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Chinese Journal of Aeronautics 2021年第5期34卷 652-665页

作者： Kang XU Shoukun wang Junzheng wang xiuwen wang Zhihua CHEN Jinge SI School of Automation Beijing Institute of Technology.Beijing 100081China Key Laboratory of Intelligent Control and Decision of Complex System Beijing Institute of TechnologyBeijing 100081China Key Laboratory Ministry of Industry and Information Technology Beijing Institute of TechnologyBeijing 100081China

There is a strong demand for Planetary Exploration Mobile robots(PEMRs)that have the capability of the traversability,stability,efficiency and high load while tackling the specialized tasks on planet *** this paper,an electric parallel wheel-legged hexapod robot which has high-adaption locomotion on the unstructured terrain is ***,the hybrid control framework,which enables robot to stably carry the heavy loads as well as to traverse the uneven terrain by utilizing both legged and wheeled locomotion,is also *** on this framework,robot controls the multiple DOF leg for performing high-adaption locomotion to negotiate obstacles via Gait Generator(GG).Additionally,by using Whole-Body Control(WBC)of framework,robot has the capability of flexibly accommodating the uneven terrain by Attitude Control(AC)kinematically adjusting the length of legs like an active suspension system,and by Force/torque Balance Control(FBC)equally distributing the Ground Reaction Force(GRF)to maintain a stable *** simulation and experiment are employed to validate the proposed framework with the physical system in the planetary analog ***,to smoothly demonstrate the performance of robot transporting heavy loads,the experiment of carrying 3-person load of about 240 kg is deployed.

关键词： Attitude control Gait generation High-adaption locomotion Obstacle avoidance Planetary exploration robot

Investigation and analysis of leveling deformation anomaly at Daixian station in Shanxi

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Geodesy and Geodynamics 2017年第2期8卷 130-135页

作者： xiuwen wang Earthquake Administration of Shanxi Province Taiyuan 030021 China State Key Observatory of Shanxi Rift System Taiyuan 030025 China Earthquake Administration of Daixian County Daixian 034200 China

The leveling measurements at Daixian station appeared increasing trend since March 25, 2013, which is credible, showing normal fault activity. According to the environmental survey, it contains some interference factors： first, the wind is big when the leveling measures in the afternoon, which has certain influence on the measurement results, but the impact is random and should be near the base value and not appear a trend. Second, the point BM3 was maintained during Sep. to Oct. in 2012 and occurred cracks in 2013, showing that the poor stability around the point. In addition, the change of recorded program is only to change the way of data record and can not affect the observation results during the same period.

关键词： Daixian station in Shanxi Leveling measurement Anomaly Investigation

Overexpression of OsKTN80a, a katanin P80ortholog, caused the repressed cell elongation and stalled cell division mediated by microtubule apparatus defects in primary root in Oryza sativa

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Journal of Integrative Plant Biology 2014年第7期56卷 622-634页

作者： Lei Wan xiuwen wang Shaoqing Li Jun Hu Wenchao Huang Yingguo Zhu State Key Laboratory of Hybrid Rice College of Life Sciences Wuhan University

Katanin, a microtubule-severing enzyme, consists of two subunits：the catalytic subunit P60, and the regulatory subunit P80. In several species, P80 functions in meiotic spindle organization, the flagella biogenesis, the neuronal development, and the male gamete production. However, the P80 function in higher plants remains elusive. In this study, we found that there are three katanin P80 orthologs （OsKTN80a, OsKTN80b, and OsKTN80c） in Oryza sativa L. Overexpression of OsKTN80a caused the retarded root growth of rice seedlings. Further investigation indicates that the retained root growth was caused by the repressed cell elongation in the elongation zone and the stalled cytokinesis in the division zone in the root tip. The in vivo examination suggests that OsKTN80a acts as a microtubule stabilizer. We＆amp;nbsp;prove that OsKTN80a, possibly associated with OsKTN60, is involved in root growth via regulating the cell elongation and division.

