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The clinical application of Yanghe Decoction

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Drug Combination Therapy 2019年第2期1卷 75-84页

Yanghe Decoction is a representative prescription of such prescriptions as warming up the yang and dissipating the *** has the functions of warming the blood and dispelling cold and *** Decoction has effects on many *** principle of this kind of disease is blood deficiency and yang,and the clinical manifestation is cold *** diseases often occur in multiple systems and in multiple *** article summarizes the compatibility of Yanghe Decoction and its clinical application by reviewing the related literature analysis in recent years,and provides a broad idea for the application of Yanghe Decoction.

关键词： Yanghe Decoction Prescription compatibility Clinical application

The combination of disease and Zheng (syndrome) on the basic of differentiation of six channels:a new pattern of disease diagnosis and treatment of traditional Chinese medicine

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Traditional Medicine Research 2017年第2期2卷 100-104页

作者： Xue Yang xiong-zhi wu Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for Cancer300060China

Traditional Chinese medicine(TCM)was formed two thousand years ago,and developed in the following *** has a unique way of looking at health and ***(syndrome)is the basic unit and key term in TCM *** is the pathological generalization of a certain stage in the development of *** based on syndrome differentiation and disease differentiation of TCM is the basic principle to know and treat diseases,and a kind of special method to study diseases in *** Han Dynasty(200 AD),doctor Zhang Zhongjing proposed Liujing Bianzheng(the differential diagnosis in accordance with the theory of six channels)to diagnose and treat diseases in Treatise on Febrile and Miscellaneous *** other words,he divided diseases into six channels diseases based on patient's *** channels diseases almost include all of the disease according to his classification *** addition,there are development rules in the progress of six channels ***,we hypothesized that combination of six channels disease and Zheng on the basic of differentiation of six channels is a new pattern of diagnosis and treatment diseases in TCM,which is beneficial to the understanding of a certain disease and makes disease treatment more convenient,fast and effective.

关键词： Traditional Chinese medicine Zheng(syndrome) Differentiation of six channels Treatment based on syndrome differentiation

Research progress on the role of cancer-associated fibroblasts in tumorigenesis and development

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Tumor Microenvironment Research 2020年第1期2卷 29-33页

作者： Xiao-Hui Liu xiong-zhi wu Tianjin Medical University Cancer Institute and Hospital National Clinical Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Tumor microenvironment plays a very important role in the growth,invasion and metastasis of tumor *** tumor interstitial microenvironment is an important part of the tumor microenvironment,which includes two parts:the non-cellular and cellular components of the tumor interstitium,specifically including the extracellular matrix,blood vessels,and interstitial *** them,activated interstitial fibroblasts,namely cancer-associated fibroblasts(CAFs),are the main components of tumor interstitial cells,which are most closely related to tumor interstitial fibrosis and tumor progress,and are expected to become a new target for cancer treatment.

关键词： Cancer-associated fibroblasts Tumor microenvironment Tumor angiogenesis Invasion Metastasis

A brief discussion on the concept of traditional Chinese medicine from the perspective of science and philosophy

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History & Philosophy of Medicine 2021年第1期3卷 12-14页

作者： xiong-zhi wu Guan-Qun Hou Affiliated Tumor Hospital of Tianjin Medical University Tianjin 300060China Shandong university of Traditional Chinese Medicine Jinan 250355China

Traditional Chinese medicine(TCM)has its own theoretical model in explaining the universe,diseases and human *** is that a complete and stable system which make TCM theory be in *** this system has not made a substantial breakthrough in the past two thousand years,only some of which details have been *** reason,why it is difficult to make a fundamental breakthrough,is that the core of this theoretical system consists of oriental philosophical concepts,such as the theory of Qi monism,Yin-Yang and Five *** is to say TCM uses philosophy to guide its medicine theory[1].

关键词： breakthrough harmony details

Tai Chi:a new star for the administration of chronic diseases?

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Traditional Medicine Research 2017年第3期2卷 118-124页

作者： Yang Hu Hao-Ran Zhang xiong-zhi wu Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinChina

Tai Chi Quan(Tai Chi),a traditional Chinese martial art,has become increasingly popular in western *** Chi integrates deep diaphragmatic breathing with body movements to achieve a harmonious balance between the body and mind,which facilitates the flow of internal energy(Qi).An increasing number of studies have reported that Tai Chi significantly benefits aerobic capacity,muscular strength,balance,and psychological *** addition,Tai Chi offers unique advantages for physical fitness and the treatment of chronic *** paper reviews the existing literatures on Tai Chi,introduces its health-promotion effects and the potential clinical applications,and summarizes recent studies that prove Tai Chi is safe and effective for patients with neurological diseases,rheumatological diseases,musculoskeletal diseases,cardiovascular diseases,chronic obstructive pulmonary diseases,and *** reviewing the literatures in this field,we conclude that the long-term results of practicing Tai Chi may benefit the cardiovascular system,motor system,respiratory system,and nervous ***,the potential role and mechanism of Tai Chi has not yet been *** studies with long follow-up periods are necessary to meet the standards of clinical applications.

关键词： Tai Chi Health Rehabilitation Chronic diseases

Relationship between tumor lymphangiogenesis and tumor metastasis

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Tumor Microenvironment Research 2019年第1期1卷 14-22页

作者： Ya-Nan Man Rui Cao xiong-zhi wu Department of Radiation Oncology The Second Hospital of Tianjin Medical UniversityTianjin 300060China Tianjin Medical University Cancer Institute and Hospital Tianjin 300070China.

