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Laboratory studies on the infectivity of human respiratory viruses:Experimental conditions,detections,and resistance to the atmospheric environment

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Fundamental Research 2024年第3期4卷 471-483页

作者： Yaohao Hu Shuyi Peng Bojiang Su Tao wang Juying Lin Wei Sun Xiaodong Hu Guohua Zhang xinming wang Ping'an Peng Xinhui Bi State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou 510640China

The environmental stability of infectious viruses in the laboratory setting is crucial to the transmission potential of human respiratory *** experimental techniques or conditions used in studies over the past decades have led to diverse understandings and predictions for the stability of viral infectivity in the atmospheric *** this paper,we review the current knowledge on the effect of simulated atmospheric conditions on the infectivity of respiratory viruses,mainly focusing on influenza viruses and coronaviruses,including severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome ***,we summarize the impact of the experimental conditions on viral stability;these involve the methods of viral aerosol generation,storage during aging and collection,the virus types and strains,the suspension matrixes,the initial inoculum volumes and concentrations,and the drying ***,we summarize and discuss the detection methods of viral infectivity and their ***,we integrate the results from the reviewed studies to obtain an overall understanding of the effects of atmospheric environmental conditions on the decay of infectious viruses,especially aerosolized ***,this review highlights the knowledge gaps in predicting the ability of viruses to maintain infectivity during airborne transmission.

关键词： Respiratory viruses Viral infectivity Laboratory simulation Atmospheric environmental condition Airborne transmission

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Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 48-55页

作者： Yeming wang Li Guo Guohui Fan Yang Han Qiao Zhang Lili Ren Hui Zhang Geng wang Xueyang Zhang Tingxuan Huang Weiyang wang Lan Chen Lixue Huang Xiaoying Gu xinming wang Jingchuan Zhong Ying wang Hui Li Jiapei Yu Zhibo Liu Chaolin Huang Bin Cao Jianwei wang National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesChina-Japan Friendship HospitalBeijing 100029China National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100029China School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeState Key Laboratory of Respiratory Health and MultimorbidityKey Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College)Ministry of EducationBeijing 100730China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical research and Data managementCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Jin Yin-tan Hospital WuhanHubei 430023China Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology and Clinical Immunology Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Ministry of Science&TechnologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(PUMCH)Key Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospsitalInstitute of Respiratory MedicineChinese

Background:The impact of corticosteroids on humoral responses in coronavirus disease 2019(COVID-19)sur-vivors during the acute phase and subsequent 6-month period remains *** study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-19 survivors 6 months after infection ***:We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2020,which involved adults hospitalized with severe COVID-19(LOTUS,ChiCTR2000029308).Anti-body samples were collected from 192 patients during hospitalization,and kinetic antibodies were monitored at all available time points after ***,plasma samples were collected from 101 COVID-19 survivors for comprehensive humoral immune measurement at the half-year follow-up *** main focus was comparing the humoral responses between patients treated with systemic corticosteroid therapy and the non-corticosteroid ***:From illness onset to day 30,the median antibody titre areas under the receiver operating characteristic curve(AUCs)of nucleoprotein(N),spike protein(S),and receptor-binding domain(RBD)immunoglobulin G(IgG)were significantly lower in the corticosteroids *** AUCs of N-,S-,and RBD-IgM as well as neutralizing antibodies(NAbs)were numerically lower in the corticosteroids group compared with the non-corticosteroid ***,peak titres of N,S,RBD-IgM and-IgG and NAbs were not influenced by *** 6-month follow-up,we observed a delayed decline for most binding antibodies,except N-IgM(𝛽−0.05,95%CI[−0.10,0.00])in the corticosteroids group,though not reaching statistical *** significant difference was observed for ***,for the half-year seropositive rate,corticosteroids significantly accelerated the decay of IgA and IgM but made no difference to N-,S-,and RBD-IgG or ***,corticosteroids group showed a trend towards d

关键词： COVID-19 Corticosteroid Immunity Antibody Humoral response

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风向角和倾角对光伏阵列风荷载的影响

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太阳能学报 2024年第1期45卷 25-31页

作者：全勇吴建高陈艳王辛铭敬海泉中机国际工程设计研究院有限责任公司长沙410021 杭州市规划和自然资源局余杭分局杭州311100 中南大学土木工程学院长沙410075

该文通过数值模拟方法,系统研究单竖排光伏阵列的风荷载特性以及风向角和倾角的影响。结果表明:光伏阵列在横风作用下,迎风侧光伏组件的风荷载系数最大;光伏组件阻力系数、升力系数以及扭矩系数均随倾角的增大而增大,且在倾角小于20°... 详细信息

