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Biomedical Applications of MXenes:From Nanomedicine to Biomaterials

Accounts of Materials Research 2022年第8期3卷 785-798页

作者： Liang Chen xinyue Dai wei Feng Yu Chen Materdicine Lab School of Life SciencesShanghai UniversityShanghai 200444P.R.China School of Medicine Shanghai UniversityShanghai 200444P.R.China

CONSPECTUS:The rise of two-dimensional(2D)materials has led to significant interest in their potential applications for nanomedicine and biomaterials in the hope that they can overcome some intrinsic limitations of conventional theranostic ***,an emerging family of 2D materials mainly made of transition metal carbides/nitrides,have drawn substantial interest in biomedical applications because of their unique physicochemical *** remarkable photothermal energy-converting capability of MXenes allows photonic hyperthermia treatment in the second near-infrared biowindow with deep tissue *** diverse choice of metal elements in MXenes endows them with the aptitudes to act as contrast agents for computed tomography and magnetic resonance *** the understanding of pathological characteristics is improved,the desirable properties and performances of nanomedicine and biomaterials have become more comprehensive,which is unlikely to be accomplished with the formulation of MXenes *** this Account,we highlight recent progress in the biomedical applications of 2D MXenes ranging from nanomedicine and *** will start by introducing major synthetic techniques for fabricating MXenes with ultrathin 2D structures and nanoscale sizes for biomedical *** then elaborate how MXenes differ from other 2D materials,showing exclusive potential in biomedical *** diverse surface compositions allow the tuning of the bandgap and surface plasmon resonance effect,which is essential for nanodynamic *** transition metal elements in MXenes could render them with enzymatic activities for nanocatalytic *** also possess favorable biodegradability and biocompatibility,facilitating the potential clinical ***,the intrinsic properties of MXenes might be insufficient to fulfill some specific requirements in advanced biomedical *** instance,the therapeutic efficiency of MXenes alone would

关键词： impaired biomaterials alone

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Quantification of Central and Eastern China's atmospheric CH_(4) enhancement changes and its contributions based on machine learning approach

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Journal of Environmental Sciences 2024年第4期138卷 236-248页

作者： xinyue Ai Cheng Hu Yanrong Yang Leying Zhang Huili Liu Junqing Zhang Xin Chen Guoqiang Bai wei Xiao College of Biology and the Environment Joint Center for sustainable Forestry in Southern ChinaNanjing Forestry UniversityNanjing 210037China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China Guang’an Vocational&Technical College Guangan 638550China HuaNan Meteorological Administration Huanan 154400China

Methane is the second largest anthropogenic greenhouse gas,and changes in atmospheric methane concentrations can reflect the dynamic balance between its emissions and ***,the monitoring of CH_(4) concentration changes and the assessment of underlying driving factors can provide scientific basis for the government’s policy making and *** is the world’s largest emitter of anthropogenic ***,due to the lack of ground-based observation sites,little work has been done on the spatial-temporal variations for the past decades and influencing factors in China,especially for areas with high anthropogenic emissions as Central and Eastern *** to quantify atmospheric CH_(4) enhancements trends and its driving factors in Central and Eastern China,we combined the most up-to-date TROPOMI satellite-based column CH_(4)(xCH_(4))concentration from 2018 to 2022,anthropogenic and natural emissions,and a random forest-based machine learning approach,to simulate atmospheric xCH_(4) enhancements from 2001 to *** results showed that(1)the random forest model was able to accurately establish the relationship between emission sources and xCH_(4) enhancement with a correlation coefficient(R^(2))of 0.89 and a root mean-square error(RMSE)of 11.98 ppb;(2)The xCH_(4) enhancement only increased from 48.21±2.02 ppb to 49.79±1.87 ppb from the year of 2001 to 2018,with a relative change of 3.27%±0.13%;(3)The simulation results showed that the energy activities and waste treatment were the main contributors to the increase in xCH_(4) enhancement,contributing 68.00% and 31.21%,respectively,and the decrease of animal ruminants contributed-6.70% of its enhancement trend.

