Cardioprotective effects of diltiazem reevaluated by a novel myocardial ischemic model in Chinese miniature swine
Cardioprotective effects of diltiazem reevaluated by a novel myocardial ischemic model in Chinese miniature swine作者机构：DepartmentofPharmacologyXiyuanHospitalChinaAcademyofChineseMedicalSciencesBeijing100091China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2007年第28卷第1期
页 面：52-57页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：Project supported by the National High Technology Research and Development Program of China(863 Program No 2002AA2Z346B)
主 题：myocardial ischemia diltiazem animal models Chinese miniature swine
摘 要：Aim:To develop a new model of myocardial ischemia in Chinese miniature swineand reevaluate the cardioprotective effects of ***:Myocardialischemia was induced by injecting self-embolus into the left anterior descending(LAD)coronary artery in qualified miniature ***(5 ***-1.d-1)wasorally administered to the swine by mixing into normal pig diet from 1 to 6 d afterself-embolus *** coronary angiography,30 point body surface electro-cardiogram(BS-ECG),hemodynamics,biochemistry,quantitative histology andpathohistology were determined 6 d after self-embolus ***:Embo-lization occurred in the LAD coronary artery of the Chinese miniature swine in-jected by *** were significant myocardial ischemia and largecardiac muscle infarction in the Chinese miniature swine,which were accompa-nied with increased BS-ECG,decreased hemodynamic indexes of the cardiac output,cardiac index,left cardiac work and left cardiac work index,and increased systemicvascular resistance *** analysis revealed myocardial degen-eration,necrosis,fibrosis,inflammatory cell infiltration and granulation tissuehyperblastosis(n=6).Diltiazem diminished the extent of the LAD embolism,ame-liorated myocardial ischemia,improved the hemodynamic indexes,increased theplasma superoxide dismutase activity,decreased the plasma malondialdehydecontent,narrowed the myocardial ischemic area and weakened the pathohistologicaldamage in the cardiac muscle(n=6).Conclusion:Myocardial ischemia induced byinjecting self-embolus into the LAD coronary artery in Chinese miniature swine isquite close to clinical pathophysiological *** is effective toinhibit the myocardial ischemia and restore the heart function in this novel model.
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