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Two New Triterpenoid Saponins from the Seeds of Aesculus chinensis

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Chinese Chemical Letters 2000年第2期11卷 139-142页

作者： xiu wei yang Jing ZHAO Yu Xin CUI (National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083) Natl. Lab. Nat. and Biomimetic Drugs Beijing Medical University Beijing 100083 China

Two new triterpenoid saponins, named isoescins IIIa (1) and IIIb (2) were isolated from the seeds of Aesculus chinensis and identified by spectroscopic analysis and chemical hydrolysis. Their structures were established as 21 beta-tigloyl-28-acetylbarringtogenol C-3 beta-O-[beta D-galactopyranosyl( 1-->2)] [beta-D-glucopyranosyl (1-->])1-beta-D-glucopyranosiduronic acid (1) and 21 beta-angeloyl-28-acetylbarringtogenol C-3 beta-O-[beta-D;galactopyranosyl (1-->2)] [beta-D-glucopyranosyl(1 -->4)]-beta-D-glucopyranosiduronic acid (2), which are geometrically isomeric.

关键词： Aesculus chinensis isoescins IIIa and IIIb

Harpagometabolins Ⅰ and Ⅱ, Two New Metabolites from Harpagoside by Human Intestinal Bacteria

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Chinese Chemical Letters 2000年第9期11卷 779-782页

作者： xiu wei yang Chen Ting ZOU Masao HATTORI National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083 Institute of Natural Products, Toyama Medical & Pharmaceutical University 2630 Sugitani, Toyama 930-01, Japan Natl. Res. Lab. Nat. Biomimetic D. Peking University Beijing 100083 China Institute of Natural Products Toyama Med. and Pharmaceutical Univ. Toyama 930-01 2630 Sugitani Japan

Harpagoside, which is one main iridoid constituent of the dried roots of Scrophularia ningpoensis Hemsl., was biotransformated by bacteria isolated from human feeal flora a.d three metabolites were obtained. The structures of the metabolites, including two new alkaloids, named bar'Pagometabolins Ⅰ (l) and Ⅱ (2), and a known alkaloid acubinine B(3), were identified by chemical methods and the spectroscopic evidences.

关键词： Scrophularia ningpoensis Harpagoside harpagometabolin Ⅰ harpagometabolin Ⅱ acubinine B.

A Pair of New Geometrically Isomeric Triterpenoid Saponins fromthe Seeds of Aesculus chinensis

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Chinese Chemical Letters 1999年第11期10卷 925-928页

作者： xiu wei yang Jing ZHAO Yu Xin CUI Li He ZHANG(National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University.Beijing 100083) Natl. Lab. Nat. and Biomimetic Drugs Beijing Medical University Beijing 100083 China

Two new triterpenoid saponins were isolated from the seeds of Aesculus chinensis by preparative HPLC. On the basis of chemical evidence and spectral data, their structures were established as 21 beta-tigloyl-28-acetylprotoaescigenin 3 beta-O-[beta-D-xylopyranosyl (1 --> 2)] [beta-D-glucopyranosyl (1 --> 4)]-beta-D-glucopyranosiduronic acid (isoescin IIa, 1) and 21 beta-tigloyl-28-acetylprotoaescigenin 3 beta-O-[beta-D-xylopyranosyl (1 --> 2)] [beta-D-glucopyranosyl (1 --> 4)]-beta-D-glucopyranosiduronic acid (isoescin IIb, 2), which are a pair of geometrical isomers.

关键词： Aesculus chinensis isoescin IIa and IIb

Three New Triterpenoid Saponins from the Seeds of Aesculus chinensis

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Chinese Chemical Letters 1999年第9期10卷 767-770页

作者： Jing ZHAO xiu wei yang Yu Xin CU Xue Hui LIU(National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University.Beijing 100083) Natl. Lab. Nat. and Biomimetic Drugs Beijing Medical University Beijing 100083 China

Three new triterpenoid saponins, escins IVc (1), IVd (2) and IVf (3) were isolated from the seeds of Aesculus chinensis. They were. determined as 22 alpha-tigloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyranosyl (1-->4)]-beta-D-glucopyranosiduronic acid 1, 22 alpha-angeloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyrano- syl (1-->4)]-beta-D-glucopyranosiduronic acid 2 and 28-tigloyl protoaescigenin-3 beta-O- [beta-D-gluco-pyranosyl (12)] [beta-D-glucopyranosyl (1-->4)] -beta-D-glucopyranosiduronic acid 3.

关键词： triterpenoid saponins Aesculus chinensis escins IVc IVd and IVf

Eleven Absorbed Constituents and 91 Metabolites of Chuanxiong Rhizoma Decoction in Rats

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 33-46页

作者： Feng Xu Lei Zhang Xin Zhao Qi-Le Zhou Guang-Xue Liu xiu-wei yang Dong-Hui yang Shao-Qing Cai Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijingChina

