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Effect of astragaloside Ⅳ on the immunoregulatory function of adipose-derived mesenchymal stem cells from patients with psoriasis vulgaris

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Journal of Traditional Chinese Medicine 2022年第4期42卷 513-519页

作者： yin xiuping ZHANG Xiaotong ZHU Rongjia SONG Ping Department of Dermatology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy(BZ0381)/Center of Excellence in Tissue Engineering Institute of Basic Medical Sciences CAMSSchool of Basic Medicine PUMCBeijing 100005China

OBJECTⅣE:To compare the phenotype and adipogenic and osteogenic differentiation capacities of adiposederived mesenchymal stem cells(AMSCs)isolated from patients with psoriasis vulgaris and healthy donors,and to explore the effects of astragalosideⅣ,a Traditional Chinese Medicine,on the immunoregulatory function of ***:AMSCs were isolated from human adipose tissue and cultured for three generations in *** phenotype and cell cycle analysis were performed by flow *** and osteogenic differentiation of AMSCs was examined by lipid(oil red O)and alkaline phosphatase staining,*** of inflammatory mediators was examined by real-time quantitative polymerase chain reaction analysis,and proliferation was quantified using the cell counting kit-8 ***:Expression of CD29,CD44,and CD73 was higher in AMSCs from healthy donors than psoriasis patients,while the reverse was true for expression of CD45,CD31,and *** from psoriasis patients had a greater ability to undergo adipogenic differentiation than cells from healthy donors,whereas there was no significant difference in osteogenic differentiation between AMSCs from the two *** with AMSCs from healthy donors,psoriasis patient-derived AMSCs expressed lower levels of the anti-inflammatory cytokines interleukin-10 and transforming growth factor-β(TGF-β)and the immune checkpoint ligand programmed cell death 1 ligand 1(PDL1)(P<0.05)and higher levels of the pro-inflammatory cytokines tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ).Incubation of AMSCs from psoriasis patients with astragalosideⅣhad no significant effect on proliferation but increased the expression of TGF-βand PDL1 and decreased the expression of IFN-γand TNF-α.CONCLUSION:AMSCs from patients with psoriasis vulgaris display abnormal proliferation and adipogenesis and an enhanced pro-inflammatory *** defects were normalized by treatment with astragalosideⅣ,suggesting that this

关键词： psoriasis mesenchymal stem cells cell proliferation astragalosideⅣ adipogenesis osteogenesis immune regulation

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Bismuth nanorods confined in hollow carbon structures for high performance sodium-and potassium-ion batteries

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Journal of Energy Chemistry 2022年第4期31卷 787-796页

作者： Hongli Long xiuping yin Xuan Wang Yufeng Zhao Liuming Yan College of Sciences&Institute for Sustainable Energy Shanghai UniversityShanghai 200444China

Bismuth has drawn widespread attention as a prospective alloying-type anode for sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs)due to its large volumetric ***,such material encounters drastic particle pulverization and overgrowth of solid-electrolyte interphase(SEI)upon repeated(de)alloying,thus causing poor rate and cycling ***,we report a unique structure design with bismuth nanorods confined in hollow N,S-codoped carbon nanotubes(Bi@NS-C)fabricated by a solvothermal method and in-situ thermal ***-situ SEM observations confirm that such a design can significantly suppress the size fining of Bi nanorods,thus inhibiting the particle pulverization and repeated SEI growth upon charging/*** as achieved Bi@NS-C demonstrates outstanding rate capability for SIBs(96.5%capacity retention at 30 A g^(-1) vs.1 A g^(-1)),and a record high rate performance for PIBs(399.5 m Ah g^(-1)@20 A g^(-1)).Notably,the as constructed full cell(Na_(3)V_(2)(PO_(4))_(3)@C|Bi@NS-C)demonstrates impressive performance with a high energy density of 219.8 W h kg^(-1) and a high-power density of 6443.3 W kg^(-1)(based on the total mass of active materials on both electrodes),outperforming the state-of-the-art literature.

