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Analysis of the Incidence and Mortality of Common Malignant Tumors in the Xishan District Residence in 2016

Proceedings of Anticancer Research 2019年第4期3卷 13-20页

作者： Dazhuo Lu Weilin Zhang Meiqiong Jiang xinxia zhou Xuejing Xia Center for Disease Control and Prevention Xishan DistrictKunming 650118Yunnan rovincesChina Xiyuan Community Health Service Center Xishan DistrictKunming 650118Yunnan rovincesChina

Objective:To analyze the cancer incidence and mortality in xishan district in 2016,and to provide scientific basis for tumor prevention and ***:The 2016 malignant tumor registration report data in xishan district were collected and analyzed,stratified according to gender and age,and the reported incidence of malignant tumor in xishan district was calculated and analyzed(all the following incidence rates belong to the reported incidence),gender,age incidence,bid acceptance rate,mortality and other related ***:The total registered population of malignant tumor in xishan district in 2016 was 540,494(268,553 males and 271,941 females),and 876 new cases were *** incidence rate was 162.07/105,the bid-winning rate was 176.39/105,the world standard rate was 91.16/105,and the cumulative rate(0-74 years old)was 10.44%.The incidence of malignant tumors in males(159.00/105)was lower than that in females(165.11/105).Incidence increases with age,rises sharply and rapidly around age 40,and declines after reaching a peak at age *** cancer,colorectal cancer,thyroid cancer and female breast cancer are common malignant tumors in the western mountainous *** accounts for about 55%of the total number of new malignant *** 2016,653 people died of malignant tumors in xishan *** mortality rate was 120.82/105(male mortality 151.11/105,female mortality 90.46/105),the bidwinning mortality rate was 43.53/105,and the bidwinning mortality rate was 57.72/*** cancer,liver cancer,colorectal cancer and stomach cancer are the malignant tumors with high mortality,accounting for about 62%of the ***:The morbidity and mortality of malignant tumors are relatively high in xishan district,and prevention and control of lung cancer,liver cancer,stomach cancer,colorectal cancer,female breast cancer and thyroid cancer should be emphasized.

关键词： Cancer Incidence rate Mortality Prevent

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Analysis of the Onset and Mortality of Common Malignant Tumors Among Registered Residents in Xishan District in 2016

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Proceedings of Anticancer Research 2020年第1期4卷 12-18页

作者： Xuejing Xia Dazhuo Lu Meiqiong Jiang xinxia zhou Weilin Zhang Xishan District Center for Disease Control and Prevention Kunming 650118Yunnan ProvinceChina Xishan District Xiyuan Community Health Service Center Kunming 650118Yunnan ProvinceChina

Objective:To analyse the cancer incidence and mortality in xishan district in 2016,and to provide scientific basis for tumor prevention and ***:The 2016 malignant tumor registration report data in xishan district were collected and analysed,stratified according to gender and age,and the reported incidence of malignant tumor in xishan district was calculated and analysed(all the following incidence rates belong to the reported incidence),gender,age incidence,bid acceptance rate,mortality and other related ***:The total registered population of malignant tumor in xishan district in 2016 was 540,494(268553 males and 271941 females),and 876 new cases were *** incidence rate was 162.07/105,the bid-winning rate was 176.39/105,the world standard rate was 91.16/105,and the cumulative rate(0-74 years old)was 10.44%.The incidence of malignant tumors in males(159.00/105)was lower than that in females(165.11/105).Incidence increases with age,rises sharply and rapidly around age 40,and declines after reaching a peak at age *** cancer,colorectal cancer,thyroid cancer and female breast cancer are common malignant tumors in the western mountainous *** accounts for about 55%of the total number of new malignant *** 2016,653 people died of malignant tumors in xishan *** mortality rate was 120.82/105(male mortality 151.11/105,female mortality 90.46/105),the bidwinning mortality rate was 43.53/105,and the bidwinning mortality rate was 57.72/*** cancer,liver cancer,colorectal cancer and stomach cancer are the malignant tumors with high mortality,accounting for about 62%of the ***:The morbidity and mortality of malignant tumors are relatively high in xishan district,and prevention and control of lung cancer,liver cancer,stomach cancer,colorectal cancer,female breast cancer and thyroid cancer should be emphasized.

