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Epigastric pain syndrome: What can traditional Chinese medicine do? A randomized controlled trial of Biling Weitong Granules

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World Journal of Gastroenterology 2020年第28期26卷 4170-4181页

作者： Yan-Dong Wen Fang Lu Ying-Pan Zhao Ping Wang Qian Yang Jun-Xiang Li Hui-Zhen Li Li-Li Chi Zheng-Hua Zhou Yan-Ping tang Jin-Kang Xu Yang Zhao Xu-Dong tang Department of Gastroenterology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Institution of Clinical Pharmacology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Gastroenterology Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Department of Gastroenterology Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250China Department of Gastroenterology The Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Gastroenterology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Department of Gastroenterology Tianjin Nankai HospitalTianjin 300100China Department of Gastroenterology The Kunshan Hospital Affiliated to Nanjing University of Chinese MedicineKunshan 215300Jiangsu ProvinceChina

BACKGROUND Recent research suggests that although prokinetic agents,acid suppressors,and radical treatment for Helicobacter pylori infection may be effective in patients with functional dyspepsia(FD),a large proportion of patients still fail to respond to these treatments or may suffer from severe adverse *** traditional Chinese medicinal herbs can regulate the status of the entire body and have special advantages in the treatment of functional *** present study was designed to verify the efficacy of Biling Weitong Granules(BLWTG),a traditional Chinese medicinal herbal compound formula,in alleviating epigastric pain syndrome(EPS)in FD patients,in an attempt to provide an effective prescription for the clinical treatment of this *** To evaluate the clinical efficacy and safety of BLWTG in treating EPS in patients with *** In this multicenter,stratified,randomized,double-blind,placebo-controlled,parallel group clinical trial,eligible patients were randomized into the BLWTG and placebo groups who were treated for 6 *** indicators including the severity and frequency of EPS and the time to pain resolution and safety indicators including adverse events were observed and *** The baseline demographic data and clinical characteristics,such as epigastric pain symptoms,pain intensity,and frequency of attacks,were matched between the two groups before *** 6 wk of treatment and after the center effect was eliminated,the epigastric pain was significantly improved in 28.33%and 85.59%of the patients in the placebo and BLWTG groups,respectively(P<0.05).At 6 wk,the resolution rate of epigastric pain was 15%and 69.49%in the placebo and BLWTG groups,respectively(P<0.05).The differences of total FD clinical score between these two groups were significant(P<0.05)at 2,4,and 6 wk(P<0.05).The scores of each item and the total score in the Functional Digestive Disorders Quality of Life Questionnaire showed significant d

关键词： Biling Weitong Granules Compound formula Traditional Chinese medicine Functional dyspepsia Epigastric pain syndrome Randomized controlled trial

Irritable bowel syndrome:Epidemiology,overlap disorders,pathophysiology and treatment

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World Journal of Gastroenterology 2023年第26期29卷 4120-4135页

作者： Kai-Yue Huang Feng-Yun Wang Mi Lv Xiang-Xue Ma Xu-Dong tang Lin Lv Institute of Digestive Diseases Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091Chin Institute of Digestive Diseases Beijing Institute of Spleen and Stomach Disease of Traditional Chinese MedicineBeijing 100091China

Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disease with a significant impact on patients’ quality of life and a high socioeconomic burden. And the understanding of IBS has changed since the release of the Rome Ⅳ diagnosis in 2016. With the upcoming Rome Ⅴ revision, it is necessary to review the results of IBS research in recent years. In this review of IBS, we can highlight future concerns by reviewing the results of IBS research on epidemiology, overlap disorders, pathophysiology, and treatment over the past decade and summarizing the latest research.

关键词： Irritable bowel syndrome Overlap Pathophysiology Treatment

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京唐高炉炉芯温度的影响因素探析

炼铁 2021年第4期40卷 12-16页

作者：唐瑞峰王凯郑凯纪鹏飞王喜元首钢京唐钢铁联合有限责任公司炼铁作业部 063200 首钢京唐钢铁联合有限责任公司 063200

简要分析了京唐高炉炉芯温度的变化情况,重点分析了炉芯温度的影响因素。通过炉芯温度来判断炉缸工作状态,要以炉底中心区域热电偶为依据,对于特大型高炉来讲,炉芯温度应该是炉底中心热电偶温度及第一环热电偶温度,而不能简单地以炉底... 详细信息

简要分析了京唐高炉炉芯温度的变化情况,重点分析了炉芯温度的影响因素。通过炉芯温度来判断炉缸工作状态,要以炉底中心区域热电偶为依据,对于特大型高炉来讲,炉芯温度应该是炉底中心热电偶温度及第一环热电偶温度,而不能简单地以炉底中心热电偶的温度来判断。认为提高入炉风量对改善死焦堆有一定促进作用,降低渣比、降低炉渣黏度能够促进炉芯温度的提高,但持续的产能过低必然引起炉芯温度的下降。

关键词：特大型高炉炉芯温度死焦堆炉缸

Expert consensus on diagnosis and treatment of ulcerative colitis with integrated traditional Chinese and Western medicine:A nursing perspective

