检索结果-南通市图书馆

Evaluation of the relative differences in building energy simulation results

在线全文

学校读者我要写书评

暂无评论

Building Simulation 2022年第11期15卷 1977-1987页

作者： Dan Wang xiufeng pang Wei Wang Chuan Wan Gang Wang Institute of Building Environment and Energy China Academy of Building ResearchBeijing 100013China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China National Engineering Research Center of Building Technology Beijing 100013China Beijing Institute of Petrochemical Technology No.19 Qingyuan RoadDaxing DistrictBeijing 102627China Department of Civil Architectural and Environmental EngineeringUniversity of MiamiMiamiFL 33146USA

Building energy modeling,also known as building energy simulation,has developed rapidly in recent years and plays a crucial role in building life-cycle *** can be employed in the design phase to predict the energy consumption of different design schemes and evaluate various control and retrofitting measures at the operation *** such simulations,it is commonly understood and accepted that the simulated relative differences are more reliable than the predictions of absolute energy ***,whether this common understanding is true is yet to be thoroughly *** this study,we investigate the simulated relative differences and the extent to which they are affected by the degree of model input *** and Monte Carlo approaches are adopted for the *** results indicate that the simulated relative differences are not as reliable as expected,and the outputs strongly depend on the degree of the model input *** the degree of deviation is less than 15%or the model inputs are within reasonable ranges,the simulated relative differences match the baseline obtained using Monte Carlo ***,the model’s error indicators meet the requirements of the ASHRAE Guideline 14–2014 when the degree of input deviation is below 15%.

关键词： simulated relative differences building energy simulation Monte Carlo simulation EnergyPlus

Genomic landscape of gastric cancer： molecular classification and potential targets

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2017年第2期60卷 126-137页

作者： Jiawei Guo Weiwei Yu Hui Su xiufeng pang Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Shanghai 200241 China

Gastric cancer imposes a considerable health burden worldwide, and its mortality ranks as the second highest for all types of cancers. The limited knowledge of the molecular mechanisms underlying gastric cancer tumorigenesis hinders the development of therapeutic strategies. However, ongoing collaborative sequencing efforts facilitate molecular classification and unveil the genomic landscape of gastric cancer. Several new drivers and tumorigenic pathways in gastric cancer, including chromatin remodeling genes, Rho A-related pathways, TP53 dysregulation, activation of receptor tyrosine kinases, stem cell pathways and abnormal DNA methylation, have been revealed. These newly identified genomic alterations await translation into clinical diagnosis and targeted therapies. Considering that loss-of-function mutations are intractable, synthetic lethality could be employed when discussing feasible therapeutic strategies. Although many challenges remain to be tackled, we are optimistic regarding improvements in the prognosis and treatment of gastric cancer in the near future.

关键词： gastric cancer chromatin remodeling RhoA p53 receptor tyrosine kinase DNA methylation

Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2019年第10期62卷 1409-1412页

作者： Juanjuan Feng Mingjin Rao Man Wang Lin Liang Zhi Chen xiufeng pang Weiqiang Lu Zhenliang Sun Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Shanghai 200241China Shanghai University of Medicine & Health Sciences Affiliated Sixth People’s Hospital South Campus Shanghai 201499China

Dear Editor,Pancreatic cancer (PCa) is a high-grade gastrointestinal malignancy more commonly occurring in elderly populations with lower than 5% overall 5-year survival rate (Hidalgo, 2010). PCa responds poorly to most chemotherapeutic agents, and therefore it is imperative to develop novel therapeutic agents that have anti-cancer activities against PCa.

关键词： malignancy survival rate imperative

Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第3期13卷 1145-1163页

作者： Juanjuan Feng Zhengke Lian Xinting Xia Yue Lu Kewen Hu Yunpeng Zhang Yanan Liu Longmiao Hu Kun Yuan Zhenliang Sun xiufeng pang Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Joint Center for Translational Medicine Southern Medical University Affiliated Fengxian HospitalShanghai 201499China Cancer Institute Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