该文通过数值模拟方法,系统研究单竖排光伏阵列的风荷载特性以及风向角和倾角的影响。结果表明:光伏阵列在横风作用下,迎风侧光伏组件的风荷载系数最大;光伏组件阻力系数、升力系数以及扭矩系数均随倾角的增大而增大,且在倾角小于20°时变化速率较大,大于20°之后体型系数趋于平缓;光伏阵列中,组件风荷载系数的遮挡效应十分明显,迎风侧光伏组件降低了背风侧组件的来流风速,使得位于下游区域的光伏组件所受风荷载显著减小,且倾角越大遮挡效应越明显。

关键词：光伏系统风荷载数值模拟风向角倾角

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数字孪生技术在智慧图书馆建设中的应用及推进措施

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河北科技图苑 2024年第2期37卷 77-81页

作者：王鑫明广西警察学院图书馆广西南宁530023

数字孪生是数字化时代所形成的一项关键技术,为智慧图书馆的转型升级打下坚实的基础。在阐述智慧图书馆建设研究现状的基础上,诠释了新型智慧图书馆——数字孪生图书馆的定义与特征,分析了数字孪生技术在智慧图书馆建设中的应用。同时,... 详细信息

数字孪生是数字化时代所形成的一项关键技术,为智慧图书馆的转型升级打下坚实的基础。在阐述智慧图书馆建设研究现状的基础上,诠释了新型智慧图书馆——数字孪生图书馆的定义与特征,分析了数字孪生技术在智慧图书馆建设中的应用。同时,提出了推进数字孪生图书馆落地的具体路径,以实现智慧图书馆的转型升级。

关键词：数字孪生智慧图书馆技术应用

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钢结构屋盖整体提升施工技术研究与分析——以浙江某高铁站项目为例

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建筑科技 2024年第5期8卷 188-192页

作者：王新明中交水利水电建设有限公司浙江宁波315135

随着高铁站设计跨度的不断增大,钢结构屋盖施工难度也随之提升。为提升大跨度钢结构屋盖整体提升的施工技术,以浙江某高铁站项目为例,对钢结构屋盖整体提升施工技术展开深入研究。对提升施工的方法、钢结构屋盖参数以及拼接施工要点进... 详细信息

随着高铁站设计跨度的不断增大,钢结构屋盖施工难度也随之提升。为提升大跨度钢结构屋盖整体提升的施工技术,以浙江某高铁站项目为例,对钢结构屋盖整体提升施工技术展开深入研究。对提升施工的方法、钢结构屋盖参数以及拼接施工要点进行了系统分析。借助仿真模拟分析,对提升过程中可能面临的荷载与组合模式进行了深入研究,并得出了相应的模拟结果。在对施工重难点进行分析的基础上,提出了有效的应对措施,为类似工程的提升施工提供技术支持和参考。

关键词：钢结构屋盖整体提升施工方法仿真模拟分析

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工程管理静态安全风险评估与控制分析——以宁波市轨道交通6号线一期工程SG6107标段项目为例

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建筑科技 2024年第4期8卷 14-16页

作者：王新明中交水利水电建设有限公司浙江宁波315135

静态安全风险评估可以全面识别和评估施工过程中可能存在的各类风险,有助于提前预测和规避潜在的问题,为项目的顺利推进提供可靠的保障。以宁波市轨道交通6号线一期工程SG6107标段项目为例,分析高桥南站施工在基坑降水、主体结构等方面... 详细信息

静态安全风险评估可以全面识别和评估施工过程中可能存在的各类风险,有助于提前预测和规避潜在的问题,为项目的顺利推进提供可靠的保障。以宁波市轨道交通6号线一期工程SG6107标段项目为例,分析高桥南站施工在基坑降水、主体结构等方面的潜在风险,对其风险指数和等级进行评估,并提出相应的风险控制措施以保障项目安全,以期为其他类似工程的安全管理提供参考。

关键词：工程管理静态安全风险风险评估风险控制

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宋代书画文本中的思想世界:以东坡书画题跋为中心

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艺术研究（哈尔滨师范大学艺术学报） 2024年第3期 51-53页

作者：王新明贵州大学

东坡书画题跋是苏轼书画思想文本重要载体。本文将东坡书画题跋文本的思想内容从“自然观”“心性观”“意道观”三个方面展开阐释,串联“自然观”“心性观”“意道观”三个旨趣间内容上互通之处,形成意理圆融的思想意涵。东坡思想内容... 详细信息