Objective:Chuanxiong Rhizoma(CR,the dried rhizomes of Ligusticum chuanxiong)is a well-known traditional Chinese medicine that promotes qi to activate blood,dispels wind,and relieves *** date,more than 118 constituents of CR have been isolated and ***,the in vivo mechanism of CR decoction is unclear and needs further *** addition,to clarify the effective forms of CR,it is essential to reveal the absorbed constituents and metabolites of *** and Methods:The absorbed constituents and metabolites in urine and plasma samples of rats orally administered with CR decoction were screened and characterized using a high-performance liquid chromatography with diode array detector and combined with electrospray ionization ion trap time-of-flight multistage mass spectrometry ***:In total,102 compounds,including 11 absorbed constituents(eight phthalides and three phthalic acids)and 91 metabolites(71 phthalide-related and 20 phenolic acid-related),were detected in drug-containing rat urine and plasma samples,among which 33 were new metabolites of either CR or its *** on the structures of these metabolites,six phthalides(ligustilide,senkyunolide I/H,senkyunolide J/N,and butylidenephthalide)and three phenolic acids(ferulic acid,isoferulic acid,and caffeic acid)were proposed as their *** were also deduced to be the main absorbed constituents of CR decoction,which should have closer relationships with its pharmacological effects than other ***-related metabolites were formed through the metabolic reactions of hydration,hydroxylation,cysteine conjugation,acetylcysteine conjugation,methanethiol conjugation,mercaptomethanol conjugation,glucuronidation,and sulfation,whereas the phenolic acid-related metabolites were mainly formed by glucuronidation and ***:Six phthalides and three phenolic acids were shown to be the main precursors of the metabolites of CR,and 33 compounds

关键词： Chuanxiong Rhizoma effective forms metabolites phenolic acids phthalides

New coumarin glucopyranosides from roots of Angelica dahurica

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Chinese Herbal Medicines 2018年第1期10卷 103-106页

作者： Ai-hong Zhao xiu-wei yang State Key Laboratory of Natural and Biomimetic Drugs Department of Natural MedicinesSchool of Pharmaceutical SciencesPeking University Health Science CenterPeking UniversityBeijing 100191China School of Life Science and Engineering Lanzhou University of TechnologyLanzhou 730050China

Objective： To investigate the chemical constituents from the roots of Angelica ***： The chemical constituents were isolated and purified by AB-8 macroporous adsorption resin and Sephadex LH-20 column as well as semi-preparative reversed phase *** chemical structures were identified by spectral ***： Ten compounds were isolated and identified as xanthoarnol-3-O-β-d-glucopyranoside（1）,angedahuricoside A（2）,angedahuricoside B（3）,isofraxidin-7-O-β-d-glucopyranoside（4）,fraxidin-8-O-β-d-glucopyranoside（5）,（-）-marmesinin（6）,（2 S,3 R）-3-hydroxymarmesinin（7）,hyuganoside V（8）,daucosterol（9）,and sucrose（10）.Conclusion： Compounds 1 –3 are new ones and compounds 4 –6 and 8 are obtained from title plant for the first time.

关键词： angedahuricoside A angedahuricoside B Angelica dahurica Benth. et Hook. f. ex Franch. et Sav coumarin glucopyranoside xanthoarnol-3-O-β-d-glucopyranoside

UFLC-DAD-ESI-IT-TOFMSn Analysis on Biotransformation of Tongmai Formula Incubated with Human Intestinal Bacteria

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Chinese Herbal Medicines 2017年第3期9卷 258-266页

作者： Shuai Wu Qi-le Zhou xiu-wei yang State Key Laboratory of Natural and Biomimetic Drugs (Peking University) Department of Natural Medicines School of Pharmaceutical Sciences Peking University Health Science Center Peking University

Objective To investigate the biotransformation of Tongmai formula（TMF） in incubated system of human intestinal flora（HIF）. Methods The technique of ultra fast liquid chromatography with diode array detector and coupled with electrospray ionization ion trap time-of-flight multistage mass spectrometry（UFLC-DAD-ESIIT-TOFMSn） was adopted to determine the products of TMF biotransformed by HIF. Results Totally 66 constituents were detected and identified according to the accurate mass measurements（〈 5 ppm） and effective MSn fragment ions. Meanwhile, the potential biotransformational pathways of compounds in TMF transformed by HIF were firstly proposed. Desugarization, hydroxylation, and methylation were the major reactions in the biotransformation mechanism of TMF by HIF. Conclusion This study will be helpful to clarify the material basis of pharmacological activities from TMF in vivo.

关键词： biotransformation human intestinal flora pharmaceutical analysis Tongmai formula UFLC-DAD-ESI-IT-TOFMSn

Ginsenoside-Rg_6, a Novel Triterpenoid Saponin from the Stem-Leaves of Panax ginseng C. A. Mey.

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Chinese Chemical Letters 2000年第10期11卷 909-912页

作者： xiu wei yang, Long Yun LI, Jian Ming TIAN, Zhi wei ZHANG, Jin Mei YE, wei Fang Gu (National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083) (Academy of Chinese Traditional Medicine and Materia Medica of Jilin Provinc Natl. Res. Lab. Nat. Biomimetic D. Peking University Beijing 100083 China Acad. Chinese Traditional Med. M. Changchun 130021 China

A novel dammarane-type triterpene oligoglycoside, named ginsenoside-Rg6 3, was isolated from the stem-leaves of Panax ginseng C. A. Mey., together with two known ones, 20(S)-ginsenoside-Rg2 1 and 20(R)-ginsenoside-Rg2 2. On the basis of chemical and physicochemical evidence , the structure of ginsenoside-Rg6 have been elucidated as 6-O-(-L-rhamnosyl-(1?2)-(-D-glucopyranosyl-dammarane-(E)-20(22), 24-diene-3(, 6(, 12(-triol.

关键词： Panax ginseng C. A. Mey. stem-leaves triterpenoid ginsenoside-Rg_6.

Simultaneous quantification of twenty-one ginsenosides and their three aglycones in rat plasma by a developed UFLC-MS/MS assay:Application to a pharmacokinetic study of red ginseng

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Simultaneous quantification of twenty-one ginsenosides and t...