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Additive manufacturing of biodegradable magnesium-based materials:Design strategies,properties,and biomedical applications

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Journal of Magnesium and Alloys 2023年第3期11卷 801-839页

作者： Farzad Badkoobeh Hossein Mostaan Mahdi Rafiei Hamid Reza Bakhsheshi-Rad Seeram Rama Krishna xiongbiao chen School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehranIran Faculty of Engineering Department of Materials and Metallurgical EngineeringArak UniversityArakIran Advanced Materials Research Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1Singapore 117576Singapore Department of Mechanical Engineering College of EngineeringUniversity of SaskatchewanSaskatoonSK S7N 5A9Canada

Magnesium(Mg)-based materials are a new generation of alloys with the exclusive ability to be biodegradable within the human/animal body.In addition to biodegradability,their inherent biocompatibility and similar-to-bone density make Mg-based alloys good candidates for fabricating surgical bioimplants for use in orthopedic and traumatology treatments.To this end,nowadays additive manufacturing(AM)along with three-dimensional(3D)printing represents a promising manufacturing technique as it allows for the integration of bioimplant design and manufacturing processes specific to given applications.Meanwhile,this technique also faces many new challenges associated with the properties of Mg-based alloys,including high chemical reactivity,potential for combustion,and low vaporization temperature.In this review article,various AM processes to fabricate biomedical implants from Mg-based alloys,along with their metallic microstructure,mechanical properties,biodegradability,biocompatibility,and antibacterial properties,as well as various post-AM treatments were critically reviewed.Also,the challenges and issues involved in AM processes from the perspectives of bioimplant design,properties,and applications were identified;the possibilities and potential scope of the Mg-based scaffolds/implants are discussed and highlighted.

关键词： Magnesium alloy Additive manufacturing 3D Printing Bone tissue engineering Scaffold Mechanical and biological properties

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Printability——A key issue in extrusion-based bioprinting

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Journal of Pharmaceutical Analysis 2021年第5期11卷 564-579页

作者： Saman Naghieh xiongbiao chen Division of Biomedical Engineering College of Engineering University of Saskatchewan Department of Mechanical Engineering College of Engineering University of Saskatchewan

Three-dimensional(3D) extrusion-based bioprinting is widely used in tissue engineering and regenerative medicine to create cell-incorporated constructs or scaffolds based on the extrusion technique.One critical issue in 3D extrusion-based bioprinting is printability or the capability to form and maintain reproducible 3D scaffolds from bioink(a mixture of biomaterials and cells).Research shows that printability can be affected by many factors or parameters,including those associated with the bioink,printing process,and scaffold design,but these are far from certain.This review highlights recent developments in the printability assessment of extrusion-based bioprinting with a focus on the definition of printability,printability measurements and characterization,and printability-affecting factors.Key issues and challenges related to printability are also identified and discussed,along with approaches or strategies for improving printability in extrusion-based bioprinting.

关键词： Extrusion 3D bioprinting Bioink Printability Tissue engineering

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Bioprinting and in vitro characterization of alginate dialdehyde-gelatin hydrogel bio‑ink

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Bio-Design and Manufacturing 2020年第1期3卷 48-59页

作者： Fu You Xia Wu Michael Kelly xiongbiao chen Division of Biomedical Engineering College of EngineeringUniversity of SaskatchewanSaskatoonSK S7N 5A9Canada Department of Neurosurgery College of MedicineUniversity of SaskatchewanSaskatoonSK S7N 5A9Canada Department of Mechanical Engineering College of EngineeringUniversity of SaskatchewanSaskatoonSK S7N 5A9Canada

Cell-laden cardiac patches have recently been emerging to renew cellular sources for myocardial infarction(MI,commonly know as a heart attack)repair.However,the fabrication of cell-laden patches with porous structure remains challenging due to the limitations of currently available hydrogels and existing processing techniques.The present study utilized a bioprinting technique to fabricate hydrogel patches and characterize them in terms of printability,mechanical and biological properties.Cell-laden hydrogel(or bio-ink)was formulated from alginate dialdehyde(ADA)and gelatin(GEL)to improve the printability,degradability as well as bioactivity.Five groups of hydrogel compositions were designed to investigate the influence of the oxidation degree of ADA and hydrogels concentration on the properties of printed scaffolds.ADA-GEL hydrogels have generally shown favorable for living cells(EA.hy926 cells and hybrid human umbilical vein endothelial cell line).The hydrogel with an oxidation degree of 10%and a concentration ratio of 70/30(or 10%ADA70-GEL30)demonstrated the best printability among the groups examined.Formulated hydrogels were also bioprinted with the living cells(EA.hy926),and the scaffolds printed were then subject to the cell culture for 7 days.Our results illustrate that the scaffolds bioprinted from 10%ADA70–GEL30 hydrogels had the best homogenous cell distribution and also the highest cell viability.Taken together,in the present study we synthesized a newly formulated bio-ink from ADA and GEL and for the fist time,used them to bioprint cardiac patches,which have the potential to be used in MI repair.

