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CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO sun QINGHUA SONG HUA LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

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Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan sun Lulin Li Jian Luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

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The Enhancing Effect of the East Asian Subtropical Westerly Jet on Summer Extreme High-Temperature Events over Central-Eastern China Since the Late 1990s

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ADVANCES IN ATMOSPHERIC SCIENCES 2025年第3期42卷 453-466页

作者： Gao, Chujie Niu, Yuyu Li, Gen sun, Shanlei Lu, Bo Li, Chaofan Xu, Bei Huang, Jinglong sun, Xiubao Hohai Univ Coll Oceanog Minist Nat Resources Nanjing 210098 Peoples R China Hohai Univ Key Lab Marine Hazards Forecasting Minist Nat Resources Nanjing 210098 Peoples R China Nanjing Univ Informat Sci & Technol Key Lab Meteorol Disaster Minist Educ KLME Nanjing 210044 Peoples R China Nanjing Univ Informat Sci & Technol Collaborat Innovat Ctr Forecast & Evaluat Meteorol Nanjing 210044 Peoples R China Chinese Acad Sci South China Sea Inst Oceanol State Key Lab Trop Oceanog Guangzhou 510301 Peoples R China China Meteorol Adm Natl Climate Ctr Lab Climate Studies Beijing 100081 Peoples R China China Meteorol Adm Natl Climate Ctr CMA NJU Joint Lab Climate Predict Studies Beijing 100081 Peoples R China Xiongan Inst Meteorol Artificial Intellegence Xiongan 071708 Peoples R China Chinese Acad Sci Ctr Monsoon Syst Res Inst Atmospher Phys Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China Jinling Inst Technol Coll Intelligent Sci & Control Engn Nanjing 211169 Peoples R China

The increase in frequency and intensity of Extreme High-temperature Events (EHEs) over Central-Eastern China (CEC) in recent decades has severely impacted social development and livelihoods. Using observation and reanalysis datasets, this study explores the effect of the East Asian subtropical westerly jet stream (EAJ) on the CEC EHEs for the summers spanning 1979-2020. Considering its general relative location to the right side of the upper-level jet stream exit region, CEC would theoretically suffer more EHEs with a stronger and northwardly-shifted EAJ in summer due to the likelihood of abnormal subsidence induced by the EAJ. However, such an EAJ-EHE connection has been unstable over the past four decades but has displayed an evident interdecadal change. Before the late 1990s, the interannual variation of the EAJ was manifested mainly by its meridional displacement in the northeastern part of East Asia;thus, the atmospheric responses were essentially located to the east of CEC, exerting less of an influence on the CEC EHEs. However, since the late 1990s, the EAJ variation has featured an intensity change in its center over the northwest portion of the CEC, which has resulted in a westward shift in atmospheric responses to cover the CEC region. Therefore, the EAJ could potentially affect the summer CEC EHEs during 2000-21. Our findings offer support for an in-depth understanding of the formation mechanisms of extreme weather/climate events of this nature and thus provide a scientific reference for seasonal climate predictions.

关键词： summer extreme high-temperature events East Asian subtropical jet atmospheric circulation central-eastern China interdecadal change

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Frog tongue-inspired wettable microfibers for particles capture

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Science Bulletin 2025年第3期70卷 383-389页

作者： Jiahui Guo Lingyu sun Han Zhang Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Shenzhen Research Institute Southeast UniversityShenzhen 518071China Chemistry and Biomedicine Innovation Center ChemBioMed Interdisciplinary Research CenterNanjing UniversityNanjing 210023China

Fibers have been of great significance in our daily lives,especially in the industrial production of *** in this area has been focused on developing microfibers with superior functions to enhance the filtration performances of the ***,inspired by the frog’s predation mechanism using its tongues to swiftly grab flying insects,we propose novel porous wettable microfibers from microfluidics to efficiently capture particles in the air for *** pre-dispersing LP emulsions into polyurethane(PU),porous microfibers dispersed with oil droplets could be continuously spun from a co-flow microfluidic device based on the quick phase inversion of *** design an optimal system with frog-tongue-like interfacial adhesion properties,the wettability performances of the porous microfibers are investigated under full,partial,and no oil coverage *** implemented in a mask,the 3D patterned networks based on the frog-tongue-inspired microfibers have been proven with remarkable particle capture performances while maintaining good air *** on these features,we believe that frog-tongue-inspired microfibers and their derived masks are of practical significance in multiple applications.

