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Comprehensive analysis of risk factors associated with submucosal invasion in patients with early-stage gastric cancer

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World Journal of Gastroenterology 2024年第47期30卷 5007-5017页

作者： Bin-Bin Yan Li-Na Cheng Hui Yang xiu-Ling Li xiu-qi wang Department of Gastroenterology Henan Provincial People's HospitalZhengzhou University People's HospitalZhengzhou 450000Henan ProvinceChina

BACKGROUND Submucosal invasion in early-stage gastric cancer(GC)is a critical determinant of prognosis and treatment strategy,significantly influencing the risk of lymph node metastasis and *** risk factors associated with submucosal invasion is essential for optimizing patient management and improving *** To comprehensively analyze clinical,imaging,and endoscopic characteristics to identify predictors of submucosal invasion in patients with early-stage differentiated *** A retrospective study was conducted at our institution from January 2019 to January 2023,including 268 patients diagnosed with early-stage differentiated GC who underwent surgical resection or endoscopic submucosal *** were collected on demographic,clinical,imaging,and endoscopic characteristics,with endoscopic images reviewed independently by two *** analysis included univariate and multivariate logistic regression to identify significant predictors of submucosal invasion,and receiver operating characteristic(ROC)curve analysis to evaluate the predictive value of continuous *** A total of 268 patients were included,with 178 males and 90 females,and a mean age of 61.5±9.8 *** analysis showed that male gender,history of alcohol consumption,smoking,and computed tomography-detected gastric wall thickening were more prevalent in patients with submucosal *** endoscopic predictors included tumor location in the upper two-thirds of the stomach,depressed morphology,marginal elevation,and high color differences on white-light endoscopy(WLE)and linked color imaging(LCI).Multivariate analysis identified upper stomach location[odds ratio(OR):5.268],depressed type(OR:5.841),marginal elevation(OR:4.132),and LCI color difference≥18.1(OR:4.479)as significant *** analysis showed moderate predictive value for lesion diameter,WLE,and LCI color differences(area under the curve:0.630,0.799,a

关键词： Submucosal invasion Early-stage gastric cancer White-light endoscopy Linked color imaging Risk factors

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The in ovo injection of methionine improves intestinal cell proliferation and differentiation in chick embryos by activating the JAK2/STAT3 signaling pathway

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Animal Nutrition 2021年第4期7卷 1031-1038页

作者： Meng-Jie Chen Jia-Yi Zhou Yi-Jun Chen xiu-qi wang Hui-Chao Yan Chun-qi Gao College of Animal Science South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition ControlGuangzhou510642China

The intestinal health of chick embryos is vital for their life-long growth,and exogenous nutrition intervention may provide sufficient nutrition for embryonic *** the present study,we investigated the effect of in ovo injection of L-methionine(L-Met)on the intestinal structure and barrier function of chick *** were 4 groups of treatments:the control(CON)group injected with phosphate-buffered saline(PBS)and the other 3 groups injected with 5,10,and 20 mg L-Met/egg,*** injection was performed on embryonic day 9(E9),and intestinal samples were collected on the day of hatching for *** results showed that,compared with the CON group,the groups administered an in ovo injection of L-Met increased relative weights of the duodenum,jejunum,and ileum(P<0.05).Hematoxylin and eosin(H&E)staining showed that the groups injected with 5,10,and 20 mg L-Met significantly increased villus height and crypt depth(P<0.05).Moreover,in ovo injection of 10 mg L-Met also increased the transepithelial electrical resistance(TEER)of the jejunum(P<0.05).Injection with 10 and 20 mg L-Met increased the expression of the tight junction proteins(ZO-1 and claudin-1)and the fluorescence signal intensity of Ki67 and villin proteins(P<0.05).Further,the protein expression of phospho-Janus kinase 2(p-JAK2)and phospho-signal transducer and activator of transcription 3(p-STAT3)was significantly increased by 10 or 20 mg L-Met injection(P<0.05).In conclusion,the injection of L-Met,especially at a dose of 10 mg,showed beneficial effects on the intestinal integrity of chick embryos due to the activation of the JAK2/STAT3 signaling *** results may provide new insights for regulating the intestinal development of embryonic chicks and the rapid growth of chicks after hatching.

