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Shaly detritus embedded epoxy-resin coated proppants

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Petroleum Science 2022年第4期19卷 1735-1744页

作者： Zhao-Hui Lu xiu-ping lan Yong Yuan Jian-Kun Zhou Si-Yuan Chen Fan Fan Ying-Chun Niu Shou-Zhen Li Kai-Yi Hu Yang Zhou Quan Xu Key Laboratory of Shale Gas Exploration Ministry of Natural ResourcesChongqing Institute of Geology and Mineral ResourcesChongqing401120China State Key Laboratory of Petroleum Resources and Prospecting Bejing Key Laboratory of Biogas Upgrading UtlizationHarvard SEAS-CUPB Joint Laboratory on Petroleum ScienceChina University of Petroleum(Beijing)Beijing102249China

Proppant plays a significant role in the hydraulic fracturing process, which can affect the production of oil and gas wells. Due to the high density and low adhesion force, the settling speed of traditional proppants is fast, which will lead to the blockage of a crack channel. In this study, a proppant with double layer structure is fabricated by coating epoxy-resin and shaly detritus on ceramic proppants for the first time,respectively. The epoxy-resin enables the shaly detritus to be coated on the proppant successfully, which can provide a new method for shaly detritus treatment. The adhesive ability of shaly detritus and epoxyresin coated proppants(SEPs) is improved by 10.4% under the load force of 500 n N, which prolongs the time for the fracture to close. At the same time, the suspending ability of SEPs is two times higher than the uncoated proppants. Once the guar gum solution concentration is 0.3 wt%, the settling time of SEPs is36.7% longer than that of the uncoated proppants, which can effectively reduce the settlement of proppants in the crack. In addition, the hydrophobicity of the SEPs is enhanced, which reduces the wateroil ratio of crude oil and increases the liquid conductivity tested by deionized water. In summary, this new proppant is expected to promote the development of unconventional oil and gas resources.

关键词： Coated proppant Shaly detritus Hydrophobicity Conductivity

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Advances and global trends of precancerous lesions of gastric cancer:A bibliometric analysis

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 371-384页

作者： Yuan-ping Jia Dian-Chun Liu Ting-lan Cao Hui-Zhong Jiang Tao Li Yuan Li Xia Ding Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Precancerous lesions of gastric cancer(PLGC)represent a critical pathological stage in the development of intestinal gastric *** detection and diagnosis are key to reducing the incidence of gastric *** advancements have been made in PLGC research in recent years,making it necessary to provide updated reviews using bibliometric *** hypothesize that this review will identify emerging trends,key research areas,and gaps in PLGC research,providing insights that could guide future studies and enhance prevention *** To comprehensively review the current state of research on PLGC,examining development trends and research *** We conducted a bibliometric analysis of PLGC-related studies published between 2004 and 2023 using the Web of Science Core Collection *** employed Software,including VOSviewer,CiteSpace,R software,and SCImago Graphica,to map scientific networks and visualize knowledge trends in terms of publication volume,countries/regions,institutions,journals,authors,and *** A total of 4097 articles were included,and overall publication volume showed an increasing *** the past two decades,China published the most articles,followed by the United States,Japan,South Korea,and *** the top 10 contributors,the United States ranked highest in institutions,authors,and citations and demonstrated the strongest international *** keywords in this field were clustered into three main categories:Risk factors,pathogenesis,and diagnosis and *** and molecular biomarkers remain key areas of *** research should explore the mechanisms of gut microbiota,immune microenvironment,metabolic reprogramming,and *** technologies,including single-cell sequencing,spatially resolved analysis,multi-omics approaches,artificial intelligence,and machine learning,will likely accelerate in-depth investigations of *** PLGC research

关键词： Precancerous lesions of gastric cancer Gastric precancerous lesion Dysplasia Bibliometric Visualization

Contributions from light level and spectral content on refractive development in young rabbits

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 390-397页

作者： xiu-ping Tang Zhi-Jin Tang Hao-Bo Fan Yun-Chun Zou Department of Ophthalmology the Second Clinical College of North Sichuan Medical College(Nanchong Central Hospital)Nanchong 637000Sichuan ProvinceChina Department of Ophthalmology Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Optometry North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

