B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy

作     者：Xinyu Tian Xiangyun Zheng Dong Tian Xinyu Tian;Xiangyun Zheng;Dong Tian

作者机构：Department of Thoracic SurgeryWest China HospitalSichuan University37 Guoxue AlleyChengdu610041China Lung Transplant Research LaboratoryInstitute of Thoracic OncologyWest China HospitalSichuan University37 Guoxue AlleyChengdu610041China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第11期

页      面：5149-5150页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Key Research and Development Project of Sichuan Provincial Science and Technology Department(No.23ZDYF2875) 

主　　题：tumour interferon 

摘      要：Recently,Lloyd Bod et *** a study in Nature that identified the B-cell immune checkpoint T cell immunoglobulin and mucin domain 1(TIM-1)and mechanistically elucidated that targeting TIM-1 enhances the responses to type I interferon(IFN-I),promotes B cells antigen presentation and activation,subsequently enhances anti-tumour responses of CD4^(+) and CD8^(+)T cells and inhibits tumour *** study provides important implications for anti-tumour therapy.