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Paleontology Knowledge Graph for Data-Driven Discovery

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Journal of Earth Science 2024年第3期35卷 1024-1034页

作者： Yiying Deng Sicun Song Junxuan Fan Mao Luo Le Yao Shaochun Dong Yukun Shi Linna Zhang Yue Wang Haipeng Xu Huiqing Xu Yingying Zhao Zhaohui Pan Zhangshuai Hou Xiaoming Li Boheng Shen xinran chen Shuhan Zhang Xuejin Wu Lida Xing Qingqing Liang Enze Wang School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Centre for Research and Education on Biological Evolution and Environment Nanjing UniversityNanjing 210023China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China School of the Earth Sciences and Resources China University of GeosciencesBeijing 100083China

A knowledge graph(KG)is a knowledge base that integrates and represents data based on a graph-structured data model or *** have made efforts to construct geosciencerelated KGs to overcome semantic heterogeneity and facilitate knowledge representation,data integration,and text ***,there is currently no comprehensive paleontology KG or data-driven discovery based on *** this study,we constructed a two-layer model to represent the ordinal hierarchical structure of the paleontology KG following a top-down construction *** ontology containing 19365 concepts has been defined up to *** this basis,we derived the synonymy list based on the paleontology KG and designed corresponding online functions in the OneStratigraphy database to showcase the use of the KG in paleontological research.

关键词： paleontology knowledge graph ontology synonymy list OneStratigraphy big data ge-ology.

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利用***技术实现物理实验三维仿真

实验室研究与探索 2024年第2期43卷 89-92,97页

作者：陈安琪熊阳陈欣然丰宇硕童亚拉李君妍湖北工业大学理学院武汉430068 湖北工业大学计算机学院武汉430068 华中师范大学信息管理学院武汉430079

虚拟仿真实验教学能弥补传统物理实验的不足,现有物理实验仿真软件大都是二维的,教学效果有限。采用*** 3D技术,以“撒克逊碗下沉实验”为例,通过构建三维模型突破平面限制,实现一个立体的、在线的交互式虚拟仿真系统:通过对实验器材和... 详细信息

虚拟仿真实验教学能弥补传统物理实验的不足,现有物理实验仿真软件大都是二维的,教学效果有限。采用*** 3D技术,以“撒克逊碗下沉实验”为例,通过构建三维模型突破平面限制,实现一个立体的、在线的交互式虚拟仿真系统:通过对实验器材和过程三维建模,实现立体仿真,设计了4种实验探究变量间关系,虚拟教师提升可观察性,视频、语音增加了趣味性。应用实践表明,该系统能大大提高教学效果。

关键词：物理实验立体仿真三维建模 Three.js技术撒克逊碗

辅酶Q10对非酒精性脂肪性肝病患者血脂和肝酶的影响:随机对照试验的系统评价和Meta分析

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胃肠病学和肝病学杂志 2024年第7期33卷 883-890页

作者：陈禹茜周本刚丁岩冰陈欣然扬州大学江苏扬州225000 扬州大学附属医院消化内科大连医科大学扬州大学转化医学研究院

目的系统评价辅酶Q10(coenzyme Q10,CoQ10)对非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患者血脂和肝酶的影响。方法计算机检索PubMed、EmBase、Cochrane Library、Web of Science、Proquest、Scopus、CNKI、SinoMed、万方以及维普数据库,收集关于CoQ10对NAFLD患者血脂和肝酶影响的随机对照试验。由2名评价员根据纳入及排除标准筛选文献、提取资料并评价纳入研究的偏倚风险,采用RevMan 5.3软件进行Meta分析。结果共纳入7项随机对照试验,包含374例患者。Meta分析结果显示:与不使用CoQ10的安慰治疗组相比,接受CoQ10治疗的NAFLD患者的血脂指标TC、LDL-C、HDL-C以及肝酶指标ALT和GGT总体上无明显下降,TG和AST下降明显。进行敏感性分析,在排除部分研究后,GGT显著降低。亚组分析显示,基于CoQ10剂量的TC、TG和ALT差异显著,基于干预时间的TG和ALT也显著降低。各研究间未发现发表偏倚。结论NAFLD患者TG和AST水平显著降低,其他血脂和肝酶指标降低并不明显;但敏感性分析和亚组分析显示在某些条件下CoQ10对TC、TG、ALT有显著作用。受纳入研究的质量和数量的影响,仍需更为严谨的多中心、大样本、双盲、随机对照试验进一步验证。

