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Synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting

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Chinese Chemical Letters 2024年第2期35卷 44-56页

作者： Yan-Long ma Shi Yan xiong-Jie Xu Hua Cao Ruibing Wang School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center Guangdong Pharmaceutical UniversityZhongshan 528458China State Key Laboratory of Quality Research in Chinese Medicine and the Institute of Chinese Medical ScienceUniversity of MacaoMacao 999078China

Due to its simplicity, high efficiency, and chemo-selectivity, bioorthogonal chemistry has shown a great application potential in ***, four bioorthogonal pairs as targeting tools, including (strept)avidin/biotin, antibody/antigen, oligonucleotide hybridization and IEDDA tools, have been developed and applied in targeted ***, all of these tools still suffer from some limitations, such as difficult modification, biochemical fragility and larger molecular weight for biological association tools, as well as chemical instability for IEDDA *** host-guest pairs with relatively small molecular sizes not only possess strong chemical stability, but also have the features of fast conjugation rate, tunable binding affinity , easy modification, and high ***, they can be used as a novel non-covalent bioorthogonal tool for *** order to further promote the development of host-guest pairs as novel bioorthogonal tools for pre-targeted delivery, we firstly calculate their conversion rate to make researcher aware of their unique advantages;next, we summarize the recent research progress in this *** future perspectives and limitations of these unique tools will be *** review will provide a systemic overview of the development of synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting, and may serve as a “go for” resort for researchers who are interested in searching for new synthetic tools to improve pre-targeting.

关键词： Bioorthogonal chemistry Synthetic host-guest pairs Pre-targeting Molecular recognition Biomedical applications

The Influence of Limestone Powder and Metakaolin Co-Blending on the Hydration Process and Mechanical Properties of Q-Phase Cement

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Journal of Wuhan University of Technology(materials Science) 2024年第5期39卷 1169-1176页

作者： xiong Xuan HE Yongjia LÜLinnü ma Jie WANG Fazhou State Key Laboratory of Silicate materials for Architectures Wuhan University of TechnologyWuhan 430070China School of materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Hubei Key Laboratory of Theory and Application of Advanced materials Mechanics School of ScienceWuhan University of TechnologyWuhan 430070China China Railway Design Corporation Tianjin 300250China

A ternary system comprising Ca_(20)Al_(26)Mg_(3)Si_(3)O_(68)(Q-phase),limestone,and metakaolin is proposed,and its hydration behavior,hydration product phases,microstructure,and mechanical properties are investigated and compared with pure Q-phase *** results indicate that the ternary system exhibits exceptional and sustained compressive strength even under a 40℃environment,significantly outperforming pure *** mechanism lies in that metakaolin effectively inhibits the transformation of metastable ***,the interactions among Q-phase,limestone,and metakaolin further enhance the cementitious *** ternary system effectively addresses potential issues of strength loss in Q-phase cement application,and as a low-carbon cementitious material system,it holds promising potential applications.

关键词： Q-phase limestone metakaolin hydration compressive strength

Carbon nanocages bridged with graphene enable fast kinetics for dual-carbon lithium-ion capacitors

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Green Energy & Environment 2024年第3期9卷 573-583页

作者： Shani Li Yanan Xu Wenhao Liu Xudong Zhang Yibo ma Qifan Peng xiong Zhang Xianzhong Sun Kai Wang Yanwei ma Institute of Electrical Engineering Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Innovation Academy for Green manufacture Beijing100190China Beijing Institute of Technology Beijing100081China School of materials Science and Engineering Zhengzhou UniversityZhengzhou450001China