东坡书画题跋是苏轼书画思想文本重要载体。本文将东坡书画题跋文本的思想内容从“自然观”“心性观”“意道观”三个方面展开阐释,串联“自然观”“心性观”“意道观”三个旨趣间内容上互通之处,形成意理圆融的思想意涵。东坡思想内容所折射的这种思想精神也是东坡人生的正向写照,东坡这样的书画思想观也让他在历史发展的变化中始终矗立而亘古不摇。系统梳理东坡书画题跋文本,有利于深化对东坡个体思想的理解,凸显宋代书画文本中蕴藏丰厚书画学思想的价值意义。

关键词：宋代东坡书画题跋自然观心性观意道观

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Carbonyl sulfide and dimethyl sulfide fluxes in an urban lawn and adjacent bare soil in Guangzhou,China

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Journal of Environmental Sciences 2011年第5期23卷 784-789页

作者： Zhigang Yi xinming wang College of Resources and Environment Fujian Agriculture and Forestry University Fuzhou 350002 China. E-mail:zgyi@*** State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

Carbonyl sulfide （COS） and dimethyl sulfide （DMS） fluxes from as urban Cynodon dactylon lawn and adjacent bare soil were measured during April-July 2005 in Guangzhou, China. Both the lawn and bare soil acted as sinks for COS and sources for DMS. The mean fluxes of COS and DMS in the lawn （-19.27 and 18.16 pmol/（m^***）, respectively） were significantly higher than those in the bare soil （-9.89 and 9.35 pmol/（m^***）, respectively）. Fluxes of COS and DMS in mowed lawn were also higher than those in bare soils. Both COS and DMS fluxes showed diurnal variation with detectable but much lower values in the nighttime than in the daytime. COS fluxes were related significantly to temperature and the optimal temperature for COS uptake was 29℃. While positive linear correlations were found between DMS fluxes and temperature. COS fluxes increased linearly with ambient COS mixing ratios, and had a compensation point of 336 ppt.

关键词： carbonyl sulfide dimethyl sulfide flux urban lawn

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Emission of oxygenated volatile organic compounds(OVOCs)during the aerobic decomposition of orange wastes

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Journal of Environmental Sciences 2015年第7期27卷 69-77页

作者： Ting Wu xinming wang State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences College of Environmental Sciences and Engineering Anhui Normal University

Oxygenated volatile organic compounds（OVOCs） emitted from orange wastes during aerobic decomposition were investigated in a laboratory-controlled incubator for a period of two months. Emission of total OVOCs（TOVOCs） from orange wastes reached 1714 mg/dry kg（330 mg/wet kg）. Ethanol, methanol, ethyl acetate, methyl acetate, 2-butanone and acetaldehyde were the most abundant OVOC species with shares of 26.9%, 24.8%, 20.3%, 13.9%, 2.8%and 2.5%, respectively, in the TOVOCs released. The emission fluxes of the above top five OVOCs were quite trivial in the beginning but increased sharply to form one ＂peak emission window＂ with maximums at days 1-8 until leveling off after 10 days. This type of ＂peak emission window＂ was synchronized with the CO2 fluxes and incubation temperature of the orange wastes, indicating that released OVOCs were mainly derived from secondary metabolites of orange substrates through biotic processes rather than abiotic processes or primary volatilization of the inherent pool in oranges. Acetaldehyde instead had emission fluxes decreasing sharply from its initial maximum to nearly zero in about four days,suggesting that it was inherent rather than secondarily formed. For TOVOCs or all OVOC species except 2-butanone and acetone, over 80% of their emissions occurred during the first week, implying that organic wastes might give off a considerable amount of OVOCs during the early disposal period under aerobic conditions.

关键词： Oxygenated volatile organiccompounds (OVOCs) Emission fluxes Orange wastes Aerobic decomposition

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Parameter identification of hysteretic model of rubber-bearing based on sequential nonlinear least-square estimation

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Earthquake Engineering and Engineering Vibration 2010年第3期9卷 375-383页

作者： Yin Qiang Zhou Li wang xinming MOE Key Lab of Structure Mechanics and Control for Aircraft Institute of Structures ＆ Strength Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

In order to evaluate the nonlinear performance and the possible damage to rubber-bearings （RBs） during their normal operation or under strong earthquakes, a simplified Bouc-Wen model is used to describe the nonlinear hysteretic behavior of RBs in this paper, which has the advantages of being smooth-varying and physically motivated. Further, based on the results from experimental tests performed by using a particular type of RB （GZN 110） under different excitation scenarios, including white noise and several earthquakes, a new system identification method, referred to as the sequential nonlinear least- square estimation （SNLSE）, is introduced to identify the model parameters. It is shown that the proposed simplified Bouc- Wen model is capable of describing the nonlinear hysteretic behavior of RBs, and that the SNLSE approach is very effective in identifying the model parameters of RBs.

关键词： parameter identification rubber-bearing hysteretic behavior Bouc-Wen model sequential nonlinear least- square estimation

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