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妊娠高血压人工智能随访系统设计与应用

医学信息学杂志 2024年第1期45卷 89-92页

作者：黄辛夷周小平郭建军盛戎蓉王忠民王珏杨娜娜殷茵南京医科大学第一附属医院南京210029

目的/意义妊娠高血压对孕产妇健康有严重危害,人工智能随访和管理系统有助于产科妊娠高血压患者身体健康。方法/过程基于大数据技术和数据平台,设计建立妊娠高血压专病人工智能随访系统,包括患者信息管理、随访数据管理、随访计划管理... 详细信息

目的/意义妊娠高血压对孕产妇健康有严重危害,人工智能随访和管理系统有助于产科妊娠高血压患者身体健康。方法/过程基于大数据技术和数据平台,设计建立妊娠高血压专病人工智能随访系统,包括患者信息管理、随访数据管理、随访计划管理、病程管理等模块。结果/结论该随访系统能辅助医生了解患者疾病变化,满足医院对门诊妊娠高血压孕产妇的随访管理要求。

关键词：妊娠高血压人工智能随访系统设计

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口令安全研究进展

计算机研究与发展 2016年第10期53卷 2173-2188页

作者：王平汪定黄欣沂北京大学信息科学技术学院北京100871 北京大学软件与微电子学院北京102600 福建师范大学数学与计算机科学学院福州350117

身份认证是确保信息系统安全的第一道防线,口令是应用最为广泛的身份认证方法.尽管口令存在众多的安全性和可用性缺陷,大量的新型认证技术陆续被提出,但由于口令具有简单易用、成本低廉、容易更改等特性,在可预见的未来仍将是最主要的... 详细信息

身份认证是确保信息系统安全的第一道防线,口令是应用最为广泛的身份认证方法.尽管口令存在众多的安全性和可用性缺陷,大量的新型认证技术陆续被提出,但由于口令具有简单易用、成本低廉、容易更改等特性,在可预见的未来仍将是最主要的认证方法.因此,口令近年来引起了国内外学者的广泛关注,涌现出了一大批关于口令安全性的研究成果.从用户生成口令时的脆弱行为入手,介绍了中英文用户口令的特征、分布和重用程度;总结了近30年来提出的几个主流口令猜测算法,并根据它们所依赖的攻击对象的信息不同进行了分类;然后,回顾了当前广泛使用的基于统计学的口令策略强度评价标准;此外,对比了当前主流的几个口令强度评价器.最后,对当前研究现状进行了总结,并对未来研究方向进行了展望.

关键词：身份认证口令安全脆弱行为猜测攻击强度评价

美国Library Journal年度图书馆学龄读者服务研究

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图书馆学研究 2022年第3期 59-68页

作者：严贝妮黄心怡安徽大学管理学院

开展高质量的学龄读者服务是公共图书馆提升未成年人服务质量,助力未成年人身心健康发展的重要环节。通过调研2012—2021年美国Library Journal年度图书馆奖获奖馆学龄读者服务现状,从服务总体情况、阅读推广服务、教育辅助服务、休闲... 详细信息

开展高质量的学龄读者服务是公共图书馆提升未成年人服务质量,助力未成年人身心健康发展的重要环节。通过调研2012—2021年美国Library Journal年度图书馆奖获奖馆学龄读者服务现状,从服务总体情况、阅读推广服务、教育辅助服务、休闲娱乐服务及空间资源服务五个方面归纳美国Library Journal年度图书馆奖获奖馆学龄读者服务实践举措,提炼其对我国公共图书馆开展学龄读者服务的五个方面启示:扩大学龄读者服务内容覆盖面,提供多元化学龄读者服务;以学龄读者身心发展规律为依据,开展学龄读者精准服务;优化STEM教育服务,加大科学素养培育工作投入力度;加强馆社合作,打造图书馆、社区与学校三位一体服务网络;提升教育效能,助力形成家庭、学校与图书馆教育合力。

关键词：美国《图书馆杂志》年度图书馆奖公共图书馆学龄读者服务实践

Effects of Different Wall-breaking Methods on Extraction of Solanesol from Stems and Leaves of Potato

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Agricultural Biotechnology 2017年第2期6卷 11-14页

