Epigastric pain syndrome: What can traditional Chinese medicine do? A randomized controlled trial of Biling Weitong Granules
作者机构：Department of GastroenterologyXiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Institution of Clinical PharmacologyXiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of GastroenterologyHebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Department of GastroenterologyDongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China Department of GastroenterologyThe Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of GastroenterologyFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Department of GastroenterologyTianjin Nankai HospitalTianjin 300100China Department of GastroenterologyThe Kunshan Hospital Affiliated to Nanjing University of Chinese MedicineKunshan 215300Jiangsu ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2020年第26卷第28期
页 面：4170-4181页
核心收录：
学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床]
基 金：National New Drug Innovation Program,No.2017ZX09304003 Special Research on Modernization of Traditional Chinese Medicine in the National Key Research and Development Program in the 13th Five-Year Plan Demonstrative Research,No.2017YFC1703703.Institutional review board statement:This study was approved by the IRB of Xiyuan Hospital of China Academy of Chinese Medical Sciences(No.2016XL011)
主 题：Biling Weitong Granules Compound formula Traditional Chinese medicine Functional dyspepsia Epigastric pain syndrome Randomized controlled trial
摘 要：BACKGROUND Recent research suggests that although prokinetic agents,acid suppressors,and radical treatment for Helicobacter pylori infection may be effective in patients with functional dyspepsia(FD),a large proportion of patients still fail to respond to these treatments or may suffer from severe adverse *** traditional Chinese medicinal herbs can regulate the status of the entire body and have special advantages in the treatment of functional *** present study was designed to verify the efficacy of Biling Weitong Granules(BLWTG),a traditional Chinese medicinal herbal compound formula,in alleviating epigastric pain syndrome(EPS)in FD patients,in an attempt to provide an effective prescription for the clinical treatment of this *** To evaluate the clinical efficacy and safety of BLWTG in treating EPS in patients with *** In this multicenter,stratified,randomized,double-blind,placebo-controlled,parallel group clinical trial,eligible patients were randomized into the BLWTG and placebo groups who were treated for 6 *** indicators including the severity and frequency of EPS and the time to pain resolution and safety indicators including adverse events were observed and *** The baseline demographic data and clinical characteristics,such as epigastric pain symptoms,pain intensity,and frequency of attacks,were matched between the two groups before *** 6 wk of treatment and after the center effect was eliminated,the epigastric pain was significantly improved in 28.33%and 85.59%of the patients in the placebo and BLWTG groups,respectively(P0.05).At 6 wk,the resolution rate of epigastric pain was 15%and 69.49%in the placebo and BLWTG groups,respectively(P0.05).The differences of total FD clinical score between these two groups were significant(P0.05)at 2,4,and 6 wk(P0.05).The scores of each item and the total score in the Functional Digestive Disorders Quality of Life Questionnaire showed significant d
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