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Increasing Trend of Summertime Synoptic Wave Train Activity over the Western North Pacific since 1950

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Journal of Meteorological Research 2020年第5期34卷 1013-1024页

作者： xinyi zhou Tim LI Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China International Pacific Research Center and Department of Atmospheric Sciences School of Ocean and Earth Science and TechnologyUniversity of HawaiiHonoluluHI 96822USA

The change of summertime synoptic-scale wave train(SWT) activity over the western North Pacific(WNP) since1950 was investigated based on the NCEP–NCAR reanalysis data. It is found that the intensity of SWT has a rising trend, while its structure and phase propagation characteristics remain unchanged. Environmental factors responsible for the rising trend are investigated. By separating the whole period into three warming phases(P1: 1950–1958, P2:1978–1986, and P3: 2006–2014), we found that even though the vertical velocity shows a rising trend, the background low-level vorticity over the monsoon trough region increases from P1 to P2 but decreases from P2 to P3, and so is the low-level barotropic energy conversion(CK). Thus, just the environmental dynamic factor could not explain the continuous rising SWT trend. On the other hand, thermodynamic factor, such as the sea surface temperature(SST), moisture, and atmospheric instability, shows a clear step-by-step increasing trend. A non-dimensional synoptic activity index(SAI) that combines the dynamic and thermodynamic factors is then proposed. This index well captures the observed long-term trend of the SWT intensity.

关键词： global warming synoptic wave train barotropic energy conversion(CK) atmospheric instability parameter synoptic activity index(SAI)

Year aridity index patterns in northwest China and the relationship to summer North Atlantic sea surface temperature

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Acta Oceanologica Sinica 2008年第3期27卷 161-171页

作者： YAN Yan ZHAO xinyi zhou Liping College of Urban and Environmental Sciences Laboratory for Earth Surface Processes of Ministry of Education Peking University Beijing 100871 China

Aim to linking the variability of drought in northwest China to the oceanic influence of North Atlantic SSTs at the background of global warming and at the regional climate change shifting stages, year aridity index variations in northwest China and summer North Atlantic sea surface temperature （SST） variations are examined for the 44 a period of 1961-2004 using singular value decomposition （SVD） analysis. Results show that the SST anomalies （SSTA）in the North Atlantic in summer reflected three basic models. The first SVD mode of SST pattern shows a dipole - like variation with the positive center located at southwest and negative center at northeast of extratropical North Atlantic. And it strongly relates to the positive trend in AI variation in northwest China. The second coupled modes display the coherent positive anomalies in extratropical North Atlantic SST and the marked opposite trend of AI variability between north and south of Xinjiang. In addition, the lag correlation analysis of the first mode of SSTA and geopotential heights at 500 hPa variations also shows that the indication of the former influencing the latter configuration, which result in higher air temperature and less precipitation when the SSTA in the North Atlantic Ocean in summer motivated Eurasian circulation of EA pattern, further to influence the wet - dry variations in northwest China by the ocean-to - atmosphere forcing.

关键词： aridity index SSTA teleconnection patterns SVD

A Deep Neural Collaborative Filtering Based Service Recommendation Method with Multi-Source Data for Smart Cloud-Edge Collaboration Applications

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Tsinghua Science and Technology 2024年第3期29卷 897-910页

作者： Wenmin Lin Min Zhu xinyi zhou Ruowei Zhang Xiaoran Zhao Shigen Shen Lu Sun Alibaba Business School Hangzhou Normal UniversityHangzhou 311121China Blockchain Laboratory of Agricultural Vegetables Weifang University of Science and TechnologyShouguang 262700China School of Computer Science Qufu Normal UniversityRizhao 276827China School of Information Engineering Huzhou UniversityHuzhou 313000China

Service recommendation provides an effective solution to extract valuable information from the huge and ever-increasing volume of big data generated by the large cardinality of user ***,the distributed and rich multi-source big data resources raise challenges to the centralized cloud-based data storage and value mining approaches in terms of economic cost and effective service recommendation *** view of these challenges,we propose a deep neural collaborative filtering based service recommendation method with multi-source data(i.e.,NCF-MS)in this paper,which adopts the cloud-edge collaboration computing paradigm to build recommendation *** specifically,the Stacked Denoising Auto Encoder(SDAE)module is adopted to extract user/service features from auxiliary user profiles and service *** Multiple Layer Perceptron(MLP)module is adopted to integrate the auxiliary user/service features to train the recommendation ***,we evaluate the effectiveness of the NCF-MS method on three public *** experimental results show that our proposed method achieves better performance than existing methods.

