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P7C3-A20 treats traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis

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Neural Regeneration Research 2024年第5期19卷 1078-1083页

作者： Zhiqing Yang Zhenchao wang Xiaoqi Deng Lingxin Zhu Zhaomeng Song Changyu Cao xinran Li School of Life Science and Engineering Foshan UniversityFoshanGuangdong ProvinceChina Foshan University Veterinary Teaching Hospital FoshanGuangdong ProvinceChina

Traumatic brain injury is a severe health problem leading to autophagy and apoptosis in the brain.3,6-Dibromo-beta-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine(P7C3-A20)can be neuroprotective in various diseases,including ischemic stroke and neurodegenerative ***,whether P7C3-A20 has a therapeutic effect on traumatic brain injury and its possible molecular mechanisms are ***,in the present study,we investigated the therapeutic effects of P7C3-A20 on traumatic brain injury and explored the putative underlying molecular *** established a traumatic brain injury rat model using a modified weight drop method.P7C3-A20 or vehicle was injected intraperitoneally after traumatic brain *** neurological deficits were found in rats after traumatic brain injury,with deterioration in balance,walking function,and learning ***,hematoxylin and eosin staining showed significant neuronal cell damage,while terminal deoxynucleotidyl transferase mediated dUTP nick end labeling staining indicated a high rate of *** presence of autolysosomes was observed using transmission electron microscope.P7C3-A20 treatment reversed these pathological *** blotting showed that P7C3-A20 treatment reduced microtubule-associated protein 1 light chain 3-Ⅱ(LC3-Ⅱ)autophagy protein,apoptosis-related proteins(namely,Bcl-2/adenovirus E1B 19-kDa-interacting protein 3[BNIP3],and Bcl-2 associated x protein[Bax]),and elevated ubiquitin-binding protein p62(p62)autophagy protein ***,P7C3-A20 can treat traumatic brain injury in rats by inhibiting excessive autophagy and apoptosis.

关键词： apoptosis autophagy cortex hippocampus motor function P7C3-A20 traumatic brain injury

Rational Design of Capping Ligands of Quantum Dots for Biosensing

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Chemical Research in Chinese Universities 2024年第2期40卷 162-172页

作者： XU xinran LIU An-an PANG Daiwen State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionResearch Center for Analytical SciencesCollege of ChemistryNankai UniversityTianjin300071P.R.China

Quantum dots have been widely applied in biosensing due to their outstanding optical *** emissions of quantum dots are mainly determined by their composition and size,as described by the Brus’s ***,in this case,their emissions are hardly regulated reversibly and responsively,which are unsuitable for biosensing and *** the last decade,capping ligands have been used for designing biosensors because of their responsive regulation on the photoluminescence of quantum ***,we first summarize the advances in characterization and calculation specific for ligands,which have helped to provide insights into the photoluminescence process and energy band theory of quantum *** then review two ways of ligand design that influence the optical properties of quantum dots:affecting the process of photoluminescence,or the orbital/electronic *** the latter case,the atoms on both the ligand and the surface of the quantum dot interact to affect the energy band structure of the quantum dot *** are presented of how these quantum dots that possess responsive properties due to the design of the ligands have been applied to *** further exploration,we hope to see advances in the fundamental understanding of the energy band structures and practical applications of these quantum dots.

关键词： Quantum dot Ligand Photoluminescence Responsiveness Sensor

Numerical simulation of the influence of aerosol radiation effect on urban boundary layer

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Science China Earth Sciences 2018年第12期61卷 1844-1858页

作者： xinran wang Xiaodong HE Shiguang MIAO Youjun DOU China Institute of Atomic Energy Beo'ing 102413China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China

With the intensification of pollution and urbanization, the aerosol radiation effect continues to play an important role in the urban boundary layer. In this paper, a winter pollution process in Beijing has been taken as an example, and a new aerosol vertical profile in the radiative parameterization scheme within the Weather Forecast Research and Forecasting(WRF) model has been updated to study the effect of aerosols on radiation and the boundary layer. Furthermore, the interactions among aerosols,urbanization, and planetary boundary layer(PBL) meteorology were discussed through a series of numerical experiments. The results show the following:(1) The optimization improves the performance of the model in simulating the distribution features of air temperature, humidity, and wind in Beijing.(2) The aerosols reduce the surface temperature by reducing solar radiation and increasing the temperature in the upper layer by absorbing or backscattering solar radiation. The changes in the PBL temperature lead to more stable atmospheric stratification, reducing the energy transfer from the surface and the height of the boundary layer.(3) With the increase in the aerosol optical depth, the atmospheric stratification most likely becomes stable over rural areas, most likely becomes stable over suburb areas, and has great difficultly becoming stable over urban areas. Aerosol radiative forcing,underlying urban surfaces, and the interaction between them are the main factors that affect the changes in the meteorological elements in the PBL.

