Th17 Cells in autoimmune diseases

作     者：Lei Han Jing Yang Xiuwen Wang Dan Li Ling Lv Bin Li 

作者机构：Division of Rheumatology Huashan Hospital Fudan University Shanghai 200040 China Key Laboratory of Molecular Virology and Immunology Unit of Molecular Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2015年第9卷第1期

页      面：10-19页

核心收录：

学科分类：090603[农学-临床兽医学] 0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0906[农学-兽医学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：Our research is supported by the National Basic Research Program of China (2014CB541803  2014CB541903)  National Natural Science Foundation of China (81330072  31370863  31200647  81271835)  National Science and Technology Major Project (2012ZX10002007-003)  and STCSM project (14JC1406100) 

主　　题：IL-17 Thl 7 cells RORγt autoimmune diseases posttranslational modification inhibitors 

摘      要：Th17 cells are a new subset of CD4^＋ T cells fungi. Accumulating evidence suggests that Tb17 cells involved in the clearance of extracellular pathogens and and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren＇s syndrome, inflammatory bowel disease, and multiple sclerosis.