The prognostic potential and immunological analysis of PTEN in pan-cancer
会议名称：《2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛》
会议日期：2021年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：pan-cancer PTEN prognostic biomarker immune infiltration mutation
摘 要：Background: Phosphatase and tensin homologue(PTEN)controls crucial signaling events and processes including cell growth, proliferation, survival, and migration. However, the expression level and the prognostic potential of PTEN have not been studied from the perspective of pan-cancer. Therefore, we aimed to analyze the expression and prognostic value of PTEN in pan-cancer and to gain insights into the association between PTEN and immune ***: The differential expression of PTEN in 27 human cancers was analyzed by Genotype-Tissue Expression(GTEx) and The Cancer Genome Atlas(TCGA) database. The effect of PTEN on the prognosis of pan-cancer was evaluated by univariate Cox analysis. In addition, the correlation between PTEN and tumor infiltrating-immune cells was analyzed via Tumor Immune Evaluation Resource(TIMER) database. In order to study the immunological and prognostic role of PTEN in cancers, the relationship between PTEN and different immune checkpoints, RNAss, DNAss, neoantigen, tumor mutational burden and microsatellite instability in pan-cancer were comprehensively *** mutations in PTEN and DNA methylation in pan-cancer were also ***: PTEN was significantly different in 24 of 27 cancers, which is up-regulated in 7 cancers and down-regulated in 17 cancers. Univariate COX survival analysis showed that PTEN was significantly correlated with overall survival(OS) of two cancers, disease-free interval(DFI) of four cancers,disease-specific survival(DSS) of two cancers and progression free interval(PFI) of three cancers. It is worth noting that although the expression of PTEN in various cancers had significant prognostic value, PTEN played a protective or harmful role in different cancers. In brain lower grade glioma(LGG), PTEN was significantly over-expressed in LGG patients, and whether it was OS(P=0.0290,hazard ratio(HR)=0.96), DFI(P=0.0036, HR=0.87), PFI(P=0.0110, HR=0.97) or DSS(P=0.0110,HR=0.95), PTEN over-expression g