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Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles

Bio-Design and Manufacturing 2024年第5期7卷 597-610页

作者： Minxuan Jia Tingting Fan Tan Jia Xin liu heng liu Qi Gu Key Laboratory of Organ Regeneration and Reconstruction State Key Laboratory of Membrane BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Orthopaedics Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

In the intricate skeletal muscle tissue,the symbiotic relationship between myotubes and their supporting vasculature is pivotal in delivering essential oxygen and *** study explored the complex interplay between skeletal muscle and endothelial cells in the vascularization ofmuscle *** harnessing the capabilities of three-dimensional(3D)bioprinting and modeling,we developed a novel approach involving the co-construction of endothelial and muscle cells,followed by their subsequent *** findings highlight the importance of the interaction dynamics between these two cell ***,introducing endothelial cells during the advanced phases of muscle differentiation enhanced myotube ***,it stimulated the development of the vascular network,paving the way for the early stages of vascularized skeletal muscle *** methodology proposed in this study indicates the potential for constructing large-scale,physiologically aligned skeletal ***,it highlights the need for exploring the delicate equilibrium and mutual interactions between muscle and endothelial *** on the multicell-type interaction model,we can predict promising pathways for constructing even more intricate tissues or organs.

关键词： Skeletal muscle Vascularization 3D bioprinting Cell interaction

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The coupling control of biological precursors and environmental factors onβ-carotane enrichment in alkaline lacustrine source rocks:A case study from the Fengcheng formation in the western Junggar Basin,NW China

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Petroleum Science 2024年第2期21卷 836-854页

作者： Mao-Guo Hou Ming Zha Hua liu Hai-Lei liu Jiang-xiu Qu Ablimit Imin xiu-Jian Ding Zhong-Fa Jiang School of Geosciences China University of PetroleumQingdaoShandong266580China Research Institute of Exploration and Development Xinjiang Petroleum Administration BureauKaramayXinjiang834000China

The organic-rich mudstones and dolostones of the Permian Fengcheng Formation(Fm.)are typically alkaline lacustrine source rocks,which are typified by impressively abundantβ-*** β-carotane has been well acknowledged as an effective indicator of biological sources or depositional ***,the specific biological sources of β-carotane and the coupling control of biological sources and environmental factors on the enrichment of β-carotane in the Fengcheng *** *** on a comprehensive investigation of the bulk,molecular geochemistry,and organic petrology of sedimentary rocks and the biochemistry of phytoplankton in modern alkaline lakes,we proposed a new understanding of the biological precursors of β-carotane and elucidated the enrichment mechanism of β-carotane in the Fengcheng *** results show that the biological precursors crucially control the enrichment of β-carotane in the Fengcheng *** haloalkaliphilic cyanobacteria are the primary biological sources of β-carotane,which is suggested by a good positive correlation between the 2-methylhopane index,7-+8-methyl heptadecanes/C_(max),C_(29%),and β-carotane/C_(max)in sedimentary rocks and the predominance of cyanobacteria with abundantβ-carotene in modern alkaline *** enrichment of β-carotane requires the reducing condition,and the paleoredox state that affects the enrichment of β-carotane appears to have a *** paleoclimate conditions do not considerably impact the enrichment of β-carotane,but they have some influence on the water's paleosalinity by affecting evaporation and *** it does not directly affect the enrichment of β-carotane in the Fengcheng Fm.,paleosalinity does have an impact on the cyanobacterial precursor supply and the preservation conditions.

关键词： β-carotane enrichment Cyanobacterial input Environmental impact Alkaline lacustrine source rocks The Fengcheng formation

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A Novel On-Site-Real-Time Method for Identifying Characteristic Parameters Using Ultrasonic Echo Groups and Neural Network

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 215-228页

作者： Shuyong Duan Jialin Zhang heng Ouyang Xu Han Guirong liu State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of TechnologyTianjin 300401China Department of Aerospace Engineering and Engineering Mechanics University of CincinnatiCincinnati 45221USA