关键词： Bioinspired Microfluidics Microfiber Wettability Mask

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Study of spatiotemporal variation and annual emission of CH_(4)in Shaoxing Yangtze River Delta,China,Using a portable CH4 detector on the UAV

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Journal of Environmental Sciences 2025年第5期151卷 140-149页

作者： Xiaobing Pang Qianqian Shang Lang Chen Songhua sun Gaosheng Zhao Zhentao Wu Canming Zhao Youhao Lu Qianqian sun Yan Lyu Baozhen Wang College of Environment Zhejiang University of TechnologyHangzhou 310000China Shaoxing Institute of Zhejiang University of Technology Shaoxing 312000China Shaoxing Ecological and Environmental Monitoring Center of Zhejiang Province Shaoxing 312000China School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China Green Intelligence Environmental School Yangtze Normal UniversityChongqing 408100China

Methane(CH_(4))is the second greenhouse gas and has a profound impact on global climate change due to its high global warming potential and *** 2022,the CH_(4)concentration was approximately 1.9 ppm,which was 264%of the pre-industrial *** spatiotemporal distribution of CH_(4)was investigated by a portable CH_(4)detector on an unmanned aerial vehicle and electric bicycles in Shaoxing,a city situated in the Yangtze River Delta,*** vertical distribution revealed CH_(4)concentration generally decreased slowly with ***,the inversion condition and low atmospheric boundary layer height(ABLH)leaded to the enhancement of CH_(4)with *** highest CH_(4)concentration(2.2±0.1 ppm,n=1428)was observed in winter and the lowest(2.0±0.2 ppm,n=1530)in *** the daily variation,CH_(4)concentration peaked at 5:00 local time(LT)and reached its lowest level at 14:00 LT,which was attributed to the daily variation of ABLH,lowest in the early morning and highest in the *** urban areas,CH_(4)concentrations showed higher levels near restaurants,natural gas stations and sewerage well,with a maximum value of 13.1 ppm,which was caused by CH_(4)emission and natural gas leakage from these *** annual CH_(4)emission in Shaoxing were estimated to be approximately 69 ton/(km^(2)·year)by the mass balance *** with other cities in the world,the CH_(4)emission is in higher level which imply some control measures should be conducted to reduce CH_(4)emission in Shaoxing.

关键词： Portable CH_(4)detector Spatiotemporal variation Annual CH_(4)emission Unmanned aerial vehicle

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The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male mice

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Journal of Environmental Sciences 2025年第5期151卷 54-67页

作者： Xiang Zuo Minghe sun Huijuan Bai Shuhui Zhang Jialu Luan Qian Yu Zhenhua Fu Qili Zhao Mingzhu sun Xin Zhao Xizeng Feng College of Life Science State Key Laboratory of Medicinal Chemical BiologyThe Key Laboratory of Bioactive MaterialsMinistry of EducationNankai UniversityTianjin 300071China Institute of Robotics&Automatic Information System College of Artificial IntelligenceNankai UniversityTianjin 300071China

17β-Trenbolone(17-TB)is well documented as an environmental endocrine disruptor in aquatic biological studies,but its effects on mammals remain poorly ***,17-TB acts as a hormone with properties similar to testosterone,and the consequences of juvenile exposure on adult social behavior remain *** A(BPA)acts as an estrogen-like hormone,compared to ***-week-old male Balb/c mice were exposed orally to 17-TB(100μg/(kg·day))and BPA(4 mg/(kg·day))for 28 *** of social interactions and a three-chamber test showed that 17-TB increased virility in male mice,intensified both male and female sexual behavior,and attracted and accepted female *** also increased social dominance through tube tests inmalemice and markedly activated the c-Fos^(+)immune response in themedial prefrontal cortex(mPFC)and basal amygdala(BLA).ELISA data showed that 17-TB and BPA exposure significantly affected serum gonadotropin-releasing hormone(GnRH),growth hormone(GH),estradiol(E2),and luteinizing hormone(LH)levels,as well as testicular lesions and androgen receptor(ARβ)and estrogen receptor(ERα)*** transcriptomic analysis further confirmed that could disrupt steroid synthesis and linoleic acid-related biometabolic *** findings suggest the influence of 17-TB and BPA exposure on sexual behavior and fertility in male mice,possibly through modulation of the hypothalamic-pituitary-gonadal *** study provides insights relevant to human reproductive health and neuro-social behavioral research,and the potential risk of environmental disturbances should not be overlooked.

关键词： 17β-Trenbolone(17-TB) Bisphenol A(BPA) hypothalamic-pituitary-gonadal axis(HPG) Sex hormones Social dominance Sexual behavior

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Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu sun Jianping GU W.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

关键词： braiding direction composite thin plate dynamic model large overall motion O313.7 three-dimensional (3D) braided composite

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Ti_(3)C_(2)T_(x) Composite Aerogels Enable Pressure Sensors for Dialect Speech Recognition Assisted by Deep Learning

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Nano-Micro Letters 2025年第5期17卷 1-15页

作者： Yanan Xiao He Li Tianyi Gu Xiaoteng Jia Shixiang sun Yong Liu Bin Wang He Tian Peng sun Fangmeng Liu Geyu Lu State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China School of Integrated Circuits Tsinghua UniversityBeijing 100084People’s Republic of China International Center of Future Science Jilin UniversityChangchun 130012People’s Republic of China

