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Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect

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Acta Pharmaceutica Sinica B 2023年第12期13卷 5121-5134页

作者： Feng Long Yao Pan Jinheng Li Suinan Sha xiubo Shi Haoyan Guo Chuanqing Huang Qian Xiao Chao Fan Xingmei zhang Jun-Bing Fan Ying Wang Cancer Research Institute Experimental Education/Administration CenterKey Laboratory of Functional Proteomics of Guangdong ProvinceSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Extracellular vesicles(EVs)have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size,biocompatibility,and high ***,we demonstrate orange-derived extracellular vesicles(OEV)nanodrugs(DN@OEV)by modifying cRGD-targeted doxorubicin(DOX)nanoparticles(DN)onto the surface of OEV,enabling significantly enhancing tumor accumulation and penetration,thereby efficiently inhibiting the growth of ovarian *** obtained DN@OEV enabled to inducement of greater transcytosis capability in ovarian cancer cells,which presented the average above 10-fold transcytosis effect compared with individual *** was found that DN@OEV could trigger receptor-mediated endocytosis to promote early endosome/recycling endosomes pathway for exocytosis and simultaneously reduce degradation in the early endosomes-late endosomes-lysosome pathway,thereby inducing the enhanced *** particular,the zombie mouse model bearing orthotopic ovarian cancer further validated DN@OEV presented high accumulation and penetration in tumor tissue by the transcytosis *** study indicated the strategy in enhancing transcytosis has significant implications for improving the therapeutic efficacy of thedrugdelivery system.

关键词： Extracellular vesicles Transcytosis Cancer treatment Drug delivery system Targeted modification Receptor-mediated endocytosis Intracellular trafficking Recycling endosome

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Examining Health of Wetlands with Multiple Ecosystem Services as Targets in China’s Coastal Regions

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Chinese Geographical Science 2020年第4期30卷 600-613页

作者： ZHOU Yangming DOU Yuehan YU xiubo zhang Li HUANG Chong WANG Yuyu LI Xiaowei LI He JIA Yifei BAKKER Martha CARSJENS Gerrit Jan ZHOU Yan DUAN Houlang School of Geography and Environment Jiangxi Normal UniversityNanchang 330022China Land Use Planning Group Wageningen University and ResearchWageningen 6700HBthe Netherlands Key Laboratory of Ecosystem Network Observation and Modelling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China Key Laboratory for Biodiversity Science and Ecological Engineering Ministry of EducationCollege of Life SciencesBeijing Normal UniversityBeijing 100875China State Key Laboratory of Resources and Environment Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Nature Conservation Beijing Forestry UniversityBeijing 100083China Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai Shandong 264003China College of Biology and Environment Nanjing Forestry UniversityNanjing 210037China

Coastal zones are key interconnectors of terrestrial and marine *** to the degradation and fragmentation of coastal wetlands,there is an urgent need to develop assessment methodology to compare the health of wetland ecosystems at different spatial *** will help efficiently develop and implement protections using easy-to-access ecosystem health *** study aims to understand the spatial distribution of coastal and inland wetland health for China’s coastal regions.A Wetland Health Index(WHI)was developed to provide a basis for policy and decision *** utilization models—Long Term Model,Open Model,Nature Reserve Model,and Protected and Economic Model—were defined in the context of China’s coastal regions to specifically examine wetland *** show that the average WHI score was 63.6 with the range of 44.8–84.3 for 35 National Nature Reserves(NNRs),and the southern NNRs generally performed better than the northern *** wetlands in the southern provinces/municipalities are relatively healthier than their northern *** competent authority has slight influence on WHI scores but duration of conservation establishment does not show a clear *** increasing economic activity,the differences in health conditions(WHI scores)of China’s coastal regions also *** Domestic Product(GDP)or economic intensification does not relate to WHI *** trade-offs between wetland management and economic development could contribute to improve health conditions,conservation and utilization of coastal and inland wetlands.