On-site and real-time non-destructive measurement of elastic constants for materials of a component in a in-service structure is a challenge due to structural complexities,such as ambiguous boundary,variable thickness,nonuniform material *** work develops for the first time a method that uses ultrasound echo groups and artificial neural network(ANN)for reliable on-site real-time identification of material *** use of echo groups allows the use of lower frequencies,and hence more accommodative to structural *** train the ANNs,a numerical model is established that is capable of computing the waveform of ultrasonic echo groups for any given set of material properties of a given *** waveform of an ultrasonic echo groups at an interest location on the surface the structure with material parameters varying in a predefined range are then computed using the numerical *** results in a set of dataset for training the ANN *** the ANN is trained,the material parameters can be identified simultaneously using the actual measured echo waveform as input to the *** tests have been conducted both numerically and experimentally to evaluate the effectiveness and accuracy of the currently proposed *** results show that the maximum identification error of numerical example is less than 2%,and the maximum identification error of experimental test is less than 7%.Compared with currently prevailing methods and equipment,the proposefy the density and thickness,in addition to the elastic ***,the reliability and accuracy of inverse prediction is significantly ***,it has broad applications and enables real-time field measurements,which has not been fulfilled by any other available methods or equipment.

关键词： Parameter identification Ultrasonic echo group High-precision modeling Artificial neural network NDT

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Experimental Investigation on Vertical Hydraulic Transport of Ores in Deepsea Mining

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China Ocean Engineering 2024年第1期38卷 42-53页

作者： liu Lei liu Jian-cheng LI Xin XU Li-xin ZHANG xiu-zhan State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Sanya Yazhou Bay Institution of Deep-sea Sci-Tech Shanghai Jiao Tong UniversitySanya 572000China China Merchants Marine And Offshore Research Institute Co. Ltd.Shenzhen 518067China China Merchants Deepsea Research Institute(Sanya)Co. Ltd.Sanya 572000China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on *** hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for industrial *** the present study,an indoor model test of the vertical hydraulic transport of particles was conducted.A noncontact optical method has been proposed to measure the local characteristics of the particles inside a vertical pipe,including the local concentration and particle *** hydraulic gradient of ore transport was evaluated with various particle size distributions,particle densities,feeding concentrations and mixture flow *** transport,the local concentration is larger than the feeding concentration,whereas the particle velocity is less than the mixture *** qualitative effects of the local concentration and local fluid velocity on the particle velocity and slip velocity were *** local fluid velocity contributes significantly to particle velocity and slip velocity,whereas the effect of the local concentration is marginal.A higher feeding concentration and mixture flow velocity result in an increased hydraulic *** effect of the particle size gradation is slight,whereas the particle density plays a crucial role in the transport.

关键词： deepsea mining vertical hydraulic transport experiment flow characteristics

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Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 444-453页

作者： Cheng-Cheng Yang xiu-Xia Yang Xiao-Jing Zhao heng Wang Zi-Han Guo Kai Jin Yang liu Bin-Hui Li Department of Ophthalmology the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Ophthalmology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina

●AIM:To evaluate the role of semaphorin 7A(Sema7A)and its associated regulatory mechanisms in modulating the barrier function of cultured human corneal epithelial cells(HCEs).●METHODS:Barrier models of HCEs were treated with recombinant human Sema7A at concentrations of 0,125,250,or 500 ng/mL for 24,48,or 72h in *** electrical resistance(TEER)as well as Dextran-fluorescein isothiocyanate(FITC)permeability assays were conducted to assess barrier *** quantify tight junctions(TJs)such as occludin and zonula occludens-1(ZO-1)at the mRNA level,reverse transcriptionpolymerase chain reaction(RT-PCR)analysis was *** was used to examine the activity of the nuclear factor-kappa B(NF-κB)signaling pathway and the production of TJs *** analyses were employed to localize the ***-linked immunosorbent assay(ELISA)and RT-PCR were utilized to observe changes in interleukin(IL)-1β*** investigate the role of NF-κB signaling activation and IL^(-1)βin Sema7A’s anti-barrier mechanism,we employed 0.1μmol/L IκB kinase 2(IKK2)inhibitor IV or 500 ng/mL IL^(-1)receptor(IL-1R)antagonist.●RESULTS:Treatment with Sema7A resulted in decreased TEER and increased permeability of Dextran-FITC in HCEs through down-regulating mRNA and protein levels of TJs in a time-and dose-dependent manner,as well as altering the localization of ***,Sema7A stimulated the activation of inhibitor of kappa B alpha(IκBα)and expression of IL-1β.The anti-barrier function of Sema7A was significantly suppressed by treatment with IKK2 inhibitor IV or IL-1R antagonists.●CONCLUSION:Sema7A disrupts barrier function through its influence on NF-κB-mediated expression of TJ proteins,as well as the expression of IL-1β.These findings suggest that Sema7A could be a potential therapeutic target for the diseases in corneal epithelium.

