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三七总皂甙对大鼠脑出血灶周围神经元Bcl-2/Bax及脑含水量变化的影响

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宁夏师范学院学报 2013年第6期34卷 112-115页

作者：朱继红王登科戴新文董克勤贺岭风宁夏师范学院医学院宁夏固原756000

研究大鼠脑出血给予三七总皂甙治疗后,神经元Bcl-2和Bax的表达有无变化,并观察脑出血大鼠在不同时间点相干/湿重法测定脑含水量的变化.神经行为学检测结果表明,脑出血组大鼠的神经功能评分分值升高;2 d后治疗组大鼠与脑出血组相比分值下... 详细信息

研究大鼠脑出血给予三七总皂甙治疗后,神经元Bcl-2和Bax的表达有无变化,并观察脑出血大鼠在不同时间点相干/湿重法测定脑含水量的变化.神经行为学检测结果表明,脑出血组大鼠的神经功能评分分值升高;2 d后治疗组大鼠与脑出血组相比分值下降(P<0.01).免疫组织化学结果显示,治疗组Bcl-2的阳性表达较脑出血组高(P<0.01)、Bax的阳性表达较脑出血组低(P<0.01),Bcl-2/Bax蛋白比值增高;脑含水量即12 h开始增加,24 h后比较明显,48 h达高峰,7 d之后与正常组无明显差异.三七总皂甙治疗组48 h^72h干预后,脑含水量明显低于其脑出血组(P<0.05).

关键词：三七总皂甙脑出血神经元脑含水量

Efficient conversion of benzene and syngas to toluene and xylene over ZnO-ZrO_(2)&H-ZSM-5 bifunctional catalysts

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Chinese Journal of Chemical Engineering 2022年第5期35卷 203-210页

作者： Xiao Zhao Xuan Shi Zhongshun Chen Long Xu Chengyi dai Yazhou Zhang xinwen Guo Dongyuan Yang Xiaoxun Ma School of Chemical Engineering Northwest UniversityXi’an 710069China International Science&Technology Cooperation Base for Clean Utilization of Hydrocarbon Resources Chemical Engineering Research Center of the Ministry of Education for Advanced Use Technology of Shanbei EnergyCollaborative Innovation Center for Development of Energy and Chemical Industry in Northern ShaanxiNorthwest UniversityXi’an 710069China School of Chemical Engineering Dalian University of TechnologyDalian 116024China Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China Shanxi yanchang Petroleum(Group)Corp.LtdXi’an 710000China

A series of ZnO-ZrO_(2) solid solutions with different Zn contents were synthesized by the urea coprecipitation method,which were coupled with H-ZSM-5 zeolite to form bifunctional *** a new benzene alkylation reagent,syngas was used instead of methanol to realize the efficient conversion of syngas and benzene into toluene and xylene.A suitable ratio of ZnO-ZrO_(2) led to the significant improvement in the catalytic performance,and a suitable amount of acid helped to increase the selectivity of toluene/xylene and reduce the selectivity of the by-products ethylbenzene and C^(9+) *** highest benzene conversion of 89.2%and toluene/xylene selectivity of 88.7%were achieved over 10%ZnO-ZrO_(2)&H-ZSM-5(Si/Al=23)at a pressure of 3 MPa and a temperature of 450℃.In addition,the effect of the zeolite framework structure on product distribution was *** to the molecular dynamics of aromatic hydrocarbons,H-ZSM-5 zeolites comprise 10-membered-ring pores,which are beneficial to the activation of benzene;hence,the conversion of benzene is higher.H-ZSM-35 and HMOR zeolites exhibited small eight-membered-ring channels,which were not conducive to the passage of benzene;hence,the by-product ethylbenzene exhibits a higher *** distance between the active centers of the bifunctional catalysts was the main factor affecting the catalytic performance,and the powder mixing method was more conducive to the conversion of syngas and benzene.

