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3D integrated photonics platform with deterministic geometry control

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Photonics Research 2020年第2期8卷 194-201页

作者： JEROME MICHON SARAH GEIGER LAN LI CLAUDIA GONCALVES HONGTAO LIN KATHLEEN RICHARDSON xinqiao jia JUEJUN HU Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Department of Biological Engineering University of DelawareNewarkDelaware 19716USA Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024China College of Optics&Photonics University of Central FloridaOrlandoFlorida 32816USA College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027China

3D photonics promises to expand the reach of photonics by enabling the extension of traditional applications to nonplanar geometries and adding novel functionalities that cannot be attained with planar devices.Available material options and device geometries are,however,limited by current fabrication methods.In this work,we pioneer a method that allows for placement of integrated photonic device arrays at arbitrary predefined locations in 3D using a fabrication process that capitalizes on the buckling of a 2D pattern.We present theoretical and experimental validation of the deterministic buckling process,thus demonstrating implementation of the technique to realize what we believe to be the first fully packaged 3D integrated photonics platform.Application of the platform for mechanical strain sensing is further demonstrated.

关键词： buckling planar photonics

The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1560-1591页

作者： Yu Fu jia Li Wenyun Cai Yulan Huang Xinlong Liu Zhongyi Ma Zhongjie Tang Xufei Bian Ji Zheng jiayun jiang Chong Li Medical Research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Institute of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Urology Urologic Surgery CenterXinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China

Intratumoral microbiota has become research hotspots,and emerges as a non-negligent new component of tumor microenvironments(TME),due to its powerful infuence on tumor initiation,metas-tasis,immunosurveillance and prognosis despite in low-biomass.The accumulations of microbes,and their related components and metabolites within tumor tissues,endow TME with additional pluralistic features which are distinct from the conventional one.Therefore,it's definitely necessary to comprehen-sively delineate the sophisticated landscapes of tumor microbe microenvironment,as well as their func-tions and related underlying mechanisms.Herein,in this review,we focused on the fields of tumor microbe microenvironment,including the heterogeneity of intratumor microbiota in different types of tu-mors,the controversial roles of intratumoral microbiota,the basic features of tumor microbe microenvi-ronment(i.e.,pathogen-associated molecular patterns(PAMPs),typical microbial metabolites,autophagy,infammation,multi-faceted immunomodulation and chemoresistance),as well as the multi-disciplinary approach-based intervention of tumor microbiome for cancer therapy by applying wild-type or engineered live microbes,microbiota metabolites,antibiotics,synthetic biology and rationally de-signed biomaterials.We hope our work will provide valuable insight to deeply understand the interplay of cancer-immune-microbial,and facilitate the development of microbes-based tumor-specific treatments.

关键词： Tumor microbe microenvironment Microbiota metabolites Immunomodulation Chemoresistance Multidisciplinary approach Genetically engineered microbiota Autophagy Outer membrane vesicles

The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells

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Chinese Journal of Traumatology 2024年第1期27卷 1-10页

作者： Zhuo Chen Meng-Wei Yao Xiang Ao Qing-jia Gong Yi Yang Jin-Xia Liu Qi-Zhou Lian Xiang Xu Ling-Jing Zuo Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing400042China College of Basic Medical Sciences Army Medical UniversityChongqing400038China Department of Orthopedics 953 Hospital of PLAShigatse Branch of Xinqiao HospitalArmy Medical UniversityShigatse857000Tibet Autonomous RegionChina Department of Rheumatology and Immunology Daping HospitalArmy Medical UniversityChongqing400042China Department of Obstetrics and Gynecology Chongqing People's HospitalChongqing401121China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Nuclear Medicine The First People's Hospital of Yunnan provinceAffiliated Hospital of Kunming University of Science and TechnologyKunming650034China

Programmed cell death 1 ligand 1(PD-L1)is an important immunosuppressive molecule,which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell death-1.The PD-L1 expression disorder plays an important role in the occurrence,development,and treatment of sepsis or other inflammatory diseases,and has become an important target for the treatment of these diseases.Mesenchymal stem cells(MSCs)are a kind of pluripotent stem cells with multiple differentiation potential.In recent years,MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune diseases.Moreover,PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various diseases.In this review,we will summarize the main regulatory mechanism of PD-L1 expression,and discuss various biological functions of PD-L1 in the immune regulation of MSCs.