关键词： Aerosol Urbanization Boundary layer Meteorological elements WRF

Band alignment and polarization engineering inκ-Ga_(2)O_(3)/GaN ferroelectric heterojunction

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Science China(Physics,Mechanics & Astronomy) 2022年第7期65卷 147-152页

作者： Yanting Chen Hongkai Ning Yue Kuang Xing-Xing Yu He-He Gong Xuanhu Chen Fang-Fang Ren Shulin Gu Rong Zhang Youdou Zheng xinran wang Jiandong Ye School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China

Ferroelectric-semiconductor heterostructures offer an alternative strategy to manipulate polarization towards advanced devices with engineered functionality and improved *** this work,we report on the heteroepitaxial construction,band structure alignment and polarization engineering of the single-phasedκ-Ga_(2)O_(3)/GaN ferroelectric/polar heterojunction.A type-II band alignment is determined at theκ-Ga_(2)O_(3)/GaN polar hetero-interface,with a valence band offset of(1.74±0.1)eV and a conduction band offset of(0.29■0.1)*** the band edge discontinuity,charge dipoles induced by spontaneous polarization lead to the observed band bending with built-in potentials of 0.9 and 0.33 eV,respectively,at theκ-Ga_(2)O_(3)surface andκ-Ga_(2)O_(3)/GaN *** polarization switching properties of ferroelectricκ-Ga_(2)O_(3)are identified with a remanent polarization of approximately 2.7μC/cm^(2)via the direct hysteresis remanent polarization/voltage(P-V)loop *** findings allow the rational design ofκ-Ga_(2)O_(3)ferroelectric/polar heterojunction for the application of power electronic devices,advanced memories and even ultra-low loss negative capacitance transistors.

关键词： wide-bandgap semiconductors ferroelectric polarization band alignment

Chemical Self-Assembly of Graphene Sheets

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Nano Research 2009年第4期2卷 336-342页

作者： Hailiang wang xinran wang Xiaolin Li Hongjie Dai Department of Chemistry and Laboratory for Advanced Materials Stanford UniversityStanfordCA 94305USA

Chemically derived and noncovalently functionalized graphene sheets(GS)were found to self-assemble onto patterned gold structures via electrostatic interactions between the functional groups and the gold *** afforded regular arrays of single graphene sheets on large substrates,which were characterized by scanning electron microscopy(SEM),Auger microscopy imaging,and Raman *** represents the fi rst time that self-assembly has been used to produce on-substrate and fully-suspended graphene electrical *** coatings on the GS were removed by high current“electrical annealing”,which restored the high electrical conductance and Dirac point of the *** sensors for highly sensitive gas detection using the self-assembled GS devices are demonstrated.

关键词： Chemically derived graphene sheets self-assembly graphene devices electrical annealing

Sulfone-based high-voltage electrolytes for high energy density rechargeable lithium batteries:Progress and perspective

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Chinese Chemical Letters 2021年第4期32卷 1309-1315页

作者： Wenya Wu Ying Bai xinran wang Chuan Wu Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Further enhancement in the energy density of rechargeable lithium batteries calls for high-voltage cathode materials and stable anodes,as well as matched high-voltage electrolytes without compromising the overall property of ***-based electrolytes have aroused great interest in recent years owing to their wide electrochemical window and high ***,significant challenges such as the complexity of synthesis,high melting point(typically above room temperature),high viscosity,and their poor compatibility with graphite-based anodes have drastically impeded their practical *** this review,recent progress of sulfone solvents in high energy density rechargeable lithium batteries is summarized theoretically and *** importantly,general improvement methods of sulfone-based electrolytes,such as adding additives and cosolvents,structural modifications of sulfo ne,superconcentrated salt strategy are briefly *** expect that this review provides inspiration for the future developments of sulfone-based high-voltage electrolytes(SHVEs)and their widespread applications in high specific energy lithium batteries.

关键词： Lithium batteries High voltage High energy density Sulfone-based electrolytes Optimizations

Insight to defects regulation on sugarcane waste-derived hard carbon anode for sodium-ion batteries

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Journal of Energy Chemistry 2021年第4期30卷 499-508页

作者： Kaihua Yu xinran wang Haoyi Yang Ying Bai Chuan Wu Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081China