关键词： ZnO-ZrO_(2) Bifunctional catalysts Aromatics Alkylation of benzene Syngas

黄芪注射液对脑出血后大鼠脑组织含水量及炎症介质ICAM-1的影响

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青海医学院学报 2014年第4期35卷 247-250页

作者：王登科谢浩平戴新文朱继红孙征刘海洋宁夏医科大学银川750004 海原县三河镇卫生院中卫755299

目的探讨黄芪注射液对大鼠脑出血后脑组织水肿及细胞间黏附分子(intercellular cell adhesion molecule-1,ICAM-1)的影响。方法将180只雄性SD大鼠随机分为正常组、模型组和治疗组。对各组大鼠进行神经功能评分;用干湿重法测定脑组织的... 详细信息

目的探讨黄芪注射液对大鼠脑出血后脑组织水肿及细胞间黏附分子(intercellular cell adhesion molecule-1,ICAM-1)的影响。方法将180只雄性SD大鼠随机分为正常组、模型组和治疗组。对各组大鼠进行神经功能评分;用干湿重法测定脑组织的含水量;应用免疫组化技术检测大鼠脑血肿周围组织中ICAM-1蛋白的表达。结果神经功能行为学检测显示脑出血后模型组和治疗组较正常组明显升高,2 d后治疗组大鼠神经功能评分较模型组明显下降(P<0.05);模型组大鼠脑出血后6 h脑组织含水量开始升高,2 d时达到高峰,治疗组脑组织含水量较模型组明显下降(P<0.05)。模型组和治疗组ICAM-1表达6 h开始增加,与模型组比较,2 d和3 d治疗组ICAM-1表达显著降低(P<0.01)。结论黄芪注射液通过抑制炎症介质ICAM-1的表达,减轻脑水肿,促进大鼠脑出血后神经功能恢复。

关键词：脑出血黄芪 ICAM-1 脑水肿大鼠

混合式教学与评估方法在系统解剖学教学中的应用

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解剖学杂志 2022年第1期45卷 77-79页

作者：戴新文李军平秦毅张莲香王登科张义伟宁夏医科大学人体解剖学与组织学胚胎学系银川750004

系统解剖学课程内容繁杂,知识点多,需要记忆的信息量大,上课学时短,课程紧等特点,往常学生都是死记硬背,导致学生对解剖学学习兴趣不高,学习效果不好,及格率低。这种传统教学模式已经不能适应现代化的信息技术与教学方法的不断融合与创... 详细信息

系统解剖学课程内容繁杂,知识点多,需要记忆的信息量大,上课学时短,课程紧等特点,往常学生都是死记硬背,导致学生对解剖学学习兴趣不高,学习效果不好,及格率低。这种传统教学模式已经不能适应现代化的信息技术与教学方法的不断融合与创新。伴随着现代信息技术的迅猛发展,以及传统教学理念的转变和教学方式的多元化.

关键词：系统解剖学现代信息技术解剖学课程教学方法及格率学习效果教学方式融合与创新

《人体解剖学》教学现状及教学模式改进与实践

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宁夏师范学院学报 2013年第6期34卷 100-102页

作者：王登科戴新文朱继红蒙兆年贺岭风韩金荣宁夏师范学院医学院宁夏固原756000

人体解剖学是一门医学基础课,在教学过程中通过融入德育、创建趣味课堂、改进教学方法和过程、鼓励学生自主学习、充分与学生网络互动等方面改进人体解剖学教学模式,取得了良好的教学效果.

