检索结果-南通市图书馆

Formulation,characterization and in vivo and in vitro evaluation of aloe-emodin-loaded solid dispersions for dissolution enhancement

引用

Journal of Traditional Chinese Medicine 2024年第1期44卷 54-62页

作者： li xiuyan LUO Yuting WANG Jinhui DU Zhimin Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese MedicineMinistry of EducationHarbin 150040China College of Pharmacy Harbin Medical UniversityHarbin 150081China Institute of Clinical Pharmacology the Second Affliated Hospital of Harbin Medical University(University Key aboratory of Drug ResearchHeilongjiang Province)Harbin 150086China Department of Clinical Pharmacology College of Pharmacy Harbin Medical UniversityHarbin 150081China State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacao 999078China

OBJECTIVE:To prepare aloe-emodin solid dispersion(AE-SD)and determine the metabolic process of AE and AE-SD in vivo.METHODS:AE-SD was prepared via solvent evaporation or solvent melting using PEG-6000 and PVP-K30 as carriers.Thermogravimetric analysis,X-ray diffraction spectroscopy,differential scanning calorimetry,Fourier transform infrared spectroscopy and scanning electron microscopy were used to identify the physical state of AESD.Optimal prescriptions were screened via the dissolution degree determination method.Using Phoenix software,AE suspension and AE-SD were subjected to a pharmacokinetic comparison study analyzing the alteration of behavior in vivo after AE was prepared as a solid dispersion.Acute toxicity was assessed in mice,and the physiological toxicity was used as the determination criterion for toxicity.RESULTS:AE-SD showed that AE existed in the carrier in an amorphous state.Compared with polyethylene glycol,polyvinylpyrrolidone(PVP)inhibited AE crystallization,causing the drug to transform from a dense crystalline state to an amorphous form and increasing the degree of drug dispersion.Therefore,it was more suitable as a carrier material for AE-SD.The addition of poloxamer(POL)was more beneficial to the stability of solid dispersions and could reduce the amount of PVP.The dissolution test confirmed that the optimal ratio of AE to the composite vector AE-PVP-POL was 1:2:2,and its dissolution effect was also optimal.Based on the pharmacokinetic comparison,the drug absorption was faster and quickly reached the peak of blood drug concentration in AE-SD compared to AE,the Cmax of AE-SD was greater than that of AE,and t1/2 and mean residence time of AE-SD were less than AE.The results showed that the drug metabolism in AE-SD was better,and the residence time was shorter.The toxicology study showed that both AE and AE-SD had no toxicity.CONCLUSION:This paper established that the solubility of the drug could be increased after preparing a solid dispersion,as demonstrated by in vitro dissolution experime

关键词： aloe-emodin solid dispersion solvent evaporation drug liberation pharmacokinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glutamate oxidase-integrated biomimetic Fe3O4 hybrids as cascade nanozymes for glutamate detection

引用

Particuology 2024年第5期88卷 192-200页

作者： Peikun li Yanchao Wang xiuyan Luo Zixin Geng Jiahui Jia Ruirui Wang Jiandong Cui Hongjie Bian Shiru Jia State Key Laboratory of Food Nutrition and Safety Laboratory of Industrial Fermentation MicrobiologyMinistry of EducationTianjin University of Science and TechnologyTianjin300457China Sports Department Hebei University of Science and TechnologyShijiazhang050000China Research Center for Fermentation Engineering of Hebei College of Bioscience and BioengineeringHebei University of Science and TechnologyShijiazhang050000China

Herein,a new nanozyme/natural enzyme hybrid biosensor was established for ultrasensitive l-glutamic acid(L-Glu)detection.The Fe3 O4 nanoparticles with peroxidase-like activity and stability was used as a nanozyme and carrier for immobilizing l-Glutamate oxidase(GLOD)through Schiffff base reaction to construct a chem-enzyme cascade detector.The resultant Fe3 O4-GOLD exhibited a wide linear range(10−500μM)and a low detection limit of 6.03μM for L-Glu detection.Furthermore,the Fe3 O4-GOLD exhibited excellent pH stability,thermal stability,reusability and storage stability.After repeated nine cycles,Fe3 O4-GOLD still retained 70%of its initial activity.Meanwhile,Fe3 O4-GOLD maintained 50%of its initial activity after storage for 20 days,while free GLOD only retained 20%of its initial activity.This strategy of integrating biomimetic Fe 3 O4 and natural enzymes for cascade catalysis makes it possible to design an efficient and stable chemo-enzyme composite catalysts,which are promising for applications in biosensing and biomimetic catalysis.

关键词： Fe3O4 nanozyme GLOD Chemo-enzymes Glutamate detection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermally-triggered grain boundary relaxation in a nanograined Ni-Mo-W alloy

引用

Nano Research 2023年第11期16卷 12800-12808页

作者： Dongsong Zeng Jiongxian li Yinong Shi xiuyan li Ke Lu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Conventionally,nanograined metals and alloys can be stabilized through segregating foreign elements at grain boundaries(GBs).Yet such an effect may be offset by formation of second phase at elevated temperatures.In this paper,by introducing minor W into a binary Ni-Mo alloy,we found precipitation of intermetallic phases was suppressed,enhancing thermal stability of the nanograined structure.Characterized faceted GBs and a high-fraction ofΣ3 coincidence site lattice(CSL)boundaries illustrate that GB structures are relaxed by formation of copious annealing twins.Adding W reduces stacking fault energy of the solid solution and facilitates the thermally-triggered GB relaxation.Suppressed precipitation of the intermetallic phases may be attributed to depletion of solutes at relaxed GBs.