A great deal of attention has been paid on developing plant-derived hard carbon(HC)materials as anodes for sodium-ion batteries(SIBs).So far,the regulation of HC has been handicapped by the well-known ambiguity of Na^(+)storage mechanism,which fails to differentiate the Na^(+)adsorption and Na^(+)insertion,and their relationship with the size of d-interlayer spacing and structural ***,bagassederived HC materials have been synthesized through a combination of pyrolysis treatment and microwave *** combined protocol has enabled to synergistically control the d-interlayer spacing and ***,the microwave activation has created slit pores into HC and these pores allow for an enhanced Na^(+)adsorption with an increased sloping capacity,establishing a strong correlation between the porosity and sloping ***,the pyrolysis treatment promotes the graphitization and it contributes to an intensified Na^(+)insertion with an increased plateau capacity,proving that the plateau capacity is largely contributed by the Na^(+)insertion between ***,the structural regulation of bagasse-derived HC has provided a proof on positively explaining the Na^(+)storage with HC *** structural changes in the pore size distribution,specific surface area,d-interlayer spacing,and the electrochemical properties have been comprehensively characterized,all supporting our understanding of Na^(+)storage *** a result,the HC sample with an optimized d-interlayer spacing and porosity has delivered an improved reversible capacity of 323.6 m Ah g^(-1) at 50 m A g^(-1).This work provides an understanding of Na^(+)storage mechanism and insights on enhancing the sloping/plateau capacity by rationally regulating the graphitization and porosity of HC materials for advanced SIBs.

关键词： Hard carbon Sodium-ion batteries Microwave activation Sodium storage mechanism

A scalable sulfuration of WS2 to improve cyclability and capability of lithium-ion batteries

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Nano Research 2016年第3期9卷 857-865页

作者： Liyan Zhou Shancheng Yan Lijia Pan xinran wang Yuqiao wang Yi Shi ing University Nanjing 210093 China School of Geography and Biological Information Nanjing University of Posts and Telecommunications Nanjing 210023 China National Laboratory of Solid State Microstructures School of Electronic Science and Engineering Nanjing University Nanjing 210093 China Jiangsu Optoelectronic Functional Materials and Engineering Laboratory School of Chemistry and Chemical Engineering Southeast University Nanjing 211189 China

Two-dimensional transition-metal dichalcogenides （WS2 and SnS2） have recently joined the family of energy storage materials （for lithium-ion batteries and supercapacitors） as a result of their favorable ion intercalation. So far, challenges in the synthesis of phase-pure WS2, restacking between WS2 nanosheets, low electronic conductivity, and the brittle nature of WS2, severely limit its use Li-ion battery application. Herein, we develop a facile low temperature solution sulfuration process to improve battery performance dramatically. The sulfuration process is demonstrated to be effective in converting WO3 impurities to WS2, and in repairing the sulfur vacancies, to improve cyclability and rate capability. Lithium-ion battery measurements demonstrate that the stable capacity of the WS2 anode could be enhanced by 48.4% via sulfuration reprocessing, i.e., from 381.7 to 566.8 rnAh/g at a relatively high current density of 0.8 A/g after 50 cycles. We further show that the sulfuration process can be readily extended to other dichalcogenides, and may provide a class of versatile electrode materials for lithium-ion batteries with improved electrochemical characteristics.

关键词： lithium-ion batteries tungsten disulfide sulfuration process anode

Observation of robust anisotropy in WS_(2)/BP heterostructures

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Nano Research 2024年第7期17卷 6749-6756页

作者： xinran Li Xing Xie Biao Wu Junying Chen Shaofei Li Jun He Zongwen Liu Jian-Tao wang Yanping Liu Institute of Quantum Physics School of PhysicsCentral South University932 South Lushan RoadChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South University932 South Lushan RoadChangsha 410083China School of Chemical and Biomolecular Engineering The University of SydneyNSW 2006Australia The University of Sydney Nano Institute The University of SydneyNSW 2006Australia Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Shenzhen Research Institute of Central South University Shenzhen 518000China

Two-dimensional(2D)anisotropic materials have garnered significant attention in the realm of anisotropic optoelectronic devices due to their remarkable electrical,optical,thermal,and mechanical *** extensive research has delved into the optical and electrical characteristics of these materials,there remains a need for further exploration to identify novel materials and structures capable of fulfilling device requirements under various ***,we employ heterojunction interface engineering with black phosphorus(BP)to disrupt the C3 rotational symmetry of monolayer WS_(2).The resulting WS_(2)/BP heterostructure exhibits pronounced anisotropy in exciton emissions,with a measured anisotropic ratio of 1.84 for neutral *** a comprehensive analysis of magnetic-field-dependent and temperature-evolution photoluminescence spectra,we discern varying trends in the polarization ratio,notably observing a substantial anisotropy ratio of 1.94 at a temperature of 1.6 K and a magnetic field of 9 *** dynamic behavior is attributed to the susceptibility of the WS_(2)/BP heterostructure interface strain to fluctuations in magnetic fields and *** findings provide valuable insights into the design of anisotropic optoelectronic devices capable of adaptation to a range of magnetic fields and temperatures,thereby advancing the frontier of material-driven device engineering.

关键词： two-dimensional materials in-plane anisotropy black phosphorus heterojunctions optoelectronic devices photoluminescence spectra