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Multi‐vital on‐skin optoelectronic biosensor for assessing regional tissue hemodynamics

SmartMat 2023年第3期4卷 84-95页

作者： Ming Xin Tong Yu Yongchang Jiang Ruowen Tao Jiean Li Feng Ran Tangsong Zhu Jinrong Huang Jing Zhang Jia‐Han Zhang Nan Hu Wei wang Qiuhong Zhang Zhao Liu xinran wang Yi Shi Lijia Pan Collaborative Innovation Center of Advanced Microstructures Jiangsu Provincial Key Laboratory of Photonic and Electronic MaterialsSchool of Electronic Science and EngineeringNanjing UniversityNanjingChina Department of Vascular Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjingChina Department of Polymer Science and Engineering School of Chemistry and Chemical EngineeringNanjing UniversityNanjingChina

Evaluation of the oxygen‐mediated effects of clinical and daily activities demands an on‐skin device that can track multi‐vital regional tissue hemodynamics *** example,peripheral arterial disease(PAD)is the third most prevalent cardiovascular disease,but the means of diagnosing and monitoring this disease are limited because the affected area is usually in the non‐pulsatile area away from the ***,we report on an ultrathin and ultralight multi‐vital near‐infrared optoelectronic biosensor for the diagnosis and rehabilitation monitoring of regional tissue hemodynamics,which is suitable for mounting on the skin for long‐term *** device can simultaneously detect tissue oxygen saturation,heart rate,arterial blood oxygen,and tissue perfusion and shows potential for various hypoxia monitoring ***,the tissue hemodynamics detected by this device showed a highly accordance with the ankle‐brachial index and CT angiography obtained by traditional clinical ***,our design was able to accurately diagnose and effectively evaluate PAD patients before and after *** on‐skin optoelectronic biosensor shows potential in biological oxygen‐mediated behavior evaluation,injury‐state monitoring,PAD clinical diagnosis optimization,and after surgery care.

关键词： biosensor cardiovascular disease flexible electronics skin inspired electronics

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High‑Mass‑Loading Electrodes for Advanced Secondary Batteries and Supercapacitors

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Electrochemical Energy Reviews 2021年第2期4卷 382-446页

作者： Feng Wu Mingquan Liu Ying Li Xin Feng Kun Zhang Ying Bai xinran wang Chuan Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081China

The growing demand for advanced electrochemical energy storage systems(EESSs)with high energy densities for electric vehicles and portable electronics is driving the electrode revolution,in which the development of high-mass-loading electrodes(HMLEs)is a promising route to improve the energy density of batteries packed in limited spaces through the optimal enlargement of active material loading ratios and reduction of inactive component ratios in overall cell ***,HMLEs face significant challenges including inferior charge kinetics,poor electrode structural stability,and complex and expensive production *** on this,this review will provide a comprehensive summary of HMLEs,beginning with a basic presentation of factors influencing HMLE electrochemical properties,the understanding of which can guide optimal HMLE *** strategies to improve the electrochemical performance of HMLEs accompanied by corresponding advantages and bottlenecks are subsequently discussed in terms of various factors ranging from inactive component modification to active material design to structural engineering at the electrode *** review will also present the recent progress and approaches of HMLEs applied in various EESSs,including advanced secondary batteries(lithium-/sodium-/potassium-/aluminum-/calcium-ion batteries,lithium metal anodes,lithium-sulfur batteries,lithium-air batteries,zinc batteries,magnesium batteries)and ***,this review will examine the challenges and prospects of HMLE commercialization with a focus on thermal safety,performance evaluation,advanced characterization,and production cost assessment to guide future development.

关键词： High mass loading Thick electrode High energy density Advanced secondary battery Supercapacitor

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Modulating contact properties by molecular layers in organic thin-film transistors

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Electron 2023年第2期1卷 82-89页

作者： Li Sun Yating Li Jiacheng Xie Liqi Zhou Peng wang Jian-Bin Xu Yi Shi xinran wang Daowei He National Laboratory of Solid State Microstructures Key Lab of Optoelectronic Devices and Systems with Extreme PerformancesSchool of Electronic Science and Engineeringand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingChina National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingChina Department of Physics University of WarwickCoventryUK Department of Electronic Engineering and Materials Science and Technology Research Center The Chinese University of Hong KongHong Kong SARChina School of Integrated Circuits Nanjing UniversitySuzhouChina

