检索结果-南通市图书馆

Network pharmacology and experimental validation of maxing Shigan decoction in the treatment of influenza virus-inducedferroptosis

引用

Chinese Journal of Natural Medicines 2023年第10期21卷 775-788页

作者： HUANG Jiawang ma xinyue LIAO Zexuan LIU Zhuolin WANG Kangyu FENG Zhiying NING Yi LU Fangguo LI Ling College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China The Medicine School of Hunan University of Chinese Medicine Changsha 410208China Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China

Influenza is an acute viral respiratory infection that has caused high morbidity and mortality *** A virus(IAV)has been found to activate multiple programmed cell death pathways,including *** is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation,leading to cell ***,little is known about how influenza viruses induce ferroptosis in the host *** this study,based on network pharmacology,we predicted the mechanism of action of maxing Shigan decoction(MXSGD)in IAV-induced ferroptosis,and found that this process was related to biological processes,cellular components,molecular function and multiple signaling pathways,where the hypoxia inducible factor-1(HIF-1)signaling pathway plays a significant ***,we constructed the mouse lung epithelial(MLE-12)cell model by IAV-infected in vitro cell experiments,and revealed that IAV infection induced cellular ferroptosis that was characterized by mitochondrial damage,increased reactive oxygen species(ROS)release,increased total iron and iron ion contents,decreased expression of ferroptosis marker gene recombinant glutathione peroxidase 4(GPX4),increased expression of acyl-CoA synthetase long chain family member 4(ACSL4),and enhanced activation of hypoxia inducible factor-1α(HIF-1α),induced nitric oxide synthase(iNOS)and vascular endothelial growth factor(VEGF)in the HIF-1 signaling *** with MXSGD effectively reduced intracellular viral load,while reducing ROS,total iron and ferrous ion contents,repairing mitochondrial results and inhibiting the expression of cellular ferroptosis and the HIF-1 signaling ***,based on animal experiments,it was found that MXSGD effectively alleviated pulmonary congestion,edema and inflammation in IAV-infected mice,and inhibited the expression of ferroptosis-related protein and the HIF-1 signaling pathway in lung tissues.

关键词： Network pharmacology Experimental validation maxing Shigan decoction Influenza Ferroptosis HIF-1 signaling pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

UltrahighQ Sr_(1+x)Y_(2)O_(4+x)(x=0-0.04)microwave dielectric ceramics for temperature-stable millimeter-wave dielectric resonator antennas

引用

Journal of Advanced Ceramics 2024年第2期13卷 155-165页

作者： Guoqiang He Yu Jiang Kaixin Song Yanjun Liu Yuan Nie Wenjie Zhang Ziqi Zhao Yinghan He xinyue ma Xiuli Chen Xu Li Huanfu Zhou Collaborative Innovation Centre for Exploration of Hidden Nonferrous Metal Deposits and Development of New materials in Guangxi Key Laboratory of Nonferrous Materials and New Processing TechnologyMinistry of EducationSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004China College of Electronic Information Hangzhou Dianzi UniversityHangzhou 310018China