关键词：非酒精性脂肪性肝病辅酶Q10 Meta分析系统评价

胃肠间质瘤患者服用甲磺酸伊马替尼仿制药和原研药的血药浓度及安全性评估

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癌变．畸变．突变 2024年第4期36卷 256-260页

作者：陈欣然刘明峰郭腾杜丽英侯娟霍丽曼河北医科大学第四医院药学部河北省临床药学重点实验室河北石家庄050011

目的:比较胃肠间质瘤患者服用甲磺酸伊马替尼仿制药与原研药的血药浓度和不良反应,为临床医生和患者选择药物提供参考。方法:收集河北医科大学第四医院2020年12月至2023年12月,在门诊使用甲磺酸伊马替尼药物的胃肠间质瘤患者,分为原研... 详细信息

目的:比较胃肠间质瘤患者服用甲磺酸伊马替尼仿制药与原研药的血药浓度和不良反应,为临床医生和患者选择药物提供参考。方法:收集河北医科大学第四医院2020年12月至2023年12月,在门诊使用甲磺酸伊马替尼药物的胃肠间质瘤患者,分为原研药甲磺酸伊马替尼片组,仿制药甲磺酸伊马替尼片组,以及仿制药甲磺酸伊马替尼胶囊组。通过高效液相色谱质谱联用仪检测患者用药后的伊马替尼及其代谢产物N-去甲基伊马替尼的血液稳态谷浓度。收集患者用药后的所有不良反应,并根据常见不良反应评估标准5.0版(CTCAE 5.0)确定不良反应等级。分析3组患者血药浓度和服药后不良反应的差异。结果:原研药组和两个仿制药组伊马替尼稳态谷浓度,N-去甲基伊马替尼稳态谷浓度,以及伊马替尼和N-去甲基伊马替尼稳态谷浓度之和,差异均无统计学意义(P均>0.05)。原研药和两个仿制药组不良反应等级也无显著差异(P均>0.05)。结论:甲磺酸伊马替尼原研药和两个仿制药安全性无显著差异。

关键词：伊马替尼仿制药原研药血药浓度不良反应队列研究

Damage on intestinal barrier function and microbial detoxification of deoxynivalenol:A review

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Journal of Integrative Agriculture 2024年第8期23卷 2507-2524页

作者： Jia chen xinran Zhang Ziqi He Dongwei Xiong Miao Long Key Laboratory of Livestock Infectious Diseases Ministry of Education/College of Animal Science and Veterinary M ShenyangAgricultural UniversityShenyang 110866China

Deoxynivalenol(DON)is a mycotoxin that is produced by various species of Fusarium and is ubiquitous in food and *** low concentrations,it can cause metabolic disorders in animals and humans and,at high concentrations,it can lead to pathological changes in the *** impact of DON on human/animal health and animal productivity has thus attracted a great deal of attention around the *** causes severe damage to the intestine,including compromised intestinal barrier,mucosal damage,weakened immune function,and alterations in gut microbiota *** effects exacerbate intestinal infections and inflammation in livestock and poultry,posing adverse effects on overall ***,research into biological methods for DON detoxification is a crucial avenue for future *** includes the utilization of adsorption,enzymatic degradation,and other biological approaches to mitigate DON's impact,offering new strategies for prevention and treatment of DON-induced *** research will focus on identifying highly efficient detoxifying microorganisms or enzymes to reduce DON levels in food and feed,thereby mitigating its risks to both animals and human health.