关键词： Cell division cell expansion Oryza sativa OsKTN8oa rootgrowth

Th17 Cells in autoimmune diseases

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Frontiers of Medicine 2015年第1期9卷 10-19页

作者： Lei Han Jing Yang xiuwen wang Dan Li Ling Lv Bin Li Division of Rheumatology Huashan Hospital Fudan University Shanghai 200040 China Key Laboratory of Molecular Virology and Immunology Unit of Molecular Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China

Th17 cells are a new subset of CD4^＋ T cells fungi. Accumulating evidence suggests that Tb17 cells involved in the clearance of extracellular pathogens and and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren＇s syndrome, inflammatory bowel disease, and multiple sclerosis.

关键词： IL-17 Thl 7 cells RORγt autoimmune diseases posttranslational modification inhibitors

Hexagonal FeS nanosheets with high-energy （001） facets： Counter electrode materials superior to platinum for dye-sensitized solar cells

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Nano Research 2016年第10期9卷 2862-2874页

作者： xiuwen wang Ying xie Buhe Bateer Kai Pan Yangtao Zhou Yi Zhang Guofeng wang Wei Zhou Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongjiang University Harbin 150080 China College of Materials and Chemical Engineering Heilongjiang Institute of Technology Harbin 150050 China

The catalytic activity of materials is highly dependent on their composition and surface structure, especially the density of low-coordinated surface atoms. In this work, we have prepared two-dimensional hexagonal FeS with high-energy （001） facets （FeS-HE-001） via a solution-phase chemical method. Nanosheets （NSs） with exposed high-energy planes usually possess better reaction activity, so FeS-HE-001 was used as a counter electrode （CE） material for dye-sensitized solar ceils （DSSCs）. FeS-HE-001 achieved an average power conversion efficiency （PCE） of 8.88% （with the PCE of champion cells being 9.10%）, which was almost 1.15 times higher than that of the Pt-based DSSCs （7.73%） measured in parallel. Cyclic voltammetry and Tafel polarization measurements revealed the excellent electrocatalytic activities of FeS-HE-001 towards the I-3/I- redox reaction. This can be attributed to the promotion of photoelectron transfer, which was measured by electrochemical impedance spectroscopy and scanning Kelvin probe, and the strong I-3 adsorption and reduction activities, which were investigated using first-principles calculations. The presence of high-energy （001） facets in the NSs was an important factor for improving the catalytic reduction of I-3. We believe that our method is a promising way for the design and synthesis of advanced CE materials for energy harvesting.

关键词： FeS nanosheets high-energy facets counter electrode first-principles calculation catalytic reduction

Enhanced photocatalytic nitrogen fixation performance via in situ constructing BiO_(2-x)/NaNbO_(3) heterojunction

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Chinese Journal of Chemical Engineering 2024年第5期69卷 92-100页

作者： Jiayu Zhang Zhihao Zeng Lin Yue Chunran Zhao Xin Hu Leihong Zhao xiuwen wang Yiming He Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China Heilongjiang Provincial Key Laboratory of Surface Active Agent and Auxiliary School of Chemistry and Chemistry EngineeringQiqihar UniversityQiqihar 161006China Department of Materials Science and Engineering Zhejiang Normal UniversityJinhua 321004China

The fabrication of heterojunction catalysts is an effective strategy to enhance charge separation efficiency,thereby boosting the performance of *** this study,BiO_(2-x)nanosheets were synthesized through a hydrothermal process and loaded onto NaNbO_(3) microcube to construct a series of BiO_(2-x)/NaNbO_(3) heterojunctions for photocatalytic N_(2) *** indicated that 2.5%BiO_(2-x)/NaNbO_(3) had the highest photocatalytic *** NH_(3) production rate under simulated solar light reached 406.4μmol·L^(-1)·g^(-1)·h^(-1),which reaches 2.6 and 3.8 times that of NaNbO_(3) and BiO_(2-x),***_(2-x)nanosheets primarily act as electron trappers to enhance the separation efficiency of charge *** strong interaction between BiO_(2-x)and NaNbO_(3) facilitates the electron migration between ***,the abundant oxygen vacancies in BiO_(2-x)nanosheets may facilitate the adsorption and activation of N_(2),which may be another possible reason of the high photocatalytic activity of the BiO_(2-x)/NaNbO_(3).This study may offer new insights for the development of semiconductor materials in photocatalytic nitrogen fixation.

