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Chinese Journal of Chemistry 2020年第12期38卷 1489-1496页

作者： xinyue song Huairong Zhang Tao Yan Tongtong Hong Shusheng Zhang Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers College of Chemistry and Chemical EngineeringLinyi UniversityLinyiShandong 276005China Shandong Sino-Japanese Center for Collaborative Research of Carbon Nonomoterials College of Chemistry and Chemical EngineeringQingdao UniversityQingdaoShandong 266071China

What is the most favorite and orig inal chem istry developed in you r research group??The sensitive detection methods and specific bioimaging strategies for tumor biomarkers,as well as the diagnosis-therapy integratio... 详细信息

关键词： diagnosis Cancer Therapy

Self-cleaning SERS sensor based on flexible Ni_(3)S_(2)/MoS_(2)@Ag@PDMS composites for label-free multiplex volatile organic compounds detection

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Nano Research 2024年第6期17卷 5529-5539页

作者： xinyue song Yongzheng Zhang Xiaohui Ren Dongyan Tang Xuelin Zhang Xin Li MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringState Key Lab of Urban Water Resource and EnvironmentHarbin Institute of TechnologyHarbin 150090China College of Textile and Clothing Yancheng Institute of TechnologyYancheng 224051China MEMS Center Harbin Institute of TechnologyHarbin 150001China

Flexible self-cleaning surface-enhanced Raman scattering(SERS)sensors are highly desirable for the detection of various environmental pollutants,including volatile organic compounds(VOCs).However,achieving sensitive detection without labeling and ensuring efficient cyclic use remain significant ***,we introduce a direct approach to create a versatile Ni_(3)S_(2)/MoS_(2)@Ag@PDMS(PDMS=polydimethylsiloxane)composite SERS substrate using chemical vapor deposition *** produced substrate shows outstanding performance,offering extremely low detection sensitivity(1.0×10^(−12)M 4-aminobenzenethiol)and high enhancement factors(approximately 107).The interactions between the rod-shaped Ni_(3)S_(2)/MoS_(2)@Ag heterostructure and the molecules facilitate the transfer of charge,resulting in an increased electric field enhancement of the exciton *** has the dual benefit of providing a self-cleaning effect and enhancing SERS ***,the substrate enables sensitive detection of VOCs gas molecules without the need for labels,achieving a minimum detectable concentration as low as 1 ppm for o-dichlorobenzene,due to the preconcentration effect of *** calculations further explain the combined effect of electromagnetic and chemical enhancement in this composite *** utilizing the developed visual SERS barcode,quick multiple detection and analysis of mixtures can be *** flexible and versatile SERS technique has significant potential for on-site detection and analysis of environmental pollutants,opening the doors for the development of a wearable in-situ SERS sensing platform.

关键词： surface-enhanced Raman scattering(SERS) quantitative detection recyclable detection volatile organic compounds(VOCs) chemical vapor deposition(CVD)

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椎间盘退变中胶原蛋白的代谢失衡

中国组织工程研究 2025年第14期29卷 3011-3019页

作者：董亦直宋鑫越姚鸣宇朱赫吴瑞霞都亚新祝勇内蒙古医科大学内蒙古自治区呼和浩特市010107 北京大学肿瘤医院内蒙古医院内蒙古自治区呼和浩特市010000

背景:腰椎间盘退行性疾病是导致腰痛和下肢神经症状的常见疾病。胶原代谢的平衡在维持椎间盘的稳定中发挥着重要的作用。目的:对椎间盘退变中胶原蛋白代谢失衡的研究进展作一综述。方法:由第一作者在中国知网、PubMed、Web of Science... 详细信息

背景:腰椎间盘退行性疾病是导致腰痛和下肢神经症状的常见疾病。胶原代谢的平衡在维持椎间盘的稳定中发挥着重要的作用。目的:对椎间盘退变中胶原蛋白代谢失衡的研究进展作一综述。方法:由第一作者在中国知网、PubMed、Web of Science数据库中检索2024年5月之前发表的相关文章,中文检索词为“椎间盘退变疾病”“胶原代谢”“胶原酶家族”“胶原合成相关因子”“细胞因子”,英文检索词为“degenerative disc disease”“Collagen metabolism”“Collagenase family”“Collagen synthesis related factors”“Collagen breakdown related factors”。最终纳入76篇文献进行综述。结果与结论:在椎间盘退变的过程中,胶原蛋白代谢的平衡在维持正常椎间盘的稳定中起到至关重要的作用。当椎间盘发生退变时,椎间盘内分泌大量促炎因子、胶原酶,并发生氧化应激反应等,使椎间盘内胶原蛋白分解增加,同时抑制生长因子、胶原蛋白合成酶、胶原蛋合成相关因子的生成,使椎间盘内胶原蛋白合成减少。上述两种情况共同作用使椎间盘内胶原蛋白的代谢平衡被打破,进一步加剧了椎间盘退变的进程。

关键词：腰椎间盘退行性疾病胶原代谢胶原酶家族胶原合成相关因子胶原分解相关因子综述

Flexible organic integrated electronics for self-powered multiplexed ocular monitoring

