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THE DEVELOPMENT OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE IN CHINA

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Bulletin of the Chinese Academy of Sciences 1995年第4期9卷 330-332页

作者： Chen Keji(xiyuan hospital, China Academy of Traditional Chinese Medicine)

Traditional Chinese Medicine is one of the scientific treasures of China. We are very fortunate to be able to apply modern scientific knowledge and methodology to inherit, reorganize and promote integrated traditional Chinese and Western medicine (TCMWM). For the past 45 years, all Chinese medical researchers and practitioners have worked diligently and achieved many

关键词：用材

Effect of combination of extracts of ginseng and ginkgo biloba on acetylcholine in amyloid beta-protein-treated rats determined by an improved HPLC

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Acta Pharmacologica Sinica 2004年第9期 16-21页

作者： Jian-xun LIU, Wei-hong CONG, Li XU, Jian-nong WANG Research Center, xiyuan hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China

AIM: To determine the concentration of acetylcholine (ACh) in amyloid beta-protein (Aβ) treated rats and offer a method determining ACh as well. METHODS: A 1-month combination of extrats of ginseng and ginkgo biloba (Naoweikang) ig administration to rats was performed daily after bilateral injection of Aβ1-40 (4 g/L, 1μL for each side) into hippocampus. After

关键词： ginseng ginkgo biloba acetylcholine high pressure liquid chromatography amyloid beta-protein

Cardioprotective effects of diltiazem reevaluated by a novel myocardial ischemic model in Chinese miniature swine

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Acta Pharmacologica Sinica 2007年第1期28卷 52-57页

作者： Jian-xun LIU~2 Zhen YU Xin-zhi LI Jian-hua FU Xiao-hong SHANG Ai-guo YAN Yue SHI Yan-lei MA Department of Pharmacology,xiyuan hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China Department of Pharmacology Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing China

Aim:To develop a new model of myocardial ischemia in Chinese miniature swineand reevaluate the cardioprotective effects of ***:Myocardialischemia was induced by injecting self-embolus into the left anterior descending(LAD)coronary artery in qualified miniature ***(5 ***-1.d-1)wasorally administered to the swine by mixing into normal pig diet from 1 to 6 d afterself-embolus *** coronary angiography,30 point body surface electro-cardiogram(BS-ECG),hemodynamics,biochemistry,quantitative histology andpathohistology were determined 6 d after self-embolus ***:Embo-lization occurred in the LAD coronary artery of the Chinese miniature swine in-jected by *** were significant myocardial ischemia and largecardiac muscle infarction in the Chinese miniature swine,which were accompa-nied with increased BS-ECG,decreased hemodynamic indexes of the cardiac output,cardiac index,left cardiac work and left cardiac work index,and increased systemicvascular resistance *** analysis revealed myocardial degen-eration,necrosis,fibrosis,inflammatory cell infiltration and granulation tissuehyperblastosis(n=6).Diltiazem diminished the extent of the LAD embolism,ame-liorated myocardial ischemia,improved the hemodynamic indexes,increased theplasma superoxide dismutase activity,decreased the plasma malondialdehydecontent,narrowed the myocardial ischemic area and weakened the pathohistologicaldamage in the cardiac muscle(n=6).Conclusion:Myocardial ischemia induced byinjecting self-embolus into the LAD coronary artery in Chinese miniature swine isquite close to clinical pathophysiological *** is effective toinhibit the myocardial ischemia and restore the heart function in this novel model.

关键词： myocardial ischemia diltiazem animal models Chinese miniature swine

Clinical Significance of Inflammation Factors in Acute Coronary Syndrome from Pathogenic Toxin

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Chinese Journal of Integrative Medicine 2009年第4期15卷 307-312页

作者：冯妍张京春郗瑞席 Department of Cardiology Xiyuan HospitalChina Academy of Chinese Medical Sciences Department of Cardiology iyuan HospitalChina Academy of Chinese Medical Sciences

The inflammation factors and roles of them in acute coronary syndrome(ACS)were explored. The similarity between the theory of pathogenic toxin in Chinese Medicine and the inflammation response theory in ACS was *** ex... 详细信息

关键词： pathogenic toxin inflammation factors acute coronary syndrome

Differential Gene Expression Profiles in Coronary Heart Disease Patients of Blood Stasis Syndrome in Traditional Chinese Medicine and Clinical Role of Target Gene