关键词： grain boundary relaxation nanograined ternary alloy thermal stability stacking fault energy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-throughput fluorescent screening of thioredoxin reductase inhibitors to inhibit Mycobacterium tuberculosis

引用

Chinese Chemical Letters 2024年第3期35卷 358-362页

作者： Fei Yan Xin Zhao Ruibo li xiuyan Han Qiulong Yan Lei Feng Xiulan Xin Jingnan Cui Xiaochi Ma Second Affiliated Hospital Dalian Medical UniversityDalian 116044China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China College of Bioengineering Beijing PolytechnicBeijing 100029China

Tuberculosis(TB)is a chronic infectious disease,which is caused by the pathogen Mycobacterium tuberculosis(Mtb)and reemerged as a global health risk with a significant proportion of multi-drug resistant and extensively drug resistant TB cases.It is very urgent to find some novel high-confidence drug targets in Mtb for discovering the effective anti-TB agents.Thioredoxin reductase(TrxR)has been identified to be a highly viable target for anti-TB drugs for its important role in protecting the pathogen from thiol-specific oxidizing stress,regulating intracellular dithiol/disulfide homeostasis and DNA replication and repair.In the present work,a near-infrared(NIR)fluorescent probe DDAT was developed for the detection of TrxR activity and used to high-throughput screen the TrxR inhibitors from natural products.Two screened TrxR inhibitors from Sappan lignum and microbial metabolites that were further used to inhibit Mycobacterium tuberculosis.All the results indicate that DDAT is a practical fluorescent molecular tool for the discovery of potential anti-TB drugs.

关键词： Thioredoxin reductase NIR fluorescent probe Fluorescence imaging High-throughput screening inhibitors Inhibit Mycobacterium tuberculosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3D time-domain forward modeling of airborne transient electromagnetism considering superparamagnetic effect

引用

Global Geology 2024年

作者： li Zizhuo liU Yunhe REN xiuyan College of Geo-Exploration Science and Technology Jilin University

The superparamagnetic effect arises from the superparamagnetism exhibited by a multitude of nano-sized magnetic mineral particles under an external electric field. This phenomenon manifests in transient electromagnetic data primarily as a deceleration in the attenuation rate of late-stage signals， a characteristic difficult to discern directly from airborne transient electromagnetic signals， consequently leading to significant misinterpretations of subterranean electrical structures. This study embarks on 3D forward modeling of airborne electromagnetic responses in the frequency domain， accounting for the superparamagnetic effect， utilizing an unstructured finite element method. Superparamagnetic responses in the time domain were obtained through frequency-time conversion. This investigation explores the influence of various parameters—such as magnetic susceptibility， time constants， and flight altitude—on the superparamagnetic effect by examining the response characteristics of typical targets. Findings indicate that in its late stages， the superparamagnetic effect can induce a relative anomaly of up to 300%. There is a positive correlation between magnetic susceptibility and the strength of the superparamagnetic effect. The influence of the time constant’s upper and lower limits on the superparamagnetic effect is minimal; however， the range between these limits significantly affects the effect， showing a negative correlation with its intensity. Higher flight altitudes weaken the superparamagnetic signal. The impact is most pronounced when superparamagnetic minerals are shallowly buried， effectively shielding the underlying geology with the characteristics of a good conductivity anomaly， but this effect diminishes with greater depth. The insights from this study provide a theoretical framework for a deeper understanding of the superparamagnetic effect in transient electromagnetic signals and for more accurate interpretations of subterranean geological and electrical structures.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Self-template formation of porous yolk-shell structure Mo-doped NiCo2O4 toward enhanced lithium storage performance as anode material

引用

Journal of Materials Science & Technology 2022年第7期102卷 186-194页

作者： Yongqiang Ren xiuyan li Yinan Wang Qinghua Gong Shaonan Gu Tingting Gao Xuefeng Sun Guowei Zhou Key Laboratory of Fine Chemicals in Universities of Shandong Jinan Engineering Laboratory for Multi-scale Functional MaterialsSchool of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Chemical Engineering and Environment Shandong Peninsula Engineering Research Center of Comprehensive Brine UtilizationWeifang University of Science and TechnologyWeifang 262700China

Hollow ternary metal oxides have shown enormous potential in lithium-ion batteries(liBs),which is ascribed to their complex chemical composition,abundant active defect sites,and the synergy effect be-tween metals.In this work,we synthesized Mo-doped NiCo_(2)O_(4) porous spheres with yolk-shell structure by using a simple self-templating method.Surprisingly,other than the yolk-shell structure we had ob-tained,the inner core of the yolk-shell was also porous,which could fully enhance the electrolyte infil-tration and promote the transmission of lithium ions(li+)and electrons(e−).The diameter of the porous core in the yolk-shell sphere was about 530 nm,and the outer shell’s thickness was up to 110 nm.In addition,the unique pores in the core appeared in the diameter of about 85 nm.With this structure,the volume expansion of the anode could be well inhibited during charge/discharge.It exhibited prominent electrochemical performance with high reversible capacity(1338 mA h g^(−1) at 100 mA g^(−1)),satisfactory cycle life(1360 mA h g^(−1) after 200 cycles at 100 mA g^(−1)),and exceptional rate capability(820 mA h g^(−1) at 2000 mA g^(−1))as anode material in liBs.

