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Distributed bearing-based formation control of unmanned aerial vehicle swarm via global orientation estimation

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Chinese Journal of Aeronautics 2022年第1期35卷 44-58页

作者： Yuwei ZHANG Xingjian WANG Shaoping WANG xinyu tian A School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Science and Technology on Aircraft Control Laboratory Beihang UniversityBeijing 100191China Ningbo Institute of Technology Beihang UniversityNingbo 315800China

Most existing formation control approaches for Unmanned Aerial Vehicle(UAV)swarm assume that global position and global coordinate frame are directly available for each *** extend the application domain,this paper proposes a distributed bearing-based formation control scheme,without any reliance on global position or global coordinate *** interactions among UAVs are described by a directed topology with two-leader *** address the issue of unavailable global coordinate frame,we first present a distributed orientation estimation law for each UAV to determine its orientation under the coordinate frame of the first *** on the orientation estimation,we then design a bearing-based formation control law to globally asymptotically track target moving ***,simulation results are provided to validate the proposed method,which show that the translation,scale and orientation of the formation can be flexibly controlled via two leaders.

关键词： Bearing measurement Formation control Global orientation estimation Two-leader structure Unmanned aerial vehicles

Progress of Indeno-type Organic Diradicaloids

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Chemical Research in Chinese Universities 2023年第2期39卷 161-169页

作者： GUO Jiaxiang tian xinyu WANG Yue DOU Chuandong State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012P.R.China

Organic diradicaloids have unusual open-shell nature and properties and are promising materials for organic electronics,spintronics,energy storage and nonlinear *** this review,we focus on indeno-type organic diradicaloids and summarize their molecular design and synthesis,as well as topological structures,open-shell characters and diradical *** molecular systems are classified into indenofluorenes and diindenoacenes,indeno-based molecules with one-dimensional,two-dimensional and unique topological structures,and heterocyclic indeno-based *** constructing these various topologicalπ-skeletons with tunable conjugation modes and variation of atomic composition,their key open-shell parameters,such as diradical characters and singlet-triplet energy gaps,along with the optical,electronic and magnetic properties,as well as stabilities are efficiently *** attention may be paid to accurate computational analysis,rational design and synthesis,and novel functions of indeno-type diradicaloids,which will promote the development of radical chemistry and materials.

关键词： Polycyclic hydrocarbon Open shell Quinoidal conjugation Diradical character Antiaromaticity

Enhancing stability of diradical polycyclic hydrocarbons via P=O-attaching

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Chinese Chemical Letters 2024年第8期35卷 309-313页

作者： Jingyuan Yang xinyu tian Liuzhong Yuan Yu Liu Yue Wang Chuandong Dou State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Soochow UniversitySuzhou 215123China

Diradical polycyclic hydrocarbons(PHs)have unique open-shell structures and interesting physical ***,owing to high reactivity of unpaired electrons,such open-shell organic diradicaloids are usually less stable than closed-shell systems,limiting their practical *** this study,we report P=O-attaching of diradical PHs as a new strategy to enhance their stability while maintaining diradi-cal *** P=O-attached PHs containing the indeno[1,2-b]fluorene,fluoreno[3,2-b]fluorene and indeno[2,1-b]fluoreneπ-skeletons,respectively,were designed and *** theoretically and ex-perimentally proved,two of them have the relatively large diradical characters and open-shell singlet diradical *** comparison to their all-carbon analogues,the attached electron-withdrawing P=O groups endow them with much lower LUMO/HOMO energy levels but preserved magnetic activities and physical properties,such as thermally accessible triplet species and multi-redox ***,the P=O groups effectively decrease their oxidation activities and thereby lead to their remarkably excellent ambient ***,this P=O-attaching strategy will be applicable to other diradical PH systems and may promote the generation of stable organic diradicaloids for radical chemistry and materials.

关键词： Polycyclic hydrocarbons Open-shell structure Diradical character Stability Oxidation activity