关键词： Cancer Incidence rate Mortality Prevent

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现代电影剪辑思维的发展——从《保镖》到《贫民窟的百万富翁》

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北京电影学院学报 2010年第6期 63-70页

作者：周新霞北京电影学院导演系

自戈达尔用跳切打破格里菲斯的零度剪辑(无缝剪辑)理念和经典叙事模式后,电影语言得到了革命性的改变。笔者试从1992年米克.杰克逊导演的影片《保镖》,1997年奥利弗.斯通导演的影片《不准掉头》和2008年丹尼.波尔导演的影片《贫民窟的... 详细信息

自戈达尔用跳切打破格里菲斯的零度剪辑(无缝剪辑)理念和经典叙事模式后,电影语言得到了革命性的改变。笔者试从1992年米克.杰克逊导演的影片《保镖》,1997年奥利弗.斯通导演的影片《不准掉头》和2008年丹尼.波尔导演的影片《贫民窟的百万富翁》三部影片,来分析电影叙事方式的改变和与之相适的剪辑思维的突破。

关键词：线性叙事非线性叙事立体时空

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“跳”出节奏 “剪”出余韵谈影片《雷》的省略魅力

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北京电影学院学报 2008年第3期 63-72页

作者：周新霞北京电影学院导演系

关于电影连贯性的传统概念不过是一种错觉，对场景意义的表达来说．至多只起辅助作用。我们看到了一连串不十分连贯的动作，但我们看到了必须看到的一切，也可以说，只是看到了必须看到的一切。

关键词：《雷》省略影片节奏辅助作用连贯性韵电影

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GCET2兔单克隆抗体的制备及其在弥漫性大B细胞淋巴瘤中初步应用

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中华病理学杂志 2016年第12期45卷 844-849页

作者：潘红阳张昕霞翁媛媛周韧浙江大学病理学与法医研究所浙江大学病理学与病理生理学系杭州310058 宜康(杭州)生物技术有限公司

目的开发制备GCET2兔单克隆抗体，研究其在弥漫性大B细胞淋巴瘤（DLBCL）诊断中的应用。方法采用兔单克隆抗体技术制备GCET2兔单克隆抗体；经免疫印迹、免疫组织化学（IHC）、免疫细胞化学和流式细胞术等方法鉴定其特异性；并用IHC法，... 详细信息

目的开发制备GCET2兔单克隆抗体，研究其在弥漫性大B细胞淋巴瘤（DLBCL）诊断中的应用。方法采用兔单克隆抗体技术制备GCET2兔单克隆抗体；经免疫印迹、免疫组织化学（IHC）、免疫细胞化学和流式细胞术等方法鉴定其特异性；并用IHC法，检测GCET2与其他DLBCL诊断相关标志物（CD10、bcl-6、MUM1、GCET1、FOXP1、Ki-67和CMYC）在81例DLBCL、5例滤泡细胞淋巴瘤和2例Burkitt淋巴瘤临床样本组织中的表达。结果GCET2（EP316）抗体能特异性识别生发中心B细胞及其来源的肿瘤组织和细胞系（Raji、Daudi和Ramos）中的GCET2蛋白；对81例DLBCL进行检测，GCET2的阳性率达到43.2%（35/81），明显高于其他生发中心标志物的阳性检出率。此外，CMYC高表达DLBCL样本在GCET2阴性表达和阳性表达样本中所占比例分别为15.2%（7/46）和2.8%（1/35）。结论本研究制备的GCET2（EP316）抗体具有良好的特异性，是一种敏感的生发中心B细胞标记抗体。GCET2与其他分子标志物联用，可能有助于提高对生发中心B细胞型DLBCL的检测敏感性。

关键词：淋巴瘤大B-细胞弥漫性生发中心抗体单克隆

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Simulation and fabrication of in vitro microfluidic microelectrode array chip for patterned culture and electrophysiological detection of neurons

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Nanotechnology and Precision Engineering 2024年第2期7卷 1-10页

作者： Yan Yang Shihong Xu Yu Deng Yaoyao Liu Kui Zhang Shiya Lv Longze Sha Qi Xu xinxia Cai Jinping Luo State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

To enable the detection and modulation of modularized neural networks in vitro,this study proposes a microfluidic microelectrode array chip for the cultivation,compartmentalization,and control of neural *** chip was designed based on the specific structure of neurons and the requirements for detection and ***-element analysis of the chip’s flow field was conducted using the COMSOL Multiphysics software,and the simulation results show that the liquid within the chip can flow smoothly,ensuring stable flow fields that facilitate the uniform growth of neurons within the microfluidic *** employing MEMS technology in combination with nanomaterial modification techniques,the microfluidic microelectrode array chip was fabricated *** hippocampal neurons were cultured on the chip,forming a well-defined neural *** electrical activity of the detected neurons was recorded,exhibiting a 23.7%increase in amplitude compared to neuronal discharges detected on an open-field microelectrode *** study provides a platform for the precise detection and modulation of patterned neuronal growth in vitro,potentially serving as a novel tool in neuroscience research.

