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Big Roles of Small Kinases:The Complex Functions of Receptor-Like Cytoplasmic Kinases in Plant Immunity and Development

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Journal of Integrative Plant Biology 2013年第12期55卷 1188-1197页

作者： Wenwei Lin xiyu ma Libo Shan Ping He Department of Plant Pathology and Microbiology and Institute for Plant Genomics and BiotechnologyTexas A&M UniversityCollege Station Department of Biochemistry and Biophysics and Institute for Plant Genomics and BiotechnologyTexas A&M UniversityCollege Station

Plants have evolved a large number of receptor-like cytoplasmic kinases （RLCKs） that often functionally and physically associate with receptor-like kinases （RLKs） to modulate plant growth, development and immune responses. Without any apparent extracellular domain, RLCKs relay intracellular signaling often via RLK complex-mediated transphosphorylation events. Recent advances have suggested essential roles of diverse RLCKs in concert with RLKs in regulating various cellular and physiological responses. We summarize here the complex roles of RLCKs in mediating plant immune responses and growth regulation, and discuss specific and overlapping functions of RLCKs in transducing diverse signaling pathways.

关键词： Phosphorylation plant development plant immunity receptor-like cytoplasmic kinases.

Modulating Co-Co bonds average length in Co_(0.85)Se_(1-x)S_(x) to enhance conversion reaction for potassium storage

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Journal of Energy Chemistry 2024年第4期91卷 111-121页

作者： Daming Chen Yuchun Liu Pan Feng Xiao Tao Zhiquan Huang xiyu Zhang Min Zhou Jian Chen Jiangsu Key Laboratory of Advanced Metallic materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189JiangsuChina Hefei National Laboratory for Physical Sciences at the Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026AnhuiChina

While alloying transition metal chalcogenides(TMCs)with other chalcogen elements can effectively improve their conductivity and electrochemical properties,the optimal alloying content is still *** this study,we study the influence of dopant concentration on the chemical bonds in TMC and reveal the associated stepwise conversion reaction mechanism for potassium ion *** to density function theory calculations,appropriate S-doping in Co0.85Se(Co_(0.85)Se_(1-x)S_(x))can reduce the average length of Co-Co bonds because of the electronegativity variation,which is thermodynamically favourable to the phase transition *** optimal Se/S ratio(x=0.12)for the conductivity has been obtained from experimental *** assembled as an anode in potassium-ion batteries(PIBs),the sample with optimized Se/S ratio exhibits extraordinary electrochemical *** rate performance(229.2 ma h g^(-1)at 10 A g^(-1))is superior to the state-of-the-art *** assembled with Prussian blue(PB)as a cathode,the pouch cell exhibits excellent performance,demonstrating its great potential for ***,the stepwise K+storage mechanism caused by the coexistence of S and Se is revealed by in-situ X-ray diffraction and ex-situ transmission electron microscopy ***,this work not only provides an effective strategy to enhance the electrochemical performance of transition metal chalcogenides but also reveals the underlying mechanism for the construction of advanced electrode materials.

关键词： Co_(0.85)Se_(1-x)S_(x) Co-Co bonds Phase transition reactions Optimal Se/s Potassium ion batteries

Enhancing hydrogen evolution and oxidation kinetics through oxygen insertion into nickel lattice

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Journal of Energy Chemistry 2024年第8期95卷 529-539,I0012页

作者： Wanli Liang xiyu Gong Jinchang Xu Zixuan Dan Fanyan Xie Hulei Yu Hao-Fan Wang Yanshuo Jin Hongjuan Wang Yonghai Cao Hui Meng Hao Yu School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510641GuangdongChina Siyuan Laboratory Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Key Laboratory of Optical Fiber Sensing and CommunicationsDepartment of PhysicsJinan UniversityGuangzhou 510632GuangdongChina GBA Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhou 510700GuangdongChina Instrumental Analysis&Research Center Sun Yat-sen UniversityGuangzhou 510275GuangdongChina School of materials Science and Engineering South China University of TechnologyGuangzhou 510641GuangdongChina