Wearable pressure sensors capable of adhering comfortably to the skin hold great promise in sound ***,current intelligent speech assistants based on pressure sensors can only recognize standard languages,which hampers effective communication for non-standard language ***,we prepare an ultralight Ti_(3)C_(2)T_(x)MXene/chitosan/polyvinylidene difluoride composite aerogel with a detection range of 6.25 Pa-1200 k Pa,rapid response/recovery time,and low hysteresis(13.69%).The wearable aerogel pressure sensor can detect speech information through the throat muscle vibrations without any interference,allowing for accurate recognition of six dialects(96.2%accuracy)and seven different words(96.6%accuracy)with the assistance of convolutional neural *** work represents a significant step forward in silent speech recognition for human–machine interaction and physiological signal monitoring.

关键词： Pressure sensor Wearable sensor Ti_(3)C_(2)T_(x) composite aerogel Dialect speech recognition

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Electrocatalytic nitrite reduction to ammonia on isolated bismuth alloyed ruthenium

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Journal of Energy Chemistry 2025年第1期100卷 369-376页

作者： Shiyao Shang Fuzhou Wang Zeyi sun Chaofan Qiang Ke Chu School of Materials Science and Engineering Lanzhou Jiaotong UniversityLanzhou 730070GansuChina

Electrochemical reduction of NO_(2)-to NH_(3)(NO_(2)-RR) is recognized as an appealing approach for achieving renewable NH_(3)synthesis and waste NO_(2)-***,we report isolated Bi alloyed Ru (Bi1Ru) as an efficient NO_(2)-RR *** calculations and in situ electrochemical measurements reveal the creation of Bi1-Ru dual sites which can remarkably promote NO_(2)-activation and suppress proton adsorption,while accelerating the NO_(2)-RR protonation energetics to render a high NO_(2)--to-NH_(3)conversion ***,Bi1Ru assembled in a flow cell delivers an NH_(3)yield rate of 1901.4μmol h^(-1)cm^(-2)and an NH_(3)-Faradaic efficiency of 94.3%at an industrial-level current density of 324.3 mA cm^(-2).This study offers new perspectives for designing and constructing p-block single-atom alloys as robust and high-current-density NO_(2)-RR catalysts toward the ammonia electrosynthesis.

关键词： Electrocatalytic reduction of NO_(2)-to NH_(3) Theoretical computations In situel ectrochemical measurements p-Block single-atom alloys

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The role of sub-continental lithosphere mantle in deep F and Cl cycling:Insight from the Dabeigou basalts,North China Craton

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Science China Earth Sciences 2025年第2期68卷 564-580页

作者： Yadong WU Jinhui YANG Jinfeng sun Hao WANG Baoquan ZHOU State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Computational Geodynamics University of Chinese Academy of SciencesBeijing 100049China

The sub-continental lithosphere mantle(SCLM)represents a mechanical barrier that separate the convecting mantle from the exosphere,and possesses the ability to sequester and release volatiles,making it an integral part in deep volatile *** we explore the SCLM in modulating F and Cl cycling through a case study from the Early Cretaceous Dabeigou basalts in the North China Craton(NCC).These lavas are associated with decratonization of the NCC,a process involving significant removal and replacement of the ancient *** Dabeigou basalts,characterized by arc magma-like trace element signatures,evolved initial^(87)Sr/^(86)Sr(0.70574–0.70578),ε_(Nd)(t)(-11.2–-11.1),andε_(Hf)(t)(-13.7–-13.4)values,along with high Fe/Mn ratios,Ni contents,andδ^(18)O values(5.8‰–6.8‰)of olivine phenocrysts,are compatible with their origination from a veined,pyroxene-rich source formed through the infiltration and interaction of hydrous silicate melts from the subducting Pacific slabs with ambient ***-hosted melt inclusions of the Dabeigou basalts have compositions similar to the whole rocks,indicating that they record pre-eruptive melt compositions forming the whole *** melt inclusions exhibit high F(1371–2316 ppm)and moderate Cl(688–900 ppm)contents,with high F/Cl ratios of 2.1±0.3(1σ).The F and Cl signatures of the Dabeigou basalts are different from those of typical arc magmas,which are commonly characterized by high Cl contents(median of~1200 ppm)and low F/Cl ratios(<1).The observed differences can be attributed to chromatographic reaction that fractionates elements of different compatibility in the metasomatic agents,with amphibole as the main mineral phase for fractionating and preserving F and *** is,amphibole crystallization prefers to retain F rather than Cl,making the metasomes in vein enriched in F and exhibiting elevated F/Cl ratios compared to original metasomatic *** is further suggested that the scenario inferred from the Dabeigou basalts mi

关键词： North China Craton Sub-continental lithosphere mantle Early Cretaceous Dabeigou basalts Melt inclusion F and Cl cycling

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