关键词： Wetland Health Index(WHI) ecosystem services wetland utilization coastal zones

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Patterning the neuronal cells via inkjet printing of self-assembled peptides on silk scaffolds

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Progress in Natural Science:Materials International 2020年第5期30卷 686-696页

作者： Weizhen Sun Yi zhang David A.Gregory Ana Jimenez-Franco Mhd Anas Tomeh Songwei Lv Jiqian Wang John W.Haycock Jian R.Lu xiubo Zhao Department of Chemical and Biological Engineering University of Sheffield Department of Materials Science & Engineering University of Sheffield School of Pharmacy Changzhou University Centre for Bioengineering and Biotechnology China University of Petroleum East China School of Physics and Astronomy University of Manchester

The patterning of neuronal cells and guiding neurite growth are important for neuron tissue engineering and cell-based biosensors. In this paper, inkjet printing has been employed to pattern self-assembled I3QGK peptide nanofibers on silk substrates for guiding the growth of neuron-like PC12 cells. Atomic force microscopy(AFM)confirmed the dynamic self-assembly of I3QGK into nanofiber structures. The printed self-assembled peptide strongly adheres to regenerated silk fibroin(RSF) substrates through charge-charge interactions. It was observed that in the absence of I3QGK, PC12 cells exhibited poor attachment to RSF films, while for RSF surfaces coated or printed with peptide nanofibers, cellular attachment was significantly improved in terms of both cell density and morphology. AFM results revealed that peptide nanofibers can promote the generation of axons and terminal buttons of PC12 cells, indicating that I3QGK nanofibers not only promote cellular attachment but also facilitate differentiation into neuronal phenotypes. Inkjet printing allows complex patterning of peptide nanofibers onto RSF substrates, which enabled us to engineer cell alignment and provide an opportunity to direct axonal development in vitro. The live/dead assay showed that printed I3QGK patterns exhibit no cytotoxicity to PC12 cells demonstrating potential for future nerve tissue engineering applications.

关键词： Neurobiology Micro-patterning Inkjet printing Self-assembling peptides PC12 cells

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Morphology controllable urchin-shaped bimetallic nickel-cobalt oxide/carbon composites with enhanced electromagnetic wave absorption performance

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Journal of Materials Science & Technology 2023年第17期148卷 250-259页

作者： Fushan Li Qiuyu Li Hideo Kimura xiubo Xie Xiaoyu zhang Nannan Wu Xueqin Sun Ben Bin Xu Hassan Algadi Rami Adel Pashameah Abdullah K.Alanazi Eman Alzahrani Handong Li Wei Du Zhanhu Guo Chuanxin Hou School of Environmental and Material Engineering Yantai UniversityYantai 264005China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264005China School of Material Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Electrical Engineering Faculty of EngineeringNajran UniversityNajran 11001Saudi Arabia Department of Chemistry Faculty of Applied ScienceUmm Al-Qura UniversityMakkah 24230Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Integrated Composites Laboratory(ICL) Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK Department of Chemical and Bimolecular Engineering University of TennesseeKnoxvilleTN 37996United States

The microscopic morphology of electromagnetic wave absorbers influences the multiple reflections of electromagnetic waves and impedance matching,determining the absorption ***,the urchin-shaped bimetallic nickel-cobalt oxide/carbon(NiCo_(2)O_(4)/C)composites are prepared via a hy-drothermal route,whose absorption properties are investigated by different morphologies regulated by changing calcination temperature.A minimum reflection loss(RL_(min))of-75.26 dB is achieved at a match-ing thickness of 1.5 mm,and the effective absorption bandwidth(EAB)of 8.96 GHz is achieved at 2 ***-advantages of the synthesized NiCo_(2)O_(4)/C composites contribute to satisfactory absorption ***,the interweaving of the needle-like structures increases the opportunities for scattering and multiple reflections of incident electromagnetic waves,and builds up a conductive network to facilitate the enhancement of conductive ***,the carbon component in the NiCo_(2)O_(4)/C composites en-hances the interfacial polarization and reduces the density of the ***,generous oxygen va-cancy defects are introduced into the NiCo_(2)O_(4)/C composites,which induces defect polarization and dipole *** summary,the ternary coordination of components,defects and morphology led to out-standing electromagnetic wave absorption,which lightened the path for improving the electromagnetic wave absorption property and enriching the family of NiCo_(2)O_(4) absorbers with excellent performance.