Objective:To summarize the research progress on the relationship between tumor lymphangiogenesis and tumor ***:PubMed and China National Knowledge Infrastructure(CNKI)database were used to search for related literatures with the keywords of"tumor,lymphangiogenesis and lymphatic metastasis".Inclusion criteria:(1)the morphology and function of tumor lymphatic vessels;(2)the markers of lymphatic vessels;(3)the mechanism of tumor lymphangiogenesis;(4)the molecular regulation mechanism of tumor ***:The lymphatic vessel wall is only composed of endothelial cells,and the basement membrane is discontinuous with high *** markers of lymphatic vessels include VEGFR-3,LYVE-1,podoplanin and thehomeoboxgene Prox-1,which facilitate the research on the function of lymphatic vessels in *** mechanism of tumor lymphangiogenesis is very complicated,and there is no conclusion *** is believed that the tumor lymphangiogenesis is mainly derived from the existing lymphatic endothelial cells in the *** the process of tumor lymphangiogenesis,many factors,such as VEGF-C,VEGF-D,VEGF-A,bFGF,PDGF-BB,Ang-2,NO and COX-2,are directly or indirectly ***,most studies believe that VEGF-C and VEGF-D are the most important regulators of tumor ***:Tumor lymphangiogenesis is closely related to tumor lymphatic *** of tumor lymphangiogenesis can open a new way for tumor treatment.

关键词： Lymphangiogenesis Tumor metastasis Biomarker Molecular mechanism

The New Understanding of Yin and Yang of TCM Physiological Model

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History & Philosophy of Medicine 2019年第1期1卷 2-7页

作者： Yong-Ning Niu Yan-Fang Mo xiong-zhi wu Zhejiang University of Traditional Chinese Medicine HangzhouChina National Hospital of Zhuang Nationalities Autonomous Region of Guangxi National Hospital Affiliated Guangxi Medical University NanningChina Affiliated Tumor Hospital of Tianjin Medical University TianjinChina

From the view of the physical model,structure and function characteristics,the material basis and clinical application of Yin-Yang theory,analysing and thinking combined with modern medical theory,this paper finds that as one of the most basic and important theory of traditional Chinese medicine(TCM),Yin-Yang theory reveals the understanding of human physiology in TCM,which has many consensuses with modern medicine,so it is worth studying further.

关键词： Yin-Yang Theory TCM Physiological Model Structural and Functional Characteristics Material Basis Clinical Practices

Dihibitory effects of Xi-Huang Pellet on the proliferation of human breast cancer SKBR3 cells

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TMR Cancer 2018年第2期1卷 1-6页

作者： Chang Liu Xiao-Hui Liu Rui Cao xiong-zhi wu Zhong-Shan-Men in-patient department Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin 300171 China

Background To observe the anti-proliferative effects and molecular mechanisms of traditional Chinese medicine prescriptions Xi-Huang pellet （XHP） on human breast cancer cell line SKBR3. Materials and Methods： Human breast cancer cell line SKBR3 was cultured. Trypan blue exclusion assay was used to investigate the anti-proliferative effects of medicine. The rates of the cell cycle were measured by ^ow cytometry （FCM）. The impacts of medicine on the protein expression were detected by Enzyme-linked immunosorbent assay （ELISA）. RNA extraction and real-time PCR were used to observe the change of RNA expression. Results： Myrrh, XHP and XHP combined 5-FU could inhibit cellproliferation and arrest SKBR3 cells at S phases. XHP combined 5-FU resulted in a significant increase of intracellular p21WAF1/CiP1 content in SKBR3 cells. XHP and XHP combined 5-FU led to a decrease of mRNA expression on cyclin A2, cyclin D1 and cyclin E in SKBR3 cells. Conclusions： XHP inhibits the proliferation of breast cancer SKBR3 cells via a significantly change of cyclins expression and p21WAF1/CIP1 pathway. 5-FU significantly enhanced the inhibitory effects of XHP on SKBR3 cells.

关键词： Xi-Huang pellet Breast cancer Proliferation 5-FU Myrrh.

The effects of Gekko sulfated glycopeptide and basic fibroblast growth factor on human fibrosarcoma HT1080 cells

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Precision Medicine Research 2019年第4期1卷 109-113页

作者： Xiao-Hui Liu Cui-Hong Zhu xiong-zhi wu Tianjin Medical University Cancer Institute and Hospital National Clinical Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China.

Background:Fibrosarcoma is a malignant soft tissue tumor of mesenchymal *** sulfated glycopeptide(GSPP),an anticancer drug in traditional Chinese medicine,could inhibited the tumor angiogenesis by targeting basic fibroblast growth factor(bFGF).bFGF promoted the proliferation of *** fibrosarcoma and fibroblasts derived from fibrous connective *** study investigated whether GSPP has the inhibitory effects on human fibrosarcoma HT1080 *** and methods:The trypan blue exclusion assay was used to determine cell viability and cell *** migration was observed by wound-healing and ***:From the first day to seventh day,HT1080 cells number of GSPP,bFGF,GSPP combined bFGF groups had not change compared with ***1080 cells migration distance and the number of migrating cells of GSPP,bFGF,GSPP combined bFGF groups were not significantly ***:GSPP did not have inhibitory effects on the proliferation and migration of human fibrosarcoma HT1080 *** further research should be carried out in order to study the mechanism of GSPP and bFGF acting on the tumor stroma.

关键词： Fibrosarcoma bFGF Gekko sulfated glycopeptides Proliferation Migration