A polymeric co-assembly of subunit vaccine with polyoxometalates induces enhanced immune responses

作     者：Xinpei Li Xiaofeng He Dongrong He Yuan Liu Kun Chen Panchao Yin Xinpei Li;Xiaofeng He;Dongrong He;Yuan Liu;Kun Chen;Panchao Yin

作者机构：South China Advanced Institute for Soft Matter Science and TechnologySchool of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and DevicesSouth China University of TechnologyGuangzhou 510640China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2022年第15卷第5期

页      面：4175-4180页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：The work was supported financially by the National Natural Science Foundation of China(Nos.22101086,21961142018,and 51873067) the Natural Science Foundation of Guangdong Province(Nos.2021A1515012024 and 2021A1515010271) 

主　　题：co-assembly immune response metal oxide cluster supramolecular interaction vaccine adjuvant 

摘      要：Long-lasting protective immune responses are expected following ***,most vaccines alone are inability to evoke an efficient *** combinatory administration of adjuvants with vaccines is critical for generating the enhanced immune ***,with biocompatible poly(4-vinylpyridine)(P4VP)as template,2.5 nm iron/molybdenum oxide cluster,{Mo_(72)Fe_(30)},is applied as an adjuvant to co-assemble with antigens of Mycobacterium bovis via hydrogen bonding at molecular *** scale integration of the antigens and{Mo_(72)Fe_(30)}and their full exposure to body fluid media contribute to the augmentation of both humoral and cellular immune responses of the vaccines after inoculation in ***-inflammatory factor IL-10 gradually increases after 2 weeks followed by a final back to normal level by the 5th *** balance between proinflammatory cytokines and anti-inflammatory factors suggests that immune system can be activated in the early stage of infection by the antigens carried by the supra-particles and secrete acute inflammatory factors for host defense and anti-inflammatory factors for immune protection.