关键词： Bioprinting Alginate dialdehyde Gelatin Bio-ink

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3D biofabrication of vascular networks for tissue regeneration:A report on recent advances

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Journal of Pharmaceutical Analysis 2018年第5期8卷 277-296页

作者： M.D.Sarker Saman Naghieh N.K.Sharma xiongbiao chen Division of Biomedical Engineering College of Engineering University of Saskatchewan Department of Mechanical Engineering College of Engineering University of Saskatchewan

Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue engineered constructs largely depends on the incorporation of a stable vascular network that eventually anastomoses with the host vasculature to support the various biological functions of embedded cells. In recent years, significant progress has been achieved with respect to extrusion, laser, micro-molding, and electrospinning-based techniques that allow the fabrication of any geometry in a layer-by-layer fashion. Moreover, decellularized matrix, self-assembled structures, and cell sheets have been explored to replace the biopolymers needed for scaffold fabrication. While the techniques have evolved to create specific tissues or organs with outstanding geometric precision, formation of interconnected, functional, and perfused vascular networks remains a challenge. This article briefly reviews recent progress in 3D fabrication approaches used to fabricate vascular networks with incorporated cells, angiogenic factors, proteins, and/or peptides. The influence of the fabricated network on blood vessel formation, and the various features, merits, and shortcomings of the various fabrication techniques are discussed and summarized.

关键词： 3D bioprinting Tissue engineering Vascularization Extrusion Laser-based printing Co-axial printing

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Printabilitye-A key issue in extrusion-based bioprinting

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Journal of Pharmaceutical Analysis 2021年第5期11卷 564-579页

作者： Saman Naghieh xiongbiao chen Division of Biomedical Engineering College of EngineeringUniversity of SaskatchewanSaskatoonSKS7N 5A9Canada Department of Mechanical Engineering College of EngineeringUniversity of SaskatchewanSaskatoonSKS7N 5A9Canada

Three-dimensional(3D)extrusion-based bioprinting is widely used in tissue engineering and regenerative medicine to create cell-incorporated constructs or scaffolds based on the extrusion technique.One critical issue in 3D extrusion-based bioprinting is printability or the capability to form and maintain reproducible 3D scaffolds from bioink(a mixture of biomaterials and cells).Research shows that printability can be affected by many factors or parameters,including those associated with the bioink,printing process,and scaffold design,but these are far from certain.This review highlights recent developments in the printability assessment of extrusion-based bioprinting with a focus on the definition of printability,printability measurements and characterization,and printability-affecting factors.Key issues and challenges related to printability are also identified and discussed,along with approaches or strategies for improving printability in extrusion-based bioprinting.

关键词： Extrusion 3D bioprinting Bioink Printability Tissue engineering

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Directing neural stem cell fate with biomaterial parameters for injured brain regeneration

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Progress in Natural Science:Materials International 2013年第2期23卷 103-112页

作者： Shenglian Yao Xi Liu Xiumei Wang Antonio Merolli xiongbiao chen Fuzhai Cui Institute for Regenerative Medicine and Biomimetic Materials Key Laboratory of Advanced Materials School of Materials Science and Engineering Tsinghua University National Engineering Laboratory for Regenerative Implantable Medical Devices Orthopaedics & Hand Surgery Unit The Catholic University School of Medicine Division of Biomedical Engineering College of Engineering University of Saskatchewan

The discovery of neural stem cells (NSCs), which have the ability to self-renew and differentiate into all types of neural lineages, offers promising prospect for the treatment of brain neurological disorders such as stroke/cerebral ischemia, traumatic brain injury and neurodegenerative disorders. However, only limited number of NSCs could survive or propagate due to tissue inflammation or blood-brain barrier. Therefore, it is necessary to develop an appropriate culture system that highly mimics the natural NSCs niche to direct stem cell fate and behavior for nerve regeneration. Both biophysical and biochemical properties of the NSC niche, including topology, mechanical properties, bioactive molecules, and their spatial and temporal presentations should be considered for the design of functionalized scaffolds, which could not only serve as the delivery vehicles of NSCs but also stimulate specific cellular responses at the molecular level, such as support endogenous or exogenous cells proliferation, migration and homing, even promote the growth of axon at the injured brain site. This review attempts to outline the varieties of biomaterial

