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Enhanced recovery after surgery for laparoscopic hepatectomy: Consensus of Chinese experts (2017)

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Laparoscopic, Endoscopic and Robotic Surgery 2018年第2期1卷 46-53页

作者：无 xiujun cai Society of Minimally Invasive Surgery Chinese College of Surgeons Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Enhanced recovery after surgery(ERAS)applies to a series of perioperative optimal measures developed from evidence-based medicine which aims to reduce traumatic stress responses,complications,and accelerating rehabilitation for patients while undergoing treatment.1 Since 1997,when Dutch surgeon Kehlet conceived the idea of ERAS,it has been applied in many fields of surgery including gastrointestinal surgery,obstetrics-gynecology,urology,orthopedics and cardiothoracic surgery.2e5 However,the concept of applying ERAS in liver surgery is a relatively new *** recent years.

关键词： surgery traumatic gastrointestinal

The origin of newborn hepatocytes in associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)-derived regeneration

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 687-690页

作者： Yifan Tong Yongfen Zhu xiujun cai Department of General Surgery 2Zhejiang Provincial Key Laboratory of Laparoscopic Technology3Department of Hepatology and InfectionSir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina

Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has attracted interest in the field of hepatobiliary surgery worldwide(1).Given the significant improvement in morbidity and mortality,the ALPPS became safer in experienced centres,while research on the mechanism of ALPPS lags far behind clinical *** basic studies showing that activated hepatic stellates via Indian hedgehog/Gli1 pathway,mitochondria metabolism and inflammation were involved in ALPPS-derived regeneration,the cellular source of rapid self-duplication of hepatocytes during ALPPS stage I has not been well-documented(2,3).Therefore,the aim of this study was to explore the origin of newborn hepatocytes during ALPPS procedure.

关键词： ALPPS metabolism mortality

Reply to:The letter to the editor“Laparoscopic liver resection for malignancies confined to Couinaud's segmentⅦin the robotic surgery era”by Zizzo et al.—laparoscopic liver resection:a first choice for liver malignancies in Couinaud's segmentⅦin the robotic surgery era

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 442-444页

作者： Jiasheng Cao Mingyu Chen Jiliang Shen xiujun cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China Key Laboratory of Endoscopic Technique Research of Zhejiang Province Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China

We are grateful for the comments of Maurizio Zizzo et al. referring to our review article focusing on the present and future of laparoscopic liver resection (LLR) (1). In fact, this comment and letter to the editor reflects the current debates on (Ⅰ) the wide-spreading indication of LLR;(Ⅱ) whether we should consider LLR as a first-choice for malignancies confined to segment Ⅶ;(Ⅲ) the advantages and disadvantages of robotic hepatectomy.

关键词： al. resection editor

Printability during projection-based 3D bioprinting

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Bioactive Materials 2022年第5期7卷 254-267页

作者： Kang Yu Xinjie Zhang Yuan Sun Qing Gao Jianzhong Fu xiujun cai Yong He State Key Laboratory of Fluid Power and Mechatronic Systems College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou450002China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment Hangzhou310016China Cancer Center Zhejiang UniversityHangzhouZhejiang 310058 China

Since projection-based 3D bioprinting(PBP)could provide high resolution,it is well suited for printing delicate structures for tissue ***,the low crosslinking density and low photo-crosslinking rate of photocurable bioink make it difficult to print fine ***,an in-depth understanding of the is ***,a research framework is established for the analysis of printability during *** gelatin methacryloyl(GelMA)-based bioink is used as an example,and the printability is systematically *** analyze the photo-crosslinking reactions during the PBP process and summarize the specific requirements of bioinks for *** standard quantized models are established to evaluate 2D and 3D printing ***,the better strategies for bioprinting five typical structures,including solid organs,vascular structures,nerve conduits,thin-wall scaffolds,and micro needles,are presented.