作者： Bingpeng WANG Jing MENG Mei GUO xinyi huang Fangyuan DONG Duolong DI Department of Pharmacy Gansu University of Medicine/Key Laboratory of Chemistry and Quality for Traditional Chinese Medicines of the College of Gansu ProvinceLanzhou 730000China Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Comprehensive Development Office of Agriculture in Ningxia Au-tonomous Region Yinchuan 750011China

In order to extract solanesol from potato stems and leaves more effectively and improve the extraction rate of solanesol, the same batch of potato stems and leaves harvested from Guyuan, Ningxia was selected as a research object, cell wall of potato stems and leaves was broken by enzymolysis with cellulase and high- speed shearing, and then reflux-extracted with 95% ethanol. Solanesol content was determined by HPLC, and extract yield was calculated. Extract yield and solanesol extraction rate was used as an index for comparison of difference between the 2 wall-breaking methods, so as to select the optimal wall-breaking method. The results showed that enzymolysis with cellulase exhibited extraction rate and extract yield of solanesol of 91.38% and 8.02%, respectively, which were better than those under high-speed shear emulsification technique. The enzymolysis wall-breaking method has the advantages of simple operation and strong feasibility.

关键词： Enzymolysis High-speed shearing Potato stems and leaves Solanesol

Emission and optical characteristics of brown carbon in size-segregated particles from three types of Chinese ships

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Journal of Environmental Sciences 2024年第8期142卷 248-258页

作者： Fengqin Yang Fan Zhang Zeyu Liu Yingjun Chen Yan Zhang Can Wu Yali Lei Shijie Liu Binyu Xiao xinyi Wan Yubao Chen Yong Han Min Cui Cheng huang Gehui Wang Key Lab of Geographic Information Science of the Ministry of Education School of Geographic SciencesEast China Normal UniversityShanghai 200241China Institute of Eco-Chongming 20 Cuiniao Rd.ChongmingShanghai 202150China State Environmental Protection Key Laboratory of Formation and Prevention of the Urban Air Pollution Complex Shanghai Academy of Environmental SciencesShanghai 200233China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200438China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Department of Civil and Environmental Engineering and State Key Laboratory of Marine Pollution The Hong Kong Polytechnic UniversityKowloon 100872Hong KongChina College of Environmental Science and Engineering Yangzhou UniversityYangzhou 225009China

Brown carbon(BrC)is one of the important light absorption substances that have high light absorption ability under short wavelength ***,limit studies have focused on the BrC emission from *** this study,size-segregated particulate matters(PM)were collected from three different types of ships,light absorption characteristics and size distribution of methanol-soluble BrC and water-soluble BrC in PM from ship exhausts were *** showed that four-stroke low-power diesel fishing boat(4-LDF)had the highest mass concentrations of methanol-soluble organic carbon(MSOC)and water-soluble organic carbon(WSOC),followed by 2-stroke high-power heavy-fuel-oil vessel(2-HHV),and fourstroke high-power marine-diesel vessel(4-HMV).While 2-HHV had obviously higher light absorption coefficients of methanol-soluble BrC(Abs365,M)and water-soluble BrC(Abs365,W)in unit weight of PM than the other two types of *** tested ships presented comparable or higher absorption efficiency of BrC in water extracts(MAE365,W)compared with other BrC emission *** of BrC was concentrated in fine particles,and the particle size distributions of both Abs365,Mand Abs365,Wshowed bimodal patterns,peaking at0.43–0.65μm and 4.7–5.8μm,***,different particle size distributions were found for MAE365,Mbetween diesel and heavy fuel oil ***,different wavelength dependence in particles with different size were also *** exhaust could be confirmed as a non-ignorable BrC emission source,and complex influencing factor could affect the light absorption characteristics of ship *** size should also be considered when light absorption ability of BrC was evaluated.