关键词： TROPOMI Methane column concentrations Anthropogenic sources Random Forest model

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Niobium carbide MXenzyme-Driven comprehensive cholesterol regulation for photoacoustic image-guided and anti-inflammatory photothermal ablation in atherosclerosis

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Bioactive Materials 2024年第6期36卷 565-579页

作者： Wenqi Pan Jingyun Cheng xinyue Cao Yi Zheng Zhenyu Yang wei Feng Yu Chen Rong Wu Department of Ultrasound Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080PR China Materdicine Lab School of Life SciencesShanghai UniversityShanghai200444PR China Shanghai Institute of Materdicine Shanghai200051PR China

Foam cells play a pivotal role in the progression of atherosclerosis progression by triggering inflammation within arterial *** release inflammatory molecules that attract additional immune cells,leading to further macrophage recruitment and plaque *** this study,we develop an osteopontin(OPN)antibody-conjugated niobium carbide(Nb_(2)C-aOPN)MXenzyme designed to selectively target and mildly ablate foam cells while reducing inflammation in the plaque *** approach utilizes photonic hyperthermia to decrease plaque size by enhancing cholesterol regulation through both passive cholesterol outflow and positive cholesterol ***_(2)C-aOPN MXenzyme exhibits multiple enzyme-mimicking properties,including catalase,superoxide dismutase,peroxidase and glutathione peroxidase,and acts as a scavenger for reactive oxygen and nitrogen *** inhibition of reactive oxygen and nitrogen species synergizes with photothermal ablation to promote positive cholesterol efflux,leading to reduced macrophage recruitment and a shift in macrophage phenotype from M1 to *** integrative strategy on cholesterol regulation and anti-inflammation highlights the potential of multifunctional 2D MXenzyme-based nanomedicine in advancing atherosclerotic regression.

关键词： Atherosclerosis MXenzyme Lipid regulation Anti-inflammation Theranostics

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两段式柠檬酸抗凝治疗在活动性出血或高危出血风险的血液透析患者中的应用效果

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中国医药导报 2023年第34期20卷 120-123页

作者：吴春香刘春晓张崔勇罗舒文韦新月罗春明广西壮族自治区柳州市工人医院肾内科广西柳州545000

目的探讨两段式柠檬酸抗凝治疗在活动性出血或高危出血风险的血液透析患者中的应用效果。方法选择2021年5月至2022年3月广西壮族自治区柳州市工人医院收治的100例活动性出血或高危出血风险的血液透析患者为研究对象,根据随机数字表法将... 详细信息

目的探讨两段式柠檬酸抗凝治疗在活动性出血或高危出血风险的血液透析患者中的应用效果。方法选择2021年5月至2022年3月广西壮族自治区柳州市工人医院收治的100例活动性出血或高危出血风险的血液透析患者为研究对象,根据随机数字表法将其分为研究组及对照组,各50例。对照组透析中采用一段式柠檬酸抗凝治疗,研究组透析中采用两段式柠檬酸抗凝治疗。比较两组的透析时间、透析器抗凝有效率、静脉壶抗凝有效率,比较两组透析血气指标和外周血清电解质水平及透析结束时血液透析尿素清除情况。记录两组不良事件的发生情况。结果研究组透析时间长于对照组,静脉壶抗凝有效率高于对照组,差异有统计学意义(P0.05)。结论对活动性出血或高危出血风险的血液透析患者,两段式柠檬酸抗凝治疗在透析时间、静脉壶抗凝有效率方面优于一段式柠檬酸抗凝治疗,尿素清除方面也更具优势。

关键词：血液透析柠檬酸分段抗凝应用效果

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Rearrangement of Actin Cytoskeleton by Zika Virus Infection Facilitates Blood–Testis Barrier Hyperpermeability

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Virologica Sinica 2021年第4期36卷 692-705页

作者： Yiwen Nie Lixia Hui Moujian Guo wei Yang Rui Huang Junsen Chen xinyue Wen Meng Zhao Ying Wu State Key Laboratory of Virology School of Basic Medical SciencesWuhan UniversityWuhan 430072China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

In recent years,various serious diseases caused by Zika virus(ZIKV)have made it impossible to be *** existence of ZIKV in semen and sexually transmission of ZIKV suggested that it can break the blood–testis barrier(BTB),or Sertoli cell barrier(SCB).However,little is known about the underlying *** this study,interaction between actin,an important component of the SCB,and ZIKV envelope(E)protein domainⅢ(EDⅢ)was inferred from coimmunoprecipitation(Co-IP)liquid chromatography–tandem mass spectrometry(LC–MS/MS)*** microscopy confirmed the role of actin filaments(F-actin)in ZIKV infection,during which part of the stress fibers,the bundles that constituted by paralleled actin filaments,were disrupted and presented in the cell *** of E and reorganized actin filaments in the cell periphery of transfected Sertoli cells suggests a participation of ZIKV E protein in ZIKV-induced F-actin *** of F-actin by cytochalasin D(CytoD)or Jasplakinolide(Jas)enhanced the infection of *** importantly,the transepithelial electrical resistance(TEER)of an in vitro mouse SCB(mSCB)model declined with the progression of ZIKV infection or overexpression of E ***-IP and confocal microscopy analyses revealed that the interaction between F-actin and tight junction protein ZO-1 was reduced after ZIKV infection or E protein overexpression,highlighting the role of E protein in ZIKV-induced disruption of the *** conclude that the interaction between ZIKV E and F-actin leads to the reorganization of F-actin network,thereby compromising BTB integrity.

