy Nomogram model

Green Synthesis of Chemically Recyclable Polyesters via Dehydrogenative Copolymerization of Diols

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Chinese Journal of Polymer Science 2023年第8期41卷 1206-1214,I0006页

作者： Wei-Ming xu Yuan-Dong Yu Meng-Xiang Ma Hui-du xu Rui-Qin Wang Yu-Peng Pan Ke-Qin Wu Wei-Ran Yang Chang-Guang Yao School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China School of Resource&Environment Nanchang UniversityNanchang 330031China Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Preparation of chemically recyclable polyesters by ring-opening polymerization(ROP)has made a considerable progress over the past few ***,this method involves cumbersome synthesis and minimal functional diversity of cyclic ***,it is of great significance to develop novel polymerization methods for direct polymerization of commercially available monomers to prepare recyclable polyesters with versatile *** present work,we report dehydrogenative copolymerization of commercialα,ω-diols to afford high molecular weight chemically recyclable aliphatic copolyesters(65.7 kg·mol^(-1))by using commercially available Milstein catalyst *** thermal properties of the obtained copolymers could be finely tuned by simply adjusting the feeding ratio of two *** incorporation of aliphatic or aromatic rings into polyester mainchain via copolymerization of 1,10-decanediol with 1,4-cyclohexanedimethanol and 1,4-benzenedimethanol could significantly improve the thermal properties of the resulting *** importantly,the obtained copolyesters were able to completely depolymerize back to original diols via hydrogenation by the same catalyst in solvent-free and mild conditions,thus offering a green and cost-effective route toward the preparation of widely used polyesters.

关键词： Chemically recyclable Dehydrogenative copolymerization Polyester Diol

A new scheme of climate-vegetation regionalization in the Hengduan Mountains Region

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Science China Earth Sciences 2024年第3期67卷 751-768页

作者： xueqin ZHANG Xiaoming xu Xiang LI Peng CUI du ZHENG Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of Sciences-Higher Education Commission of PakistanIslamabad 45320Pakistan

The Hengduan Mountains Region(HMR) is essential for the future ecological protection, clean energy production,Sichuan-Xizang and Yunnan-Xizang railways, and other major infrastructure projects in China. The distributions of climate and vegetation exhibit significant regional differentiation and vertical zonality due to the rugged longitudinal ranges and gorges and the complex disaster-prone environments in HMR. Therefore, it is urgent to develop the climate-vegetation regionalization in HMR to effectively satisfy the national requirements such as agricultural production and ecological protection, mountain disaster risk prevention, and major project construction. We here develop a new scheme of climate-vegetation regionalization with the latest demarcation outcome of HMR, the ground observation from 122 meteorological stations in HMR and its surrounding areas during 1990–2019, and the high-precision remote sensing data of land cover types. The new scheme first constructs the regionalization index system, fully considering the extraordinarily complicated geomorphic pattern of mountains and valleys, the scarcity of meteorological observations, and the remarkable differentiation of climate and vegetation in HMR. The system consists of three primary regionalization indices(i.e., days with daily average temperature steady above 10°C, aridity index, and main vegetation types, dividing the temperature zones, moisture regions, and vegetation subregions, respectively) and three auxiliary indices of the accumulated temperature above 10°C, and the temperatures in January and July. Then, the HMR is divided into five temperature zones, 20 moisture regions, and 55 vegetation subregions. Compared with previous regionalization schemes, the new scheme optimizes the climate spatial interpolation model of thin plate smoothing spline suitable for the unique terrain in HMR. Moreover, the disputed division index threshold between different climatic zones(regions) is scientifically clarifi

关键词： Climate-vegetation regionalization Thin plate smoothing spline(TPSS) GeoDetector Stepwise downscaling pane division method Hengduan Mountains Region

Assignment of unanchored scaffolds in genome of Brassica napus by RNA-seq analysis in a complete set of Brassica rapa-Brassica oleracea monosomic addition lines

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Journal of Integrative Agriculture 2019年第7期18卷 1541-1546页