关键词：人体解剖学教学方法改革实践

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黄芪对大鼠脑出血后半暗带神经元凋亡的影响

青海医学院学报 2014年第2期35卷 132-135页

作者：王登科朱继红戴新文蒙兆年孙征张海宇刘海洋宁夏师范学院医学院固原756000 宁夏医科大学银川750004

目的探讨黄芪对大鼠脑出血后半暗带神经元的保护作用。方法利用Narrowalley Test检测各组大鼠的神经行为学指标;用免疫组织化学法检测Caspase-3蛋白表达和TUNEL阳性细胞数。结果神经行为学检测结果显示,模型组和治疗组大鼠的评分值较正... 详细信息

目的探讨黄芪对大鼠脑出血后半暗带神经元的保护作用。方法利用Narrowalley Test检测各组大鼠的神经行为学指标;用免疫组织化学法检测Caspase-3蛋白表达和TUNEL阳性细胞数。结果神经行为学检测结果显示,模型组和治疗组大鼠的评分值较正常组明显升高,随着时间推移,治疗组大鼠评分值较模型组明显下降,有显著性差异(P<0.05);与模型组比较,治疗组Caspase-3和TUNEL的阳性细胞数明显降低(P<0.01)。结论黄芪能够减缓半暗带神经元凋亡,减轻脑出血后由于神经损伤导致的功能障碍,促进神经功能恢复。

关键词：脑出血黄芪凋亡半暗带大鼠

Bioinformatics Analysis on Pathogenic Genes of Botrytis cinerea Pers.

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Agricultural Biotechnology 2018年第1期7卷 57-61,86页

作者： Qiang ZHANG Wenting dai xinwen JIN Xuhui WANG Xinjiang Agricultural Reclamation Academy of Science Shihezi 832000 China Organisms Energy Research Institute in XinJiang Academy of Agriculture Science Urumqi 830091 China

With reported pathogenic genes of Botrytis cirterea Pers. and unknown proteins related to pathogencity as experimental materials, the pathogenic genes were studied by bioinformatics methods, and these unknown proteins were analyzed with bioinforrnaties tools and softwares, so as to lay a theoretical basis for the control of tomato grey mould at molecular level in future. The results showed that through the alignment analysis by DNAMAN software, three pairs of unknown pro- teins with higher comprehensive matching degrees were obtained, and these proteins were predicted to be coded by hrp gene cluster of type Ili secretion system; through Bioedit and ProtParam, the amino acid composition, size, molecular weight, isoelectrie point and hydrophobicity of the each of the six unknown proteins were obtained; and corresponding secondary structures were obtained using DNAMAN. The results of this study could guide deep research of such genes.

关键词： Tomato Grey mould Pathogenic gene Bioinformatics

SSR Molecular Marker for Late Blight Resistance Gene in Tomato CLN2037

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Agricultural Biotechnology 2018年第2期7卷 1-4,14页

作者： Qiang ZHANG Wenting dai xinwen JIN Xuhui WANG Xinjiang Academy of Agricultural and Reclamation Science Organisms Energy Research Institute Xinjiang Academy of Agriculture ScienceUrumqi 830091China

[Objectives] The research aimed to investigate the genetic rule of the disease resistance of tomato CLN2037,find molecular markers linked with disease-resistant genes and locate the disease-resistant genes. [Methods] BCr,BCs and F2 were constructed from tomato CLN2037 and susceptible cultivar T2-03,and their resistance to late blight was identified and analyzed by inoculating the disease in the seedling stage of tomatoes. The genetic linkage analysis was made based on the genetic linkage map constructed by ICu GI using group segregation method and 90 pairs of tomato SSR primers. [Results]The resistance of CLN2037 to late blight was controlled by a single recessive gene. The polymorphic bands amplified by primer DM0231 had a linkage relationship with resistance genes. The size of the polymorphism fragment was 226 bp with the genetic linkage distance of 2. 67 c M,and the disease resistance gene was localized on CCPB272-03741.[Conclusions]DM0231 could be used as a molecular marker for molecular breeding of tomato against late blight,which laid the foundation for further fine localization of late blight resistance genes.

关键词： Tomato Late blight Disease-resistant gene SSR molecular markerHome

The Deactivation Mechanism of Micro-B-ZSM-5 in Methanol-to-Propene Conversion

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The Deactivation Mechanism of Micro-B-ZSM-5 in Methanol-to-P...