AIM:To compare the effects of manipulating light levels versus manipulating the spectral content of short wavelengths(blue light)of ambient lighting on refractive development in young ***:A total of 32 healthy 3-week-old rabbits were randomly assigned to one of the four groups with 8 in each group for 12wk:Control group(NC)under low blue light(output ratio of blue light 1.8%)at low illuminance(341 lx),HI group under low blue light(output ratio of blue light 1.6%)at high illuminance(5057 lx),simulating natural light(S-NL)group under high blue light(output ratio of blue light 4.9%)at high illuminance(5052 lx),and MB group under high blue light(output ratio of blue light 5.2%)at low illuminance(342 lx).The lighting in each group were provided by light emitting diode(LED)lamps emitting visible light(range 380-780 nm)in addition to(or not)LED lamps only emitting short wavelength(range 380-500 nm).Refraction,axial length,and corneal curvature radius were assessed by retinoscopy,ultrasonography and keratometry,*** data of both eyes for each animal were used as single values and compared among ***:During the 12-week intervention,all animals had an emmetropization *** decrease of refraction in rabbits in HI group was similar to S-NL group,both slower than that of NC group(P0.05).CONCLUSION:The light levels per se but not the rich in spectral content of short wav

关键词： emmetropization myopia refractive error illuminance short wavelengths

Bridging bioengineering and nanotechnology: Bone marrow derived mesenchymal stem cell-exosome solutions for peripheral nerve injury

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World Journal of Stem Cells 2025年第1期17卷 80-85页

作者： Jun Chang xiu-Mei Yin Man Zhang Jian-Wei Liu lan Zhao First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China School of Acupuncture&Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Peripheral nerve injury(PNI)is a common disease that is difficult to nerve regeneration with current ***,Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells(BMSCs)in promoting nerve regeneration,revealing broad prospects for BMSCs trans-plantation in alleviating *** confirmed the fact that BMSCs significantly alleviate PNI,but there are shortcomings such as low cell survival rate and immune rejection,which limit the wide application of ***-derived exosomes(Exos)are considered as a promising cell-free nanomedicine for PNI,avoiding the ethical issues of *** in combination with bioengineering therapeutics(including extracellular matrix,hydrogel)brings new hope for PNI,provides a favorable microenvironment for neurological restoration and a therapeutic strategy with a favorable safety profile,significantly increases ex-pression of neurotrophic factors,promotes axonal and myelin regeneration,and demonstrates a strong potential to enhance ***,engineered Exos exhibit better properties,such as stronger targeting and more beneficial *** article briefly describes the role of nanotechnology and bioe-ngineering therapies for BMSCs in PNI,proposes clinical application prospects and challenges of nanotechnology and bioengineering BMSCs-derived Exos in PNI to improve the efficacy of BMSCs in the treatment of PNI.

关键词： Mesenchymal stem cells Peripheral nerve injury Nanotechnology Exosome Bioengineering MicroRNA

基于肠系膜理念的克罗恩病外科治疗的研究进展

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中华外科杂志 2025年第2期63卷 107-113页

作者：兰平张宗进何真中山大学附属第六医院普通外科(结直肠外科) 广东省结直肠盆底疾病研究重点实验室广州市黄埔区中六生物医学创新研究院人体微生态与老年慢性疾病教育部重点实验室广州510655

近年来, 随着对肠系膜研究的深入, 发现其血管、神经、淋巴组织、脂肪组织等结构在克罗恩病的发生和发展过程中发挥重要作用, 且病变程度与疾病进展、手术难度、术中并发症的发生及术后复发相关。针对肠系膜病变优化的克罗恩病手术策略... 详细信息

近年来, 随着对肠系膜研究的深入, 发现其血管、神经、淋巴组织、脂肪组织等结构在克罗恩病的发生和发展过程中发挥重要作用, 且病变程度与疾病进展、手术难度、术中并发症的发生及术后复发相关。针对肠系膜病变优化的克罗恩病手术策略受到学界的广泛关注, 国内外多项回顾性研究发现扩大肠系膜切除和Kono-S吻合术可降低克罗恩病术后复发率, 但最新的前瞻性随机对照试验研究未取得预期结果, 基于肠系膜的手术策略仍缺乏证据, 需进一步研究明确其有效性和适用范围。本文总结肠系膜在克罗恩病外科治疗中的研究进展, 以期为克罗恩病外科规范治疗和研究提供新的思考和方向。

关键词：克罗恩病肠系膜扩大肠系膜切除 Kono-S吻合术后复发

土壤中生物降解塑料的降解过程及其对土壤动物的影响

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环境科学 2025年第2期46卷 1145-1154页

作者：张莉娟陈洁敖瑞雪赵秀兰西南大学资源环境学院重庆400715 重庆市农业资源与环境研究重点实验室重庆400715

生物降解塑料被认为是替代传统塑料,解决塑料残留污染的有效途径之一,但其降解性能及其对生态系统的影响受到广泛关注.生物降解塑料主要由生物降解聚合物构成,同时添加了少量添加剂以满足所需的物理、化学性能或使用功能.土壤中生物降... 详细信息

