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Clinical application of procalcitonin combined with interleukin-6 in the diagnosis of systemic inflammatory response syndrome

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Journal of Hainan Medical University 2018年第20期24卷 21-24页

作者： ying Zhai Li Ma Xin-Xin xiu Xin-huan Cui Jian-Yi Zhao Clinical Laboratory the Second Hospital of Bazhou CityBazhouHebei065700China Pediatric Department the Second Hospital of Bazhou CityBazhouHebei065700China

Objective:To investigate the clinical application value of procalcitonin(PCT) combined with interleukin-6(IL-6) in the diagnosis of systemic inflammatory response syndrome(SIRS). Methods: 115 cases of SIRS patients were divided into sepsis group(n=46) and non-infectious SIRS group(n=69). The serum levels of PCT, IL-6 were detected within 24 h of admission in two groups. White blood cell count (WBC), neutrophil counts (N), neutrophil percentage (N %), C - reactive protein (CRP) and acute physiology and chronic health evaluation (APACHEⅡ score), sequential organ failure score (SOFA score) were ***:APACHEⅡscore, SOFA score, hospital mortality had statistical differences between sepsis group and noninfectious SIRS group (P < 0.05). The serum levels of CRP、PCT、IL-6 and N% in sepsis group were higher than those in noninfectious SIRS group(P<0.05). PCT and IL - 6 were positively correlated with APACHEⅡ scores (r = 0.580, 0.463), N, N %, PCT, IL - 6 were positively correlated with SOFA scores (r = 0.371, 0.393, 0.371, 0.393), PCT was positively related with hospital mortality (r = 0.349). ROC curve analysis showed that compared with CRP, N, N% and other inflammatory markers, the AUC of PCT, il-6 and infection score was larger, and the value of diagnosis was ***:The combined detection of PCT and IL-6 is more effective than single detection in prognosis of sepsis.

关键词： Systemic inflammatory response syndrome Procalcitonin Interleukin-6 Systemic inflammatory response syndrome(SIRS)

Repair of bile duct defect with degradable stent and autologous tissue in a porcine model

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World Journal of Gastroenterology 2012年第37期18卷 5205-5210页

作者： Yue-Long Liang Yi-Chen Yu Kun Liu Wei-Jia Wang Jiang-Bo ying Yi-Fan Wang xiu-Jun Cai Second Department of General Surgery Sir Run Run Shaw Hospital Zhejiang Univer- sity Hangzhou 310016 Zhejiang Province China Institute of Minimally Invasive Surgery Zhejiang University Hangzhou 310016 Zhejiang Province China

AIM： To introduce and evaluate a new method to re- pair bile duct defect with a degradable stent and au- tologous tissues. METHODS： Eight Ba-Ma mini-pigs were used in this study, Experimental models with common bile duct （CBD） defect （0,5-1,0 cm segment of CBD resected） were established and then CBD was reconstructed by duct to duct anastomosis with a novel degradable stent made of poly [sebacic acid-co-（1,3-propanediol）-co- （1,2-propanediol）]. In addition, a vascularized greater omentum was placed around the stent and both ends of CBD. Cholangiography via gall bladder was per- formed for each pig at postoperative months 1 and 3 to rule out stent translocation and bile duct stricture. Complete blood count was examined pre- and post- operatively to estimate the inflammatory reaction. Liver enzymes and serum bilirubin were examined pre- and post-operatively to evaluate the liver function. Five pigs were sacrificed at month 3 to evaluate the healing of anastomosis. The other three pigs were raised for one year for long-term observation. RESULTS： All the animals underwent surgery success- fully. There was no intraoperative mortality and no bile leakage during the observation period, The white blood cell counts were only slightly increased on day 14 and month 3 postoperatively compared with that before operation, the difference was not statistically significant （P = 0.652）. The plasma level of alanine aminotrans- ferase on day 14 and month 3 postoperatively was also not significantly elevated compared with that before operation （P = 0.810）. Nevertheless, the plasma level of y-glutamyl transferase was increased after opera- tion in both groups （P = 0.004）, especially 2 wk after operation. The level of serum total bilirubin after opera- tion was not significantly elevated compared with that before operation （P = 0.227）, so did the serum direct bilirubin （P = 0.759）. By cholangiography yia gall blad- der, we found that the stent maintained its integrity of shape and was sti

关键词： Degradable stent Bile duct defect Biliaryreconstruction Autologous tissue Omentum

氧对饵掺杂硅纳米晶粒电子结构和光学性质的影响

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人工晶体学报 2012年第2期41卷 334-337页

作者：王秀丽王英龙梁伟华傅广生河北大学物理科学与技术学院保定071002

采用第一性原理,对O与Er共掺杂硅纳米晶粒的电子结构及光学性质进行了计算。计算结果表明:O原子的掺杂没有影响Er掺硅纳米晶粒的禁带宽度;Er掺硅纳米晶粒结构在紫外区的吸收峰因O原子的掺入明显加强,红外区源于Er原子的吸收峰峰值减小。