Lithium-ion capacitors(LICs) combining the advantages of lithium-ion batteries and supercapacitors are considered a promising nextgeneration energy storage device. However, the sluggish kinetics of battery-type anode cannot match the capacitor-type cathode, restricting the development of LICs. Herein, hierarchical carbon framework(HCF) anode material composed of 0D carbon nanocage bridged with 2D graphene network are developed via a template-confined synthesis process. The HCF with nanocage structure reduces the Li^(+) transport path and benefits the rapid Li^(+) migration, while 2D graphene network can promote the electron interconnecting of carbon nanocages. In addition, the doped N atoms in HCF facilitate to the adsorption of ions and enhance the pseudo contribution, thus accelerate the kinetics of the anode. The HCF anode delivers high specific capacity, remarkable rate capability. The LIC pouch-cell based on HCF anode and active HCF(a-HCF) cathode can provide a high energy density of 162 Wh kg^(-1) and a superior power density of 15.8 kW kg^(-1), as well as a long cycling life exceeding 15,000cycles. This study demonstrates that the well-defined design of hierarchical carbon framework by incorporating 0D carbon nanocages and 2D graphene network is an effective strategy to promote LIC anode kinetics and hence boost the LIC electrochemical performance.

关键词： Hierarchical carbon framework Nanocage ZIF Graphene Lithium-ion capacitors

FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation

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World Journal of Gastroenterology 2014年第39期20卷 14430-14441页

作者： Jun Yao Chun-Suo Zhou xiong ma Bai-Qing Fu Li-Sheng Tao Miao Chen Ya-Ping Xu Department of Gastroenterology the People’s Hospital Affiliated to Jiangsu University Department of Gastroenterology Renji Hospital Shanghai Jiao Tong University School of Medicine Department of Pathology the Zhenjiang First People’s Hospital

AIM: To examine the effect of farnesoid X receptor (FXR) activation by GW4064 on endotoxin-induced hepatic inflammation in nonalcoholic fatty liver disease (NAFLD) and the underlying mechanism.

关键词： Farnesoid X receptor Nonalcoholic fatty liver disease GW4064 Nonalcoholic fatty liver disease activity score Lipopolysaccharide-induced hepatic inflammation macrophage activation

Single-step-etched ultra-compact metamaterial grating coupler enabled by a hierarchical inverse design approach

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 119-126页

作者： Qiao Wang Ruiqi Luo Nan Liu maojing Hou Bo xiong Guandong Liu Wei ma Intelligent Network Research Institute Zhejiang LabHangzhou 311100China State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310027China

With the concept of metamaterials introduced into integrated photonics,subwavelength structures have gained popularity for their ability to create devices with ultra-compact size,high performance,and versatile ***,traditional metamaterial design methods are usually based on empirical templates and physical approximations,lacking the ability to design free-form metamaterial structures and optimize entire devices *** this work,we propose a hierarchical inverse design approach that combines a conventional effective refractive index based metamaterial structures design with a follow-up global topology *** empirical metamaterial grating coupler design based on effective refractive index engineering faces inaccurate index extraction and insufficient approximation of wavevector matching conditions,which deteriorates coupling efficiency,especially for fully-etched devices with the decreased tapering ***,a subsequent overall topology optimization step can well compensate for the negative effect of the shrinking device footprint to increase the efficiency of the metamaterial grating *** demonstrate a 23μm×10μm ultra-compact metamaterial grating coupler with single-stepetched to couple light between a fiber and a 500 nm single-mode silicon waveguide in the *** measurement shows an insertion loss of 3.17 dB and a 3 dB bandwidth of 77 nm,making it the smallest footprint device ever reported.

关键词： waveguide hierarchical inverse

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大豆玉米带状复合种植技术初探

作物研究 2024年第2期38卷 153-156页

作者：喻勇湛厚观李俭梅马雄吴依衍肖冬根汨罗市农业农村局湖南汨罗414400

大豆玉米带状复合种植模式是农业农村部推广的稳玉米、扩大豆的种植模式,目标是在保证玉米基本不减产的基础上,通过间种或套种增收一季大豆。2022—2023年,汨罗市对大豆玉米带状复合种植模式进行试验与示范推广,全市种植面积达2000 hm^(... 详细信息

大豆玉米带状复合种植模式是农业农村部推广的稳玉米、扩大豆的种植模式,目标是在保证玉米基本不减产的基础上,通过间种或套种增收一季大豆。2022—2023年,汨罗市对大豆玉米带状复合种植模式进行试验与示范推广,全市种植面积达2000 hm^(2),玉米平均单产6900 kg/hm^(2),大豆平均单产1740 kg/hm^(2),与单作玉米相比,玉米单产仅减少690 kg/hm^(2),且全市增产大豆约3500 t,2年合计增收2100多万元。重点介绍了大豆玉米带状复合种植模式从整地到收获的全程规范化栽培技术。