Nickel-based materials,including metallic Ni and Ni oxide,have been widely studied in the exploration of non-precious-metal hydrogen electrocatalysts,but neither pure Ni nor NiO is ideal for the hydrogen evolution reaction(HER)and hydrogen oxidation reaction(HOR).In this paper,an oxygen insertion strategy was applied on nickel to regulate its hydrogen electrocatalytic performance,and the oxygen-inserted nickel catalyst was successfully obtained with the assistance of tungsten dioxide support(denoted as O-Ni/WO_(2)).The partial insertion of oxygen in Ni maintains the face-centered cubic arrangement of Ni atoms,simultaneously expanding the lattice and increasing the lattice ***,the adsorption strength of^(*)H and^(*)OH on Ni is optimized,thus resulting in superior electrocatalytic performance of0-Ni/WO_(2)in alkaline HER/*** Tafel slope of O-Ni/WO_(2)@NF for HER is 56 mV dec^(-1),and the kinetic current density of O-Ni/WO_(2)for HOR reaches 4.85 ma cm^(-2),which is ahead of most currently reported *** proposed strategy of inserting an appropriate amount of anions into the metal lattice could provide more possibilities for the design of high-performance catalysts.

关键词： Hydrogen evolution Hydrogen oxidation Nickel Oxygen insertion Adsorption free energy

Network analysis of suicide ideation and depression-anxiety symptoms among Chinese adolescents

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General Psychiatry 2024年第2期37卷 216-223页

作者： Shuyin Xu Yumeng Ju xiyu Wei Wenwen Ou Mohan ma Guanyi Lv Xiaotian Zhao Yaqi Qin Yunjing Li Liang Li Mei Huang Siqi Yang Yimei Lu Yafei Chen Junwu Liu Jin Liu Bangshan Liu Yan Zhang Department of Psychiatry National Clinical Research Center for Mental Disordersand National Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangshaHunanChina Mental Health Institute of Central South University China National Technology Institute on Mental DisordersHunan Technology Institute of PsychiatryHunan Key Laboratory of Psychiatry and Mental HealthHunan Medical Center for Mental HealthChangshaHunanChina

Background The co-occurrence of depression and anxiety among adolescents is typically associated with suicide *** The study aimed to investigate the symptom-level relationship between suicide ideation and the comorbidity of depression and *** 1501 adolescents aged 12-19 years were assessed using the Patient Health Questionnaire(PHQ-9)and the Generalized Anxiety Disorder Scale,and 716 adolescents who scored≥5 on both scales were selected as *** analysis was used to identify the network structure of depressive symptoms and anxiety *** were categorised into either the suicide ideation or non-suicide ideation groups based on their scoring on the suicide-related item in PHQ-9.A comparison was made between the depression-anxiety symptom networks of the two ***‘Restlessness’,‘sad mood’and‘trouble relaxing’were the most prominent central symptoms in the depression-anxiety symptom network,and‘restlessness’,‘nervousness’and‘reduced movement’were the bridge symptoms in this network.‘Sad mood’was found to be directly related to‘suicide ideation’with the highest *** network structure was significantly different in properties between the suicide ideation group and the non-suicide ideation group,with‘restlessness’and‘sad mood’exhibiting significantly higher influence in the network of the suicide ideation group than that in the non-suicide ideation *** Restlessness and sad mood could be targeted for the intervention of depression-anxiety symptoms among adolescents with suicide ideation.

关键词： symptoms adolescent assessed

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颗粒流变破碎与堆石料流变应变计算

水力发电 2023年第10期49卷 77-84,91页

作者：迟世春郭宇马锡钰贾宇峰大连理工大学建设工程学部工程抗震研究所辽宁大连116024

流变是堆石坝的主要变形,当前主要采用室内三轴流变试验加以测量,并通过拟合试验结果得到流变经验公式。但流变试验的时间长,且试验工况要覆盖坝料种类、级配与密度变化并需满足插值方法要求,实际操作困难,简化试验工况则影响插值计算... 详细信息