关键词： Zika virus(ZIKV) Envelope protein Actin filaments Sertoli cell barrier(SCB) Blood-testis barrier(BTB)

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The Amygdala Responds Rapidly to Flashes Linked to Direct Retinal Innervation:A Flash-evoked Potential Study Across Cortical and Subcortical Visual Pathways

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Neuroscience Bulletin 2021年第8期37卷 1107-1118页

作者： Yanmei Chen Yiling Ni Jianhong Zhou Hua Zhou Qian Zhong xinyue Li Jichuan Zhang Yuanye Ma Jingkuan wei Department of Basic Medicine Medical SchoolKunming University of Science and TechnologyKunming650550China State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming650500China

Rapid detection and response to visual threats are critical for survival in *** amygdala(AMY)is hypothesized to be involved in this process,but how it interacts with the visual system to do this remains *** recording flash-evoked potentials simultaneously from the superior colliculus(SC),lateral posterior nucleus of the thalamus,AMY,lateral geniculate nucleus(LGN)and visual cortex,which belong to the cortical and subcortical pathways for visual fear processing,we investigated the temporal relationship between these regions in visual processing in rats.A quick flash-evoked potential(FEP)component was identified in the *** emerged as early as in the LGN and was approximately 25 ms prior to the earliest component recorded in the SC,which was assumed to be an important area in visual *** quick P1 component in the AMY was not affected by restraint stress or corticosterone injection,but was diminished by RU38486,a glucocorticoid receptor *** injecting a monosynaptic retrograde AAV tracer into the AMY,we found that it received a direct projection from the *** results confirm the existence of a direct connection from the retina to the AMY,that the latency in the AMY to flashes is equivalent to that in the sensory thalamus,and that the response is modulated by glucocorticoids.

关键词： Subcortical visual pathway Amygdala Superior colliculus Corticosterone Flash-evoked potential

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Development and implementation of a dynamic and 4D GIS based on semantic location model

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Geo-Spatial Information Science 2019年第3期22卷 193-213页

作者： Xinyan Zhu Tao Hu xinyue Ye wei Guo Liang Huang Hanjiang Xiong Haojun Ai Bing She Qing Xiong Lian Duan State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina Collaborative Innovation Center of Geospatial Technology Wuhan UniversityWuhanChina Center for Geographic Analysis Harvard UniversityCambridgeMAUSA Department of Informatics New Jersey Institute of TechnologyNewarkNJUSA Intelligent Transportation System Research Center Wuhan University of TechnologyWuhanChina University of Michigan Ann ArborUSA Geography Science and Planning School Guangxi Normal UniversityNanningChina Key Laboratory of Environment Change and Resources Use in Beibu Gulf Guangxi Teachers Education UniversityNanningChina

In the big data era,robust solutions are obliged to be proposed to integrate and represent data from different formats and with different contents to assist the *** cartographic and geographic information systems have limited capabilities for solving these *** paper describes an automatic and comprehensive system that conducts data fusion from all potentially related *** this system,a new Semantic Location Model(SemLM)is established to present the semantic concepts and location feature and demonstrate how locations are *** the SemLM,various types of location descriptors in different application scenarios can be analyzed and ***,considering the challenges involved in data-intensive computation and visualization,this paper implements a Place-based Pan-Information System(P2S)as an innovative 4D system that dynamically associates and visualizes place-based information,using public security as the case study.

关键词： Place-based pan-information system(P2S) big data semantic location model ubiquitous information 4D map

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Recent advances and applications of single atom catalysts based electrochemical sensors

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Nano Research 2024年第4期17卷 2994-3013页

作者： Mingyue Wang Mingfu Ye Jieyue Wang Yong Xu Zhendong Wang xinyue Tong Xinya Han Kui Zhang Wenhai Wang Konglin Wu Xianwen wei Institute of Clean Energy and Advanced Nanocatalysis(iClean) School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China Anhui International Research Center of Energy materials green manufacturing and biotechnology School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China Carbon Cycle and Emission Control Research Center Low-Carbon Research InstituteAnhui University of TechnologyMaanshan 243002China