关键词： human corneal epithelial barrier function transepithelial electrical resistance zonula occludens-1 occludin nuclear factor-kappa B

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Efficient reduction and adsorption of Cr(Ⅵ)using FeCl_(3)-modified biochar:Synergistic roles of persistent free radicals and Fe(Ⅱ)

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Journal of Environmental Sciences 2024年第3期137卷 626-638页

作者： Shujie Hu Chengshuai liu Hongling Bu Manjia Chen Ying-heng Fei National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and ManagementInstitute of Eco-environmental and Soil SciencesGuangdong Academy of SciencesGuangzhou 510650China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of ScienceGuiyang 550081China School of Environment Science and Engineering Guangzhou UniversityGuangzhou 510006China College of Resources and Environment Chongqing SchoolUniversity of Chinese Academy of SciencesChongqing 400714China School of Environmental Science and Engineering Guangdong University of TechnologyGuangzhou 510006China

Transition metal iron and persistent free radicals(PFRs)both affect the redox properties of biochar,but the electron transfer relationship between them and the coupling reduction mechanism of Cr(Ⅵ)requires further *** untangle the interplay between iron and PFRs in biochar and the infuences on redox properties,FeCl_(3)-modified rice husk biochar(FBCs)was prepared and its reduction mechanism for Cr(Ⅵ)without light was *** FBCs had higher surface positive charges,oxygen-containing functional groups,and PFRs compared with pristine rice husk biochar(BC).Phenoxyl PFRs with high electrondonating capability formed in *** pronounced electron paramagnetic resonance signals showed that the PFRs preferred to form at lower Fe(Ⅲ)*** a high concentration of Fe(Ⅲ)would be reduced to Fe(Ⅱ)and consumed the formed *** kinetics and X-ray photoelectron spectroscopy analysis indicated that the FBCs effectively enhanced the Cr(Ⅵ)removal efficiency by 1.54-8.20 fold and the Cr(Ⅵ)reduction efficiency by 1.88-9.29 fold compared to those of *** quenching and competitive reductant addition experiments revealed that the higher Cr(Ⅵ)reduction performance of FBCs was mainly attributed to the formed PFRs,which could contribute to~74.0%of Cr(Ⅵ)reduction by direct or indirect electron *** PFRs on FBCs surfaces could promote the Fe(Ⅲ)/Fe(Ⅱ)cycle through single electron transfer and synergistically accelerate~52.3%of Cr(Ⅵ)*** study provides an improved understanding of the reduction mechanism of iron-modified biochar PFRs on Cr(Ⅵ)in environments.

关键词： Biochar Iron-modification Cr(Ⅵ) Electron transfer Reduction mechanism

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Optimal search path planning of UUV in battlefeld ambush scene

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Defence Technology（防务技术） 2024年第2期32卷 541-552页

作者： Wei Feng Yan Ma heng Li Haixiao liu Xiangyao Meng Mo Zhou Naval Research Institute Beijing100161China

Aiming at the practical application of Unmanned Underwater Vehicle(UUV)in underwater combat,this paper proposes a battlefield ambush scene with UUV considering ocean ***,by establishing these mathematical models of ocean current environment,target movement,and sonar detection,the probability calculation methods of single UUV searching target and multiple UUV cooperatively searching target are given ***,based on the Hybrid Quantum-behaved Particle Swarm Optimization(HQPSO)algorithm,the path with the highest target search probability is ***,through simulation calculations,the influence of different UUV parameters and target parameters on the target search probability is analyzed,and the minimum number of UUVs that need to be deployed to complete the ambush task is demonstrated,and the optimal search path scheme is *** method proposed in this paper provides a theoretical basis for the practical application of UUV in the future combat.

关键词： Battlefield ambush Optimal search path planning UUV path Planning Probability of cooperative search

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Preparation and Rheological Characterization of Long Chain Branching Polyglycolide

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Chinese Journal of Polymer Science 2024年第8期42卷 1177-1184页

作者： Wei-Lin liu Ming-Fu Lyu heng-Yuan Zhang Jian-Ye liu Shi-Jun Zhang Beijing University of Chemical Technology Beijing 100029China SINOPEC(Beijing)Research Institute of Chemical Industry Co. Ltd.Beijing 100013China

The long chain branching(LCB)polyglycolide(PGA)was successfully prepared by the successive reactions of the terminal hydroxyl groups of PGA with triglycidyl isocyanurate(TGIC)and pyromellitic dianhydride(PMDA).The influence of LCB produced by functional group reaction on rheological and crystallization behavior was studied and discussed through linear rheology,uniaxial elongation and DSC(differential scanning calorimetry).The much higher viscosity and the more notable strain hardening behavior of modified PGA indicates the LCB with high degree of entanglements are *** melt strength of PGA is finally improved greatly and can make su re that the supercritical CO_(2)foaming can be carried out successfully.