Microwave dielectric ceramics should be improved to advance mobile communication technologies *** this study,we prepared Sr_(1+x)Y_(2)O_(4+x)(x=0-0.04)ceramics with nonstoichiometric Sr^(2+)ratios based on our previously reported SrY_(2)O_(4) microwave dielectric ceramic,which has a low dielectric constant and an ultrahigh quality factor(Q value).The ceramic exhibited a 33.6% higher Q-by-frequency(Q×f)value(Q≈12,500)at x=0.02 than SrY_(2)O_(4).All Sr_(1+x)Y_(2)O_(4+x)(x=0-0.04)ceramics exhibited pure phase structures,although variations in crystal-plane spacings were *** ceramics are mainly composed of Sr-O,Y1-O,and Y_(2)-O octahedra,with the temperature coefficient of the resonant frequency(τ_(f))of the ceramic increasing with Y_(2)-O octahedral *** ceramic comprises uniform grains with a homogeneous elemental distribution,clear grain boundaries,and no obvious cavities at x=*** Sr_(1+x)Y_(2)O_(4+x)(x=0-0.04)ceramics exhibited good microwave dielectric properties,with optimal performance observed at x=0.02(dielectric constant(εr)=15.41,Q×f=112,375 GHz,and τ_(f)=-17.44 ppm/℃).The τ_(f) value was reduced to meet the temperaturestability requirements of 5G/6G communication systems by adding CaTiO_(3),with Sr_(1.02)Y_(2)O_(4.02)+2wt% CaTiO_(3) exhibiting ε_(r)=16.14,Q×f=51,004 GHz,andτf=0 ppm/℃.A dielectric resonator antenna prepared using Sr_(1.02)Y_(2)O_(4.02)+2wt%CaTiO_(3) exhibited a central frequency of 26.6 GHz,with a corresponding gain and efficiency of 3.66 dBi and 83.14%,***,Sr_(1.02)Y_(2)O_(4).02-based dielectric resonator antennas are suitable for use in 5G millimeter-wave band(24.5-27.5 GHz)applications.

关键词： millimeter wave microwave dielectric ceramics dielectric resonator antenna nonstoichiometric ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent progress in carbon-based electrochemical catalysts:From structure design to potential applications

引用

Nano Research Energy 2023年第2期2卷 3-25页

作者： Jixin Yan Fenghui Ye Quanbin Dai xinyue ma Zhihai Fang Liming Dai Chuangang Hu State Key Laboratory of Organic-Inorganic Composites College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China Australian Carbon materials Centre(A-CMC) School of Chemical EngineeringUniversity of New South WalesSydneyNSW 2052Australia Department of macromolecular Science and Engineering Case School of EngineeringCase Western Reserve UniversityClevelandOhio 44106USA

Advances in research and development of carbon-based metal-free electrocatalysts(C-MFECs)have provided potential alternatives to precious metal catalysts for various reactions important to renewable energy and environmental *** timely but critical review provides an overview of recent breakthroughs(within the past 5 years or so)on C-MFECs in all aspects,including the design and regulation of intrinsic catalytic active sites,design and synthesis of carbon composite and hybrid carbon catalysts,mechanism understanding,and potential applications in clean energy storage and energy/chemical *** challenges and future opportunities in the field of metal-free carbon electrocatalysis are also discussed to provide forward-looking opportunities for their potential applications in various catalytic processes of practical significance.

关键词： carbon-based metal-free electrocatalysts intrinsic regulation structural design optimized composition newly developed application

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bisulfite-mediated base-free decarboxylative carbonylsulfination of alkenes:access to β-keto sultines

引用

Science China Chemistry 2024年

作者： Yongxin Zhang Pan Zhou xinyue ma Xiaoxiao Yang Xing Fang Yuxi Wang Chao Shu State Key Laboratory of Green Pesticide Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction CCNU-uOttawa Joint Research Centre College of Chemistry Central China Normal University (CCNU) Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Normal University

A straightforward three-component decarboxylative cross-coupling of α-keto acids, alkenes and sodium bisulfite is established for the construction of otherwise challenging-to-access β-keto sultine derivatives. This reaction involves the photoinduced carbonylsulfination of alkenes and utilizes sodium bisulfite as both a sulfur dioxide surrogate and buffer agent for deprotonation of α-keto carboxylic acids. Of note, the practical procedure featured broad substrate scope and group tolerance for diverse biologically important molecules under mild and operationally simple conditions, using an organic photocatalyst. Mechanistic studies indicated that the transformation proceeds an apparent two-pronged radical addition/radical-polar crossover/SO2insertion/ionic cyclization relay process, distinct from traditional alkenes bifunctionalization.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Penta-core silver pyrazine complexes extended Keggin-type phosphomolybdate with excellent supercapacitor performance

Penta-core silver pyrazine complexes extended Keggin-type ph...