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npj Flexible Electronics 2022年第1期6卷 763-770页

作者： Baojun Lin Meng Wang Chao Zhao Shijie Wang Kai Chen Xiao Li Zaishang Long Chenxu Zhao xinyue song Sen Yan Laili Wang Wei Ma State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’anChina State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’anChina School of Information and Communications Engineering Xi’an Jiaotong UniversityXi’anChina

Smart contact lens has drawn extensive research interests due to the noninvasive real-time detection of the human body to provide biomedical information for health ***,it has been difficult to accurately measure the physiological signals in tears,and the use of external power source has also hindered the future ***,we demonstrated an organic electrochemical transistor based multiplexed sensors self-powered by the organic solar cells(OSCs).The integrated device was fabricated via simple process including solution blade-coating and thermal *** were optimized to provide optimal operation voltage for the sensors that exhibit semilog-linear response to the glucose and calcium ions in tear fluids without any peripheral *** sensing signals can be transmitted to the laptop wirelessly through a near filed communication *** integrated self-powered multiplexed sensing device will provide real-time monitoring of the biomarkers in tears,prospected to be installed on the smart contact lens for the early detection and diagnosis of diabetes.

关键词： diagnosis smart blade

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规整填料干塔压降与波纹齿角的关系

化工学报 2007年第11期58卷 2764-2769页

作者：罗淑娟宋新月费维扬清华大学化工系化学工程联合国家重点实验室北京100084

研究了规整填料压降和波纹齿角的关系,以期探索强化传统规整填料性能的新途径。干填料层压降可分解为3部分:气流在交叉单元碰撞所产生的压降,气流在填料层间改变方向所产生的压降以及塔壁区摩擦力所产生的压降。用计算流体力学(CFD)计... 详细信息

研究了规整填料压降和波纹齿角的关系,以期探索强化传统规整填料性能的新途径。干填料层压降可分解为3部分:气流在交叉单元碰撞所产生的压降,气流在填料层间改变方向所产生的压降以及塔壁区摩擦力所产生的压降。用计算流体力学(CFD)计算了这3部分压降。结果表明,当波纹齿角从90°减小到20°时,干填料层压降大幅度下降。实验数据也验证了CFD模拟计算结果。

关键词：规整填料压降波纹齿角计算流体力学模拟

领导幽默对员工追随行为的影响:一个有调节的中介模型

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中国软科学 2021年第S01期 226-237,286页

作者：李文静宋鑫悦东北财经大学工商管理学院辽宁大连116025

基于情感事件理论和社会交换理论,构建有调节的中介模型,研究领幽默对员工追随行为的影响作用,并讨论上下级关系的中介效应和权力距离导向的调节效应。运用统计软件SPSS 25.0对269份样本数据进行分析,实证结果显示:上下级关系在领导幽... 详细信息

基于情感事件理论和社会交换理论,构建有调节的中介模型,研究领幽默对员工追随行为的影响作用,并讨论上下级关系的中介效应和权力距离导向的调节效应。运用统计软件SPSS 25.0对269份样本数据进行分析,实证结果显示:上下级关系在领导幽默与员追随行为间起中介作用,员工的权力距离导向在调节领导幽默与员工追随行为之间关系的同时也能够调节上下级关系的中介作用。研究成果对与探索领导幽默对员工追随行为的作用机制和作用边界具有一定的理论意义,也对企业管理实践具有一定的指导作用。

关键词：领导幽默追随行为上下级关系权力距离导向

The prognostic potential and immunological analysis of PTEN in pan-cancer

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The prognostic potential and immunological analysis of PTEN ...

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Lin Wang Xiaoxiao He Xue Long xinyue song Minjie Wei Lin Zhao China Medical University

Background: Phosphatase and tensin homologue(PTEN)controls crucial signaling events and processes including cell growth, proliferation, survival, and migration. However, the expression level and the prognostic potential of PTEN have not been studied from the perspective of pan-cancer. Therefore, we aimed to analyze the expression and prognostic value of PTEN in pan-cancer and to gain insights into the association between PTEN and immune ***: The differential expression of PTEN in 27 human cancers was analyzed by Genotype-Tissue Expression(GTEx) and The Cancer Genome Atlas(TCGA) database. The effect of PTEN on the prognosis of pan-cancer was evaluated by univariate Cox analysis. In addition, the correlation between PTEN and tumor infiltrating-immune cells was analyzed via Tumor Immune Evaluation Resource(TIMER) database. In order to study the immunological and prognostic role of PTEN in cancers, the relationship between PTEN and different immune checkpoints, RNAss, DNAss, neoantigen, tumor mutational burden and microsatellite instability in pan-cancer were comprehensively *** mutations in PTEN and DNA methylation in pan-cancer were also ***: PTEN was significantly different in 24 of 27 cancers, which is up-regulated in 7 cancers and down-regulated in 17 cancers. Univariate COX survival analysis showed that PTEN was significantly correlated with overall survival(OS) of two cancers, disease-free interval(DFI) of four cancers,disease-specific survival(DSS) of two cancers and progression free interval(PFI) of three cancers. It is worth noting that although the expression of PTEN in various cancers had significant prognostic value, PTEN played a protective or harmful role in different cancers. In brain lower grade glioma(LGG), PTEN was significantly over-expressed in LGG patients, and whether it was OS(P=0.0290,hazard ratio(HR)=0.96), DFI(P=0.0036, HR=0.87), PFI(P=0.0110, HR=0.97) or DSS(P=0.0110,HR=0.95), PTEN over-expression g