关键词： deep neural collaborative filtering multi-source data cloud-edge collaboration application stackeddenoising auto encoder multiple layer perceptron

Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging

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International Journal of Oral Science 2021年第3期13卷 251-260页

作者： Qian Wang Lulingxiao Nie Pengfei Zhao xinyi zhou Yi Ding Qianming Chen Qi Wang State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Periodontology West China Hospital of StomatologySichuan UniversityChengduChina

Hyperglycemia induces chronic low-grade inflammation(inflammaging),which is a newly identified contributor to diabetes-related tissue lesions,including the inflammatory bone loss in *** is also a secondary senescent pattern mediated by an increased burden of senescent cells and senescence-associated secretory phenotype(SASP).Macrophage is a key SASPspreading cell and may contribute to the maintenance of SASP response in the periodontal *** a transgenic diabetic model(BLKS/J-Lepr^(db)/lepr^(db)mice)we identified striking senescence of the periodontium in young(18-wk)-diabetic mice accompanied by amassed p16^(+)-macrophages and enhanced early SASP *** to high glucose in vitro,bone marrow-derived macrophage(BMDM)revealed a strong GLUT1 m RNA response driving the elevated-glucose ***1 is a representative and facilitative glucose transporter in macrophages with potential roles in hyperglycemia-induced *** this study,both GLUT1 and the downstream GTPase Rheb expression upregulated in the gingiva of diabetic mice with impaired ***,SASP release and p16/p21 signaling were proven to be triggered by m TOR phosphorylation in BMDM and antagonized by restricting glucose uptake in GLUT1^(-/-)*** together,our findings suggest that elevated-GLUT1 sensor responded to high glucose is important for macrophage senescence and SASP response,generated as a result of hyperglycemia,and it is a potential molecular mechanism for the exacerbation of periodontitis in diabetes.

关键词： elevated macrophage lesions

Facile synthesis of two-dimensional MoS_(2)/WS_(2) lateral heterostructures with controllable core/shell size ratio by a one-step chemical vapor deposition method

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Science China(Physics,Mechanics & Astronomy) 2021年第10期64卷 88-94页

作者： Baofan Sun Jiajun Chen xinyi zhou Min Liu Yaping Wu Yuanzheng Xia Xu Li Zhiming Wu Junyong Kang Department of Physics Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient DevicesFujian Provincial Key Laboratory of Semiconductor Materials and ApplicationsXiamen UniversityXiamen 361005China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093China

Heterostructures based on two-dimensional(2D) transition-metal dichalcogenides(TMDCs) possess unique electronic and optical properties, which open up unprecedented opportunities in nanoscale optoelectronic devices. Synthesizing high-quality 2D TMDC heterostructures with different core/shell size ratios is of great significance for practical applications. Here, we report a simple one-step chemical vapor deposition(CVD) method for fabricating MoS2/WS2 lateral heterostructures with controllable core/shell size ratio. An ultrathin MoO3/WO3 film prepared by thermal evaporation was used as the precursor, and a step-like heating process was adopted to separately grow MoS2 and WS2 monolayers by taking advantage of the different melting points of MoO3 and WO3 sources. High-quality MoS2/WS2 lateral heterostructures with sharp interfaces were fabricated by optimizing the key growth parameters. Furthermore, the core/shell size ratio of heterostructures could be easily controlled by changing the thickness ratio of MoO3/WO3 film, and an approximately linear dependence between them is revealed. Compared with MoS2 or WS2 monolayers, the MoS2/WS2 heterostructure exhibited a shortened exciton lifetime owing to the type-Ⅱ energy band alignment, which is conducive to the application of high-performance devices. This work provides a facile strategy for the synthesis of 2D lateral heterostructures with controllable size ratio.