关键词： Projection-based printing(PBP) 3D bioprinting GelMA bioink Rheological analysis

UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGCip in hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1856-1868页

作者： Junjie Xu Lin Ji Yeling Ruan Zhe Wan Zhongjie Lin Shunjie Xia Liye Tao Junhao Zheng Liuxin cai Yifan Wang Xiao Liang xiujun cai Key Laboratory of Laparoscopic Technology of Zhejiang Province Department of General SurgerySir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and EquipmentHangzhouChina Zhejiang University Cancer Center HangzhouChina Liangzhu Laboratory Zhejiang University Medical CenterHangzhouChina

The treatment for hepatocellular carcinoma(HCC)is promising in recent years,but still facing critical *** first targeted therapy,sorafenib,prolonged the overall survival by ***,resistance often occurs,largely limits its *** was found to target the electron transport chain complexes,which results in the generation of reactive oxygen species(ROS).To maintain sorafenib resistance and further facilitate tumor progression,cancer cells develop strategies to overcome excessive ROS production and obtain resistance to oxidative stress-induced cell *** the present study,we investigated the roles of ROS in sorafenib resistance,and found suppressed ROS levels and reductive redox states in sorafenib-resistant HCC *** in sorafenib-resistant cells maintained greater functional and morphological integrity under the treatment of ***,cellular oxygen consumption rate and mitochondria DNA content analyses revealed fewer numbers of mitochondria in sorafenib-resistant *** investigation attributed this finding to decreased mitochondrial biogenesis,likely caused by the accelerated degradation of peroxisome proliferator-activated receptor y coactivator ip(PGC1P).Mechanistic dissection showed that upregulated UBQLN1 induced PGCip degradation in a ubiquitination-independent manner to attenuate mitochondrial biogenesis and ROS production in sorafenib-resistant cells under sorafenib ***,clinical investigations further indicated that the patients with higher UBQLN1 levels experienced worse recurrence-free *** conclusion,we propose a novel mechanism involving mitochondrial biogenesis and ROS homeostasis in sorafenib resistance,which may offer new therapeutic targets and strategies for HCC patients.

关键词： homeostasis resistance overcome

Development of synthetic lethality in cancer:molecular and cellular classification

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Signal Transduction and Targeted Therapy 2020年第1期5卷 434-447页

作者： Shijie Li Win Topatana Sarun Juengpanich Jiasheng Cao Jiahao Hu Bin Zhang Diana Ma xiujun cai Mingyu Chen Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of Medicine310016 HangzhouChina School of Medicine Zhejiang University310058 HangzhouChina Key Laboratory of Laparoscopic Technology of Zhejiang Province 310016 HangzhouChina Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease 310016 HangzhouChina Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment 310016 HangzhouChina Zhejiang University Cancer Center 310000 HangzhouChina

Recently,genetically targeted cancer therapies have been a topic of great *** lethality provides a new approach for the treatment of mutated genes that were previously considered unable to be targeted in traditional genotype-targeted *** increasing researches and applications in the clinical setting made synthetic lethality a promising anticancer treatment ***,the current understandings on different conditions of synthetic lethality have not been systematically assessed and the application of synthetic lethality in clinical practice still faces many ***,we propose a novel and systematic classification of synthetic lethality divided into gene level,pathway level,organelle level,and conditional synthetic lethality,according to the degree of specificity into its biological *** preclinical findings of synthetic lethality in recent years will be reviewed and classified under these different ***,synthetic lethality targeted drugs in clinical practice will be briefly ***,we will explore the essential implications of this classification as well as its prospects in eliminating existing challenges and the future directions of synthetic lethality.

关键词： specificity drugs synthetic

Laparoscopic liver resection in China

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Laparoscopic, Endoscopic and Robotic Surgery 2018年第1期1卷 2-4页

作者： xiujun cai Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

In 1991,laparoscopic liver resection(LLR)was firstly reported by Reich and was subsequently firstly reported in China in 1994 by Zhou.1,2 Dramatic improvements had been made in this procedure in the ensuing 26 *** first and second international consensus conferences on laparoscopic liver resection were held in 2008 and 2014 and will continue to be held every 6 *** international laparoscopic liver society formed in 2016 and its first international congress will be held in Paris in July *** advantage of LLR had been recognized by patients and surgeons and is gradually replacing conventional open liver resection in some regions of the world.