关键词： In ovo injection Chick Intestine L-methionine JAK2/STAT3

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Microencapsulated Schwann cell transplantation inhibits P2X3 receptor expression in dorsal root ganglia and neuropathic pain

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Neural Regeneration Research 2018年第11期13卷 1961-1967页

作者： Ya-Ling Zhang De-Jian Chen Bao-Lin Yang Tao-Tao Liu Jia-Juan Li xiu-qi wang Guo-Yong Xue Zeng-Xu Liu Department of Anatomy Basic Medical School Nanchang University NanchangJiangxi Province China First Affiliated Hospital of Nanchang University Nanchang jiangxi Province China Fourth Clinical Medical College of Nanchang University Nanchang Jiangxi Province China Second Clinical Medical College of Nanchang University Nanchang Jangxi Province China Queen Mary College of Nanchang University Nanchang Jiangxi Province China

Schwann cell transplantation is a promising method to promote neural repair, and can be used for peripheral nerve protection and myelination. Microcapsule technology largely mitigates immune rejection of transplanted cells. We previously showed that microencapsulated olfactory ensheathing cells can reduce neuropathic pain and we hypothesized that microencapsulated Schwann cells can also inhibit neuropathic pain. Rat Schwann cells were cultured by subculture and then microencapsulated and were tested using a rat chronic constriction injury（CCI） neuropathic pain model. CCI rats were treated with Schwann cells or microencapsulated Schwann cells and were compared with sham and CCI groups. Mechanical withdrawal threshold and thermal withdrawal latency were assessed preoperatively and at 1, 3, 5, 7, 9, 11 and 14 days postoperatively. The expression of P2X3 receptors in L4-5 dorsal root ganglia of the different groups was detected by double-label immunofluorescence on day 14 after surgery. Compared with the chronic constriction injury group, mechanical withdrawal threshold and thermal withdrawal latency were higher, but the expression of P2X3 receptors was remarkably decreased in rats treated with Schwann cells and microencapsulated Schwann cells, especially in the rats transplanted with microencapsulated Schwann cells. The above data show that microencapsulated Schwann cell transplantation inhibits P2X3 receptor expression in L4-5 dorsal root ganglia and neuropathic pain.

关键词： nerve regeneration neuropathic pain peripheral nerve injury sciatic nerve microencapsulation Schwann cells P2X3 receptor dorsal root ganglion chronic constriction injury cell transplantation neural repair neural regeneration

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Growth of embryo and gene expression of nutrient transporters in the small intestine of the domestic pigeon(Columba livia)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第6期16卷 511-523页

作者： Ming-xia CHEN Xiang-guang LI Jun-xian YANG Chun-qi GAO Bin wang xiu-qi wang Hui-chao YAN College of Animal Science South China Agricultural University/Key Laboratory of Chicken GeneticsBreeding and ReproductionMinistry of Agriculture/Guangdong Provincial Key Laboratory of Agro-Animal Genomics/South China Collaborative Innovation Center for Poultry Disease Control and Product Safety Guangdong Fengli Agricultural Comprehensive Development Co. Ltd.