作者： HUO Dong-ao ZHU Bin TIAN Gui-fu du xu-ye GUO Juan CAI Meng-xian School of Life Sciences Buckwheat Research CenterGuizhou Normal University

The economically valuable oil crop Brassica napus(AACC,2 n=38),which arose from interspecific hybridization between the diploid ancestors Brassica rapa(AA,2 n=20) and Brassica oleracea(CC,2 n=18),has a complex *** than 10% of the assembled sequences,most of which belong to the C subgenome,have not been anchored to the corresponding ***,a complete set of monosomic alien addition lines(MAALs,C1–C9) with each of the nine C-subgenome chromosomes added to the extracted A subgenome was obtained from the allotetraploid *** donor Oro,after the ancestral ***(RBR Oro) genome was *** MAALs effectively reduced the complexity of the *** ***,we determined the expression values of genes on unanchored scaffolds in the MAALs and RBR ***,multiple comparisons of these gene expression values were used to determine the affiliations of the nonanchored scaffolds on which the genes were *** total,54.68%(44.11 Mb) of the 80.67 Mb of non-anchored scaffolds belonging to the C subgenome were assigned to corresponding C *** work highlights the potential value of these MAALs in improving the genome quality of ***.

关键词： Brassica napus genome sequence RNA-seq monosomic alien addition lines scaffolds

Tongqiao Huoxue Decoction ameliorates learning and memory defects in rats with vascular dementia by up-regulating the Ca^(2+)-CaMKII-CREB pathway

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Chinese Journal of Natural Medicines 2015年第11期13卷 823-830页

作者： GE Chao-Liang WANG Xin-Ming HUANG Zhao-Gang XIA Quan WANG Ning xu du-Juan The First Affiliated Hospital of Anhui Medical University of Pharmacy Department the Third-Grade Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine Anhui College of Traditional Chinese Medicine Anhui Province Key Laboratory of Chinese Medicine Research and Development

The present study was aimed at determining the effects of Tongqiao Huoxue Decoction （TQHXD） on the Ca2＋-CaMKII-CREB pathway and the memory and learning capacities of rats with vascular dementia （VD）. The rat VD model was established by using an improved bilateral carotid artery ligation method. The Morris water maze experiment was used to evaluate the ethology of the VD rats following treatments with TQHXD at 3.01, 6.02, and 12.04 ***-1 per day for 31 days. At the end of experiment, the hippocampus were harvested and analyzed. Western blotting and RT-PCR were used to measure the expression levels of calmodulin-binding protein kinase II（CaMKII）, protein kinase A（PKA）, cAMP-response element binding protein（CREB）, and three N-methyl-D-aspart^c acid receptor subunits （NR1, NR2A, and NR2B）. Our results revealed that TQHXD could alleviate the loss of learning abilities and increase the memory capacity （P 〈 0.05 and P 〈 0.01 vs the model group, respectively）. The treatment with 6.02 and 12.04 ***-1 of TQHXD significantly up-regulated the Ca2＋-CaMKII-CREB pathway in the hippocampus. In conclusion, TQHXD showed therapeutic effects on a bilateral carotid artery ligation-induced vascular dementia model, through the up-regulation of calcium signalling oathwavs.

关键词： Tongqiao Huoxue Decoction Vascular dementia Calcium Learning and memory

Association analysis of grain traits with SSR markers between Aegilops tauschii and hexaploid wheat(Triticum aestivum L.)

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Journal of Integrative Agriculture 2015年第10期14卷 1936-1948页

作者： ZHAO Jing-lan WANG Hong-wei ZHANG Xiao-cun du xu-ye LI An-fei KONG Ling-rang State Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University Taishan Polytechnic