引用

中国化学会第十届全国无机化学学术会议

作者： xinyue ma Liping cui Kai Yu Baibin Zhou Key Laboratory for Photonic and Electronic Bandgap materials Ministry of Education Harbin Normal University

A penta-core silver pyrazine complexes extended Keggin-type phosphomolybdate,[(Ag(pz)Cl){PMoO}]has been synthesized by hydrothermal *** silver and six pz are interlinked to form a hexahedral ring *** addition,eight silver,six pz and two chlorines are alternately joined to form an irregular macrocyclic *** ring units are connected by common edges to form a 2-D metal organic *** the way of edge-sharing,each macroring unit is connected with two adjacent macroring units and four hexahedral rings,meanwhile each hexahedral ring is also connected to two analogues and six macrocyclic units around ***{PMo}anion cluster is attached to Ag of two rings and is enclosed in the circle to form unique metal-organic *** three-dimensional network structure is formed by the interaction of Ag3-Cl1-Ag1 between adjacent metal-organic *** compound acts as a supercapacitor electrode material with higher specific capacitance (1189 F g,2.4 A g) and good cycle stability(capacitance retention of 85.3%after 5000 cycles).The impedance spectrum of does not change much after cycles,which further suggests that the compound is an efficient and stable supercapacitor material.

关键词： Keggin Hydrothermal synthesis Phosphomolybdate Supercapacitor

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A novel fluorescent structure-switching aptasensor for the sensitive detection of acrylamide based on AuNPs-assisted separation of ssDNA

Advanced Agrochem

引用

Advanced Agrochem 2023年第3期2卷 276-283页

作者： Ningyi Xu xinyue ma Yue Cao Huan Wang Han Wu Hongru Zheng Chuanyu Yang Ruiqi Zou Jiayi Liu Chunyan Sun Yuan Yuan Department of Food Quality and Safety College of Food Science and EngineeringJilin UniversityChangchun130062China Jilin Province Product Quality Supervision and Inspection Institute Changchun130103China

Fluorescent aptasensor was developed for acrylamide(AAm)detection by utilizing the adsorption effect of Au nanoparticles(AuNPs)and fluorescence properties of SYBR Green I(SGI)towards double-stranded DNA(dsDNA).Compared to the binding of aptamer with AAm,the higher affinity of aptamer with cDNA may facilitate a structure switching from the aptamer/AAm complex to aptamer/cDNA *** free aptamers were adsorbed onto AuNPs and separated by ***,SGI was introduced as a fluorescent reporter for quantitative *** to conventional AuNPs-based colorimetric detection,the sensitivity of this strategy was improved by 3.18-fold in the range of 0.005–50 mg/L with a low detection limit of 4.68μg/*** method has been successfully applied to analyze fried twists and ***,it is a low-cost and general method that provides guidance for the development of rapid screening technology in the field.

关键词： Aptamer Acrylamide Au nanoparticles Separation Fluorescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

食品中金黄色葡萄球菌定量风险评估的研究进展

引用

食品工业科技 2021年第22期42卷 390-397页

作者：黄欣悦陈娟马欣玥华中农业大学食品科学技术学院教育部环境食品学重点实验室蛋品加工技术国家地方联合工程研究中心湖北武汉430000 西南民族大学食品科学与技术学院四川成都610041

随着生活水平的不断提高,人们对于食品的安全性也愈发重视。金黄色葡萄球菌是引发食源性疾病的主要原因之一,在自然界中分布广泛。近年来由其引发的食品安全事件频发,严重威胁着人体健康。食品在生产、加工及运输过程中都极易受其污染... 详细信息

随着生活水平的不断提高,人们对于食品的安全性也愈发重视。金黄色葡萄球菌是引发食源性疾病的主要原因之一,在自然界中分布广泛。近年来由其引发的食品安全事件频发,严重威胁着人体健康。食品在生产、加工及运输过程中都极易受其污染而造成食品安全问题,因此对食品中金黄色葡萄球菌的风险进行定量评估是一项十分重要的工作。本文主要从危害识别、危害特征描述、暴露评估和风险特征描述四个方面,详细阐述了国内外在食品中金黄色葡萄球菌的风险评估工作,进一步对现有研究的不足之处提出了建议并展望了未来的研究方向,以期为构建危害分析与关键控制点的确定工作起到一定的指导作用。