The objective of this study was to investigate the relationship between gene expression of nutrient（amino acid, peptide, sodium and proton） transporters in the small intestine and embryonic growth in domestic pigeons（Columba livia）. One hundred and twenty-five fertilized eggs were randomly assigned into five groups and were incubated under optimal conditions（temperature of 38.1 °C and relative humidity of 55%）. Twenty embryos/birds from each group were sacrificed by cervical dislocation on embryonic day（E） 9, 11, 13, 15 and day of hatch（DOH）. The eggs, embryos（without yolk sac）, and organs（head, brain, heart, liver, lungs, kidney, gizzard, small intestine, legs, and thorax） were dissected, cleaned, and weighed. Small intestine samples were collected for RNA isolation. The m RNA abundance of intestinal nutrient transporters was evaluated by real-time reverse transcription-polymerase chain reaction（RT-PCR）. We classified these ten organs into four types according to the changes in relative weight during embryonic development. In addition, the gene expression of nutrient transporters was differentially regulated by embryonic day. The m RNA abundances of b^0,＋AT, EAAT3, y^＋LAT2, Pep T1, LAT4, NHE2, and NHE3 increased linearly with age, whereas m RNA abundances of CAT1, CAT2, LAT1, EAAT2, SNAT1, and SNAT2 were increased to higher levels on E9 or E11 and then decreased to lower levels until DOH. The results of correlation analysis showed that the gene expressions of b^0,＋AT, EAAT3, Pep T1, LAT4, NHE2, NHE3, and y^＋LAT2 had positive correlations with body weight（0.71〈correlation coefficient（CC）〈0.82, P〈0.0001）, while CAT1, CAT2, EAAT2, SNAT1, and SNAT2 had negative correlations with body weight（-0.86〈CC〈-0.64, P〈0.0001）. The gene expressions of b^0,＋AT, EAAT3, LAT4, Pep T1, NHE2, NHE3, and y^＋LAT2 showed positive correlations with intestinal weight（0.80〈CC〈0.91, P〈0.0001）, while CAT1, CAT2, and EAAT2 showed negative correlations with intestinal weight（-0.84〈CC〈-0.67, P〈0.0

关键词： Embryonic growth Nutrient transporters Gene expression Small intestine Pigeons

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Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured Lantang swine skeletal muscle satellite cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第6期16卷 549-559页

作者： Chun-qi GAO Yin-ling ZHAO Hai-chang LI Wei-guo SUI Hui-chao YAN xiu-qi wang College of Animal Science South China Agricultural University/National Engineering Research Center for Breeding Swine Industry /Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding Davis Heart & Lung Research Institute Wexner Medical Center at the Ohio State University

Proliferation suppression and apoptosis are the prominent characteristics induced by heat stress（HS） in cells, whereas the effects of HS on cell growth（mass accumulation） are unknown. In this study, Lantang swine（an indigenous breed of China） skeletal muscle satellite cells（SCs） were pre-cultured at 37 °C for 24 h. The HS group was subjected to HS at 41 °C, while the control group was maintained at 37 °C. Heat shock protein 70（HSP70） expression and SC size are significantly increased（P〈0.05） by HS, but cell proliferation is suppressed（P〈0.05） and apoptosis is induced（P〈0.05）. HS led to a lower percentage of SCs in the G0/G1 phase（P〈0.05） together with a higher percentage of SCs in the S phase（P〈0.05）. However, the percentage of SCs in the G2/M phase was decreased（P〈0.05） at 48 h but then increased（P〈0.05） at 72 h with HS. In addition, the phosphorylation ratios of protein kinase b（Akt）, ribosomal protein S6 kinase（S6K）, and ribosomal protein S6 were increased（P〈0.05） by HS. Nevertheless, the phosphorylation ratios of the 4E binding protein 1 and the eukaryotic initiation factor-4E were indistinguishable（P〉0.05） from those of the control group. The phosphorylation ratio of the mammalian target of rapamycin（m TOR）（Ser^2448） increased（P〈0.05） within 48 h, and apparent differences were abrogated at 72 h（P〉0.05）. Moreover, cleaved caspase-3 expression was increased at 72 h（P〈0.05）. These findings indicate that HS induces apoptosis and disrupts cell cycle distribution to decrease the number of cells. Additionally, HS can promote SC growth via an activated Akt/m TOR/S6 K signaling pathway.