关键词： NiCo_(2)O_(4)/C Oxygen vacancies Interfacial polarization Electromagnetic wave absorber

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Effects of Biochar-based Organic Fertilizer on Accumulation of Total Flavonoid Contents in Dandelion

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Journal of Northeast Agricultural University(English Edition) 2024年第4期31卷 46-53页

作者： Jiang Xinmei zhang Yuxin Liu Hanbing Cheng Yao Liu xiubo Liu Weili Ma Wei College of Horticulture and Landscape Architecture Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Horticultural Crop Biology and Germplasm Creation in the Northeast Region of the Ministry of Agriculture Harbin 150030China Jiamusi College Heilongjiang University of Chinese MedicineJiamusi 154007HeilongjiangChina College of Pharmacy Heilongjiang University of Chinese MedicineHarbin 150040China

In order to study the effects of biochar-based organic fertilizer on the accumulation of the total flavonoid contents in dandelion after sowing,the experiment applied four levels of treatments of carbon-based organic fertilizer(0.15,0.30,0.45,and 0.60 kg•m^(-2)),and the base fertilizer that only applied conventional chemical fertilizer was used as the *** total flavonoid contents and physiological indices of dandelion in different growth periods were *** results showed that the accumulation of the total flavonoid contents in leaves and roots of dandelion improved significantly by applying biochar-based organic fertilizer(0.15,0.30,0.45,and 0.60 kg•m^(-2)),with the highest total flavonoid occurred in the 0.45 kg•m^(-2) biochar-based organic fertilizer *** with dandelion growing,the total flavonoid contents in leaves were first elevated,and then decreased,with the maximum reached at 95 days after sowing(anthesis).While the total flavonoid contents in roots were elevated *** total flavonoid contents accumulation in dandelion were positively correlated with net photosynthetic rate,stomatal conductance,transpiration rate,soluble sugar content,soluble protein,nitrate nitrogen,and available potassium,while negatively correlated with intercellular CO_(2) concentration.

关键词： dandelion total flavonoid contents biochar-based organic fertilizer photosynthesis soil nutrient

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鄱阳湖湿地3种优势植物枯落物分解过程及碳氮同位素分异特征

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湖泊科学 2023年第5期35卷 1694-1704页

作者：张全军于秀波张广帅中国气象局气象探测中心北京100081 中国科学院地理科学与资源研究所中国科学院生态系统网络观测与模拟重点实验室北京100101 国家海洋环境监测中心大连116023 中国科学院大学北京100049

植物枯落物分解是维持湿地生态系统能量流动、物质循环和养分平衡的关键生态过程。于2017年11月—2018年4月在鄱阳湖湿地开展野外原位分解实验。利用分解袋法对3种优势植物芦苇(Phragmites australis)、南荻(Triarrhena lutarioriparia... 详细信息