关键词： Ternary metal oxides Yolk-shell structure Porous inner core Anode material lithium-ion batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A gate-tunable artificial synapse based on vertically assembled van der Waals ferroelectric heterojunction

引用

Journal of Materials Science & Technology 2022年第33期128卷 239-244页

作者： Yaning Wang Wanying li Yimeng Guo Xin Huang Zhaoping Luo Shuhao Wu Hai Wang Jiezhi Chen xiuyan li Xuepeng Zhan Hanwen Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Material Science and Engineering University of Science and Technology of ChinaShenyang 110016China Department of Applied Physics Aalto UniversityAaltoFinland School of Information Science and Engineering(ISE) Shandong UniversityQingdao 266237China

Memtransistor,a multi-terminal device that combines both the characteristics of a memristor and a transistor,has been intensively studied in two-dimensional layered materials(2 DLM),which show potential for applications in such as neuromorphic computation.However,while often based on the migration of ions or atomic defects in the conduction channels,performances of memtransistors suffer from the poor reliability and tunability.Furthermore,those known 2 DLM-based memtransistors are mostly constructed in a lateral manner,which hinders the further increasing of the transistor densities per area.Until now,fabricating non-atomic-diffusion based memtransistors with vertical structure remains challenging.Here,we demonstrate a vertically-integrated ferroelectric memristor by hetero-integrating the 2 D ferroelectric materials CuInP_(2)S_(6)(CIPS)into a graphite/CuInP_(2)S_(6)/MoS_(2)vertical heterostructure.Memristive behaviour and multi-level resistance states were realized.Essential synaptic behaviours including excitatory postsynaptic current,paired-pulse-facilitation,and spike-amplitude-dependent plasticity are successfully mimicked.Moreover,by applying a gate potential,the memristive behaviour and synaptic features can be effectively gate tuned.Our findings pave the way for the realization of novel gate-tunable ferroelectric synaptic devices with the capability to perform complex neural functions.

关键词： van der Waals heterostructures Ferroelectrics Memristor Artificial synapse Neuromorphic computing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu Qian Zhang Xufeng Wang Jing Jin Chengwei Wu li Feng xiuyan Yang Mingzhu Zhao Yingyi Chen Shaoyong Lu Zhen Zheng Xiaobing Lan Yi Wang Yan Zheng Xuefeng Lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour metastasis.SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer.However,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be discovered.Here,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/L.Moreover,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/L.The allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural analyses.Importantly,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver metastasis.To our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic cancer.It not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

70 nm: The most unstable grain size in Cu prepared by surface mechanical grinding treatment

引用

Nano Materials Science 2020年第1期2卷 32-38页

作者： Xin Zhou xiuyan li Ke Lu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang110016China

The stability of Cu with different average grain sizes prepared by surface mechanical grinding treatment were investigated under the conditions of isothermal annealing and uniaxial tension.In both conditions,experimental results revealed that the stability of the grains decreased with the decrease of grain size when the grain size was above 70–75 nm,while the stability of the grains increased with the decrease of grain size when the grain size was below 70–75 nm.The grains of about 70–75 nm in size showed the worst stability in both thermal and mechanical conditions due to having the highest level of average atom free energy and their large amount of high energy grain boundary with large curvature.This size was very close to the calculated smallest size achievable by severe plastic deformation based on the grain refinement mechanism of dislocation evolution under present processing condition,at which both the highest density of dislocation and highest energy should be produced and induces poor stability.Below 70 nm,the deformation mechanism of nanograined Cu was transformed into a partial dislocation motion,which activated mechanically induced grain boundary(GB)relaxation accompanied by GB flattening and GB energy decrease and resulted in enhanced stability.This discovery offers the potential for developing nanograined metals with high strength and high stability.

关键词： Nanograins Thermal stability Mechanical stability Atom free energy Copper Severe plastic deformation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design for reliability with the advanced integrated circuit(IC) technology: challenges and opportunities

引用

Science China(Information Sciences) 2019年第12期62卷 242-245页

作者： Zhigang JI Haibao CHEN xiuyan li School of Microelectronics Shanghai Jiaotong University

Reliability assurance is of great importance for any commercial products, and the integrated circuit(IC) is no exception. Unlike the yield issues that are time-independent and can be screened through burn-in before ta... 详细信息

关键词： Design for reliability with the advanced integrated circuit IC challenges and opportunities technology

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：