生物降解塑料被认为是替代传统塑料,解决塑料残留污染的有效途径之一,但其降解性能及其对生态系统的影响受到广泛关注.生物降解塑料主要由生物降解聚合物构成,同时添加了少量添加剂以满足所需的物理、化学性能或使用功能.土壤中生物降解塑料的生物降解过程经历了生物退化、聚合物解聚及生物同化和矿化这3个阶段,并受多种因素的影响.其中,生物降解塑料的性质是影响降解的决定性因素,土壤中的生物或非生物因素也会干扰降解过程.生物降解塑料在降解过程中会释放出大量的微塑料、添加剂、低聚物和单体等到土壤环境中,以上残留物易被土壤动物摄入,从而对土壤动物的生长、繁殖和行为等产生一系列毒理学影响.此外,生物降解微塑料还可以与其他污染物相互作用,对土壤动物产生联合毒性.最后对未来重点研究的方向进行了展望.

关键词：生物降解塑料生物降解微塑料(MPs) 土壤动物毒性

黄河流域双向直接投资协调发展对碳生产率的影响研究

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陕西师范大学学报(哲学社会科学版) 2025年第1期54卷 87-101页

作者：方兰李璐平李军陕西师范大学西北历史环境与经济社会发展研究院陕西西安710119 西安石油大学经济管理学院陕西西安710065

双碳目标下,促进外国对华直接投资和我国对外直接投资的双向协调发展对黄河流域高质量发展至关重要。基于修正的STIRPAT模型,利用2006—2022年黄河流域9省(区)的面板数据描述典型特征事实,继而实证检验双向直接投资协调发展对碳生产率... 详细信息

双碳目标下,促进外国对华直接投资和我国对外直接投资的双向协调发展对黄河流域高质量发展至关重要。基于修正的STIRPAT模型,利用2006—2022年黄河流域9省(区)的面板数据描述典型特征事实,继而实证检验双向直接投资协调发展对碳生产率的影响。基准结果显示:双向直接投资协调发展促进碳生产率提升,且二者之间存在显著的“倒U型”关系,经过系列稳健性检验与内生性处理,该结论仍然成立。机制分析表明:双向直接投资协调发展可以促进产业规模扩大和资本劳动比提升,促进碳生产率提升;研发强度负向调节双向直接投资协调发展的效应。建议加强国内国际两个市场、两种资源联动效应,扩大双向直接投资规模,同时兼顾投资结构优化,激发对外开放活力,畅通技术创新渠道,关注双向直接投资与研发强度的协同发展,促进黄河流域在“双循环”下实现低碳转型。

关键词：双向国际直接投资碳生产率黄河流域绿色低碳发展

垃圾分类对城乡一体化模式垃圾处理碳减排的影响分析:以宝鸡市为例

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环境科学 2025年第1期46卷 100-106页

作者：兰剑闫东杰王永平玉亚西安建筑科技大学环境与市政工程学院陕西省环境工程重点实验室西安710055 陕西省环境科学研究院西安710061

生活垃圾处理是重要的人为温室气体排放源,明确垃圾分类处理前后各环节的碳排放强度,对助力“双碳”目标具有重要意义.基于宝鸡市2021年生活垃圾产生相关数据,结合城乡生活垃圾一体化处置模式,采用IPCC清单指南碳排放因子法,核算了宝鸡... 详细信息

生活垃圾处理是重要的人为温室气体排放源,明确垃圾分类处理前后各环节的碳排放强度,对助力“双碳”目标具有重要意义.基于宝鸡市2021年生活垃圾产生相关数据,结合城乡生活垃圾一体化处置模式,采用IPCC清单指南碳排放因子法,核算了宝鸡市城乡生活垃圾分类前后各处理环节的碳排放强度.结果表明,减少农村简易填埋比例可减碳59451.62 t(以CO_(2)-eq计),2021年宝鸡市垃圾分类处理后总碳减排可达251617.37 t(以CO_(2)-eq计);垃圾分类处理前CH4占碳排放的96.75%,分类处理后CO_(2)占碳排放的83.74%;垃圾分类处理后,助燃剂的消耗每年可产生碳排放1167.16 t(以CO_(2)-eq计),占直接碳排放的0.38%;渗滤液和焚烧烟气处理的药品消耗每年会产生碳排放2126.91 t(以CO_(2)-eq计),占间接碳排放的9.95%.深入完善生活垃圾分类体系,改变处理方式,提高填埋气(LFG)的收集利用率,强化覆盖层的CH4氧化能力等是可行的碳减排措施.

关键词：垃圾分类简易填埋助燃剂城乡一体化碳减排