关键词： Heat stress Swine Cell proliferation Cell growth Apoptosis Akt/mTOR/S6K pathway

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A report of a new late toxic effect of lenvatinib

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Chinese Medical Journal 2020年第6期133卷 747-748页

作者： Bing Yuan Jin-Long Zhang Mao-qiang wang Yan wang Jie-Yu Yan xiu-qi wang Jin-Xin Fu Department of Interventional Radiology the General Hospital of People's Liberation ArmyBeijing 100853China

To the Editor:Hepatocellular carcinoma(HCC)is the third most lethal malignancy globally.[1]Besides sorafenib,lenvatinib is currently the second approved targeted agent for the first-line treatment of HCC in *** is an oral multikinase inhibitor that targets vascular endothelial growth factor(VEGF)receptors 1 to 3,fibroblast growth factor receptors 1 to 4,platelet-derived growth factor receptor a,RET,and KIT.[2]Patients who received lenvatinib experienced diarrhoea,and alope and more instances of hypertension,proteinuria,and ***,we report two patients that developed irreversible pancreatic atrophy as a novel adverse event of lenvatinib.

关键词： atrophy targeted irreversible

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老年晚期恶性梗阻性黄疸3种姑息治疗方法的疗效比较

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中国内镜杂志 2015年第11期21卷 1148-1151页

作者：程黎娜丁辉杨惠王修齐郑州大学人民医院(河南省人民医院)消化内科河南郑州450003

目的对3种姑息性减黄治疗对老年晚期恶性梗阻性黄疸的疗效进行比较。方法 2011年1月-2012年12月该院的95例老年晚期恶性梗阻性黄疸患者,按照治疗方法分为胆肠吻合组、经皮经肝穿刺胆管引流术(PTCD)组和经内镜逆行胰胆管造影(ERCP)胆管... 详细信息

目的对3种姑息性减黄治疗对老年晚期恶性梗阻性黄疸的疗效进行比较。方法 2011年1月-2012年12月该院的95例老年晚期恶性梗阻性黄疸患者,按照治疗方法分为胆肠吻合组、经皮经肝穿刺胆管引流术(PTCD)组和经内镜逆行胰胆管造影(ERCP)胆管支架置入组,对3种姑息性治疗措施的治疗效果、术后近期并发症、住院时间及患者的生存时间进行回顾性研究。结果 ERCP胆管支架置入组较胆肠吻合组近期并发症、住院时间明显减少;PTCD组较胆肠吻合组住院时间明显缩短,近期并发症明显减少;ERCP组较PTCD组术后并发症减少。3组之间术后黄疸消退、肝功恢复情况及生存时间差异无统计学意义。结论 ERCP胆管支架置入作为一种微创性姑息性治疗手段具有创伤小、痛苦轻、效果好和适应证广等优点,对老年患者恶性梗阻性黄疸等症状的改善及生存质量的提高具有确切疗效,应优先选用。

关键词：晚期恶性梗阻性黄疸经内镜逆行胰胆管造影胆肠吻合术经皮经肝穿刺胆管引流术

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A 14-year multi-institutional collaborative study of Chinese pelvic floor surgical procedures related to pelvic organ prolapse

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Chinese Medical Journal 2021年第2期134卷 200-205页

