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基于设备行为关联图的非侵入式多标签负荷分解改进方法

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中国电机工程学报 2024年第1期44卷 95-104,I0008页

作者：陈鑫沛余涛杨家俊余盛灿广东省电网智能量测与先进计量企业重点实验室(华南理工大学电力学院) 广东省广州市510640

非侵入式负荷分解技术作为目前用户用电信息监测的主要手段,对推动能源效率提升和需求侧优化管理具有重要意义。针对目前负荷分解模型过分依赖电器本身的用电特征,而忽视用户用电习惯所提供的信息,导致分解效果始终难以改善的问题,该文... 详细信息

非侵入式负荷分解技术作为目前用户用电信息监测的主要手段,对推动能源效率提升和需求侧优化管理具有重要意义。针对目前负荷分解模型过分依赖电器本身的用电特征,而忽视用户用电习惯所提供的信息,导致分解效果始终难以改善的问题,该文提出一种考虑用户用电行为的多标签负荷分解改进方法。改进后的模型是两个网络串行的架构。第一个网络结合用户用电行为实现多标签类型识别;第二个网络在识别结果基础上完成各个在线电器的能量分解。文中通过设备行为关联图来表示用户的用电习惯。模型随用户用电不断完成行为更新,并逐渐为用户生成独特的网络图,为负荷分解提供行为依据。最后使用公开数据集REDD和REFIT对提出方法进行仿真和评估。实验结果表明,提出的方法能够准确获取各电器的用电信息,且与现有先进方法相比有明显的改进,证明了考虑用户用电行为的多标签方法是一种有效可行的负荷分解思路。

关键词：非侵入式负荷监测能量分解多标签识别设备行为关联图

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基于PAM4数字光标签的WDM光网络监测

中国激光 2024年第2期51卷 118-129页

作者：杨桃王雪李开宣张冰洁石屿陈舒阳陈昕培北京邮电大学信息光子学与光通信国家重点实验室北京100876

波分复用(WDM)光网络具有波长和节点数目众多、传输路径动态重构、业务/资源动态调度等特点,亟须发展低成本、高可靠的在线监测技术,以保障光网络的安全稳定运行。本文提出了一种基于四进制脉冲幅度调制(PAM4)数字光标签的低成本、高可... 详细信息

波分复用(WDM)光网络具有波长和节点数目众多、传输路径动态重构、业务/资源动态调度等特点,亟须发展低成本、高可靠的在线监测技术,以保障光网络的安全稳定运行。本文提出了一种基于四进制脉冲幅度调制(PAM4)数字光标签的低成本、高可靠、高效率监测方案,并创新设计了PAM4光标签加载、探测和处理等整套机制与方法,配合所提出的基于PAM4光标签序列特征的光功率监测误差修正方法以及基于频谱峰值的功率计算方法,所提方案可以准确高效地监测波长通道光功率、估计光信噪比(OSNR)并恢复数字标签信息等。搭建了16 GBaud偏振复用QPSK/16QAM WDM光传输仿真系统和离线实验平台,验证结果表明所提方案在25跨段长距离传输后的通道光功率监测误差不超过0.65 dB,OSNR估计误差不超过0.6 dB,性能略优于传统的基于差分相移键控(DPSK)低阶调制格式的光标签监测方案。

关键词：光通信波分复用光标签光功率光信噪比监测

Toll样受体2(TLR2)与结核分枝杆菌感染的相关研究进展

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细胞与分子免疫学杂志 2024年第4期40卷 367-372页

作者：陈瑞枫王瑄马枫茜周鑫沛吴利先大理大学基础医学院微生物学与免疫学教研室云南大理671000 南昌大学玛丽女王学院江西南昌330031 大理大学基础医学院人体解剖学教研室云南大理671000

Toll样受体2(TLR2)是白细胞表面表达的一种模式识别受体,已发现多种配体可以激动或抑制TLR2的活化,进而调控免疫细胞的炎症和凋亡状态。结核分枝杆菌(MTB)通常寄生在巨噬细胞中,但MTB感染机体后,包括巨噬细胞在内的多种免疫细胞表面的T... 详细信息

Toll样受体2(TLR2)是白细胞表面表达的一种模式识别受体,已发现多种配体可以激动或抑制TLR2的活化,进而调控免疫细胞的炎症和凋亡状态。结核分枝杆菌(MTB)通常寄生在巨噬细胞中,但MTB感染机体后,包括巨噬细胞在内的多种免疫细胞表面的TLR2都可与其相互作用,释放细胞因子,影响MTB在体内的状态和增殖。在分子层面,TLR2的多态性有待更多探索,目前研究的大部分TLR2的多态性被认为与MTB的易感性无关。文中总结了TLR2与配体、感染后免疫调节活动、多态性与MTB易感性等方面的研究进展。

关键词：结核分枝杆菌(MTB) Toll样受体2(TLR2) 细胞因子多态性综述

A polymeric co-assembly of subunit vaccine with polyoxometalates induces enhanced immune responses

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Nano Research 2022年第5期15卷 4175-4180页