关键词： lateral heterostructures controllable size ratio chemical vapor deposition thermal evaporation one-step growth

Targeting RAS mutants in malignancies:successes,failures,and reasons for hope

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Cancer Communications 2023年第1期43卷 42-74页

作者： Hang Yang xinyi zhou Dongliang Fu Chenqin Le Jiafeng Wang Quan zhou Xiangrui Liu Ying Yuan Kefeng Ding Qian Xiao Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and InterventionMinistry of EducationThe Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009P.R.China Department of Pharmacology and Department of Gastroenterology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejiang 310058P.R.China Department of Cell Biology School of Basic Medical SciencesZhejiang UniversityHangzhouZhejiang 310058P.R.China Cancer Center Zhejiang UniversityHangzhouZhejiang 310058P.R.China Department of Medical Oncology the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310058P.R.China

RAS genes are the most frequently mutated oncogenes and play critical roles in the development and progression of *** mutation,isoform(KRAS,HRAS,and NRAS),position,and type of substitution vary depending on the tissue *** decades of developing RAS-targeted therapies,only small subsets of these inhibitors are clinically effective,such as the allelespecific inhibitors against *** the remaining RAS mutants would require further experimental elucidation ofRAS signal transduction,RASaltered metabolism,and the associated immune *** study reviews the mechanisms and efficacy of novel targeted therapies for different RAS mutants,including KRAS allele-specific inhibitors,combination therapies,immunotherapies,and metabolism-associated therapies.

关键词： RAS mutation Signal transduction RAS-targeted therapy Combination therapy Immunotherapy Cancer metabolism

Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson's Disease

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Research 2022年第4期2022卷 531-546页

作者： Guowang Cheng Xueliang Liu Yujing Liu Yao Liu Rui Ma Jingshan Luo xinyi zhou Zhenfeng Wu Zhuang Liu Tongkai Chen Yu Yang Key Laboratory of Modern Preparation of Traditional Chinese Medicine Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Institute of Molecular Medicine(IMM) Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China School of Cellular and Molecular Medicine University of BristolBristol BS81THUK Institute of Functional Nano e Soft Materials Laboratory(FUNSOM) Soochow UniversitySuzhouJiangsu 215123China

Parkinson's disease(PD)is the second most common neurodegenerative disease globally,and there is currently no effective treatment for this *** accumulation of reactive oxygen species(ROs)and neuroinflammation are major contributors to PD ***,ultrasmall nanoscale coordination polymers(NCPs)coordinated by ferric ions and natural product curcumin(Cur)were exploited,showing efficient neuroprotection by scavenging excessive radicals and suppressing *** a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse PD model,such ultrasmall Fe-Cur NCPs with prolonged blood circulation and BBB traversing capability could effectively alleviate oxidative stress,mitochondrial dysfunction,and inflammatory condition in the midbrain and striatum to reduce PD ***,this study puts forth a unique type of therapeutics-based NCPs that could be used for safe and efficient treatment of PD with potential in clinical translation.

关键词： inflammation pathogenesis clinical

METTL5 regulates cranial suture fusion via Wnt signaling

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Fundamental Research 2023年第3期3卷 369-376页

作者： Kexin Lei Ruoshi Xu Qian Wang Qiuchan Xiong xinyi zhou Qiwen Li Dutmanee Seriwatanachai Shuibin Lin Chenchen zhou Quan Yuan State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China Department of Oral Biology Faculty of DentistryMahidol UniversityBangkok 73170Thailand Center for Translational Medicine Precision Medicine InstituteThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

METTL5 is a methyltransferase that mediates eukaryotic 18S ribosomal RNA m^(6)A modification,and its mutations lead to intellectual disability,microcephaly,and facial dysmorphism in ***,the role of METTL5 in craniofacial development remains poorly *** study demonstrates that Mettl5 knockout mice exhibit poor ossification,widened cranial sutures,and a cleidocranial dysplasia-like *** of Mettl5 leads to increased proliferation and decreased osteogenic differentiation of suture mesenchymal stem ***,we find that Wnt signaling is significantly downregulated after Mettl5 ***,we reveal an essential role of METTL5 in craniofacial development and osteogenic differentiation of suture mesenchymal stem cells,making METTL5 a potential diagnostic and therapeutic target for craniofacial developmental diseases.

关键词： METTL5 N6-methyladenosine Cranial suture Osteogenic differentiation Mesenchymal stem cells

METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis

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International Journal of Oral Science 2022年第3期14卷 287-296页

作者： Qiuchan Xiong Caojie Liu Xin Zheng xinyi zhou Kexin Lei Xiaohan Zhang Qian Wang Weimin Lin Ruizhan Tong Ruoshi Xu Quan Yuan State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Thoracic Oncology Cancer Centerand Laboratory of Clinical Cell TherapyWest China HospitalSichuan UniversityChengduChina

The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic *** METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains *** we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced *** of Mettl3 led to increased basal cell proliferation and decreased cell division in taste *** Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation ***,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and *** study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.

关键词： METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis RNA