流变是堆石坝的主要变形,当前主要采用室内三轴流变试验加以测量,并通过拟合试验结果得到流变经验公式。但流变试验的时间长,且试验工况要覆盖坝料种类、级配与密度变化并需满足插值方法要求,实际操作困难,简化试验工况则影响插值计算精度。为此,提出一种计算堆石料流变的简化方法,设想可进行加载速率足够慢的三轴试验,使试样中凡受力大于长期强度的颗粒有时间充分破碎,得到的应力-应变-体变曲线则包含流变应变,与不含流变的常规三轴试验曲线比较,得到流变应变。算例计算表明,通过计算得到的流变应变与试验值相当,流变模型参数符合预期。

关键词：堆石料流变变形颗粒破碎颗粒长期强度计算方法简化

基于电子鼻和BP神经网络对‘黑珍珠’鲜食玉米产地的区分和识别

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食品工业科技 2024年第13期45卷 239-245页

作者：马洪江郝曦煜高铭于有强杨书恒刘士伟马喜山王文鑫段盛林王雪黑龙江北纬四十七绿色有机食品有限公司黑龙江齐齐哈尔161532 黑龙江飞鹤乳业有限公司北京100016 中国食品发酵工业研究院有限公司北京100015

以‘黑珍珠’鲜食玉米为研究对象,采用电子鼻技术分别测定了黑龙江、陕西两大产区共计200个鲜食玉米样品的气味传感器响应值原始数据,通过主成分分析(Principal component analysis,PCA)、判别因子分析(Discriminant function analysis,... 详细信息

以‘黑珍珠’鲜食玉米为研究对象,采用电子鼻技术分别测定了黑龙江、陕西两大产区共计200个鲜食玉米样品的气味传感器响应值原始数据,通过主成分分析(Principal component analysis,PCA)、判别因子分析(Discriminant function analysis,DFA)对不同产地鲜食玉米的挥发性风味进行了区分,采用软独立建模分析(Soft independent modeling class analogy,SIMCA)建立了黑龙江‘黑珍珠’鲜食玉米的判定模型,并通过Pytorch软件建立了反向传播神经网络(Back propagation neural network,BP神经网络)模型,对不同产地的‘黑珍珠’鲜食玉米进行鉴别区分。结果表明,不同产地的‘黑珍珠’鲜食玉米的挥发性风味虽有相似之处但具有明显的产地特征,SIMCA模型可实现对未知样品是否来自黑龙江产区的有效识别(正确率为97%),BP神经网络模型则可对未知产地的‘黑珍珠’鲜食玉米样品进行产地预测及鉴别,平均正确率达99.44%。采用电子鼻技术结合BP神经网络模型可以准确的区分和识别‘黑珍珠’鲜食玉米产地。

关键词：鲜食玉米电子鼻主成分分析软独立建模 BP神经网络产地鉴别

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中国监理企业面临的环境风险及应对策略

水电与新能源 2013年第5期27卷 6-9页

作者：马锡渝湖北清江水电开发有限责任公司湖北长阳443503

针对当前中国工程建设监理企业在现实中所面临的一些尴尬局面,从法律法规、建设主管部门和建设单位、施工企业、监理企业内部等多维度、多角度分析中国监理企业面临的风险因素,进而从企业自律、调整战略思维、强化管理、培养稳定核心人... 详细信息

针对当前中国工程建设监理企业在现实中所面临的一些尴尬局面,从法律法规、建设主管部门和建设单位、施工企业、监理企业内部等多维度、多角度分析中国监理企业面临的风险因素,进而从企业自律、调整战略思维、强化管理、培养稳定核心人才等方面提出了监理企业的应对策略。

关键词：工程监理风险策略

2011-2022年北京某医院15岁及以上住院结核性脑膜炎患者的变化趋势及流行病学特征分析

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疾病监测 2024年第4期39卷 427-432页

作者：黄麦玲李波尚希钰曹玉清史珂杜亚东李琦马艳首都医科大学附属北京胸科医院北京101149 中国中医科学院中医临床基础医学研究所北京100700 新乡医学院第一附属医院河南新乡453100