关键词：纳米晶粒掺杂电子结构光学性质

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超声手术手柄振动系统的有限元与实验分析

压电与声光 2005年第6期27卷 704-707页

作者：陈颖周兆英章刚华朱俊华清华大学精密仪器与机械学系精密测试技术与仪器国家重点实验室北京100084

给出了有限元法求解压电耦合振动的原理,利用有限元软件ANSYS对手柄振动系统进行了模态分析和谐响应分析,得到了精确的纵振动振型以及刀头的振幅、系统振幅放大系数等结果。并分析了施加的电压、压电片数和阻尼对刀头振幅的影响。利用... 详细信息

给出了有限元法求解压电耦合振动的原理,利用有限元软件ANSYS对手柄振动系统进行了模态分析和谐响应分析,得到了精确的纵振动振型以及刀头的振幅、系统振幅放大系数等结果。并分析了施加的电压、压电片数和阻尼对刀头振幅的影响。利用动态信号分析仪对手柄的谐振频率进行了测试,结果与有限元计算的谐振频率非常接近。

关键词：超声振动系统谐振频率振幅有限元

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戊二酸二甲酯水解工艺的研究

中北大学学报（自然科学版） 2011年第5期32卷 600-605页

作者：李秀华范欣华南理工大学化学与化工学院广东广州510641

用001×7型阳离子交换树脂催化水解戊二酸二甲酯制取戊二酸,考查了反应温度、反应时间、水与戊二酸二甲酯的物质的量比、树脂浓度等工艺条件对戊二酸收率的影响,筛选出了戊二酸二甲酯水解反应制取戊二酸的最优条件:油浴温度为130℃,水... 详细信息

用001×7型阳离子交换树脂催化水解戊二酸二甲酯制取戊二酸,考查了反应温度、反应时间、水与戊二酸二甲酯的物质的量比、树脂浓度等工艺条件对戊二酸收率的影响,筛选出了戊二酸二甲酯水解反应制取戊二酸的最优条件:油浴温度为130℃,水与戊二酸二甲酯物质的量比12∶1,反应时间为2 h,催化剂浓度为170 g/L,戊二酸的收率为88.84%.重复试验结果证明:树脂性能稳定,可以重复多次使用.

关键词：戊二酸二甲酯戊二酸阳离子交换树脂催化水解

To what extent should the intestinal be resected proximally after radiotherapy:hint from a pathological view

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Gastroenterology Report 2020年第4期8卷 277-285,I0001页

作者： Pei-huang Wu Qing-hua Zhong Teng-Hui Ma Qi-Yuan Qin Xiao-Yan huang ying-Yi Kuang huai-Ming Wang Zi-Xu Yuan Lei Wang Dai-Ci Chen Guangdong Institute of Gastroenterology GuangzhouGuangdong 510655China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China

Background:Neoadjuvant chemoradiotherapy(nCRT)is associated with post-operative anastomotic complications in rectal-cancer *** involving at least one non-irradiated margin reportedly significantly reduces the risk of post-operative anastomotic complications in radiation ***,the exact scope of radiotherapy on the remaining sigmoid colon remains ***:We evaluated the radiation damage of proximally resected colorectal segments in 44 patients with rectal cancer,who received nCRT followed by conventional resection(nCRT-C,n=21)or proximally extended resection(nCRT-E,n=23).The segments from another 13 patients undergoing neoadjuvant chemotherapy(nCT)were used as *** dissected these samples at a distance of 2 cmbetween the two adjacent *** damage in proximally resected colorectal segments was evaluated using the radiation injury score(RIS)and the concentration and distribution patterns of ***:Compared to those in the nCT group,the nCRT group showed higher RIS,levels of angiostatin,and proportion of diffuse pattern of *** increasing distance from the tumor site,these parameters all gradually decreased;and the differences came to be not significant at the site that is over 20cm from the *** nCRT-E group showed lower RIS(median:2 vs 4,P=0.002)and a greater proportion of non-diffuse angiostatin(87%vs 55%,P=0.039)at the proximal margins compared with the nCRT-C ***:The severity of the radiation damage of the proximal colon is inversely proportional to the proximal-resection margin *** damage was left on the proximal margin that was over 20cm from the *** of an initial length of20cm from the tumor may be beneficial for rectal-cancer patients after nCRT.