关键词： deoxynivalenol(DON) intestinal barrier function mucus barrier immune function flora composition biological detoxification

Observation of robust anisotropy in WS_(2)/BP heterostructures

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Nano Research 2024年第7期17卷 6749-6756页

作者： xinran Li Xing Xie Biao Wu Junying chen Shaofei Li Jun He Zongwen Liu Jian-Tao Wang Yanping Liu Institute of Quantum Physics School of PhysicsCentral South University932 South Lushan RoadChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South University932 South Lushan RoadChangsha 410083China School of Chemical and Biomolecular Engineering The University of SydneyNSW 2006Australia The University of Sydney Nano Institute The University of SydneyNSW 2006Australia Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Shenzhen Research Institute of Central South University Shenzhen 518000China

Two-dimensional(2D)anisotropic materials have garnered significant attention in the realm of anisotropic optoelectronic devices due to their remarkable electrical,optical,thermal,and mechanical *** extensive research has delved into the optical and electrical characteristics of these materials,there remains a need for further exploration to identify novel materials and structures capable of fulfilling device requirements under various ***,we employ heterojunction interface engineering with black phosphorus(BP)to disrupt the C3 rotational symmetry of monolayer WS_(2).The resulting WS_(2)/BP heterostructure exhibits pronounced anisotropy in exciton emissions,with a measured anisotropic ratio of 1.84 for neutral *** a comprehensive analysis of magnetic-field-dependent and temperature-evolution photoluminescence spectra,we discern varying trends in the polarization ratio,notably observing a substantial anisotropy ratio of 1.94 at a temperature of 1.6 K and a magnetic field of 9 *** dynamic behavior is attributed to the susceptibility of the WS_(2)/BP heterostructure interface strain to fluctuations in magnetic fields and *** findings provide valuable insights into the design of anisotropic optoelectronic devices capable of adaptation to a range of magnetic fields and temperatures,thereby advancing the frontier of material-driven device engineering.

关键词： two-dimensional materials in-plane anisotropy black phosphorus heterojunctions optoelectronic devices photoluminescence spectra

High photoelectric conversion efficiency and fast relaxation time of FA_(0.4)MA_(0.6)PbI_(3) applied in ultrafast modulation of terahertz waves

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Journal of Energy Chemistry 2024年第4期91卷 299-305页

作者： Zhibo Xu Ying Zeng xinran Zhao Xiaoyin chen Aoyu Fan Furi Ling Jiang Li Jianquan Yao School of Optics and Electronic Information Huazhong University of Science and TechnologyWuhan 430074HubeiChina College of Precision Instrument and Optoelectronics Engineering Tianjin UniversityTianjin 300072China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900SichuanChina School of Information Engineering Wuhan University of TechnologyWuhan 430070HubeiChina National Engineering Research Center of Fiber Optic Sensing Technology and Networks Wuhan University of TechnologyWuhan 430070HubeiChina Hubei Key Laboratory of Broadband Wireless Communication and Sensor Networks Wuhan 430070HubeiChina

Active control of terahertz(THz)waves is attracting tremendous attentions in terahertz communications and active photonic ***,due to its excellent photoelectric conversion performance and simple manufacturing process,has emerged as a promising candidate for optoelectronic ***,the exploration of perovskites in optically controlled THz modulators is still *** this work,the photoelectric properties and carrier dynamics of FA_(0.4)MA_(0.6)PbI_(3)perovskite films were investigated by optical pumped terahertz probe(OPTP)*** ultrafast carrier dynamics reveal that FA_(0.4)MA_(0.6)PbI_(3)thin film exhibits rapid switching and relaxation time within picosecond level,suggesting that FA_(0.4)MA_(0.6)PbI_(3)is an ideal candidate for active THz devices with ultrafast ***,as a proof of concept,a FA_(0.4)MA_(0.6)PbI_(3)-based metadevice with integrating plasma-induced transparency(PIT)effect was fabricated to achieve ultrafast modulation of THz *** experimental results demonstrated that the switching time of FA_(0.4)MA_(0.6)PbI_(3)-based THz modulator is near to 3.5 ps,and the threshold of optical pump is as low as 12.7μJ cm^(-2).The simulation results attribute the mechanism of ultrafast THz modulation to photo-induced free carriers in the FA_(0.4)MA_(0.6)PbI_(3)layer,which progressively shorten the capacitive gap of PIT *** study not only illuminates the potential of FA_(0.4)MA_(0.6)PbI_(3)in THz modulation,but also contributes to the field of ultrafast photonic devices.