关键词： Catalyst Solar energy Hydrothermal BiO_(2-x)/NaNbO_(3) Photocatalytic N_(2)-fixation

g-C_(3)N_(4)/TiO_(2-X) heterojunction with high-efficiency carrier separation and multiple charge transfer paths for ultrasensitive SERS sensing

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Chinese Chemical Letters 2024年第10期35卷 524-529页

作者： Xin Jiang Han Jiang Yimin Tang Huizhu Zhang Libin Yang xiuwen wang Bing Zhao College of Chemistry and Chemical Engineering Technology Innovation Center of Industrial Hemp for State Market RegulationQiqihar UniversityQiqihar 161006China College of Pharmacy Jjiamusi UniversityJjiamusi 154007China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

The combination of interface engineering and defect engineering is a promising strategy for developing new semiconducting surface-enhanced Raman scattering(SERS)***,an organic/inorganic hybrid g-C_(3)N_(4)/TiO_(2-X)heterojunction with synchronous generation of strong interface effect and abundan surface oxygen vacancy(OV)defect was prepared by a simple sol-hydrothermal procedure with a help of *** to the improved substrate-to-molecule charge transfer(CT)from joint contribution of high efficiency carrier separation induced by strong interface coupling effect and multiple CT paths derived from abundant surface OV,g-C_(3)N_(4)/TiO_(2-X)substrate exhibits greatly enhanced SERS effect for non-resonan4-mercaptobenzoic acid(4-MBA)*** enhancement factor of g-C_(3)N_(4)/TiO_(2-X)substrate for 4-MBA i as high as 5.57×10^(6),and the substrate exhibits ultra-high stability and excellent spectral reproducibility More meaningfully,the developed g-C_(3)N_(4)/TiO_(2-X)heterojunction can be used to execute an ultrasensitive detection for antibiotic residues in real water system,even comprehensive evaluation of multi-componen residues.

关键词： SERS Semiconductor Heterojunction Surfacedefect Detection

Retrospective analysis of results of treatment for nasopharyngeal carcinoma in Macao

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Chinese Journal of Cancer Research 2014年第2期26卷 148-158页

作者： Huiqin Dou Dongyan Hu Chileong Lam Yunsheng Liu xiuwen wang Wendong Zhang Department of Stomatology Qilu Hospital of Shandong University Department of Clinical Oncology Qilu Hospital of Shandong University Department of Clinical Oncology Conde S.Januario General Hospital

Background： Nasopharyngeal carcinoma （NPC） is a common malignancy in Southeast Asia, however, a full consensus has not yet been reached as to the value of comprehensive treatment for NPC. This study was designed to evaluate the epidemiological characteristics of NPC and their prognostic value, as well as the long-term efficacy of NPC treatment. Patients and methods： A total of 248 patients, with different stages of NPC, were included in this study. Results： The 5-year overall survival （OS） rates for patients in stages I, II, lII and IV were 90.48%, 76.71%, 76.89% and 33.87%, respectively （P=0.000）, while the respective 5-year progression-free survival （PFS） rates were 85.15%, 72.36%, 63.88% and 26.26% （P=0.000）. The respective 5-year OS rates, according to stage, for the group that received radiotherapy combined with chemotherapy and for the group that received radiotherapy only were as follows： stages I and II, 81.67% and 79.59% （P=0.753）; stage III, 79.91% and 70.38% （P=0.143）; stage IV,, 35.22% and 0% （P=0.000）. The respective 5-year PFS rates in these groups were as follows： stages I and II, 75.83% and 74.98% （P=0.814）; stage III, 74.08% and 42.25% （P=0.027）; stage IV,, 27.31% and 0% （P=0.000）. Conclusions： Clinical staging appears to be the most important prognostic factor for NPC. As the stage number increases, both the 5-year OS and PFS significantly decrease. Adding chemotherapy to radiotherapy was not advantageous for patients with stage I or II NPC, however the addition of chemotherapy to radiotherapy significantly improved OS and PFS in patients with stage IV NPC. The addition of chemotherapy improved PFS, but not OS in patients with stage III NPC.