关键词： pan-cancer PTEN prognostic biomarker immune infiltration mutation

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过渡金属电解水催化剂的非金属掺杂研究进展

无机化学学报 2024年第2期40卷 289-306页

作者：张永政郭旭宋欣月李欣哈尔滨工业大学化工与化学学院哈尔滨150001 哈尔滨工业大学环境学院哈尔滨150001

过渡金属基材料成本相对较低,催化性能较为优异,是在全水分解领域最有希望替代贵金属基电催化剂的候选材料之一,但有限的活性位点、相对较差的电导率等因素限制了其广泛应用。非金属元素掺杂能够调节主体材料电子结构,优化吸附能,从而... 详细信息

过渡金属基材料成本相对较低,催化性能较为优异,是在全水分解领域最有希望替代贵金属基电催化剂的候选材料之一,但有限的活性位点、相对较差的电导率等因素限制了其广泛应用。非金属元素掺杂能够调节主体材料电子结构,优化吸附能,从而对过渡金属基电催化剂的活性与稳定性产生积极影响,缩减其与贵金属材料性能差距。本文总结了近年来非金属元素改性在过渡金属基电催化材料中的相关研究,系统综述了非金属元素掺杂的方法和不同非金属元素的掺杂效果,从物理化学性质的改变和电子结构的变化多角度分析了非金属元素改性对过渡金属基材料的影响,最后对非金属元素掺杂过渡金属基电催化剂的未来发展方向作出了展望。

关键词：过渡金属电催化剂非金属元素掺杂电解水

肿瘤微环境刺激响应型上转换光动力诊疗体系的构建和发展

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化学学报 2020年第7期78卷 657-669页

作者：闫涛刘振华宋昕玥张书圣临沂大学化学化工学院/山东省肿瘤标志物检测技术重点实验室临沂276005 山东师范大学化学化工与材料科学学院济南250014

光动力治疗是一种新型的非侵入式肿瘤治疗方法,具有创伤性和毒性小、选择性好、无耐药性、可重复治疗等突出优点,在癌症的治疗上取得了显著的成效.为了增加光动力治疗的组织穿透深度,研究者提出构建基于上转换纳米颗粒(upconversion nan... 详细信息

光动力治疗是一种新型的非侵入式肿瘤治疗方法,具有创伤性和毒性小、选择性好、无耐药性、可重复治疗等突出优点,在癌症的治疗上取得了显著的成效.为了增加光动力治疗的组织穿透深度,研究者提出构建基于上转换纳米颗粒(upconversion nanoparticles,UCNPs)的光动力诊疗探针(简称上转换光动力诊疗探针).基于发光共振能量转移过程,上转换光动力诊疗探针利用UCNPs在近红外光激发下发射的荧光激活负载的光敏剂发挥光动力疗效,有助于实现深层肿瘤的治疗.新型的上转换光动力诊疗探针通过多功能一体化的结构组合设计可以实现靶向运输、成像诊断以及刺激响应的按需治疗,是未来纳米医药发展的必然趋势.目前,研究者越来越关注构建基于肿瘤微环境刺激响应型上转换光动力诊疗体系,以提高治疗体系的靶向性,改善光动力治疗效果,并减小对周围正常组织的毒性.本工作主要讨论了基于pH、酶及过氧化氢刺激响应型上转换光动力诊疗体系的构建和发展,并对其发展前景进行了展望.

关键词：光动力治疗上转换纳米颗粒肿瘤微环境刺激响应诊疗一体化

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列斐伏尔空间理论及其诗学效应

四川职业技术学院学报 2024年第3期34卷 104-110页

作者：宋昕玥南京师范大学文学院江苏南京210000

空间理论是当今文艺学、美学领域中的一个新兴方向,空间逐渐从外在客观的容器变成人类主观的空间感。列斐伏尔将空间理论从二元论发展成三元论,建构了感知的空间、构想的空间、亲历的空间,分别对应于空间实践、空间表象与表征性空间。... 详细信息

空间理论是当今文艺学、美学领域中的一个新兴方向,空间逐渐从外在客观的容器变成人类主观的空间感。列斐伏尔将空间理论从二元论发展成三元论,建构了感知的空间、构想的空间、亲历的空间,分别对应于空间实践、空间表象与表征性空间。三元空间是三位一体的同构关系,存在持续生产的辩证过程。列斐伏尔空间理论为空间介入文学研究提供了可能性,它重释了文学研究的空间内涵,开拓了文艺批评的空间维度,推动了文艺理论的空间转向。

关键词：列斐伏尔空间诗学《空间的生产》三元空间辩证法