关键词：食品金黄色葡萄球菌危害识别危害特征描述暴露评估风险特征描述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国古代史学会通思想探研

引用

史学史研究 2020年第3期 19-31页

作者：马新月北京师范大学历史学院北京100875

"会通"一词最早出现在先秦时期的《周易·系辞》中,用以表明卦爻之会合变通。经过两汉至魏晋隋唐时期学者们的阐释和运用,其内涵得以不断丰富发展,在原有含义的基础上还衍生出了"执一"与"折中"的观念。随着会通概念的产生和发展,史家会... 详细信息

"会通"一词最早出现在先秦时期的《周易·系辞》中,用以表明卦爻之会合变通。经过两汉至魏晋隋唐时期学者们的阐释和运用,其内涵得以不断丰富发展,在原有含义的基础上还衍生出了"执一"与"折中"的观念。随着会通概念的产生和发展,史家会通的史学意识也开始萌生,在早期的史书编纂和历史评论中都有所体现。到了宋代,理学的发展促进了会通思想的深化,会通成为历史撰述的思想主旨,由此被正式纳入史学思想的范畴。明清时期,胡应麟、黄宗羲、章学诚等史家在继承和系统总结前人史学会通思想的基础上,深入探讨了会通之义的"一"与"中"的关系,推进了这一思想的哲理化发展。中国古代史学会通思想是对传统通史撰述精神的传承与创新,体现了中国古代史学注重历史撰述的客观性、史学认识的通识性以及突出史家独断之学等特点。

关键词：会通会合变通执一折中独断之学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

具身认知视角下的职业教育教学策略初探

引用

职业技术教育 2018年第23期39卷 35-38页

作者：马欣悦华东师范大学职业教育与成人教育研究所

具身认知是是指身体在认知过程中发挥关键作用,通过身体的体验及其活动方式形成相应的认知。具身认知理论在职业教育教学中包含使知识现实化、生动化、动态化的涵义,它具有具身性、情境性和生成性等特点。具身认知视角下的职业教育教学... 详细信息

具身认知是是指身体在认知过程中发挥关键作用,通过身体的体验及其活动方式形成相应的认知。具身认知理论在职业教育教学中包含使知识现实化、生动化、动态化的涵义,它具有具身性、情境性和生成性等特点。具身认知视角下的职业教育教学应扎根环境、在课堂上构建现实场景及在学习中促进师生对话等。

关键词：具身认知职业教育教学策略

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

人际同步对合作行为的促进机制及解释模型

引用

心理科学进展 2022年第6期30卷 1317-1326页

作者：马昕玥崔丽莹上海师范大学教育学院心理学系上海200234

同步作为集体仪式的核心要素,对群体生存和发展具有重要意义。人际同步是一种特殊的协调行为,具有锁时锁相的特征。近年来研究发现同步能够促进合作等亲社会行为,具体的促进机制包括神经生理的激活、社会联结感的增强、认知灵敏度的提... 详细信息

同步作为集体仪式的核心要素,对群体生存和发展具有重要意义。人际同步是一种特殊的协调行为,具有锁时锁相的特征。近年来研究发现同步能够促进合作等亲社会行为,具体的促进机制包括神经生理的激活、社会联结感的增强、认知灵敏度的提高和积极情绪的唤起,学者们也从不同角度提出了三种不同的解释模型:自我-他人重叠模型、合作加强模型和集体沸腾模型。未来的研究需要进一步剖析同步行为的亲社会功能,厘清同步效应的调节机制、特异性和普适性。

关键词：人际同步合作社会联结感群体身份认同自我-他人表征重叠

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：