关键词： PD-L1 MSCs Immunomodulation

有机相中乙醛对脂肪酶催化酯交换反应的影响研究

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山东化工 2024年第6期53卷 45-47,51页

作者：周亚梅刘佳王欣巧马世蓉重庆化工职业学院重庆401228

以戊二醛活化后的聚脲多孔材料为载体固定荧光假单胞菌脂肪酶,将得到的固定酶用于催化(R,S)-1-苯乙醇和乙酸乙烯酯酯交换反应,反应过程中副产物乙醛对脂肪酶的催化活性和立体选择性会产生抑制作用。考察了乙醛存在下乙醛浓度、反应溶剂... 详细信息

以戊二醛活化后的聚脲多孔材料为载体固定荧光假单胞菌脂肪酶,将得到的固定酶用于催化(R,S)-1-苯乙醇和乙酸乙烯酯酯交换反应,反应过程中副产物乙醛对脂肪酶的催化活性和立体选择性会产生抑制作用。考察了乙醛存在下乙醛浓度、反应溶剂、反应温度对酶催化能力的影响。结果表明,乙醛存在下脂肪酶的催化活性和选择性受到明显抑制。当乙醛浓度为0.025 mol/L时,以正己烷为溶剂,40℃下利用固定酶催化(R,S)-1-苯乙醇与乙酸乙烯酯的酯交换反应,此时酶的催化活性和选择性受到的抑制最小。重复使用5次后,体系转化率由第一次49.3%下降至19.4%,对映体选择率下降至26%,表明乙醛的存在加速了酶活性的损失。

关键词：乙醛固定酶催化活性立体选择性

Noninvasive Detection of Cerebral Blood Flow and Blood Oxygen Based on Inductive Sensing Technology and Near Infrared Spectroscopy

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Journal of Beijing Institute of Technology 2024年第3期33卷 204-212页

作者： Cheng Zhou Zexiang Lyu Maoting Zhang Xin Zou Liang Wei Feng Wang Mingxin Qin jia Xu jian Sun College of Biomedical Engineering Army Medical UniversityChongqing 400038China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Department of Medical Engineering Xinqiao HospitalChongqing 400037China

The synchronous monitoring of cerebral blood flow and blood oxygen levels plays a pivotal role in the prevention,diagnosis,and treatment of cerebrovascular diseases.This study introduces a novel noninvasive device utilizing inductive sensing and near-infrared spectroscopy technology to facilitate simultaneous monitoring of cerebral blood flow and blood oxygen levels.The device consists of modules for cerebral blood flow monitoring,cerebral blood oxygen monitoring,control,communication,and a host machine.Through experiments conducted on healthy subjects,it was confirmed that the device can effectively achieve synchronous monitoring and recording of cerebral blood flow and blood oxygen signals.The results demonstrate the device’s capability to accurately measure these signals simultaneously.This technology enables dynamic monitoring of cerebral blood flow and blood oxygen signals with potential clinical applications in preventing,diagnosing,treating cerebrovascular diseases while reducing their associated harm.

关键词： cerebrovascular disease synchronous monitoring inductive sensing near infrared spec-troscopy(NIRS)

Heterogeneity of the tumor immune microenvironment and clinical interventions

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Frontiers of Medicine 2023年第4期17卷 617-648页

作者： Zheng Jin Qin Zhou jia-Nan Cheng Qingzhu jia Bo Zhu Department of Oncology Xinqiao HospitalArmy Medical UniversityChongqing 400037China Key Laboratory of Tumor Immunotherapy Chongqing 400037China Research Institute GloriousMed Clinical Laboratory(Shanghai)Co.Ltd.Shanghai 201318China Institute of Life Sciences Chongqing Medical UniversityChongqing 400016China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China

The tumor immune microenvironment(TIME)is broadly composed of various immune cells,and its heterogeneity is characterized by both immune cells and stromal cells.During the course of tumor formation and progression and anti-tumor treatment,the composition of the TIME becomes heterogeneous.Such immunological heterogeneity is not only present between populations but also exists on temporal and spatial scales.Owing to the existence of TIME,clinical outcomes can differ when a similar treatment strategy is provided to patients.Therefore,a comprehensive assessment of TIME heterogeneity is essential for developing precise and effective therapies.Facilitated by advanced technologies,it is possible to understand the complexity and diversity of the TIME and its influence on therapy responses.In this review,we discuss the potential reasons for TIME heterogeneity and the current approaches used to explore it.We also summarize clinical intervention strategies based on associated mechanisms or targets to control immunological heterogeneity.