MEK is a canonical effector of mutant KRAS;however,MEK inhibitors fail to yield satisfactory clinical outcomes in KRAS-mutant ***,we identified mitochondrial oxidative phosphorylation(OXPHOS)induction as a profound metabolic alteration to confer KRAS-mutant non-small cell lung cancer(NSCLC)resistance to the clinical MEK inhibitor *** flux analysis demonstrated that pyruvate metabolism and fatty acid oxidation were markedly enhanced and coordinately powered the OXPHOS system in resistant cells after trametinib treatment,satisfying their energy demand and protecting them from *** molecular events in this process,the pyruvate dehydrogenase complex(PDHc)and carnitine palmitoyl transferase IA(CPTIA),two rate-limiting enzymes that control the metabolic flux of pyruvate and palmitic acid to mitochondrial respiration were activated through phosphorylation and transcriptional ***,the co-administration of trametinib and IACS-010759,a clinical mitochondrial complex I inhibitor that blocks OXPHOS,significantly impeded tumor growth and prolonged mouse ***,our findings reveal that MEK inhibitor therapy creates a metabolic vulnerability in the mitochondria and further develop an effective combinatorial strategy to circumvent MEK inhibitors resistance in KRAS-driven NSCLC.

关键词： KRAS-mutant lung cancer MEK inhibitors Drug resistance Metabolic rewiring Mitochondrial oxidative phosphorylation Pyruvate dehydrogenase complex Carnitine palmitoyl transferase IA

在线全文

学校读者我要写书评

暂无评论

基于学习进阶理念的科技服务人才培养模式

管理现代化 2020年第3期40卷 95-98页

作者：赵楠逄秀凤华东师范大学教师教育学院华东师范大学生命科学学院上海200062

基于科技服务人才教育在组织机构、课程资源、培训师资等方面的困境,借助科学教育领域的学习进阶理念,构建了涵盖职业教育与评价的科技服务人才培养模式,通过域外项目解析而阐释其具体应用和潜在优势,借此为科技服务人才培养提供一种有... 详细信息

基于科技服务人才教育在组织机构、课程资源、培训师资等方面的困境,借助科学教育领域的学习进阶理念,构建了涵盖职业教育与评价的科技服务人才培养模式,通过域外项目解析而阐释其具体应用和潜在优势,借此为科技服务人才培养提供一种有效的实施路径。

关键词：学习进阶人才培养创新人才科技服务科学教育

模型预测控制在暖通空调领域应用研究综述与展望

在线全文

学校读者我要写书评

暂无评论

建筑科学 2021年第12期37卷 111-119,130页

作者：王丹逄秀锋王伟绿色建筑环境与节能技术北京市重点实验室北京工业大学北京100124 中国建筑科学研究院有限公司北京100013

随着先进绿色技术与系统的应用推广,模型预测控制作为一种前馈控制方法,在暖通空调领域逐步得到重视,以弥补传统控制方法的不足。为了充分了解模型预测控制已有的研究成果并开展更深入的研究,本文对暖通空调领域模型预测控制技术的国内... 详细信息

随着先进绿色技术与系统的应用推广,模型预测控制作为一种前馈控制方法,在暖通空调领域逐步得到重视,以弥补传统控制方法的不足。为了充分了解模型预测控制已有的研究成果并开展更深入的研究,本文对暖通空调领域模型预测控制技术的国内外研究现状进行了分析总结。首先,本文阐述了暖通空调领域应用模型预测控制的意义,阐明了模型预测控制的基本概念及其特点;其次,对比分析了白箱模型、灰箱模型和黑箱模型3种预测模型建立方法的优缺点,探讨了模型预测控制中常用的优化算法,综合分析了模型预测控制在模拟仿真研究和实验测试研究的应用效果;最后,指出现有研究的不足,提出未来暖通空调领域模型预测控制研究应积极探索预测模型建立的新方法,并加强模型预测控制的实际应用效果分析。

关键词：暖通空调模型预测控制建模方法优化算法应用效果分析

Experimentally-determined characteristics of radiant systems for office buildings