关键词： Microfluidic Microelectrode array In vitro Neural chip

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Impaired Spatial Firing Representations of Neurons in the Medial Entorhinal Cortex of the Epileptic Rat Using Microelectrode Arrays

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Research 2024年第2期2023卷 541-552页

作者： Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan Botao Lu Wei Liang Fanli Kong Luyi Jing Wei Xu Juntao Liu Mixia Wang Yirong Wu xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Epilepsy severely impairs the cognitive behavior of *** remains unclear whether epilepsy-induced cognitive impairment is associated with neuronal activities in the medial entorhinal cortex(MEC),a region known for its involvement in spatial *** explore this neural mechanism,we recorded the spikes and local field potentials from MEC neurons in lithium-pilocarpine-induced epileptic rats using self-designed microelectrode *** the open field test,we identified spatial cells exhibiting spatially selective firing properties and assessed their spatial representations in relation to the progression of ***,we analyzed theta oscillations and theta modulation in both excitatory and inhibitory ***,we used a novel object recognition test to evaluate changes in spatial cognitive ability of epileptic *** the epilepsy modeling,the spatial tuning of various types of spatial cells had suffered a rapid and pronounced damage during the latent period(1 to 5 d).Subsequently,the firing characteristics and theta oscillations were *** the chronic period(>10 d),the performance in the novel object experiment *** conclusion,our study demonstrates the detrimental effect on spatial representations and electrophysiological properties of MEC neurons in the epileptic latency,suggesting the potential use of these changes as a"functional biomarker"for predicting cognitive impairment caused by epilepsy.

关键词： epilepsy impaired involvement

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关于区域学测数据分析的再思考

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江苏教育研究 2019年第13期 48-51页

作者：周新霞连云港市连云区教育局教科室

区域学测数据分析,是县区教研室进行教学管理、研判教学质量的重要途径。传统的区域学测数据分析选取"一分四率一位次"等数据,不能直观体现进(退)步情况、无法进行纵向和横向比较。"研教合一"理念下的区域学测数据分析,选取区总排名占... 详细信息

区域学测数据分析,是县区教研室进行教学管理、研判教学质量的重要途径。传统的区域学测数据分析选取"一分四率一位次"等数据,不能直观体现进(退)步情况、无法进行纵向和横向比较。"研教合一"理念下的区域学测数据分析,选取区总排名占比率、参考率、区均分达成率、区均分达成率进步值、区均分达成率区间值、区均分达成率区间进步值等数据,从"达标+增值"的角度,准确反映学校、学科教学水平在区域内所处位次、达标程度、增值情况,为促进区域教育均衡发展、规范学校办学行为、引导管理者和教师正确归因提供重要依据。

关键词：学测数据分析区域管理教育均衡规范办学正确归因

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Improving the response of 2D COFs to the surface doping strategies through rational design of their chemical structure

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Science China Materials 2024年第10期67卷 3272-3281页

作者： Xin Feng Xuefeng Liang xinxia Li zhou Fang Weiqiang Wei Lisheng Zhang Yan He Huifang Li College of Electromechanical Engineering Shandong Engineering Laboratory for Preparation and Application of High-Performance Carbon-MaterialsQingdao University of Science&TechnologyQingdao 266061China

The chemical structure of covalent organic frameworks(COFs)plays a key role in their response to the surface doping strategy used for tuning their electronic character,but it is still not fully *** explore a rational design proposal for their chemical structure,the electronic properties of three n-doped typical COFs,including boroncontaining(COF-1),triazine-based(CTF),and C–C bondlinked(GCOF)COFs,were investigated theoretically in this *** expected,the chemical doping effects are different for these *** dispersion of the frontier bands,the nuclear-independent chemical shift(NICS)aromaticity index results,distribution of the electron localization function(ELF),and Hirshfeld charge population plots show that part of the transferred electron from dopants will be offset by the intralayer charge transfer of ***,chemical doping effects are more significant if the electron distribution in the COFs is more *** means the response of COFs to the surface doping strategy should be dominated by the conjugation degree of their chemical *** results prove that the intrinsic conjugation degree of COFs plays a key role in such doping functionalization strategies,which are expected to provide more useful information for the initial structure design of COF materials and facilitate their practical applications as active electronic transport materials in nanoscale devices.

关键词： COF monolayers adsorption doping strategy energy level alignment conjugation degree density functional theory

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Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinson’s disease

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Bio-Design and Manufacturing 2024年第4期7卷 439-452页

作者： Luyi Jing Zhaojie Xu Penghui Fan Botao Lu Fan Mo Ruilin Hu Wei Xu Jin Shan Qianli Jia Yuxin Zhu Yiming Duan Mixia Wang Yirong Wu xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep *** microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise *** this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain *** results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned *** addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the ***,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN *** with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned *** may be a cause of sleep and motor disorders associated with ***,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.

关键词： Functional localization Implantable microelectrode arrays Parkinson’s disease Subthalamic nucleus

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