Seven important grain traits, including grain length（GL）, grain width（GW）, grain perimeter（GP）, grain area（GA）, grain length/width ratio（GLW）, roundness（GR）, and thousand-grain weight（TGW）, were analyzed using a set of 139 simple sequence repeat（SSR） markers in 130 hexaploid wheat varieties and 193 Aegilops tauschii accessions worldwide. In total, 1 612 alleles in Ae. tauschii and 1 360 alleles in hexaploid wheat（Triticum aestivum L.） were detected throughout the D genome. 197 marker-trait associations in Ae. tauschii were identified with 58 different SSR loci in 3 environments, and the average phenotypic variation value（R2） ranged from 0.68 to 15.12%. In contrast, 208 marker-trait associations were identified in wheat with 66 different SSR markers in 4 environments and the average phenotypic R2 ranged from 0.90 to 19.92%. Further analysis indicated that there are 6 common SSR loci present in both Ae. tauschii and hexaploid wheat, which are significantly associated with the 5 investigated grain traits（i.e., GA, GP, GR, GL, and TGW） and in total, 16 alleles derived from the 6 aforementioned SSR loci were shared by Ae. tauschii and hexaploid wheat. These preliminary data suggest the existence of common alleles may explain the evolutionary process and the selection between Ae. tauschii and hexaploid wheat. Furthermore, the genetic differentiation of grain shape and thousand-grain weight were observed in the evolutionary developmental process from Ae. tauschii to hexaploid wheat.

关键词： association analysis grain traits Aegilops tauschii Triticum aestivum SSR markers

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呼吸面罩产品技术审评关注点探讨

中国医疗器械信息 2024年第5期30卷 7-9页

作者：柴谦刘凤林王晓晨杜文新张梅杜旭楚姗姗山东省食品药品审评查验中心山东济南250000

呼吸面罩是患者进行无创呼吸机通气时气体进入患者体内的重要通道。文章基于相关产品的审评经验积累并结合《呼吸面罩注册审查指导原则》的编写工作对呼吸面罩产品在技术审评中的主要关注点进行解析,包括主要性能指标、生物相容性评价... 详细信息

呼吸面罩是患者进行无创呼吸机通气时气体进入患者体内的重要通道。文章基于相关产品的审评经验积累并结合《呼吸面罩注册审查指导原则》的编写工作对呼吸面罩产品在技术审评中的主要关注点进行解析,包括主要性能指标、生物相容性评价、产品消毒灭菌研究等内容,以期为呼吸面罩产品的注册申报及技术审评提供参考。

关键词：呼吸面罩产品技术要求生物相容性评价技术审评关注点

miR164c and miR168a regulate seed vigor in rice^∞

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Journal of Integrative Plant Biology 2020年第4期62卷 470-486页

作者： Yan Zhou Shiqi Zhou Liping Wang duo Wu Hailan Cheng xu du Dandan Mao Chunlai Zhang Xiaocheng Jiang College of Life Sciences Hunan Normal UniversityChangsha 410081China Guangxi Subtropical Crops Research Institute Nanning 530001China Shanxi Key Laboratory for Arid Crop Cultivation and Ecology Agronomy CollegeShanxi Agricultural UniversityJinzhong 030801China

Micro RNAs(miRNAs)are key regulators of gene expression in many important biological processes of ***,few miRNAs have been shown to regulate seed ***,we conducted microarray assays to analyze miRNA expression levels in seeds of the rice(Oryza sativa L.)cultivar *** showed significant differences in the expression of 11 miRNAs between artificially aged and untreated control *** these,osa-miR164c was transcriptionally upregulated,while osamiR168 a was downregulated in artificially aged seeds;this was verified by quantitative real-time PCR *** the same aging condition,osa-miR164c overexpression in OE164c transgenic seeds and osa-miR168a silencing in MIM168a transgenic seeds of the rice cultivar Kasalath led to lower germination rates,whereas osa-miR164c silencing Rin MIM164c and osa-miR168a overexpression in OE168a resulted in higher seed germination rates compared with wild-type ***,changes in cytomembrane permeability of seeds and in the expression level of osa-miR164c target genes(OsPM27 and OsPSK5)and osamiR168a target genes(OsAGO1 and OsPTR2)under aging conditions coincided with changes in seed vigor induced by osa-miR164c and osa-miR168 ***,genetic manipulation of miRNAs has important implications in the development of crop cultivars with high vigor and extended life span of seeds.

关键词： miR16 manipulation analysis.