Tumor biomarkers for diagnosis,prognosis and targeted therapy

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2391-2476页

作者： Yue Zhou Lei Tao Jiahao Qiu Jing Xu xinyu Yang Yu Zhang xinyu tian Xinqi Guan Xiaobo Cen Yinglan Zhao Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Pharmacy Sichuan UniversityChengdu 610041China School of Medicine Tibet UniversityLhasa 850000China National Chengdu Center for Safety Evaluation of Drugs State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Tumor biomarkers,the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression,have been demonstrated to possess critical and encouraging value in screening and early diagnosis,prognosis prediction,recurrence detection,and therapeutic efficacy monitoring of *** the past decades,continuous progress has been made in exploring and discovering novel,sensitive,specific,and accurate tumor biomarkers,which has significantly promoted personalized medicine and improved the outcomes of cancer patients,especially advances in molecular biology technologies developed for the detection of tumor ***,we summarize the discovery and development of tumor biomarkers,including the history of tumor biomarkers,the conventional and innovative technologies used for biomarker discovery and detection,the classification of tumor biomarkers based on tissue origins,and the application of tumor biomarkers in clinical cancer *** particular,we highlight the recent advancements in biomarker-based anticancer-targeted therapies which are emerging as breakthroughs and promising cancer therapeutic *** also discuss limitations and challenges that need to be addressed and provide insights and perspectives to turn challenges into opportunities in this ***,the discovery and application of multiple tumor biomarkers emphasized in this review may provide guidance on improved precision medicine,broaden horizons in future research directions,and expedite the clinical classification of cancer patients according to their molecular biomarkers rather than organs of origin.

关键词： diagnosis breakthrough biomarkers

Thienothiophene-centered ladder-type π-systems that feature distinct quinoidal π-extension

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Chinese Chemical Letters 2024年第5期35卷 249-253页

作者： Jiaxiang Guo Zeyi Li tianyu Zhang xinyu tian Yue Wang Chuandong Dou State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials Soochow UniversitySuzhou 215123China

Quinoidalπ-conjugated structures,a kind of fundamental subunits for organicπ-systems,may produce some intriguing optical,electronic and magnetic properties of polycyclic hydrocarbons(PHs).Herein,we report two thienothiophene-centered ladder-type polycyclic molecules(1 and 2),which possess one quinoidal thienothiophene moiety and two para-quinodimethane(p-QDM)subunits,*** theoretically and experimentally studied,while 1 is a fully closed-shell molecule,2 owns an open-shell structure along with partial contribution of tetraradical state that is induced by the resonance of ***,although 2 has a largerπ-conjugated skeleton and open-shell electronic state,it exhibits larger bandgap and blue-shifted *** the other hand,the reversible oxidation activity of 1 enables the preparation of its dication 1^(2+),and the studies on its single-crystal and aromatic structures demonstrate that its two positive charges are delocalized onto the oxygen atoms,thus achieving fullyπ-extended structure and near-infrared *** study not only gains insight into quinoidalπ-subunits,but also provides an important basis for the development of antiaromatic and open-shellπ-electron materials.

关键词： Thienothiophene Quinoidal conjugation Open-shell structure Aromaticity Photophysical properties

Forward modeling and inversion of the relation model between the gas content of plume and its seismic attribute

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Acta Oceanologica Sinica 2021年第5期40卷 120-128页

作者： Canping Li Jiachun You Yanchun Tan Fengying Chen Yilin Liu Zihao Guo xinyu tian School of Electronics and Information Engineering Guangdong Ocean UniversityZhanjiang 524088China Southern Marine Science and Engineering Guangdong Laboratory(Zhanjiang) Zhanjiang 524006China School of Geophysics Chengdu University of TechnologyChengdu 610059China

The methane bubble plume attracts interest because it offers direct evidence of seafloor gas leakage and plays an indirect role in the exploration and identification of natural gas *** this study,based on established plume models and their migration sections,three amplitude-class attributes were extracted from three formations for the migration sections of five plumes,and the correlation between the gas content and seismic attribute was *** the gas content increases,the amplitude attribute correspondingly increases,and the linear correlation is relatively ***,correlation coefficients between gas content and amplitude attributes are close to *** using linear fitting,the relation model between the gas content of the plume and the seismic attribute was *** relation model was subsequently used to invert the gas content from a real databearing *** of the gas content section of the plume with the attribute section and real seismic section reveals common distribution characteristics,namely,the color of the section in the lower right corner is *** the amplitude value is large in the seismic section of the real plume,the amplitude attribute value is also large in the corresponding attribute section,and the inverted value of the gas content is also large(because gas content and amplitude are linearly correlated),which indicates that the plume bubbles of the section in the lower right corner is intensively ***,the obtained gas content section of the plume can reflect the distribution of the plume bubble content more simply and intuitively,from which the distribution law of seafloor bubbles can be deduced,and this lays a foundation for the further estimation of the gas content of the plume and hydrate reserves.