作者： Zhi-Jing Sun xiu-qi wang Jing-He Lang Tao Xu Yong-Xian Lu Ke-qin Hua Jin-Song Han Huai-Fang Li Xiao-Wen Tong Ping wang Jian-Liu wang Xin Yang Xiang-Hua Huang Pei-Shu Liu Yan-Feng Song Hang-Mei Jin Jing-Yan Xie Lu-Wen wang qing-Kai Wu Jian Gong Yan wang Li-Qun wang Zhao-Ai Li Hui-Cheng Xu Zhi-Jun Xia Li-Na Gu qing Liu Lan Zhu Department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China Department of Obstetrics and Gynecology Graduate School of Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China Department of Epidemiology and Biostatistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijing 100730China Department of Obstetrics and Gynecology The Fourth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200433China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100083China department of Obstetrics and Gynecology Tongji HospitalTongji UniversityShanghai 200065China Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationChengduSichuan 061110China Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Department of Obstetrics and Gynecology The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 075100China Department of Obstetrics and Gynecology Qilu Hospital of Shandong UniversityJinanShandong 250002China Department of Obstetrics and Gynecology 900 Hospital of the Joint Logistics TeamFuzhouFujian 350025China Department of Obstetrics and Gynecology Women’s HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310000China Department of Obstetrics and Gynecology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000China Department of Obstetrics and Gynecology Shanghai Jiao Tong University Sixth HospitalShanghai 200300China Department of Gyn

Background:It has been a global trend that increasing complications related to pelvic floor surgeries have been reported over *** current study aimed to outline the development of Chinese pelvic floor surgeries related to pelvic organ prolapse(POP)over the past 14 years and investigate the potential influence of enhanced monitoring conducted by the Chinese Association of Urogynecology since ***:A total of 44,594 women with POP who underwent pelvic floor surgeries between October 1,2004 and September 30,2018 were included from 22 tertiary academic medical *** data were reported voluntarily and obtained from a *** compared the proportion of each procedure in the 7 years before and 7 years after September 30,*** data were analyzed by performing Z test(one-sided).Results:The number of different procedures during October 1,2011-September 30,2018 was more than twice that during October 1,2004-September 30,*** pelvic floor surgeries related to POP,the rate of synthetic mesh procedures increased from 38.1%(5298/13,906)during October 1,2004-September 30,2011 to 46.0%(14,107/30,688)during October 1,2011-September 30,2018,whereas the rate of non-mesh procedures decreased from 61.9%(8608/13,906)to 54.0%(16,581/30,688)(Z=15.53,P<0.001).Regarding synthetic mesh surgeries related to POP,the rates of transvaginal placement of surgical mesh(TVM)procedures decreased from 94.1%(4983/5298)to 82.2%(11,603/14,107)(Z=20.79,P<0.001),but the rate of laparoscopic sacrocolpopexy(LSC)procedures increased from 5.9%(315/5298)to 17.8%(2504/14,107).Conclusions:The rate of synthetic mesh procedures increased while that of non-mesh procedures decreased *** rate of TVM procedures decreased while the rate of LSC procedures increased *** registration number:NCT03620565,https://***.

关键词： Laparoscopic sacrocolpopexy Pelvic organ prolapse Synthetic mesh Transvaginal placement of surgical mesh

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On the Existence of Ground State Solutions to a Quasilinear Schr?dinger Equation involving p-Laplacian

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Acta Mathematicae Applicatae Sinica 2023年第2期39卷 381-395页

作者： Ji-xiu wang qi GAO School of Mathematics and Statistics Hubei University of Arts and ScienceXiangyang 441053China Department of Mathematics School of ScienceWuhan University of TechnologyWuhan 430070China

We consider the following quasilinear Schrodinger equation involving p-Laplacian-Δpu+V(x)|u|^(p-2)u-Δp(|u|^(2η))|u|^(2η-2)u=λ|u|^(q-2)u/|x|^(μ)+|u|^(2ηp*(v)-2)u/|x|^(v)in R^(N),where N>p>1,η≥p/2(p-1),p0,μ,ν∈[0,p).Via the Mountain Pass Theorem and the Concentration Compactness Principle,we establish the existence of nontrivial ground state solutions for the above problem.

关键词： quasilinear Schrodinger equation critical Hardy-Sobolev exponent ground state solutions singularities

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia xiu-Jun Zhan Charity Ngina qing-Rui Zhang Xiao-Ge Li qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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