The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells

作     者：Zhuo Chen Meng-Wei Yao Xiang Ao Qing-Jia Gong Yi Yang Jin-Xia Liu Qi-Zhou Lian Xiang Xu Ling-Jing Zuo Zhuo Chen;Meng-Wei Yao;Xiang Ao;Qing-Jia Gong;Yi Yang;Jin-Xia Liu;Qi-Zhou Lian;Xiang Xu;Ling-Jing Zuo

作者机构：Department of Stem Cell&Regenerative MedicineState Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing400042China College of Basic Medical SciencesArmy Medical UniversityChongqing400038China Department of Orthopedics953 Hospital of PLAShigatse Branch of Xinqiao HospitalArmy Medical UniversityShigatse857000Tibet Autonomous RegionChina Department of Rheumatology and ImmunologyDaping HospitalArmy Medical UniversityChongqing400042China Department of Obstetrics and GynecologyChongqing People's HospitalChongqing401121China Department of MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Nuclear MedicineThe First People's Hospital of Yunnan provinceAffiliated Hospital of Kunming University of Science and TechnologyKunming650034China 

出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)

年 卷 期：2024年第27卷第1期

页      面：1-10页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported in part by the general project of Chongqing natural science foundation(cstc2021jcyj-msxmX1017) the key project of science and technology in Chongqing(CSTC2021jscx-gksb-N0026) National Natural Science Foundation of China(32100643) 

主　　题：PD-L1 MSCs Immunomodulation 

摘      要：Programmed cell death 1 ligand 1(PD-L1)is an important immunosuppressive molecule,which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell *** PD-L1 expression disorder plays an important role in the occurrence,development,and treatment of sepsis or other inflammatory diseases,and has become an important target for the treatment of these *** stem cells(MSCs)are a kind of pluripotent stem cells with multiple differentiation *** recent years,MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune ***,PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various *** this review,we will summarize the main regulatory mechanism of PD-L1 expression,and discuss various biological functions of PD-L1 in the immune regulation of MSCs.