在线全文

学校读者我要写书评

暂无评论

建筑节能(中英文) 2018年第7期 118-118页

作者： Hongyuan Jia xiufeng pang Philip Haves 侯恩哲

Radiant heating and cooling systems have significant energy-saving potential and are gaining popularity in commercial buildings. The main aim of the experimental study reported here was to characterize the behavior of radiant cooling systems in a typical office environment,including the effect of ceiling fans on stratification,the variation in comfort conditions from perimeter to core,control on operative temperature vs. air temperature and the effect of carpet on cooling capacity. The goal was to limit both the first cost and the perceived risk associated with such systems. Two types of radiant systems,the radiant ceiling panel( RCP) system and the radiant slab( RS) system,were investigated. The experiments were carried out in one of the test cells that constitute the FLEXLAB test facility at the Law rence Berkeley National Laboratory in March and April 2016. In total,tentest cases( five for RCP and five for RS) were performed,covering a range of operational conditions. In cooling mode,the air temperature stratification is relatively small in the RCP,with a maximum value of 1. 6 K. The observed stratification effect was significantly greater in the RS,tw ice as much as that in the *** maximum increase in dry bulb temperature in the perimeter zone due to solar radiation was 1. 2 K for RCP and 0. 9 K for RS-too small to have a significant impact on thermal comfort. The use of ceiling fans was able to reduce any excess stratification and provide better indoor comfort,if required. The use of thin carpet requires a 1 K low er supply chilled water temperature to compensate for the added thermal resistance,somew hat reducing the opportunities for water-side free cooling and increasing the risk of condensation. In both systems,the difference betw een the room operative temperature and the room air temperature is small when the cooling loads are met by the radiant systems. This makes it possible to use the air temperature to control the radiant systems in lieu of the op

关键词： Radiant systems Stratification Operative temperature Variation in comfort FLEXLAB

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

大型公共建筑柔性调节综合评价方法研究

建筑科学 2023年第12期39卷 244-254页

作者：孙甄淇逄秀锋衷逸群李鑫王丹绿色建筑环境与节能技术北京市重点实验室北京工业大学北京100124 国家建筑工程技术研究中心北京100013 中国建筑科学研究院有限公司深圳分公司广东深圳518057 信息学部北京工业大学北京100124

由于全球气候变暖等环境问题,需要采取措施减少碳排放,为此我国提出了“双碳”目标,可再生能源也因此得到了大量的应用。但这类能源自身的不稳定性会对电网平稳运行造成影响,基于建筑柔性调节的需求侧响应是解决方法之一,而发展该技术... 详细信息

由于全球气候变暖等环境问题,需要采取措施减少碳排放,为此我国提出了“双碳”目标,可再生能源也因此得到了大量的应用。但这类能源自身的不稳定性会对电网平稳运行造成影响,基于建筑柔性调节的需求侧响应是解决方法之一,而发展该技术的前提是对其潜力的量化和合理评价。本文针对大型公共建筑,探讨其柔性调节潜力量化和评价的方法。首先通过对比分析确定了“转移负载”的调节方法,并对相关边界条件进行了详细规定;然后从柔性的不同维度出发,根据现有文献最常用的指标构建了评价指标体系;随后基于改进后的CRITIC赋权法赋予各指标权重,并构建了线性加权评价模型;最后基于辨识度理论,以夏热冬暖地区的大型办公建筑为例建立EnergyPlus能耗模型,对该方法进行了分析与验证。

关键词：双碳柔性调节综合评价方法转移负载 CRITIC赋权法辨识度

在线全文

学校读者我要写书评

暂无评论

肠道细菌产物胞壁酰二肽的研究进展

老年医学与保健 2023年第1期29卷 148-152页

作者：赵璐佳石斌庞秀峰同济大学医学院上海200092 同济大学附属杨浦医院急诊科上海200090

肠道被称为多器官功能障碍综合征的发动机,肠源性脓毒症和肠道细菌移位在危重症救治中日益受到关注。肠道细菌移位的重要途径之一是细菌产物移位。而作为革兰氏阳性菌和阴性菌的细胞壁最小肽聚糖免疫活性物质,细菌产物胞壁酰二肽(muramy... 详细信息

肠道被称为多器官功能障碍综合征的发动机,肠源性脓毒症和肠道细菌移位在危重症救治中日益受到关注。肠道细菌移位的重要途径之一是细菌产物移位。而作为革兰氏阳性菌和阴性菌的细胞壁最小肽聚糖免疫活性物质,细菌产物胞壁酰二肽(muramyl dipeptide,MDP)肠道移位对机体的免疫与代谢具有重大的影响。本文重点关注MDP的肠道移位机制及其调控方法(包括MDP转运途径、作用靶点、信号通路和炎性损伤路径),聚焦MDP对免疫和代谢的影响。

关键词：胞壁酰二肽线粒体免疫代谢