Niobium carbide MXenzyme-Driven comprehensive cholesterol regulation for photoacoustic image-guided and anti-inflammatory photothermal ablation in atherosclerosis
作者机构：Department of UltrasoundShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080PR China Materdicine LabSchool of Life SciencesShanghai UniversityShanghai200444PR China Shanghai Institute of MaterdicineShanghai200051PR China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2024年第36卷第6期
页 面：565-579页
核心收录：
学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
主 题：Atherosclerosis MXenzyme Lipid regulation Anti-inflammation Theranostics
摘 要：Foam cells play a pivotal role in the progression of atherosclerosis progression by triggering inflammation within arterial *** release inflammatory molecules that attract additional immune cells,leading to further macrophage recruitment and plaque *** this study,we develop an osteopontin(OPN)antibody-conjugated niobium carbide(Nb_(2)C-aOPN)MXenzyme designed to selectively target and mildly ablate foam cells while reducing inflammation in the plaque *** approach utilizes photonic hyperthermia to decrease plaque size by enhancing cholesterol regulation through both passive cholesterol outflow and positive cholesterol ***_(2)C-aOPN MXenzyme exhibits multiple enzyme-mimicking properties,including catalase,superoxide dismutase,peroxidase and glutathione peroxidase,and acts as a scavenger for reactive oxygen and nitrogen *** inhibition of reactive oxygen and nitrogen species synergizes with photothermal ablation to promote positive cholesterol efflux,leading to reduced macrophage recruitment and a shift in macrophage phenotype from M1 to *** integrative strategy on cholesterol regulation and anti-inflammation highlights the potential of multifunctional 2D MXenzyme-based nanomedicine in advancing atherosclerotic regression.
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