作者： xinpei Li Xiaofeng He Dongrong He Yuan Liu Kun chen Panchao Yin South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510640China

Long-lasting protective immune responses are expected following vaccination.However,most vaccines alone are inability to evoke an efficient protection.The combinatory administration of adjuvants with vaccines is critical for generating the enhanced immune responses.Herein,with biocompatible poly(4-vinylpyridine)(P4VP)as template,2.5 nm iron/molybdenum oxide cluster,{Mo_(72)Fe_(30)},is applied as an adjuvant to co-assemble with antigens of Mycobacterium bovis via hydrogen bonding at molecular scale.Molecular scale integration of the antigens and{Mo_(72)Fe_(30)}and their full exposure to body fluid media contribute to the augmentation of both humoral and cellular immune responses of the vaccines after inoculation in mice.Anti-inflammatory factor IL-10 gradually increases after 2 weeks followed by a final back to normal level by the 5th week.The balance between proinflammatory cytokines and anti-inflammatory factors suggests that immune system can be activated in the early stage of infection by the antigens carried by the supra-particles and secrete acute inflammatory factors for host defense and anti-inflammatory factors for immune protection.

关键词： co-assembly immune response metal oxide cluster supramolecular interaction vaccine adjuvant

The study on the safety and efficacy of amnion graft for preventing the recurrence of moderate to severe intrauterine adhesions

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Genes & Diseases 2020年第2期7卷 266-271页

作者： Changjiang Li Aiqi Cai Congcong Sun Benyuan Wu xinpei chen Yanhua Mao Yingfeng Zhang Yating Gou Jie Yu Yuhan Wang Huanhuan Yu Jia Wang Department of Obstetrics and Gynecology University-Town Hospital of Chongqing Medical UniversityChongqingChina

Transcervical resection of adhesion(TCRA)is the standard treatment for the intrauterine adhesions,but the recurrence of adhesions is a tough problem for the gynecologist.In addition,the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions(IUAs).Hence,we designed this study to explore the safety and efficacy of fresh amnion grafts for preventing the recurrence after TCRA for patients with moderate to severe IUAs.One hundred patients with moderate to severe IUAs who presented with a history of hypomenorrhea,amenorrhea and infertility were included in the study from January 2015 to December 2017.Patients were divided into amnion group(52 patients)and chitosan group(48 patients).Fresh amnion grafts or intrauterine injections of chitosan were administered after TCRA.Transvaginal ultrasonography(TVUS)and hysteroscopy were performed at the first and third month after the operation.The surgical procedures for all patients were completed successfully without relevant complications.In amnion group,8 patients exhibited relapse in the first month and 2 patients in three months after surgery;in chitosan group,23 women exhibited relapse in the first month and 18 patients in three months after surgery.Statistical analysis revealed that the recurrence rate of adhesion in amnion group was significantly lower than those of chitosan group in the first and three months after surgery(P1=0.000,P2=0.000).After TCRA,fresh amnion graft plays a significant role in preventing further adhesions than injections of chitosan.

关键词： Amnion graft Asherman’s syndrome Intrauterine adhesions Recurrence of adhesion Transcervical resection of adhesion

大气压脉冲微波Ar/N_(2)等离子体射流的时空特性研究

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中国科学：物理学、力学、天文学 2024年第3期54卷 158-171页

作者：陈兆权王伟业陈思乐王超徐笑娟王兵周郁明卢新培安徽工业大学安徽省高校电力电子与运动控制重点实验室马鞍山243032 华中科技大学强电磁工程与新技术国家重点实验室武汉430074

在空气环境中,很难形成特定形貌的微波等离子体射流.本文构建了双气体通道同轴谐振放电装置,在空气环境中产生了脉冲微波Ar/N_(2)双层等离子体射流.实验测量了Ar/N_(2)等离子体射流电离发展的时空演变过程:(1)使用高速相机测量等离子体... 详细信息

在空气环境中,很难形成特定形貌的微波等离子体射流.本文构建了双气体通道同轴谐振放电装置,在空气环境中产生了脉冲微波Ar/N_(2)双层等离子体射流.实验测量了Ar/N_(2)等离子体射流电离发展的时空演变过程:(1)使用高速相机测量等离子体射流形貌的瞬态变化,发现电离的初始阶段和结束阶段存在光辐射增强的放电影像;(2)使用瑞利散射装置测量等离子体射流的电子密度,发现电子密度值达到10^(21)m^(-3)数量级,且在脉冲微波的上升沿和下降沿各有一次电离波峰;(3)使用单色仪测量特定波长段光谱的瞬态变化,追踪N_(2)^(+)谱线从首次出现到稳定发展、直至最后衰减消失的过程.结合实验测量结果和电磁仿真分析,发现脉冲微波的上升沿和下降沿各有一次增强电离过程,揭示了脉冲微波Ar/N_(2)双层等离子体射流的特殊放电形貌是时空局域增强电离致使.