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Journal of Integrative Nursing 2023年第1期5卷 1-7页

作者： Bing XU Miao LIU Hairong HU Jing ZHANG Yanping HUANG Ling tang Department of Gastroenterology Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina Department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina Department of Gastroenterology Xiyuan HospitalChinese Academy of Traditional Chinese MedicineBeijingChina

Ulcerative colitis(UC)is a chronic nonspecific intestinal inflammatory disease of unclear etiology,characterized by continuous and diffuse inflammatory changes of colorectal *** recent years,the incidence rate of UC in China has increased year by year,but there is no effective cure method in Western *** Chinese medicine treatment based on syndrome differentiation has the unique advantages of simplicity,convenience,effectiveness,and low ***,integration of Chinese and Western medicine has become an important strategy for UC diagnosis and treatment,and has made significant progress in *** the basis of learning from a number of consensuses at home and abroad,combined with Chinese research results and the actual clinical situation of traditional Chinese and Western medicine,the UC group of the Chinese Association of Integrative Medicine has formulated the expert consensus on the diagnosis and treatment of UC with integrated traditional Chinese and Western *** this consensus,the pathogenesis,etiology and pathogenesis,diagnosis,integrated traditional Chinese and Western medicine treatment,and chronic disease management with integrated traditional Chinese and Western medicine for UC were recommended by *** article interprets the consensus from the perspective of nursing in order to provide reference basis for clinical nursing workers.

关键词： Consensus continuing care integrated traditional Chinese and Western medicine nursing nursing perspective traditional Chinese medicine ulcerative colitis

A Preparation Model of Chinese Medicine Decoction Placebo

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Chinese Journal of Integrative Medicine 2017年第8期23卷 631-634页

作者： BIAN Li-qun LI Bao-shuang LI Zhen-hua WANG Feng-yun WEN Yan-dong tang Xu-dong Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China

Chinese medicine（CM）decoction placebo is one of the key factors restricting the placebo-controlled clinical trial of *** this article,based on the analysis of the difficulties in preparing CM placebo,the production requirements for placebo were put ***,in accordance with clinical practices,a production method and evaluation process of CM decoction placebo was proposed,to provide a reference for clinical research.

关键词： placebo decoction Chinese medicine preparation model

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白内障患者的视功能及生存质量评价

重庆医科大学学报 2014年第11期39卷 1667-1671页

作者：肖旗彬周希瑗马华峰姚华陶金豆汤燕玲重庆医科大学附属第二医院眼科重庆400010

目的：评价重庆市复明工程白内障患者手术前后的主观视功能、生存质量。方法：通过流动白内障筛查选择接受手术的患者,应用世界卫生组织和美国眼科研究所为发展中国家所开发的生存质量（quality of life,QOL）量表、视功能（vision func... 详细信息

目的：评价重庆市复明工程白内障患者手术前后的主观视功能、生存质量。方法：通过流动白内障筛查选择接受手术的患者,应用世界卫生组织和美国眼科研究所为发展中国家所开发的生存质量（quality of life,QOL）量表、视功能（vision function,VF）量表在术前及术后3个月对患者进行问卷调查。由复明工程组织对患者进行免费白内障囊外摘除术联合后房型人工晶体植入术。结果：最终334名患者完成术前及术后3个月的调查。受调查患者平均年龄为（70.45±9.78）岁。手术前后VF、QOL比较差异均有统计学意义,手术后较手术前评分增高（P〈0.001）。严重盲（severe blindness,SB）组患者VF提高值分别高于视力损伤（vision impairment,VI）组和单眼盲（unilateral blindness,UL）组,差别均有统计意义（PVI=0.008,PUL=0.042）;SB组患者QOL提高值分别高于VI组和UL组,差别均有统计意义（P〈0.001）。不同年龄组VF提高值比较差异无统计学意义（F=0.397,P=0.755）,小于60岁年龄组和大于等于81岁年龄组的QOL提高值均高于60-69岁年龄组,差别均有统计意义（P〈60=0.038,P≥81=0.009）。结论：“重庆市百万贫困白内障复明工程”术后患者主观视功能和生存质量较术前提高,该项目手术效果良好,应该继续实施此类利民工程,同时也应该加强防盲手术过程的质量控制,并重视术后长期随访。

关键词：白内障手术视功能生存质量

基于生物信息学的心肌缺血/再灌注损伤与坏死性凋亡共表达基因分析

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中国医科大学学报 2024年第1期53卷 67-74页

作者：赵耀伟李宏玉马西元孟享泓唐强黑龙江中医药大学研究生院哈尔滨150006 黑龙江中医药大学附属第二医院康复科哈尔滨150001

目的基于生物信息学分析心肌缺血/再灌注损伤(MI/RI)与坏死性凋亡共表达基因并验证。方法基因表达图谱(GEO)数据库下载MI/RI表达谱数据(GSE67308和GSE19875),对GSE67308表达谱进行差异表达分析,筛选差异表达基因(DEGs)并进行基因集富分... 详细信息