关键词： Terahertz modulation Perovskites Metamaterials Plasmon-induced transparency

The mid-domain effect in flowering phenology

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Plant Diversity 2024年第4期46卷 502-509页

作者： Yanjun Du Rongchen Zhang xinran Tang Xinyang Wang Lingfeng Mao Guoke chen Jiangshan Lai Keping Ma School of Tropical Agriculture and Forestry(School of Agricultural and Rural Affairs School of Rural Revitalization)Hainan UniversityHaikou 570228China HNU-ASU Joint International Tourism College Hainan UniversityHaikou 570228China School of Ecological and Environmental Sciences East China Normal UniversityShanghai 200062China College of Ecology and Environment Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China

The timing of flowering is an important driver of species distribution and community assembly ***,we still have much to learn about the factors that shape flowering diversity(i.e.,number of species flowering per period) in plant *** potential explanation of flowering diversity is the mid-domain effect,which states that geometric constraints on species ranges within a bounded domain(space or time) will yield a mid-domain peak in diversity regardless of ecological ***,we determine whether the mid-domain effect explains peak flowering time(i.e.,when most species of communities are flowering) across *** used phenological data of 16,267 herbaceous and woody species from the provincial Flora in China and species distribution data from the Chinese Vascular Plant Distribution Database to determine relationships between the observed number of species flowering and the number of species flowering as predicted by the mid-domain effect model,as well as between three climatic variables(mean minimum monthly temperature,mean monthly precipitation,and mean monthly sunshine duration).We found that the mid-domain effect explained a significant proportion of the temporal variation in flowering diversity across all species in ***,the mid-domain effect explained a greater proportion of variance in flowering diversity at higher latitudes than at lower *** patterns of flowering diversity for both herbaceous and woody species were related to both the mid-domain effect and environmental *** findings indicate that including geometric constraints in conjunction with abiotic and biotic predictors will improve predictions of flowering diversity patterns.

关键词： Flowering diversity Functional biogeography Latitudinal gradient Macroecology Macrophenology Null model

Genome-wide identification of the CONSTANS-LIKE(COL)family and mechanism of fruit senescence regulation by PpCOL8 in sand pear(Pyrus pyrifolia)

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Journal of Integrative Agriculture 2024年第4期23卷 1222-1237页

作者： Yue Xu Shurui Song Huiying Wang Xilong Cao xinran Zhao Wenli Wang Liyue Huo Yawei Li Misganaw Wassie Bin Lu Liang chen Haiyan Shi College of Horticulture Hebei Agricultural UniversityBaoding 071001China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China

Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and ***,the industrial development of pear fruit is significantly limited by its short shelf *** acid(SA),a well-known phytohormone,can delay fruit senescence and improve shelf ***,the mechanism by which SA regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly *** this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide *** COL genes were divided into three subgroups according to the structural domains of the COL *** COL8,with two B-box motifs and one CCT domain,belonged to the first *** contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third *** four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit ***,the expression of Pp COL8 was inhibited by exogenous SA treatment,while SA up-regulated the expression of Pp COL9a and Pp ***,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and SA up-regulated its *** the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit *** contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit *** co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit *** re

关键词： Pyrus pyrifolia CONSTANS-LIKE gene salicylic acid fruit senescence MADS