Relationship between tumor lymphangiogenesis and tumor metastasis

作     者：Ya-Nan Man Rui Cao Xiong-Zhi Wu 

作者机构：Department of Radiation OncologyThe Second Hospital of Tianjin Medical UniversityTianjin 300060China Tianjin Medical University Cancer Institute and HospitalTianjin 300070China. 

出 版 物：《Tumor Microenvironment Research》 (肿瘤微环境研究)

年 卷 期：2019年第1卷第1期

页      面：14-22页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Lymphangiogenesis Tumor metastasis Biomarker Molecular mechanism 

摘      要：Objective:To summarize the research progress on the relationship between tumor lymphangiogenesis and tumor ***:PubMed and China National Knowledge Infrastructure(CNKI)database were used to search for related literatures with the keywords oftumor,lymphangiogenesis and lymphatic metastasis.Inclusion criteria:(1)the morphology and function of tumor lymphatic vessels;(2)the markers of lymphatic vessels;(3)the mechanism of tumor lymphangiogenesis;(4)the molecular regulation mechanism of tumor ***:The lymphatic vessel wall is only composed of endothelial cells,and the basement membrane is discontinuous with high *** markers of lymphatic vessels include VEGFR-3,LYVE-1,podoplanin and thehomeoboxgene Prox-1,which facilitate the research on the function of lymphatic vessels in *** mechanism of tumor lymphangiogenesis is very complicated,and there is no conclusion *** is believed that the tumor lymphangiogenesis is mainly derived from the existing lymphatic endothelial cells in the *** the process of tumor lymphangiogenesis,many factors,such as VEGF-C,VEGF-D,VEGF-A,bFGF,PDGF-BB,Ang-2,NO and COX-2,are directly or indirectly ***,most studies believe that VEGF-C and VEGF-D are the most important regulators of tumor ***:Tumor lymphangiogenesis is closely related to tumor lymphatic *** of tumor lymphangiogenesis can open a new way for tumor treatment.