关键词： Nasopharyngeal carcinoma (NPC) treatment retrospective analysis Macao

Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment

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Cancer Biology & Medicine 2018年第4期15卷 443-451页

作者： Jing wang Yizhuo Zhao Qiming wang Li Zhang Jianhua Shi Zhehai wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo xiuwen wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li Department of Pulmonary Oncology Tianjin Medical University Cancer Institute and Hospital Department of Respiratory Medicine Shanghai Chest Hospital Department of Medical Oncology Henan Province Tumor Hospital Department of Respiratory Medicine Peking Union Medical College Hospital Department of Medical Oncology Linyi Cancer Hospital Department of Internal Medicine Shandong Cancer Hospital Department of Thoracic Oncology Jilin Cancer Hospital Department of Thoracic Surgery The First Affiliated Hospital of Guangzhou Medical University Department of Medical Oncology Cancer Hospital Chinese Academy of Medical Sciences Department of Biostatistics School of Public Health Nanjing Medical University Department of Respiratory Medicine Lanzhou Military General Hospital Department of Head and Neck Oncology Hunan Cancer Hospital Department of Chemotherapy Qilu Hospital of Shandong University Department of Medical Oncology The First Affiliated Hospital of Xi'an Jiaotong University Department of Respiratory and Critical Diseases Tang Du Hospital Department of Oncology Yunnan Cancer Hospital General Department Capital Medical University Beijing Chest Hospital

Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard *** study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the ***:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo ***–Meier analysis and log-rank test were performed to compare PFS and *** proportional hazards model was adopted for multivariate prognostic ***:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for ***,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of *** posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of ***:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were

关键词： Non-small cell lung cancer anlotinib third- or further-line therapy prognostic factor analysis

Severe acute respiratory syndrome coronavirus 2-specific T-cell responses are induced in people living with human immunodeficiency virus after booster vaccination

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中华医学杂志(英文版) 2024年第22期137卷 2734-2744页

作者： wang xiuwen Li Yongzheng Jin Junyan Chai Xiaoran Ma Zhenglai Duan Junyi Zhang Guanghui Huang Tao Zhang Xin Zhang Tong Wu Hao Cao Yunlong Su Bin Beijing Key Laboratory for HIV/AIDS Research Sino-French Joint Laboratory for HIV/AIDS Research Clinical and Research Center for Infectious Diseases Beijing Youan Hospital Capital Medical University Beijing China Biomedical Pioneering Innovation Center (BIOPIC) Peking University Beijing China Cancer and Stem Cell Biology Program Duke-NUS Medical School Singapore Changping Laboratory Beijing China

Background: T-cell-mediated immunity is crucial for the effective clearance of viral infection, but the T-cell-mediated immune responses that are induced by booster doses of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in people living with human immunodeficiency virus (PLWH) remain ***: Forty-five PLWH who had received antiretroviral therapy (ART) for more than two years and 29 healthy controls (HCs) at Beijing Youan Hospital were enrolled to assess the dynamic changes in T-cell responses between the day before the third vaccine dose (week 0) and 4 or 12 weeks (week 4 or week 12) after receiving the third dose of inactivated SARS-CoV-2 vaccine. Flow cytometry, enzyme-linked immunospot (ELISpot), and multiplex cytokines profiling were used to assess T-cell responses at the three timepoints in this ***: The results of the ELISpot and activation-induced marker (AIM) assays showed that SARS-CoV-2-specific T-cell responses were increased in both PLWH and HCs after the third dose of the inactivated SARS-CoV-2 vaccine, and a similar magnitude of immune response was induced against the Omicron (B.1.1.529) variant compared to the wild-type strain. In detail, spike-specific T-cell responses (measured by the ELISpot assay for interferon γ [IFN-γ] release) in both PLWH and HCs significantly increased in week 4, and the spike-specific T-cell responses in HCs were significantly stronger than those in PLWH 4 weeks after the third vaccination. In the AIM assay, spike-specific CD4+ T-cell responses peaked in both PLWH and HCs in week 12. Additionally, significantly higher spike-specific CD8+ T-cell responses were induced in PLWH than in HCs in week 12. In PLWH, the release of the cytokines interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-α), and IL-22 by peripheral blood mononuclear cells (PBMCs) that were stimulated with spike peptides increased in week 12. In addition, the levels of IL-4 and IL-5 were higher in PLW

关键词： HIV People living with HIV SARS-CoV-2 vaccine T-cell responses Omicron variant