关键词：玉米大豆复合种植技术

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Inhibition of p38 mitogen-activated protein kinase attenuates experimental autoimmune hepatitis: Involvement of nuclear factor kappa B

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World Journal of Gastroenterology 2007年第31期13卷 4249-4254页

作者： xiong ma Yi-Tao Jia De-Kai Qiu ShanghaiJiaotong University School of Medicine Shanghai Institute ofDigestive Disease Shanghai 200001 China

To investigate the role of p38 mitogen-activated protein kinase （p38maPK） in murine experimental autoimmune hepatitis （EAH）.METHODS： To induce EAH, the syngeneic S-100 antigen emulsified in complete Freud＇s adjuvant was injected intraperitoneally into adult male C57BI/6 mice. Liver injury was assessed by serum ALT and liver histology. The expression and activity of p38 maPK were measured by Western blot and kinase activity assays. In addition, DNA binding activities of nuclear factor kappa B （NF-KB） were analyzed by electrophoretic mobility shift assay. The effects of SB203580, a specific p38 maPK inhibitor, on liver injuries and expression of proinflammatory cytokines （interferon-y, IL-12, IL-1β and TNF-α） were ***： The activity of p38 maPK and NF-~：B was increased and reached its peak 14 or 21 d after the first syngeneic S-100 administration. Inhibition of p38 maPK activation by SB203580 decreased the activation of NF-~：B and the expression of proinflammatory cytokines. Moreover, hepatic injuries were improved significantly after SB203580 administration.

关键词： Autoimmune hepatitis p38 mitogen-activatedprotein kinase Nuclear factor kappa B Proinflammatorycytokines

Enhancing Data Forwarding Efficiency in SIoT with Multidimensional Social Relations

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Computers, materials & Continua 2024年第1期78卷 1095-1113页

作者： Fang Xu Songhao Jiang Yi ma manzoor Ahmed Zenggang xiong Yuanlin Lyu School of Computer and Information Science Hubei Engineering UniversityXiaogan432000China School of Computer Science and Information Engineering Hubei UniversityWuhan430062China Artificial Intelligence Industrial Technology Research Institute Hubei Engineering UniversityXiaogan432000China

Effective data communication is a crucial aspect of the Social Internet of Things(SIoT)and continues to be a significant research *** paper proposes a data forwarding algorithm based on Multidimensional Social Relations(MSRR)in SIoT to solve this *** proposed algorithm separates message forwarding into intra-and cross-community forwarding by analyzing interest traits and social connections among *** new metrics are defined:the intensity of node social relationships,node activity,and community *** the community,messages are sent by determining which node is most similar to the sender by weighing the strength of social connections and node *** a node performs cross-community forwarding,the message is forwarded to the most reasonable relay community by measuring the node activity and the connection between *** proposed algorithm was compared to three existing routing algorithms in simulation *** indicate that the proposed algorithmsubstantially improves message delivery efficiency while lessening network overhead and enhancing connectivity and coordination in the SIoT context.

关键词： SIoT data forwarding social attributes social relations community

Nitrogen–sulfur co-doped porous carbon derived from asphalt as efficient catalyst for oxygen reduction

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Rare Metals 2024年第1期43卷 380-388页

作者： Jing-Sheng ma Ming-Zai Wu Ling Chen Li-Xing Zhang Ying xiong Key Laboratory of Structure and Functional Regulation of Hybrid materials Ministry of EducationInstitute of EnergyHefei Comprehensive National Science CenterAnhui UniversityHefei 230601China

As an environment-friendly and low-cost petrochemical by-product, asphalt has great potential in the preparation of metal-free oxygen reduction electrocatalysts with excellent performance and outstanding stability. In this paper, we converted asphalt into porous carbon nanosheets by a simple activation method, using potassium citrate as the swelling agent.

关键词： stability porous catalyst