植物枯落物分解是维持湿地生态系统能量流动、物质循环和养分平衡的关键生态过程。于2017年11月—2018年4月在鄱阳湖湿地开展野外原位分解实验。利用分解袋法对3种优势植物芦苇(Phragmites australis)、南荻(Triarrhena lutarioriparia)和薹草(Carex cinerascens)枯落物纤维素和木质素分解过程和δ^(13)C、δ^(15)N分异特征开展了模拟实验研究。结果表明:芦苇、南荻和薹草枯落物的纤维素和木质素的分解速率、干物质残留率以及δ^(13)C、δ^(15)N差异性极显著,造成这种差异的主要原因是不同种类植物枯落初始化学特性的不同,尤其是C/N和木质素/N的不同。枯落物中纤维素和木质素的分解速率都表现芦苇最大,薹草次之,南荻最小。Olson负指数衰减模型能非常好地模拟和预测3种植物枯落物的分解过程。伴随分解过程,3种植物枯落物δ^(13)C上下波动,总体上呈显著降低的趋势,而δ^(15)N则都呈现波动性的略有升高趋势,这说明在枯落物分解过程的不同阶段内,受枯落物基质质量和微生物代谢活动的双重影响,^(13)C与^(15)N既有释放也有富集。δ^(13)C与枯落物纤维素和木质素分解速率都有极显著的正相关关系。δ^(15)N与分解速率相关性不显著,这说明除了氮元素的迁移转化外,还有其他因素影响δ^(15)N的变化。本研究有助于加深枯落物分解过程中基质质量调控机制的认识,深化对鄱阳湖湿地生物地球化学循环过程的科学理解。

关键词：鄱阳湖湿地植物枯落物纤维素木质素分解过程 δ^(13)C δ^(15)N 稳定同位素

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Sources of organic carbon supporting the dry-season food web of a sublake in wetlands of Poyang Lake

Sources of organic carbon supporting the dry-season food web...

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“全球变化下的海洋与湖沼生态安全”学术交流会

作者： Huan zhang Yuyu WANG Shaoxia XIA Bin CHEN xiubo YUA Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences University of Chinese Academy of Sciences College of Nature Conservation Beijing Forestry University Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

Benthic food web in lakes is generally supported by autochthonous primary production, and by terrestrial detritus derived from the surrounding catchment. Several studies have highlighted the importance of allochthonous input, but the effects of subsidy of that carbon source are not well understood in floodplain lakes of wetland, especially when thousands of herbivorous migrated waterfowl winter in that area and the water level is deceding. With stable isotope signatures(δ13C and δ15N) of four primary food sources and aquatic consumers, we used SIAR model to identify the relative importance of different production sources supporting the macroinvertebrate food web in a floodplain sublake of wetlands in Lake Poyang during the late dry season. Our data showed that Carex spp. was the predominant primary food source, potentially contributing 35%3% organic carbon to the biomass of aquatic consumers in the sublake of wetlands, although its C:N ratio was much lower than other sources. For most of macroinvertebrate species, phytoplankton, and possibly particulate organic matter in the seston, were the other major carbon sources that they utilized. However, we did not find benthic algae or Vallisneria natans as thought to be important food sources for benthic primary consumers due to their low biomass during the cold and low water period. Our findings underpin the importance of allochthonous carbon sources, and further provide a view that migratory waterfowl may facilitate those subsidize which can support the biomass and productivity of consumer taxa in wetlands of Lake Poyang when availability of food sources is limited.

关键词： allochthonous Carex spp. macroinvertebrates wetland stable isotope

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京津城际铁路轨道不平顺谱特征分析

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中国铁道科学 2008年第5期29卷 25-30页

作者：张曙光康熊刘秀波铁道部运输局北京100844 中国铁道科学研究院北京100081

为提高京津城际铁路轨道不平顺谱的计算精度,基于轨道不平顺变化率和线性插值方法以及小波分析方法,给出剔除轨道不平顺异常值算法和轨道不平顺零均值化处理算法,用于京津城际铁路轨道不平顺检测数据的预处理。运用周期图法计算京津城... 详细信息