Single atom catalysts(SACs)have attracted considerable attention due to their unique structures and excellent catalytic performance,especially in the area of catalysis science and energy conversion and *** recent years,SACs have emerged as a new type of sensing material for constructing electrochemical sensors(ECSs),presenting excellent sensitivity,selectivity,and ***,we review the recent advances of SACs in electrochemical sensing and discuss the status quo of current SAC-based ***,the fundamentals of SAC-based ECSs are outlined,including the involved central metal atoms and various supports of SACs in this field,the detection mechanisms,and improving strategies of SAC-based ***,the important applications of SAC-based ECSs are listed and classified,covering the detection of reactive oxygen and nitrogen species,environmental pollutants,disease biomarkers,and ***,based on abundant reported cases,the current conundrums of SAC-based ECSs are summarized,and the prediction of their future developing trends is also put forward.

关键词： single atom catalysts(SACs) electrochemical sensors(ECSs) reactive oxygen and nitrogen species environmental pollutants disease biomarkers pharmaceuticals

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SemiSynBio:A new era for neuromorphic computing

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Synthetic and Systems Biotechnology 2024年第3期9卷 594-599页

作者： Ruicun Liu Tuoyu Liu Wuge Liu Boyu Luo Yuchen Li xinyue Fan Xianchao Zhang wei Cui Yue Teng State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing100071China Institute of Information Network and Artificial Intelligence Jiaxing UniversityJiaxing314001China South China University of Technology Guangzhou510641China

Neuromorphic computing has the potential to achieve the requirements of the next-generation artificial intelligence(AI)systems,due to its advantages of adaptive learning and parallel ***,biocomputing has seen ongoing development with the rise of synthetic biology,becoming the driving force for new generation semiconductor synthetic biology(SemiSynBio)***-based biomolecules could potentially perform the functions of Boolean operators as logic gates and be used to construct artificial neural networks(ANNs),providing the possibility of executing neuromorphic computing at the molecular ***,we briefly outline the principles of neuromorphic computing,describe the advances in DNA computing with a focus on synthetic neuromorphic computing,and summarize the major challenges and prospects for synthetic neuromorphic *** believe that constructing such synthetic neuromorphic circuits will be an important step toward realizing neuromorphic computing,which would be of widespread use in biocomputing,DNA storage,information security,and national defense.

关键词： Neuromorphic computing Synthetic biology Biocomputing Artificial intelligence Neuromorphic genetic circuits

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STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke

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Stroke & Vascular Neurology 2024年第2期9卷 153-164页

作者： Wenyu Li Nan Shen Lingqi Kong Hongmei Huang xinyue Wang Yan Zhang Guoping Wang Pengfei Xu wei Hu Department of Neurology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina

background Ischaemia-evoked neuroinflammation is a critical pathogenic event following ischaemic *** D(GSDMD)-associated pyroptosis represents a type of inflammation-associated programmed cell death,which can exacerbate neuroinflammatory responses and brain *** of interferon genes(STING)was recently described as a vital innate immune adaptor protein associated with ***,the regulatory effects of STING on microglial pyroptosis post-stroke have not been well *** STING-knockout and wild-type(WT)mice were subjected to middle cerebral artery occlusion(MCAO).STING small interfering RNA(siRNA)was transfected into BV2 cells before oxygen-glucose deprivation/reoxygenation(OGD/R).STING-overexpressing adeno-associated virus(AAV)and NOD-like receptor family pyrin domain containing 3(NLRP3)siRNA were administered by stereotaxic injection.2,3,5-Triphenyl tetrazolium chloride(TTC)staining,TdT-mediated dUTP nick end labeling(TUNEL)staining,Fluoro-Jade C(FJC)staining,neurobehavioural tests,immunohistochemistry,cytokine antibody array assay,transmission electron microscopy,immunoblot,Enzyme-linked immunosorbent assay(ELISA)and quantitative real-time polymerase chain reaction(qRT-PCR)were carried ***-immunoprecipitation assays were used to investigate the interplay between STING and *** STING expression was increased after MCAO and mainly detected on *** deletion alleviated brain infarction,neuronal damage and neurobehavioural impairment in mice subjected to *** knockout suppressed microglial activation and the secretion of inflammatory chemokines,accompanied by mitigation of microglial *** upregulation of microglial STING by AAV-F4/80-STING aggravated brain injury and microglial ***,co-immunoprecipitation showed that STING bound to NLRP3 in *** of NLRP3 siRNA reversed AAV-F4/80-STING-induced deterioration of microglial pyropt

关键词： NLRP3 cerebral inflammation

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