关键词： Polyglycolide(PGA) Long chain branching(LCB) Rheology

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F-doped orthorhombic Nb_(2)O_(5) exposed with 97% (100) facet for fast reversible Liþ-Intercalation

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Green Energy & Environment 2024年第4期9卷 723-731页

作者： Xiaodi liu Yufeng Tang Dan Zhang Guangyin liu Xinwei Luo Yi Shang xiu Li Jianmin Ma College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang473061China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China

Orthorhombic Nb_(2)O_(5)(T-Nb_(2)O_(5))is attractive for fast-charging Li-ion batteries,but it is still hard to realize rapid charge transfer kinetics for Li-ion ***,F-doped T-Nb_(2)O_(5) microﬂowers(F-Nb_(2)O_(5))are rationally synthesized through topotactic ***,F-Nb_(2)O_(5) are assembled by single-crystal nanoﬂakes with nearly 97%exposed(100)facet,which maximizes the exposure of the feasible Li^(+)transport pathways along loosely packed 4g atomic layers to the electrolytes,thus effectively enhancing the Li^(+)-intercalation ***,the band gap of F-Nb_(2)O_(5) is reduced to 2.87 eV due to the doping of F atoms,leading to enhanced electrical *** synergetic effects between tailored exposed crystal facets,F-doping,and ultrathin building blocks,speed up the Li^(+)/electron transfer kinetics and improve the pseudocapacitive properties of F-Nb_(2)O_(5).Therefore,F-Nb_(2)O_(5) exhibit superior rate capability(210.8 and 164.9 mAh g^(-1) at 1 and 10 C,respectively)and good long-term 10 C cycling performance(132.7 mAh g^(-1) after 1500 cycles).

关键词： Exposed facets Orthorhombic Nb_(2)O_(5) F-doping Pseudocapacitive intercalation anode Li-ion storage

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QBIoT:A Quantum Blockchain Framework for IoT with an Improved Proof-of-Authority Consensus Algorithm and a Public-Key Quantum Signature

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Computers, Materials & Continua 2024年第7期80卷 1727-1751页

作者： Ang liu Qing Zhang Shengwei Xu Huamin Feng xiu-bo Chen Wen liu Network and Information Management Division Beijing Electronic Science and Technology InstituteBeijing100070China Department of Cyberspace Security Beijing Electronic Science and Technology InstituteBeijing100070China Information Security Institute Beijing Electronic Science and Technology InstituteBeijing100070China General Office Beijing Electronic Science and Technology InstituteBeijing100070China Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China

The Internet of Things(IoT)is a network system that connects physical devices through the Internet,allowing them to ***,IoT has become an integral part of our lives,offering convenience and smart ***,the growing number of IoT devices has brought about a corresponding increase in cybersecurity threats,such as device vulnerabilities,data privacy concerns,and network *** blockchain technology with IoT has proven to be a promising approach to enhance IoT ***,the emergence of quantum computing poses a significant challenge to the security of traditional classical cryptography used in blockchain,potentially exposing it to quantum *** support the growth of the IoT industry,mitigate quantum threats,and safeguard IoT data,this study proposes a robust blockchain solution for IoT that incorporates both classical and post-quantum security ***,we present the Quantum-Enhanced Blockchain Architecture for IoT(QBIoT)to ensure secure data sharing and integrity ***,we propose an improved Proof of Authority consensus algorithm called“Proof of Authority with Random Election”(PoARE),implemented within QBIoT for leader selection and new block ***,we develop a publickey quantum signature protocol for transaction verification in the ***,a comprehensive security analysis of QBIoT demonstrates its resilience against cyber threats from both classical and quantum *** summary,this research introduces an innovative quantum-enhanced blockchain solution to address quantum security concernswithin the realmof *** proposedQBIoT framework contributes to the ongoing development of quantum blockchain technology and offers valuable insights for future research on IoT security.

关键词： IoT quantum blockchain public-key quantum signature quantum hash function

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