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Chinese Journal of Integrative Medicine 2009年第2期15卷 101-106页

作者：马晓娟殷惠军陈可冀 Department of Cardiovascular Disease Xiyuan HospitalChina Academy of Traditional Chinese Medicine

Objective:To investigate the differential gene expression profiles in coronary heart disease(CHD) patients of blood-stasis syndrome(BSS) by oligonucleotide microarray technique,and the clinical significance of target ***:Subjects were assigned to CHD patients with BSS(n=8),CHD patients without BSS (n=8),and BSS patients without CHD(n=8) based on coronary angiography and the diagnostic criteria of BSS. The sex- and age-matched healthy volunteers(n=8) were enrolled as the control *** blood s...

关键词： coronary heart disease blood-stasis syndrome differential gene expression profile target gene

Study of the Relationship between Carotid Intima-media Thickness and Traditional Chinese Medicine Syndrome of Dyslipidemia

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Chinese Journal of Integrative Medicine 2009年第2期15卷 112-116页

作者：雷燕王振华赵浩刘剑刚 xiyuan hospital China Academy of Chinese Medical Sciences

Objective:The study aimed to explore the relationship between the carotid intima-media thickness (IMT),lipids,high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy) and other indices of laboratory and the traditional Chinese medicine(TCM) syndrome of ***:A total of 152 dyslipidemia patients and 8 healthy people(taken as the control group) were *** to the theory of the TCM syndrome,152 dyslipidemia patients were assigned to 4 groups:the stagnation of phlegm(SP) group,t...

关键词： dyslipidemia traditional Chinese medicine syndrome carotid ultrasonic test carotid intimamedia thickness triglyceride blood rheology

Appraisal of the Prognosis in Patients with Acute Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention

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Chinese Journal of Integrative Medicine 2009年第3期15卷 236-240页

作者：马晓娟殷惠军陈可冀 Department of Cardiovascular Diseases xiyuan hospital China Academy of Chinese Medical Sciences

Acute myocardial infarction(AMI) is still the leading factor causing crippling and death in cardiovascular *** coronary intervention(PCI) can significantly reduce inpatient mortality and incidence of *** owing to the existence of restenosis,in-stent thrombosis,etc.,recurrent post-PCI cardiovascular events and high repeatability of hospitalization,as well as its crippling rate and mortality, remain a serious threat to the society and the patients ***,the appraisal ...

关键词： myocardial infarction percutaneous coronary intervention prognosis

The Mechanical Research of Yuxingeng Fluid on Early Ventricular Remodeling in Wistar Rats with Acute Myocardial Infarction (AMI)

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The Mechanical Research of Yuxingeng Fluid on Early Ventricu...

Parkinson's Disease Prevented and Treated with Chinese Medicine

全国中青年中西医结合学术（英语）交流会议

作者： Shi Dazhuo, Dong Guoju, Liu Jiangang xiyuan hospital, China Academy of Traditional Chinese Medicine (Beijing, 100091)

Objective To examine the acting mechanism of Yuxingeng fluid(YXGF) on early ventricular remodeling in wistar rats with acute myocardial infarction(AMI) by measuring the cardiac index(CI),left ventricular weight(LVW) and cardiac myocyte dimension and observing the concentration of endothelin(ET) and angiotensin II (Ang II) in the plasma and myocardium. Method: AMI models were established by ligaturing left anterior descending coronary artery and the rats with AMI were randomly divided into 6 groups: namely, model group, sham-operated group, captopril group, high-dose YXGF group, middle-dose YXGF group and low-dose group. From the next day after modeling, the rats were given YXGF through the stomach tube and lasted for 4 weeks. And then, CI, LVW and concentration of ET and Ang II in the plasma and myocardium were tested. Results: Comparing with model control group, high-dose YXGF, middle-dose YXGF and captopril can significantly decrease CI, LVW, cardiac cell dimension and content of ET and Ang II in both plasma and myocardium (P<0.05 and P<0.01). Conclusion: YXGF can remarkably reduce the LVW, CI and concentration of ET and Ang II, lowering concentration of ET and Ang II may be one of mechanisms intervening the pathological course of the early ventricular remodeling in rats with AMI.

关键词： YXGF acute myocardial infarction early ventricular remodeling

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Parkinson's Disease Prevented and Treated with Chinese Medic...