关键词： Laparoscopic Liver resection Hepatectomy Minimally invasive surgery

CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma:a cross-talk between FGF21 and the NRF2 pathway

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Science China(Life Sciences) 2022年第10期65卷 1998-2016页

作者： Jiang Chen Shi Jiang Huijiang Shao Bixia Li Tong Ji Daniel Staiculescu Jiayan He Jie Zhao Liuxin cai Xiao Liang Junjie Xu xiujun cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Laparoscopic Technology of Zhejiang Province Hangzhou 310016China Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease Hangzhou 310016China Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment Hangzhou 310016China Cancer Center Zhejiang UniversityHangzhou 310058China Department of Radiation Oncology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Department of Hepatobiliary and Pancreatic Surgery Shaoxing People’s HospitalShaoxing 312000China Department of Hematology Ningbo First HospitalZhejiang UniversityNingbo 315010China

The treatment of hepatocellular carcinoma(HCC)has been dominated by multikinase inhibitors for more than a ***,drug resistance can severely restrict the efficacy of these *** CRISPR/CAS9 genome library screening,we evaluated Kelch-like ECH-associated protein 1(KEAP1)as a key regulator of sorafenib’s susceptibility in *** also investigated whether KEAP1’s knockdown can stabilize nuclear factor(erythroid-derived 2)-like 2(NRF2)protein levels that led to sorafenib’s resistance,including an NRF2 inhibitor that can synergize with sorafenib to abolish HCC’s growth in vitro and in ***,we clarified that fibroblast growth factor 21(FGF21)is an important downstream regulator of NRF2 in ***,we observed that FGF21 bound to NRF2 through the C-terminus of FGF21,thereby stabilizing NRF2 by reducing its ubiquitination and generating a positive feedback loop in sorafenib-resistant *** findings,therefore,propose that targeting FGF21 is a promising strategy to combat HCC sorafenib’s resistance.

关键词： hepatocellular carcinoma(HCC) CRISPR screen Kelch-like ECH-associated protein 1(KEAP1) fibroblast growth factor 21(FGF21) nuclear factor(erythroid-derived 2)-like 2(NRF2)

Development and validation of a nomogram for survival benefit of lymphadenectomy in resected gallbladder cancer

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 480-489页

作者： Mingyu Chen Jian Lin Jiasheng Cao Hepan Zhu Bin Zhang Angela Wu xiujun cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China Key Laboratory of Endoscopic Technique Research of Zhejiang Province Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China Longyou People’s Hospital Quzhou 324400China Medicine University of MelbourneMelbourneVICAustralia

Background:Due to absence of large,prospective,randomized,clinical trial data,the potential survivalbenefit of lymphadenectomy with different number of regional lymph nodes(LNs)remains *** aim to create a predicting model to help estimate individualized potential survival benefit oflymphadenectomy with more regional LNs for patients with resected gallbladder cancer(GBC).Methods:Patients with resected GBC were selected from the Surveillance,Epidemiology,and End Resultsdatabase who were diagnosed between 2004 and *** included age,race,sex,grade,histologicalstage,tumor sizes and receipt of non-primary *** types of multivariate survival regression modelswere constructed and *** best model performance was tested by the external validation data fromour ***:A total of 1,669 patients met the inclusion criteria for this *** lognormal survival modelshowed the best performance and was tested by the external validation data,including 193 patients withresected GBC from our ***,which based on the accelerated failure time parametricsurvival model,were built to estimate individualized survival.C-index,was up to 0.754 and 0.710 in internalvalidation for more and less regional LNs removed,*** of internal and external calibrationcurves showed good agreement between predicted and observed outcomes in the 1-,3-,and 5-year overallsurvival(OS).Conclusions:A predicting model can be used as a decision model to predict which patients may obtainbenefit from lymphadenectomy with more regional LNs.

关键词： Gallbladder cancer(GBC) nomogram lymphadenectomy predicting model overall survival(OS)