关键词： Bismuth anode Hollow structure Composites High rate performance Sodium-and potassium-ion batteries

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Free-standing SnNb_(2)O_(6)@CSN film as flexible anode for high performance sodium-ion batteries

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Chinese Chemical Letters 2023年第7期34卷 284-288页

作者： Xuemin yin Tao Liu xiuping yin Xiaochen Feng Yiming Liu Qinhao Shi Xingli Zou Yufeng Zhao Institute for Sustainable Energy and College of Sciences Shanghai UniversityShanghai 200444China Department of Materials Science and Engineering Shanghai UniversityShanghai 200072China

Free-standing electrodes are promising candidates for flexible rechargeable batteries, toward the application of flexible energy storage devices, due to their merits of additive-free, lightweight, and high energy density. Herein, we report a free-standing SnNb_(2)O_(6)@CSN flexible film with SnNb_(2)O_(6) encapsulated in 3D carbon skeleton nanofibers by electrospinning and carbonization processes as flexible anode for sodium-ion batteries(SIBs). The 3D carbon skeleton nanofibers serve as ion/electron transport pathway to improve the electrochemical reaction kinetics and meanwhile alleviate the volume changes of SnNb_(2)O_(6) during charge-discharge processes. The as-constructed half-cell(SnNb_(2)O_(6)@CSN‖Na) exhibits excellent cycling stability of 99.2 m Ah/g at 0.5 A/g after 950 cycles(coulombic efficiency of ~100%) and a high rate performance of 108.6 mAh/g at 10 A/g. In addition, the pouch cell can light up the LEDs at different bending angles(0°, 90°, 180°). This research shows a promising anode material for flexible energy storage electronics.

关键词： Free-standing SnNb_(2)O_(6)@CSN Anode Sodium-ion batteries Flexible material

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Insight into the influence of ether and ester electrolytes on the sodium-ion transportation kinetics for hard carbon

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Nano Research 2023年第8期16卷 10922-10930页

作者： xiuping yin Zhaomin Wang Yang Liu Zhixiu Lu Hongli Long Tao Liu Jiujun Zhang Yufeng Zhao College of Sciences&Institute for Sustainable Energy Shanghai UniversityShanghai 200444China

The electrochemical performance of hard carbon(HC)materials is closely related to the electrolyte used in the sodium ion batteries(SIBs).Conventional electrolytes carbonate(EC)demonstrates low initial Columbic efficiency(ICE)and poor rate performance,which is one of the main bottlenecks that limits the practical application of *** electrolyte(diglyme)was reported to improve the rate performance of ***,the underlying mechanism for the excellent rate capability is still lack of in-depth *** this work,the differences of sodium-ion diffusion between ether and carbonate-base electrolytes in HCs are analyzed layer by ***,when sodium-ions are diffused in electrolyte,the diffusion coefficient of sodium-ion in ether electrolyte is about 2.5 times higher than that in ester electrolytes by molecular dynamics(MD)simulation and experimental ***,when the solvated sodium-ions are diffused into the solid electrolyte interphase(SEI)interface and the HCs material,the enhanced charge transfer kinetics(thin SEI layer(4.6 vs.12 nm)and low RSEI(1.5 vs.24Ω))at the SEI combined with low desolvation energy(0.248 eV)are responsible for high-rate performance and good cycling stability of HC in ether ***,high diffusion coefficient,low desolvation energy,and good interface are the intrinsic reasons for enhanced rate performance in ether electrolyte,which also has guiding significance for the design of other high-rate electrolytes.

关键词： sodium-ion batteries hard carbon(HC) ether electrolyte desolvation energy transportation kinetics

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Fast and extensive intercalation chemistry in Wadsley-Roth phase based high-capacity electrodes

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Journal of Energy Chemistry 2022年第6期31卷 601-611,I0017页

作者： Miao Wang Zhenpeng Yao Qianqian Li Yongfeng Hu xiuping yin Aibing Chen Xionggang Lu Jiujun Zhang Yufeng Zhao Institute for Sustainable Energy&College of Sciences Shanghai UniversityShanghai 200444China Department of Chemistry and Chemical Biology Harvard University12 Oxford StreetCambridgeMA 02138United States Materials Genome Institute Shanghai UniversityShanghai 200444China Canadian Light Source 44 Innovation BoulevardSaskatoonSK S7N 2 V3Canada College of Chemical and Pharmaceutical Engineering Hebei University of Science and Technology70 Yuhua RoadShijiazhuang 050018China State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced FerrometallurgyShanghai UniversityShanghai 200444 China Key Laboratory of Applied Chemistry Yanshan UniversityQinhuangdao 066004HebeiChina School of Resource and Environmental Sciences Wuhan UniversityWuhan 430072HubeiChina

Wadsley-Roth (W-R) structured oxides featured with wide channels represent one of the most promising material families showing compelling rate performance for lithium-ion ***,we report an indepth study on the fast and extensive intercalation chemistry of phosphorus stabilized W-R phase PNb_(9)O_(25) and its application in high energy and fast-charging *** explore the intercalation geometry of PNb_(9)O_(25) and identify two geometrical types of stable insertion sites with the total amount much higher than conventional intercalation-type *** reveal the ion transportation kinetics that the Li ions initially diffuse along the open type Ⅲ channels and then penetrate to edge sites with low kinetic *** the lithiation,no remarkable phase transition is detected with nearly intact host phosphorous niobium oxide ***,the oxide framework of PNb_(9)O_(25) keeps almost unchanged with all the fast diffusion channels and insertion cavities well-maintained upon cycling,which accomplishes the unconventional electrochemical performance of W-R structured electrodes.