目的基于生物信息学分析心肌缺血/再灌注损伤(MI/RI)与坏死性凋亡共表达基因并验证。方法基因表达图谱(GEO)数据库下载MI/RI表达谱数据(GSE67308和GSE19875),对GSE67308表达谱进行差异表达分析,筛选差异表达基因(DEGs)并进行基因集富分析和生物信号通路分析。对GSE67308表达谱数据进行免疫细胞浸润分析。利用分子标记数据库(MSigDB)和京都基因与基因组数据库(KEGG)检索坏死性凋亡相关基因,将DEGs与其交叉构建蛋白质-蛋白质相互作用(PPI)网络确定关键基因。通过单细胞测序分析平台分析关键基因在心脏各细胞类型中的表达情况,同时使用GSE19875数据集对关键基因表达进行验证。结果共鉴定出1054个DEGs,其中363个上调,691个下调。基因富集分析显示,DEGs功能主要与凋亡过程、免疫反应、细胞内信号转导调节相关;生物信号通路分析显示,DEGs主要参与TNF、NF-κB等信号通路的调控。免疫浸润分析结果表明,MI/RI心肌组织中自然杀伤细胞、单核细胞等免疫浸润程度高。PPI网络分析显示Il1b、TNF、Birc3、Ripk1是坏死性凋亡的关键基因。单细胞测序分析表明,白细胞中关键基因表达升高。GSE19875数据集中与对照组比较,MI/RI模型组中Il1b、TNF、Birc3、Ripk1表达显著升高(P<0.01)。结论MI/RI和参与调控坏死性凋亡的TNF信号通路、NF-κB信号通路高度相关;Il1b、TNF、Birc3、Ripk1是同时参与调节MI/RI和坏死性凋亡的关键基因;IL-1b、TNf、Birc3、Ripk1可能作为坏死性凋亡关键调节因子参与MI/RI过程。

关键词：心肌缺血/再灌注损伤坏死性凋亡共表达基因生物信息学

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分子信标在一类特殊的整数规划问题中的应用

合肥工业大学学报（自然科学版） 2022年第10期45卷 1334-1340页

作者：徐如解殷志祥唐震杨静崔建中王夕远安徽理工大学数学与大数据学院安徽淮南232001 上海工程技术大学数理与统计学院上海201620 安徽理工大学电气与信息工程学院安徽淮南232001 淮南联合大学计算机系安徽淮南232001

分子信标具有高灵敏度、易操作以及检测成本低等优点,因此广泛地应用于DNA计算中;此外,金(Au)表面对荧光团具有猝灭能力,可以取代猝灭基团。文章将分子信标固定在Au表面上,构建一种高灵敏的分子信标模型,该模型可用于求解一类特殊的整... 详细信息

分子信标具有高灵敏度、易操作以及检测成本低等优点,因此广泛地应用于DNA计算中;此外,金(Au)表面对荧光团具有猝灭能力,可以取代猝灭基团。文章将分子信标固定在Au表面上,构建一种高灵敏的分子信标模型,该模型可用于求解一类特殊的整数规划问题。首先将变量映射成固定在Au表面上的分子信标,且设计出不同的输入链表示变量的不同取值;其次根据变量的取值向试管中加入不同的输入链;在输入链加入后,试管中出现不同荧光信号,然后根据荧光信号的显示来判断约束条件的可行解;最后搜寻问题的最优解。与传统的分子信标模型相比,该模型允许反复清洗过程,可用于大规模检测,更易于应用于疾病监测、医药检测中。

关键词：分子信标荧光信号整数规划 Au表面 DNA计算

Evidence-Based Chinese Medicine Clinical Practice Guideline for Stomach Pain in Hong Kong

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Chinese Journal of Integrative Medicine 2017年第10期23卷 793-800页

作者： ZHONG Linda LD SHI Nan-nan DAI Liang ZIEA Tat Chi NG Bacon tang Xu-dong BIAN Zhao-xiang LU Ai-ping Hong Kong Chinese Medicine Study Centre Hong Kong Baptist University Hong Kong SAR China School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR China Institute of Basic Research in Clinical Medicine China Academy of Traditional Chinese Medicine Beijing (100091) China Department of Chinese Medicine Hong Kong Hospital Authority Hong Kong SAR China Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing (100091) China

Stomach pain in Chinese medicine（CM） is a very common disorder in clinical practice and it has been listed as one of the pilot three conditions in Hong Kong to develop evidence-based CM clinical practice guidelines（CM CPGs）. The aim of this stomach Pain CPG is to summarize the treatment methods of stomach pain with CM and evaluate reasonably, then to guide local licensed CM practitioners and provide beneficial reference for social medical decision makers and patients. In this manuscript, we defined stomach pain in CM and the category of chronic gastritis in Western medicine. The clinical manifestation, CM pattern classification, and CM intervention including herbal medicine treatment based on pattern differentiation, symptomatic treatment, acupuncture treatment, regulation and nursing were illustrated.

关键词： clinical practice guideline Chinese medicine pattern Chinese herbal medicine stomach pain