关键词： tumor immune heterogeneity clinical intervention tumor microenvironment

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除氨循环喷淋填料塔系统建模及运行优化控制

环境工程学报 2022年第7期16卷 2249-2256页

作者：陈楚夫贾志洋晋欣桥上海交通大学机械与动力工程学院上海200240

喷淋填料塔是一种常见除氨设备。将喷淋除氨系统作为研究对象,以次氯酸溶液为喷淋液体,并对系统的优化运行进行研究。基于除氨逆流喷淋填料塔效率模型和系统溶液循环动态模型,建立了除氨循环喷淋填料塔系统仿真器,提出了一种以次氯酸溶... 详细信息

喷淋填料塔是一种常见除氨设备。将喷淋除氨系统作为研究对象,以次氯酸溶液为喷淋液体,并对系统的优化运行进行研究。基于除氨逆流喷淋填料塔效率模型和系统溶液循环动态模型,建立了除氨循环喷淋填料塔系统仿真器,提出了一种以次氯酸溶液消耗量最小为目标的优化控制策略,通过仿真进行了验证,并与其他2个固定喷淋量控制策略进行了对比。与文献数据相比,喷淋填料塔效率模型的偏差在±3%以内,表明建立的仿真器精度较高。仿真验证结果表明:优化控制策略可使排放气体中氨浓度达到国标GB14554的排放限值要求,而且处理后的废液中氨含量低于其他2个控制策略;在相同的运行时长内,优化控制策略与2个固定喷淋量策略对比,次氯酸的消耗量分别节约34%和18%,说明提出的运行优化控制策略可有效节约次氯酸消耗。本研究提出的优化策略可有效提升除氨喷淋填料塔的运行效率。

关键词：除氨喷淋填料塔次氯酸溶液除氨效率模型溶液循环模型

MOLECULAR DESIGN OF FUNCTIONAL BIOMATERIALS FOR BIOMEDICAL APPLICATIONS

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MOLECULAR DESIGN OF FUNCTIONAL BIOMATERIALS FOR BIOMEDICAL A...

Neoantigens in precision cancer immunotherapy:from identification to clinical applications

第四届国际高分子化学学术讨论会

作者： xinqiao jia Amit K.Jha Sarah E.Grieshaber Longxi Xiao Chao Liu Department of Materials Science and Engineering Delaware Biotechnology Institute University of Delaware

＜正＞Due to their biocompatibility,high water content,and tissue-like viscoelasticity,hydrogels are widely exploited as tissue engineering scaffolds.Traditional hydrogels are macroscopic entities definedby the soluble polymeric precursors that are randomly interconnected,lacking the structural complexity,mechanical robustness and functional diversity seen in the natural extracellular matrices（ECM）.We are

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Chinese Medical Journal 2022年第11期135卷 1285-1298页

作者： Qiao Zhang Qingzhu jia Jing Zhang Bo Zhu Institute of Cancer Xinqiao HospitalArmy Medical UniversityChongqing 400037China Department of Hematology and Oncology The 988th Hospital of Joint Logistic Support Force of PLAKaifengHenan 475003China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Centre for Biomedical EngineeringSchool of Engineering MedicineSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China.

Immunotherapies targeting cancer neoantigens are safe,effective,and precise.Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing;proteomic techniques such as mass spectrometry;and bioinformatics tools based on high-throughput sequencing data,mass spectrometry data,and biological databases.Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines,neoantigen-specific CD8+and CD4+T cells,and neoantigen-pulsed dendritic cells.In addition,neoantigens can be used as biomarkers to assess immunotherapy response,resistance,and prognosis.Therapies based on neoantigens are an important and promising branch of cancer immunotherapy.Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application.This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy.

关键词： Precision cancer immunotherapy Neoantigen Anti-tumor immunity T cells Vaccination