关键词： Wadsley-Roth phase PNb_(9)O_(25) Intercalation chemistry Ion transportation kinetics Lithium-ion batteries

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A comprehensive modification enables the high rate capability of P2-Na_(0.75)Mn_(0.67)Ni_(0.33)O_(2) for sodium-ion cathode materials

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Journal of Energy Chemistry 2022年第6期31卷 442-449,I0013页

作者： Xiaochen Feng Yong Li Qinhao Shi Xuan Wang xiuping yin Jing Wang Zhonghong Xia Haiyan Xiao Aibing Chen Xinxin Yang Yufeng Zhao Institute for Sustainable Energy/College of Science Shanghai UniversityShanghai 200444China Key Laboratory of Applied Chemistry Yanshan UniversityQinhuangdao 066004HebeiChina College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018HebeiChina School of Materials Science and Engineering Shanghai UniversityShanghai 200444China

The Na^(+)/vacancy ordering can effectively affect the electrochemical behavior of P2-type cathode *** this work we proposed an integrated strategy by attaining a high Na content,In^(3+) doping in conjunction with NaInO_(2) coating in the P2-Na_(0.75)Mn_(0.67)Ni_(0.33)O_(2) which can inhibit the sodium vacancy order,smooth the electrochemical curve,and enhance the structural stability and rate capability.A combination of X-ray diffraction analysis and DFT calculation indicate that the In(3+) ions in the Na layer serve as"pillars”to stabilize the layered structure,especially for high current density *** P2-Na_(0.75)Mn_(0.67)Ni_(0.33)In_(0.02)O_(2) with an impressive sodium content exhibits a remarkable reversible capacity of 109.6 mAh g^(-1),superior rate capability capacity of 79.8 mAh g^(-1)at 20 C,and 85%capacity retention after 100 cycles at 5 *** work demonstrates an efficient approach for the comprehensive optimization of sodium ion cathode materials.

关键词： Sodium-ion batteries Cathode P2-type layered oxides In doping DFT

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某多金属矿露天开采终了边坡结构参数分析及稳定性验算

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矿产保护与利用 2024年第4期44卷 74-84页

作者：刘国寅孙发院丁军明杜德岗尹修平张鲲华昆明坤泽矿业技术有限责任公司云南昆明650051 云南亚融矿业科技有限公司云南昆明650033

露天多金属矿山的边坡稳定性是确保矿山安全生产和环境保护的关键问题。采用正交实验设计、极限平衡法和FLAC3D数值模拟等方法,对某露天矿山终了边坡的结构参数进行系统分析,并对其稳定性进行验证。通过正交实验设计,考察了不同坡高、... 详细信息

露天多金属矿山的边坡稳定性是确保矿山安全生产和环境保护的关键问题。采用正交实验设计、极限平衡法和FLAC3D数值模拟等方法,对某露天矿山终了边坡的结构参数进行系统分析,并对其稳定性进行验证。通过正交实验设计,考察了不同坡高、坡角和地质条件下的边坡稳定性参数,并结合简化Bishop法和Morgenstern−Price法计算了安全系数。结果表明,在自然条件下,各坡面的安全系数均大于1.17,符合规范要求。为了进一步验证边坡的稳定性,采用FLAC3D数值模拟结合强度折减法进行三维稳定性分析。模拟结果表明,在边坡顶部和表面局部区域存在一定风险,但整体安全系数为1.78,表明边坡处于稳定状态。本研究不仅为露天矿山边坡设计和稳定性评价提供了理论依据和实践指导,也为类似工程项目提供了借鉴,具有提升矿山开采安全性和延长矿山寿命的重要价值。