关键词： Ship emission Brown carbon Light absorption Size distribution

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丛枝菌根真菌对番茄生长和根结线虫病的影响

中国蔬菜 2024年第2期 100-105页

作者：周丽颜陆建增黄馨怡孙兆智吴凤芝高丹美东北农业大学园艺园林学院黑龙江哈尔滨150030

为探究AMF对番茄植株生长的影响及对根结线虫的抑制作用,通过温室盆栽试验,在番茄幼苗期接种摩西球囊霉(Funneliformismosseae)与南方根结线虫2龄幼虫,并以不添加摩西球囊霉处理为对照。结果表明,与CK相比,接种AMF后,番茄幼苗地上部鲜... 详细信息

为探究AMF对番茄植株生长的影响及对根结线虫的抑制作用,通过温室盆栽试验,在番茄幼苗期接种摩西球囊霉(Funneliformismosseae)与南方根结线虫2龄幼虫,并以不添加摩西球囊霉处理为对照。结果表明,与CK相比,接种AMF后,番茄幼苗地上部鲜、干质量均显著增加,分别增加18.1%、24.8%;根结线虫病病情指数降低29.5%;植株中N、P、K含量分别增加6.9%、80.5%、63.0%;土壤铵态氮、硝态氮、有效磷、速效钾含量分别增加6.8%、20.7%、8.1%、7.8%。可见,接种AMF具有促进番茄生长、抑制番茄根结线虫病的发生、增加植株养分及土壤速效养分含量的作用。

关键词：番茄丛枝菌根真菌(AMF) 根结线虫病植株生物量土壤养分

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TCM-HIN2Vec:A strategy for uncovering biological basis of heart qi deficiency pattern based on network embedding and transcriptomic experiment

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 264-274页

作者： Lihong Diao xinyi Fan Jiang Yu Kai huang Edouard C.Nice Chao Liu Dong Li Shuzhen Guo School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Department of Biochemistry and Molecular Biology Monash UniversityClayton VIC 3800Australia Beijing Institute of Lifeomics Beijing 102206China State Key Laboratory of Medical Proteomics Beijing 102206China National Center for Protein Sciences(Beijing) Beijing 102206China Beijing Proteome Research Center Beijing 102206China

Objective To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal *** We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic ***,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public ***,we predicted HQD pattern genes using a heterogeneous network-embedding *** then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using ***,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment *** Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune ***,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency ***,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating *** Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD *** our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.

关键词： Qi deficiency pattern Heart failure Biological basis Network embedding Transcriptome

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装配式模块化建筑与模块节点研究进展

建筑钢结构进展 2022年第2期24卷 40-49页

作者：黄馨仪舒展李征上海大学力学与工程科学学院上海200444 同济大学土木工程学院上海200092

与传统建筑相比,模块化建筑因其建设快速高效、品质卓越、施工过程安全、施工时间可预测、资源浪费少和促进环境可持续性发展等优点而受到推广。模块化建筑往往涉及到多种结构体系和建筑材料,其中,钢制构件在模块化建筑中应用最为广泛... 详细信息

与传统建筑相比,模块化建筑因其建设快速高效、品质卓越、施工过程安全、施工时间可预测、资源浪费少和促进环境可持续性发展等优点而受到推广。模块化建筑往往涉及到多种结构体系和建筑材料,其中,钢制构件在模块化建筑中应用最为广泛。综述了装配式模块化建筑与模块节点的最新研究进展。首先,介绍了装配式模块化建筑的分类、材料和结构形式,讨论了不同类型模块化建筑的结构性能。此外,由于模块化建筑的结构性能高度依赖于模块的节点连接,对现有模块化节点,特别是钢结构模块间和模块内部的节点形式进行了系统的梳理。最后,阐述了模块化建筑发展面临的主要挑战和未来发展前景。从国内外研究进展可见,模块化建筑充分满足了当前建筑结构工业化的需要。为促进我国下一阶段模块化建设的发展和应用提供了重要的参考。

关键词：装配式模块模块化建筑钢结构体系集装箱建筑连接节点

E674Q(Shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease

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Genes & Diseases 2024年第2期11卷 1022-1034页

作者： Yongfang Zhang xinyi Xie Boyu Chen Lina Pan Jianping Li Wanbing Wang Jintao Wang Ran Tang Qiang huang Xiaofen Chen Rujing Ren Zhentao Zhang Wei Fu Gang Wang Department of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China Shenzhen Research Institute of Xiamen University ShenzhenGuangdong 518063China

Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic ***,a novel missense mutation,APP E674Q(also named“Shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(LOAD)who developed memory decline in his *** results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 F-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied Swedish APP mutation(KM670/671NL),which was predicted to be pathogenic in *** dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by *** in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.Furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 J ***-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical Swedish ***,we report a strong amyloidogenic effect of the E674Q substitution in *** our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing LOAD.

关键词： Alzheimer's disease Amyloid beta APP mutation E674Q Late onset