关键词： methane plume natural gas hydrate gas content seismic attribute linear fitting

Extracellular vesicles based electrochemical biosensors for detection of cancer cells:A review

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Chinese Chemical Letters 2020年第7期31卷 1737-1745页

作者： Hui Xie Kaili Di Rongrong Huang Adeel Khan Yanyan Xia Hongpan Xu Chang Liu Tingting Tan xinyu tian Han Shen Nongyue He Zhiyang Li Department of Clinical Laboratory Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityNanjing 210008China Department of Clinical Laboratory Yizheng Hospital of Nanjing Drum Tower Hospital Group.Yizheng 211900China Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringNational Demonstration Center for Experimental Biomedical Engineering Education(Southeast University)Southeast UniversityNanjing 210096China Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province Hunan Key Laboratory of Biomedical Nanomaterials and DevicesHunan University of TechnologyZhuzhou 412007China

Extracellular vesicles(EVs)derived from cancer cells are considered as ideal biomarker for liquid biopsy in cancer diagnosis,and are stable and *** methods for the detection of EVs are prefe rred over co nventional methods such as Western blotting and enzyme-linked immunosorbent assay for their high sensitivity and real-time *** article summaries studies proposing the electrochemical methods utilizing immunological and molecular methodologies for detecting EVs derived biomacromolecules such as miRNAs and transme mbrane protein for cancer ***,the electrochemical detection methods are compared and future prospects for the development of electrochemical methods for EVs detection are concluded.

关键词： Cancerous Extracellular vesicles Electrochemical Biosensors Detection

基于火电机组分级深度调峰的电力系统经济调度及效益分析

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电网技术 2017年第7期41卷 2255-2262页

作者：林俐田欣雨新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206

以风电规模化并网为背景,分析了我国现有火电机组的深度调峰能力,借鉴Manson-Coffin公式,给出了变负荷调峰下的机组损耗成本计算方法,建立了火电机组全过程调峰成本的分段函数;在全额接纳风电的基础上,以调度周期内火电机组总发电成本... 详细信息

以风电规模化并网为背景,分析了我国现有火电机组的深度调峰能力,借鉴Manson-Coffin公式,给出了变负荷调峰下的机组损耗成本计算方法,建立了火电机组全过程调峰成本的分段函数;在全额接纳风电的基础上,以调度周期内火电机组总发电成本最小为目标,建立了基于分级深度调峰的电力系统经济调度模型。以某实际电网为研究对象,给出了不同调度策略下仿真结果,进而分析了基于等效替代的火电机组深度调峰效益。结果表明,对于算例系统,适当提高部分机组的调峰深度至额定容量的55%,可以提高整个系统的调峰效益;但是随着调峰深度的进一步增加,整个系统的火电机组深度调峰效益逐渐减小,在调峰深度大于额定容量的65%以后,深度调峰效益低于基本调峰。在规模化风电并网背景下,研究结果对制定相关火电机组参与深度调峰辅助服务的效益分析提供理论参考。

关键词：深度调峰分级调峰火电机组调峰效益等效替代

Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn's disease

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World Journal of Gastroenterology 2018年第5期24卷 623-630页

作者： Grace Gathungu Yuanhao Zhang xinyu tian Erin Bonkowski Leahana Rowehl Julia Krumsiek Billy Nix Claudia Chalk Bruce Trapnell Wei Zhu Rodney Newberry Lee Denson Ellen Li Department of Pediatrics Division of Pediatric Gastroenterology Stony Brook University Department of Medicine Division of Gastroenterology Stony Brook University Department of Pediatrics Cincinnati Children’s Hospital Medical Center Department of Medicine Washington University St.Louis Applied Mathematics and Statistics Stony Brook University

AIM To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor(GMCSF) auto-antibodies(Ab) level and time to surgical recurrence after initial surgery for Crohn's disease(CD). METHODS We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA Ig G and Ig A, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16 L1, and rs13361189 in IRGM. Cox proportional-hazards models were used to assess the predictors of surgical *** Ninety six percent of patients underwent initial ileocecal resection(ICR) or ileal resection(IR) and subsequently 40% of patients required a second ICR/IR for CD. GMCSF Ab level was elevated at a median of 3.81 mcg/mL. Factors predicting faster time to a second surgery included elevated GM-CSF Ab [hazard ratio(HR) 3.52, 95%CI: 1.45-8.53, P = 0.005] and elevated GM-CSF cytokine(HR = 2.48, 95%CI: 1.31-4.70, P = 0.005). Factors predicting longer duration between first and second surgery included use of Immunomodulators(HR = 0.49, 95%CI: 0.31-0.77, P = 0.002), the interaction effect of low GM-CSF Ab levels and smoking(HR = 0.60, 95%CI: 0.45-0.81, P = 0.001) and the interaction effect of low GM-CSF cytokine levels and ATG16 L1(HR = 0.65, 95%CI: 0.49-0.88, P = 0.006).CONCLUSION GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior.

关键词： Inflammatory bowel disease granulocytemacrophage colony-stimulating factor antibody Crohn’s disease surgery