为提高京津城际铁路轨道不平顺谱的计算精度,基于轨道不平顺变化率和线性插值方法以及小波分析方法,给出剔除轨道不平顺异常值算法和轨道不平顺零均值化处理算法,用于京津城际铁路轨道不平顺检测数据的预处理。运用周期图法计算京津城际铁路的轨道不平顺谱。对计算结果的统计分析表明:京津城际铁路的轨道不平顺谱服从自由度为2的χ2分布,可以用轨道不平顺中位数谱表示;除部分波段外,京津城际铁路的轨道不平顺谱均低于我国铁路时速200 km以上既有线路的轨道不平顺谱和德国铁路的轨道不平顺低干扰谱,说明京津城际铁路轨道平顺状态较好。

关键词：轨道不平顺谱异常值零均值化中位数谱数据处理计算方法京津城际铁路

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Cipherchain:A Secure and Efficient Ciphertext Blockchain via mPECK

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Journal of Quantum Computing 2020年第1期2卷 57-83页

作者： Hailin Chen Gang Xu Yuling Chen xiubo Chen Yixian Yang Ruibin Fan Kaixiang zhang Huizhong Li Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Guizhou University Sate Key Laboratory of Public Big DataGuizhou550025China North China University of Technology School of Computing Science and TechnologyBeijingChina Webank Shenzhen518000China

Most existing blockchain schemes are based on the design concept“openness and transparency”to realize data security,which usually require transaction data to be presented in the form of ***,it inevitably brings the issues with respect to data privacy and operating *** this paper,we proposed a novel blockchain scheme called Cipherchain,which can process and maintain transaction data in the form of ciphertext while the characteristics of immutability and auditability are *** in our scheme,transactions can be encrypted locally based on a searchable encryption scheme called multi-user public key encryption with conjunctive keyword search(mPECK),and can be accessed by multiple specific participants after appended to the globally consistent distributed *** introducing execution-consensus-update paradigm of transaction flow,Cipherchain cannot only make it possible for transaction data to exist in the form of ciphertext,but also guarantee the overall system performance not greatly affected by cryptographic operations and other local execution *** addition,Cipherchain is a promising scheme to realize the technology combination of“blockchain+cloud computing”and“permissioned blockchain+public blockchain”.

关键词： Blockchain Cipherchain cloud computing mPECK

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双脉冲HiPIMS放电特性及CrN薄膜高速率沉积

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金属学报 2019年第3期55卷 299-307页

作者：吴厚朴田修波张新宇巩春志哈尔滨工业大学先进焊接与连接国家重点实验室哈尔滨150001

提出了一种新型的高功率脉冲磁控溅射(HiPIMS)技术,即放电由脉宽短、电压高的引燃脉冲和脉宽长、电压低的工作脉冲2部分组成的双脉冲高功率脉冲磁控溅射技术,目的是解决传统高功率脉冲磁控溅射沉积速率低的问题。研究了引燃脉冲电压及... 详细信息

提出了一种新型的高功率脉冲磁控溅射(HiPIMS)技术,即放电由脉宽短、电压高的引燃脉冲和脉宽长、电压低的工作脉冲2部分组成的双脉冲高功率脉冲磁控溅射技术,目的是解决传统高功率脉冲磁控溅射沉积速率低的问题。研究了引燃脉冲电压及传统高功率脉冲磁控溅射条件对Cr靶在Ar气气氛下的放电特性的影响,并制备CrN薄膜。结果表明:随着引燃脉冲电压的施加,双脉冲高功率脉冲磁控溅射Cr靶放电瞬间建立,并获得较高的峰值电流,而传统HiPIMS模式的输出是渐渐爬升的三角波电流;与传统高功率脉冲磁控溅射相比,单位功率下双脉冲高功率脉冲磁控溅射具有更高的基体电流积分以及更多的Ar^+和Cr^0数量;引燃脉冲电压为590 V时,双脉冲高功率脉冲磁控溅射单位功率下CrN薄膜沉积速率为2.52μm/(h·kW),比传统高功率脉冲磁控溅射提高近3倍。

关键词：双脉冲高功率脉冲磁控溅射引燃脉冲放电特性 CrN薄膜

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