关键词：边坡稳定性 Bishop法 Morgenstern−price法强度折减理论 FLAC3D

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基于脏腑功能与结构论中医学脾藏与解剖学脾脏不同

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中医药学报 2024年第3期52卷 1-6页

作者：黄一钦尹秀平高艳王义国周宇航张启明陕西中医药大学第一临床医学院陕西咸阳712046 中国中医科学院医学实验中心北京100700 滨州医学院中西医结合学院山东烟台264003

关于中、西医学同名脏器“脾”的认识,历来学者们争议不断,难以形成统一的认识。本文以中医脾藏的功能为基础,以功能异常引发的症状作为中医学和西医学的连接点,以期阐明两者之间的关系。研究发现,中医学脾藏与解剖学脾脏的内涵完全不同... 详细信息

关于中、西医学同名脏器“脾”的认识,历来学者们争议不断,难以形成统一的认识。本文以中医脾藏的功能为基础,以功能异常引发的症状作为中医学和西医学的连接点,以期阐明两者之间的关系。研究发现,中医学脾藏与解剖学脾脏的内涵完全不同,①中医学脾藏运化功能定位于消化系统功能,中医学脾藏统血功能定位于凝血、抗凝血系统功能,中医脾藏主肌肉功能定位于躯体运动系统功能;②解剖学脾脏的储血、调节血量功能可归属于中医肝藏的功能范畴,解剖学脾脏的造血功能可归属于中医肾藏的功能范畴,解剖学脾脏的免疫功能可归属于中医肾藏的功能范畴。基于以上研究结果,在今后的研究中可将脏腑功能、异常症状作为探讨中、西医学同名脏器两者之间的关系以及中医五藏客观化研究的落脚点。

关键词：脾藏脾脏功能定位功能性五藏

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Sedimentary systems of the Oligocene Huagang Formation in the central anticline zone of the Xihu Depression,East China Sea Shelf Basin

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Energy Geoscience 2024年第1期5卷 275-282页

作者： Wenbo Zheng Guofeng yin Li Sun Shuijian Wei xiuping Wei Bo Niu Petroleum Exploration and Production Research Institute of SINOPEC Beijing100083China Shanghai Offshore Oil&Gas Branch SINOPECShanghai200120China

The Xihu Depression is the largest hydrocarbon-bearing depression of the East China Sea Shelf Basin(also referred to as the ECSSB).However,the depositional systems and reservoir distribution of the Oligocene Huagang Formation in the Xihu Depression are still *** the guidance of sedimentology and stratigraphy,this study documented a marine-terrestrial transitional environment in the restricted bay setting of the Oligocene Huagang Formation through core description,well logging,and seismic data *** study also revealed that the Oligocene Huagang Formation is dominated by tidal delta,estuary,and gravity flow deposits in the central anticline zone of the Xihu *** new understanding of the sedimentary systems and the discovery of the transgressive gap in the eastern Diaoyu Islands uplift explain the origin of fine-grained sediments and the EW-trending sand bodies in the central depression and the sand bodies parallel to shoreline in the west slope belt,which cannot be explained by previous study results,such as southern transgression or fluvial deltas and even lacustrine ***,the tidal channels,tidal sand flats,and gravity flow sand bodies formed by the transgressive tides are high-quality *** study will provide a basis for well placement and serve as guidance for the selection of favorable hydrocarbon exploration areas in the Xihu Depression.

关键词： Estuary Sedimentary system Oligocene Huagang Formation Central anticline Xihu Depression East China Sea Shelf Basin

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Copper-catalyzed conjugate addition of allene-derived nucleophiles to alkenyl-substituted carboxamides

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Chinese Chemical Letters 2024年第3期35卷 239-242页

作者： Bin Fu Yue Zhao xiuping Yuan Yanfei Li Jianjun yin Simin Wang Tao Xiong Qian Zhang Jilin Province Key Laboratory of Organic Functional Molecular Design&Synthesis Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun 130012China

Catalytic Michael addition reaction represents a fundamental importance in organic synthetic *** corresponding conversions toward intrinsically low reactive enamide remains an ongoing *** herein report a copper-catalyzed conjugate addition of allenes toβ-substituted alkenyl amides,one of the most challenging Michael *** present method utilizes readily available allenes as the latent carbon-based nucleophiles and simple,commonβ-substituted alkenyl amides as starting materials,unlike previous methods that usually preinstall an activating group to improve the reactivity of amide or uses highly reactive stoichiometric quantities of ***,this approach shows good functional group compatibility and can be implemented under mild reaction conditions with excellent level of chemo-and regioselectivities.

关键词： CuH catalysis Allenes Unsaturated amide Conjugate addition Regioselectivity

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