Advanced organic devices and circuits demand both ultrahigh charge carrier mobilities and ultralow-resistance ***,due to a larger access resistance in staggered organic thin-film transistors(OTFTs),the achievement of ultralow contact resistance(Rc)is still a *** modulation of contact resistance by molecular layers near the interface has been rarely ***,we demonstrate that fewlayer organic single crystals are grown on hafnium oxide(HfO_(2))by solution-shearing *** utilize these organic crystals to fabricate bottom-gate staggered OTFTs with different contact *** results show that the contact properties of OTFTs are obviously modulated by crystal *** tri-layer(3L)evaporated-Au C10-DNTT OTFTs exhibit optimal electrical performance,including ultralow Rc of 5.6Ω⋅cm,recorded transfer length of 0.4μm,field-effect mobility over 14 cm^(2)V^(−1)s^(−1),threshold voltage lower than 0.3 V,and long-term air stability over 8 *** main cause is that the metal atoms can penetrate into the charge transport layer,with damage-free,in 3L evaporated-Au OTFTs;nevertheless,it cannot be realized in other *** to layer stacking of conjugated molecules and polymers,our strategy can efficiently modulate the contact resistance to aid the development of highperformance organic devices and circuits.

关键词： contact resistance mobility organic thin-film transistor single crystal

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Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2186-2195页

作者： Xuerui Zhang Lulu Song Lin Li Banghui Zhu Lina Huo Zhaoqing Hu xinran wang Jie wang Mengyue Gao Jing Zhang Zichun Hua The State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjingChina Changzhou High-Tech Research Institute of Nanjing University and Jiangsu Target Pharma Laboratories Inc ChangzhouChina School of Biopharmacy China Pharmaceutical UniversityNanjingChina

Inflammatory bowel disease(IBD)is a chronic and relapsing disorder for many people associated with poor *** there are some clinical drugs for IBD treatment,the development of effective therapeutics on IBD patients has always been ***,we show that externalized phosphatidylserine(PS)is observed on the surface of colonic *** A5(ANXA5)with high affinity for PS has a good targeting to the colon and effectively alleviates experimental *** contrast,ANXA5 mutant(A5m)lacking the PS-binding ability,has no accumulation in the colon and no therapeutic effects on *** investigations indicate that ANXA5 reduces the inflammatory cell infiltration by inhibiting endothelial cell activation dependent on PS-binding *** the increasing of PS exposure on activated HUVECs(human umbilical vein endothelial cells),ANXA5 binding induces the internalization of TLR4 via PS-dependent *** provide new insights on the molecular mechanism of ANXA5 for its anti-inflammatory *** data suggest that PS-externalization is a potential target of ANXA5 aiming at targeted drug delivery(TDD)for IBD treatment.

关键词： colonic colon drugs

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NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第11期22卷 959-965页

作者： Lisha ZHOU Changsheng DONG Zhuoming XU xinran wang Luyi ZHANG Siyuan CHEN Jiahao CHEN Yingying ZHU Department of Basic Medicine Medical CollegeTaizhou UniversityTaizhou 318000China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Lung cancer,which is exacerbated by environmental pollution and tobacco use,has become the most common cause of cancer-related deaths worldwide,with a five-year overall survival rate of only 19%(Siegel et al.,2020;Yang et al.,2020;Yu and Li,2020).Nearly 85%of lung cancers are non-small cell lung cancers,of which lung adenocarcinoma is the most common subtype accounting for 50%of non-small cell lung cancer *** present,radiotherapy is the primary therapeutic modality for lung cancer at different stages,with significant prolongation of survival time(Hirsch et al.,2017;Bai et al.,2019;Shi et al.,2020).

关键词： al. lung resistance

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鼻肠管尖端定位方法的研究进展

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中华护理杂志 2022年第11期57卷 1401-1405页

作者：王硕张晓雪王欣然首都医科大学宣武医院普外ICU 北京市100053 首都医科大学宣武医院普外科北京市100053

鼻肠管是临床肠内营养支持的重要途径之一,尖端位置正确是鼻肠管正常使用的前提。目前,临床使用的鼻肠管尖端定位方法主要包括腹部X线摄影定位法、体外测量法、消化液判定法、腹部听诊法、数字减影血管造影法、超声定位法、电磁导航定... 详细信息