目的分析结核性脑膜炎(TBM)的流行病学特征及其不同特征患者的变化趋势,为今后制定相关防治策略提供参考。方法收集2011-2022年首都医科大学附属北京胸科医院电子病历系统中15岁及以上住院患者中的所有TBM病例(包括确诊、临床诊断、疑... 详细信息

目的分析结核性脑膜炎(TBM)的流行病学特征及其不同特征患者的变化趋势,为今后制定相关防治策略提供参考。方法收集2011-2022年首都医科大学附属北京胸科医院电子病历系统中15岁及以上住院患者中的所有TBM病例(包括确诊、临床诊断、疑似病例),采用描述性统计方法分析TBM不同分类、性别、年龄、合并症、并发症及合并其他结核患者占比的变化趋势。结果住院结核病患者33807例,TBM为1176例(3.48%),其中,男性641例(54.51%)、老年人226例(占19.22%)、农牧民438例(占37.24%)、存在合并症患者682例(占57.99%),并发其他结核患者1060例(占90.14%)、发生并发症患者769例(占65.31%),确诊患者仅190例(占16.16%)。TBM占比总体呈下降趋势(4.76%~2.77%),老年TBM(10.00%~40.22%)、发生并发症(54.00%~67.39%)、合并症(40.00%~82.61%)及确诊TBM(5.00%~25.00%)患者比例呈上升趋势。结论结核性脑膜炎患者中,老年患者占比逐年增高,合并症及并发症发生率居高不下。因此,应提高对老年结核性脑膜炎的重视程度,加强对结核性脑膜炎合并症及并发症的管理。

关键词：结核病结核性脑膜炎流行病学特征

基于网络药理学及分子对接探讨青风藤治疗痛风性关节炎的作用机制

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现代药物与临床 2024年第5期39卷 1155-1162页

作者：杨熹予杨舒然张晋源马浩天王亦冰赵振宇天津中医药大学天津301600 天津医科大学朱宪彝纪念医院天津300000 军事科学院军事医学研究院天津300041

目的基于网络药理学及分子对接技术探讨青风藤治疗痛风性关节炎的作用机制。方法运用中药系统药理学数据库与分析平台(TCMSP),获取青风藤的活性成分,并通过SwissTarget Prediction数据库预测其靶点。使用GeneCards、OMIM、DisGenet、TT... 详细信息

目的基于网络药理学及分子对接技术探讨青风藤治疗痛风性关节炎的作用机制。方法运用中药系统药理学数据库与分析平台(TCMSP),获取青风藤的活性成分,并通过SwissTarget Prediction数据库预测其靶点。使用GeneCards、OMIM、DisGenet、TTD数据库获取与痛风性关节炎相关的靶点,通过维恩图找到两者的共同靶点,并将其输入STRING平台和Cytoscape 3.9.1构建蛋白质相互作用(PPI)网络图。利用DAVID数据库对共同靶点进行基因本体(GO)生物学富集分析和京都基因与基因组百科全书(KEGG)通路富集分析。借助AutoDockTools分子对接和可视化处理。结果获得青风藤6种有效活性成分,药物与疾病靶点交集后获得84个关键靶点,PPI显示核心靶点有前列腺素内过氧化物合酶2(PTGS2)、过氧化物酶体增殖物激活受体G(PPARG)、转录因子AP-1(JUN)、Toll样受体4(TLR4)、一氧化氮合酶2(NOS2)等。KEGG通路分析,可能涉及了癌症通路、肿瘤坏死因子(TNF)、Th17细胞分化、核因子κB(NF-κB)通路、脂质和动脉粥样硬化通路等。分子对接结果显示,青风藤的主要活性成分青藤碱、β-谷甾醇、拉兹马宁碱、乌心石环氧内脂、千金藤啶碱与关键蛋白PPARG、NOS2、PTGS2、TLR4表现出良好的结合能力。结论青风藤具有多成分、多靶点特性,通过多途径来缓解炎症反应,对治疗痛风急性关节炎的发作具有潜在的疗效。

关键词：青风藤痛风性关节炎网络药理学分子对接青藤碱 β-谷甾醇拉兹马宁碱