关键词： NSCs niche Biomaterial design Brain tissue engineering Nerve regeneration

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大型LNG储罐气顶升作业安全管理要点分析

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化工管理 2024年第11期 155-157,161页

作者：魏雄标陈君海洋石油工程股份有限公司天津300452

储罐气顶升作业作为LNG工程的重大节点及关键工序,具有施工难度大,安全风险高,施工工艺复杂等特点,是LNG工程中安全风险最高的一道工序。文章从风险分析、作业流程、人员管理、工器具管理等方面进行分析,提出全面规范储罐气顶升作业的... 详细信息

储罐气顶升作业作为LNG工程的重大节点及关键工序,具有施工难度大,安全风险高,施工工艺复杂等特点,是LNG工程中安全风险最高的一道工序。文章从风险分析、作业流程、人员管理、工器具管理等方面进行分析,提出全面规范储罐气顶升作业的各项安全管理措施,保证每个过程和关键点处于受控状态,确保作业的顺利开展。

关键词： LNG工程储罐气顶升安全管理石油化工

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Modeling of Piezoelectric Actuators Based on a New Rate-Independent Hysteresis Model

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Modern Mechanical Engineering 2011年第2期1卷 25-30页

作者： Jingyang Peng xiongbiao chen 不详

Accurate model representatives of piezoelectric actuators (PEAs) are important for both understanding the dynamic behaviors of PEAs and control scheme development. However, among the existing models, the most widely used classical Preisach hysteresis model are incapable of representing the commonly-encountered one-sided (non-negative voltage input range) hysteresis behaviors of PEAs. To solve this problem, a new rate-independent hysteresis model was developed for the one-sided hysteresis and then integrated with the models representative of creep and dynamics to form a single model for the PEAs. Experiments were carried out to validate the developed models.

关键词： Piezoelectric Actuator Hysteresis

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涉金属历史遗留矿山污染防治全过程技术规范体系构建研究

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环境工程技术学报 2024年第2期14卷 520-527页

作者：邹天远乔雄彪张宗文孙宁生态环境部环境规划院

涉金属历史遗留矿山(区)重金属污染是我国长期存在、仍未良好解决的生态环境问题,是影响我国生态安全的重要风险源。“十二五”以来,涉金属历史遗留矿山污染防治得到了快速发展,但由于我国整治历程总体较短,整治技术尚不成熟,相关标准缺... 详细信息

涉金属历史遗留矿山(区)重金属污染是我国长期存在、仍未良好解决的生态环境问题,是影响我国生态安全的重要风险源。“十二五”以来,涉金属历史遗留矿山污染防治得到了快速发展,但由于我国整治历程总体较短,整治技术尚不成熟,相关标准缺乏,整治的迫切性和系统性要求更加凸显,涉金属历史遗留矿山污染防治仍任重道远。目前,我国直接针对历史遗留矿山的技术规范文件较少,系统有效的工程技术规范标准体系尚未建立,导致涉金属历史遗留矿山(区)污染防治和风险管控效果不佳。分析了涉金属矿山污染防治中存在的典型生态环境问题,系统梳理了历史遗留矿山污染防治工程参考借鉴的技术规范,对比了现状技术文件与现实需求的差异性;依据全面性、针对性、系统性、协调性的原则,从调查与监测、评价评估、方案编制、工程勘察与设计、治理修复工程实施、工程验收与成效评估、信息系统建设7个维度,构建了我国涉金属历史遗留矿山(区)污染防治技术规范体系框架,提出技术规范性文件制定需求,以期为环境管理者和标准研究者提供决策参考。建议下一步在全面开展历史遗留矿山调查工作的基础上,尽快建立各类历史遗留矿山(区)污染防治技术标准,为“十四五”时期贯彻落实生态环境保护规划、深入打好污染防治攻坚战提供保障。

关键词：涉金属历史遗留矿山污染防治全过程技术规范体系

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A Survey of Modeling and Control of Piezoelectric Actuators

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Modern Mechanical Engineering 2013年第1期3卷 1-20页

作者： Jingyang Peng xiongbiao chen Department of Mechanical Engineering University of Saskatchewan Saskatoon Canada

Piezoelectric actuators (PEAs) have been widely used in micro- and nanopositioning applications due to their fine resolution, fast responses, and large actuating forces. However, the existence of nonlinearities such as hysteresis makes modeling and control of PEAs challenging. This paper reviews the recent achievements in modeling and control of piezoelectric actuators. Specifically, various methods for modeling linear and nonlinear behaviors of PEAs, including vibration dynamics, hysteresis, and creep, are examined;and the issues involved are identified. In the control of PEAs as applied to positioning, a review of various control schemes of both model-based and non-model-based is presented along with their limitations. The challenges associated with the control problem are also discussed. This paper is concluded with the emerging issues identified in modeling and control of PEAs for future research.

关键词： Piezoelectric Actuators Modeling Control

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