鼻肠管是临床肠内营养支持的重要途径之一,尖端位置正确是鼻肠管正常使用的前提。目前,临床使用的鼻肠管尖端定位方法主要包括腹部X线摄影定位法、体外测量法、消化液判定法、腹部听诊法、数字减影血管造影法、超声定位法、电磁导航定位法等,不同定位方法的应用现状和准确性存在较大差异。该文针对以上定位方法进行综述,旨在为临床实践提供参考。

关键词：鼻肠管肠内营养定位标记综述护理

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High photoelectric conversion efficiency and fast relaxation time of FA_(0.4)MA_(0.6)PbI_(3) applied in ultrafast modulation of terahertz waves

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Journal of Energy Chemistry 2024年第4期91卷 299-305页

作者： Zhibo Xu Ying Zeng xinran Zhao Xiaoyin Chen Aoyu Fan Furi Ling Jiang Li Jianquan Yao School of Optics and Electronic Information Huazhong University of Science and TechnologyWuhan 430074HubeiChina College of Precision Instrument and Optoelectronics Engineering Tianjin UniversityTianjin 300072China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900SichuanChina School of Information Engineering Wuhan University of TechnologyWuhan 430070HubeiChina National Engineering Research Center of Fiber Optic Sensing Technology and Networks Wuhan University of TechnologyWuhan 430070HubeiChina Hubei Key Laboratory of Broadband Wireless Communication and Sensor Networks Wuhan 430070HubeiChina

Active control of terahertz(THz)waves is attracting tremendous attentions in terahertz communications and active photonic ***,due to its excellent photoelectric conversion performance and simple manufacturing process,has emerged as a promising candidate for optoelectronic ***,the exploration of perovskites in optically controlled THz modulators is still *** this work,the photoelectric properties and carrier dynamics of FA_(0.4)MA_(0.6)PbI_(3)perovskite films were investigated by optical pumped terahertz probe(OPTP)*** ultrafast carrier dynamics reveal that FA_(0.4)MA_(0.6)PbI_(3)thin film exhibits rapid switching and relaxation time within picosecond level,suggesting that FA_(0.4)MA_(0.6)PbI_(3)is an ideal candidate for active THz devices with ultrafast ***,as a proof of concept,a FA_(0.4)MA_(0.6)PbI_(3)-based metadevice with integrating plasma-induced transparency(PIT)effect was fabricated to achieve ultrafast modulation of THz *** experimental results demonstrated that the switching time of FA_(0.4)MA_(0.6)PbI_(3)-based THz modulator is near to 3.5 ps,and the threshold of optical pump is as low as 12.7μJ cm^(-2).The simulation results attribute the mechanism of ultrafast THz modulation to photo-induced free carriers in the FA_(0.4)MA_(0.6)PbI_(3)layer,which progressively shorten the capacitive gap of PIT *** study not only illuminates the potential of FA_(0.4)MA_(0.6)PbI_(3)in THz modulation,but also contributes to the field of ultrafast photonic devices.

关键词： Terahertz modulation Perovskites Metamaterials Plasmon-induced transparency

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Uniform wurtzite MnSe nanocrystals with surface-dependent magnetic behavior

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纳米研究：英文版 2013年第4期6卷 275-285页

作者： Jie Zhang Fan Zhang Xuebing Zhao xinran wang Lifeng Yin Chongyun Liang Min wang Ying Li Jiwei Liu Qingsong Wu Renchao Che Department of Materials Science and Laboratory of Advanced Materials Fudan University Shanghai 200433 China Department of Chemistry lucian University Shanghai 200433 China National Laboratory of Microstructures School of Electronic Science and Engineering Nanjing University Nanjing 210093 China Department of Physics Fudan University Shanghai200433 China

锰硒化物(MnSe ) 作为一个重要磁性的半导体拥有唯一的磁性，但是 MnSe nanocrystals 的合成和性质是因为无能，与另外的半导体 nanocrystals 相比开发获得高质量的 MnSe 的更少，特别在亚稳的 wurtzite 结构。这里，我们成功地经由负... 详细信息