关键词： radiation injury proximally extended resection angiostatin rectal cancer neoadjuvant chemoradiotherapy

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基于可拓多层次状态分类的终端区利用率评价

系统工程与电子技术 2013年第12期35卷 2533-2539页

作者：李印凤胡明华谢华彭瑛南京航空航天大学民航学院江苏南京211106

建立了空间、时间、容量3个维度多层次机场终端区利用率评价指标体系,采用可拓层次分析法与状态分类评价法相结合的综合评价方法,对终端区评价日利用率等级进行评判。该方法实现了定性与定量方法的有效结合,能准确、全面评价机场终端区... 详细信息

建立了空间、时间、容量3个维度多层次机场终端区利用率评价指标体系,采用可拓层次分析法与状态分类评价法相结合的综合评价方法,对终端区评价日利用率等级进行评判。该方法实现了定性与定量方法的有效结合,能准确、全面评价机场终端区的利用率等级,对促进空域充分合理使用及提高空域管理水平具有重要指导意义。以杭州机场终端区为例,确定了单跑道机场利用率的阈值分布,结果表明该终端区利用率等级为良,实例验证了该方法的可行性。

关键词：利用率指标体系可拓多层次状态分类机场终端区

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FRP-螺栓联合加固RC梁抗弯试验研究

中国矿业大学学报 2011年第2期40卷 202-206页

作者：管延华蒋斌松宋修广中国矿业大学力学与建筑工程学院深部岩土力学与地下工程国家重点实验室江苏徐州221116 山东大学土建与水利学院山东济南250061

为了改善FRP与混凝土之间的黏结效果,一种新型的表面黏贴FRP与机械锚固联合加固技术,即FRP-螺栓联合加固技术被提出,结合在役钢筋混凝土桥梁的损伤特点,分别采用传统的表面黏贴FRP桥梁加固技术与FRP-螺栓联合加固技术对试验梁的抗弯性... 详细信息

为了改善FRP与混凝土之间的黏结效果,一种新型的表面黏贴FRP与机械锚固联合加固技术,即FRP-螺栓联合加固技术被提出,结合在役钢筋混凝土桥梁的损伤特点,分别采用传统的表面黏贴FRP桥梁加固技术与FRP-螺栓联合加固技术对试验梁的抗弯性能进行了详细的室内对比试验研究,对两种加固方式下的完整试验梁和预裂试验梁的试验结果进行了比较,分析了预裂度对加固效果的影响.结果表明:FRP-螺栓联合加固技术是一种更加可靠的桥梁加固方法,能够提高正截面的抗弯承载能力40%;螺栓预紧锚固FRP能够很好地抑制FRP在混凝土表面的剥离,有效提高FRP与混凝土表面之间黏结力.

关键词： FRP 螺栓加固抗弯承载力

Altered Wnt Signaling Pathway in Cognitive Impairment Caused by Chronic Intermittent Hypoxia： Focus on Glycogen Synthase Kinase-3β and β-catenin

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Chinese Medical Journal 2016年第7期129卷 838-845页

作者： Yue-ying Pan Yan Deng Sheng Xie Zhi-hua Wang YuWang Jie Ren Hui-Guo Liu Department of Respiratory and Critical Care Medicine Tongji Hospital Tongli Medical College Huazhong University of Science and Technology Key Laboratory of Respiratory Disease of the Ministry of Health Wuhan Hubei 430030 China

Background： Cognitive impairment is a severe complication caused by obstructive sleep apnea （OSA）. The mechanisms of causation are still unclear. The Wntβ-catenin signaling pathway is involved in cognition, and abnormalities in it are implicated in neurological disorders. Here, we explored the Wntβ-catenin signaling pathway abnormalities caused by chronic intermittent hypoxia （CIH）, the most characteristic pathophysiological component of OSA. Methods： We divided 32 4-week-old male C57/BL mice into four groups of eight each： a CIH ＋ normal saline （NS） group, CIH ＋ LiCI group, sham CIH ＋ NS group, and a sham CIH ＋ LiCI group. The spatial learning performance of each group was assessed by using the Morris water maze （MWM）. Protein expressions of glycogen synthase kinase-β （GSK-β） and β-catenin in the hippocampus were examined using the Western blotting test. EdU labeling and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining methods were used, respectively, to determine the proliferation and apoptosis of neurons in the hippocampal dentate gyrus region. Results： Mice exposed to CIH showed impaired spatial learning performance in the MWM, including increased mean escape latencies to reach the target platform, decreased mean times passing through the target platform and mean duration in the target quadrant. The GSK-313 activity increased, and expression of β-catenin decreased significantly in the hippocampus of the CIH-exposed mice. Besides, CIH significantly increased hippocampal neuronal apoptosis, with an elevated apoptosis index. Meanwhile, LiCI decreased the activity of GSK-β and increased the expression of β-catenin and partially reversed the spatial memory deficits in MWM and the apoptosis caused by CIH. Conclusions： Wntβ-catenin signaling pathway abnormalities possibly play an important role in the development of cognitive deficits among mice exposed to CIH and that LiCI might attenuate CIH-induced cognitive impairment via Wntβ-c

关键词： β-catenin Chronic Intermittent Hypoxia Cognition Glycogen Synthase kinase-3β Hippocampus Obstructive SleepApnea