关键词：微波放电电离机理等离子体射流电磁模拟

Cortical Deficits are Correlated with Impaired Stereopsis in Patients with Strabismus

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Neuroscience Bulletin 2023年第7期39卷 1039-1049页

作者： Sida Xi Yulian Zhou Jing Yao xinpei Ye Peng Zhang Wen Wen chen Zhao Department of Ophthalmology and Visual Science Eye and ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200031China Key Laboratory of Myopia Fudan UniversityMinistry of HealthShanghai 200031China Shanghai Key Laboratory of Visual Impairment and Restoration Fudan UniversityShanghai 200031China Department of Radiology Eye and ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

In this study,we explored the neural mechanism underlying impaired stereopsis and possible functional plasticity after strabismus surgery.We enrolled 18 stereo-deficient patients with intermittent exotropia before and after surgery,along with 18 healthy controls.Functional magnetic resonance imaging data were collected when participants viewed three-dimensional stimuli.Compared with controls,preoperative patients showed hypoactivation in higher-level dorsal(visual and parietal)areas and ventral visual areas.Pre-and postoperative activation did not significantly differ in patients overall;patients with improved stereopsis showed stronger postoperative activation than preoperative activation in the right V3A and left intraparietal sulcus.Worse stereopsis and fusional control were correlated with preoperative hypoactivation,suggesting that cortical deficits along the two streams might reflect impaired stereopsis in intermittent exotropia.The correlation between improved stereopsis and activation in the right V3A after surgery indicates that functional plasticity may underlie the improvement of stereopsis.Thus,additional postoperative strategies are needed to promote functional plasticity and enhance the recovery of stereopsis.

关键词： Stereopsis Binocular disparity Functional magnetic resonance imaging Strabismus Intermittent exotropia

Bacteria-assisted delivery and oxygen production of nano-enzyme for potent radioimmunotherapy of cancer

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Nano Research 2022年第8期15卷 7355-7365页

作者： Jing Ni Hailin Zhou Jingyu Gu xinpei Liu Jie chen Xuan Yi Kai Yang State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection&School for Radiological and Interdisciplinary Sciences(RADX)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China School of Pharmacy Jiangsu Key Laboratory of Inflammation and Molecular Drug TargetsNantong UniversityNantong 226001China Dushu Lake Hospital Affiliated to Soochow University Medical Center of Soochow UniversitySuzhou 215123China

Tumor-targeting attenuated Salmonella could induce certain antitumor therapeutic effect through its proliferation characteristic and the consequent activated immune response,while host defense cells represented by neutrophils would trap and eliminate these invading bacteria via producing excess hydrogen peroxide(H_(2)O_(2))-including reactive oxygen species in the bacteriainfected tumor,thereby impairing the efficacy of the bacteria treatment of tumor.Herein,we attempt to combine bacteria treatment and oxygen-dependent radioimmunotherapy of tumor through injection of neutrophil-targeted nano-catalase into the bacteria-treated mice for perfect tumor treatment outcome.Denatured albumin is used to coat catalase and deliver it to the neutrophils infiltrated in bacteria-infected tumor tissue.Taking advantage of the generating H_(2)O_(2)by neutrophils,easily-diffused oxygen is produced and spread the whole tumor under the catalysis of nano-enzyme,leading to enhanced radiotherapy of hypoxic tumor cells.Moreover,the optimized tumor microenvironment,synergistically caused by potent immune-stimulation of bacteria,generating oxygen and tumor radiotherapy,would boost the antitumor immunity.This novel combination therapy strategy holds great promise to provide new ideas for future clinical cancer treatment.

关键词： bacteria neutrophil hydrogen peroxide denatured albumin radiotherapy

Stepwise optimization of single-ion conducting polymer electrolytes for high-performance lithium-metal batteries

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Journal of Energy Chemistry 2023年第5期80卷 174-181,I0005页

作者： Xu Dong Zhen chen xinpei Gao Alexander Mayer Hai-Peng Liang Stefano Passerini Dominic Bresser Helmholtz Institute Ulm(HIU) Helmholtzstrasse 1189081 UlmGermany Karlsruhe Institute of Technology(KIT) P.0.Box 364076021 KarlsruheGermany

Single-ion conducting polymer electrolytes(SIPEs)are promising candidates for high-energy and highsafety lithium-metal batteries(LMBs).However,their insufficient ionic conductivity and electrochemical stability hinder their practical application.Herein,three new SIPEs,i.e.,poly(1,4-phenylene ether ether sulfone)-Li(PEES-Li),polysulfone-Li(PSF-Li),and hexafluoropolysulfone-Li(6FPSF-Li),all containing covalently tethered perfluorinated ionic side chains,have been designed,synthesized,and compared to investigate the influence of the backbone chemistry and the concentration of the ionic group on their electrochemical properties and cell performance.Especially,the trifluoromethyl group in the backbone and the concentration of the ionic function appear to play an essential role for the charge transport and stability towards oxidation,and the combination of both yields the best-performing SIPE with high ionic conductivity of ca.2.5×10^(-4)S cm^(-1),anodic stability of more than 4.8 V,and the by far highest capacity retention in Li‖LiNi0.6Co0.2Mn0.2O2cells.

关键词： single-ion conductor Polymer electralyte Backbone chemistry NCMu22 cathode Lithium-metal battery