锰硒化物(MnSe ) 作为一个重要磁性的半导体拥有唯一的磁性，但是 MnSe nanocrystals 的合成和性质是因为无能，与另外的半导体 nanocrystals 相比开发获得高质量的 MnSe 的更少，特别在亚稳的 wurtzite 结构。这里，我们成功地经由负担得起一致水晶尺寸的一条胶体的途径制作了 wurtzite MnSe nanocrystals 并且定制形状。胺表面活化剂的选择有约束力的力量是在形状控制和形状进化的决定因素。如果在反应解决方案的 oleylamine 的部分被 trioctylamine 代替，子弹形状能被转变成梭形状，并且四足动物形状的 nanocrystals 能在 trioctylamine 系统被形成。三维(3D ) 塑造子弹的 nanorods 的结构被先进传播电子显微镜(TEM ) 表明了 3D 断层摄影术技术。高分辨率的 TEM (HRTEM ) 和电子精力损失光谱学(鳗) 显示出那平面缺点的结构象叠差错和 twinning 沿着那样[001 ] 方向在子弹形状的生长期间产生。根据小心的 HRTEM 观察，我们为 wurtzite MnSe nanotetrapods 的形成建议 quadra 双胞胎核心生长机制。而且，由于他们的 noncompensated，表面旋转的 wurtzite MnSe nanocrystals 表演 lowtemperature 表面纺纱眼镜行为和堵住的温度与增加 nanocrystals 的表面区域 / 卷比率从 8.4 K 增加到 18.5 K。我们的结果提供 wurtzite MnSe nanocrystals 的系统的研究。

关键词：纤锌矿结构表面活性剂纳米晶体行为透射电子显微镜形状控制电子能量损失谱磁性半导体

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基于可达性的站域立体步行系统活力耦合研究

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地下空间与工程学报 2023年第6期19卷 1751-1759页

作者：王欣然殷子渊深圳大学建筑与城市规划学院广东深圳518000

大量研究认为轨道系统与城市街道可达性的叠加效应能集聚城市空间要素,轨交站域地上与地下步行网络系统耦合效应对公共空间品质有重要影响。以深圳市前海城市设计为研究对象,基于地铁站域的可达性以及现有研究成果,对轨交站域地面步行... 详细信息

大量研究认为轨道系统与城市街道可达性的叠加效应能集聚城市空间要素,轨交站域地上与地下步行网络系统耦合效应对公共空间品质有重要影响。以深圳市前海城市设计为研究对象,基于地铁站域的可达性以及现有研究成果,对轨交站域地面步行街道、地下步行通路活力指标进行提取量化,采用空间句法、网络分析、衰减叠加等方式做出数据分析,并通过熵权法分别对地上、地下步行网络进行指标集成,从而对街道综合活力的分布差异进行可视化。基于GIS平台对地上地下步行网络活力模拟值进行耦合计算,识别出方案设计阶段步行网络中三种耦合状态,针对耦合较差的区域提出初步改进策略。

关键词：步行系统活力耦合可达性

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Light-modulated vertical heterojunction phototransistors with distinct logical photocurrents

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Light(Science & Applications) 2020年第1期9卷 407-416页

作者： Jiayue Han Meiyu He Ming Yang Qi Han Fang wang Fang Zhong Mengjian Xu Qing Li He Zhu Chongxin Shan Weida Hu Xiaoqing Chen xinran wang Jun Gou Zhiming Wu Jun wang School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of Science500 Yutian RoadShanghai 200083China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Henan Key Laboratory of Diamond Optoelectronic Materials and Devices School of Physics and EngineeringZhengzhou UniversityZhengzhou 450001China National Laboratory of Solid State Microstructures School of Electronic Science and Engineeringand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054China

The intriguing carrier dynamics in graphene heterojunctions have stimulated great interest in modulating the optoelectronic features to realize high-performance ***,for most phototransistors,the photoresponse characteristics are modulated with an electrical gate or a static *** this paper,we demonstrate a graphene/C_(60)/pentacene vertical phototransistor to tune both the photoresponse time and photocurrent based on light *** exploiting the power-dependent multiple states of the photocurrent,remarkable logical photocurrent switching under infrared light modulation occurs in a thick C_(60) layer(11 nm)device,which implies competition of the photogenerated carriers between graphene/C_(60) and C_(60)/***,we observe a complete positive-negative alternating process under continuous 405 nm ***,infrared light modulation of a thin C_(60)(5 nm)device results in a photoresponsivity improvement from 3425 A/W up to 7673 A/W,and we clearly probe the primary reason for the distinct modulation results between the 5 and 11 nm C_(60) *** addition,the tuneable bandwidth of the infrared response from 10 to 3×10^(3) Hz under visible light modulation is *** distinct types of optical modulation phenomena and logical photocurrent inversion characteristics pave the way for future tuneable logical photocurrent switching devices and high-performance phototransistors with vertical graphene heterojunction structures.

关键词： heterojunction transistors optoelectronic

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