检索结果-南通市图书馆

Development and validation of an emergency bloodstream infection score for predicting in-hospital mortality in patients with community-acquired bloodstream infections

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2023年第4期14卷 280-286页

作者： Xinlei Wang Yao Sun Xiaoyu Ni Shu Zhang Department of Emergency West China HospitalSichuan UniversityChengdu 610041Chiha

BACKGROUND:Community-acquired bloodstream infections(CABSIs)are common in the emergency departments,and some progress to sepsis and even lead to death.However,limited information is available regarding the prediction of patients with high risk of death.METHODS:The Emergency Bloodstream Infection Score(EBS)for CABSIs was developed to visualize the output of a logistic regression model and was validated by the area under the curve(AUC).The Mortality in Emergency Department Sepsis(MEDS),Pitt Bacteremia Score(PBS),Sequential Organ Failure Assessment(SOFA),quick Sequential Organ Failure Assessment(qSOFA),Charlson Comorbidity Index(CCI),and McCabe–Jackson Comorbid Classification(MJCC)for patients with CABSIs were computed to compare them with EBS in terms of the AUC and decision curve analysis(DCA).The net reclassification improvement(NRI)index and integrated discrimination improvement(IDI)index were compared between the SOFA and EBS.RESULTS:A total of 547 patients with CABSIs were included.The AUC(0.853)of the EBS was larger than those of the MEDS,PBS,SOFA,and qSOFA(all P<0.001).The NRI index of EBS in predicting the in-hospital mortality of CABSIs patients was 0.368(P=0.04),and the IDI index was 0.079(P=0.03).DCA showed that when the threshold probability was<0.1,the net benefit of the EBS model was higher than those of the other models.CONCLUSION:The EBS prognostic models were better than the SOFA,qSOFA,MEDS,and PBS models in predicting the in-hospital mortality of patients with CABSIs.

关键词： Community-acquired bloodstream infection Risk factors In-hospital mortality Emergency department

Effects of layer number and initial pressure on continuum-based buckling analysis of multi-walled carbon nanotubes accounting for van der Waals interaction

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2022年第12期43卷 1857-1872页

作者： xinlei LI Jianfei wang Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

The structural instability of multi-walled carbon nanotubes(MWCNTs) has captured extensive attention due to the unique characteristic of extremely thin hollow cylinder structure. The previous studies usually focus on the buckling behavior without considering the effects of the wall number and initial pressure. In this paper, the axial buckling behavior of MWCNTs with the length-to-outermost radius ratio less than 20 is investigated within the framework of the Donnell shell theory. The governing equations for the infinitesimal buckling of MWCNTs are established, accounting for the van der Waals(vd W) interaction between layers. The effects of the wall number, initial pressure prior to buckling, and aspect ratio on the critical buckling mode, buckling load, and buckling strain are discussed, respectively. Specially, the four-walled and twenty-walled CNTs are studied in detail, indicating the fact that the buckling instability may occur in other layers besides the outermost layer. The obtained results extend the buckling analysis of the continuum-based model, and provide theoretical support for the application of CNTs.

关键词： multi-walled carbon nanotubes(MWCNTs) buckling load cylindrical shell model instability region buckling mode

Decomposition analysis of CO_(2) emissions of electricity and carbon-reduction policy implication: a study of a province in China based on the logarithmic mean Divisia index method

在线全文

学校读者我要写书评

暂无评论

Clean Energy 2023年第2期7卷 340-349页

作者： Fuyuan Yang Xiaobin Yang Xueqin Tian Xinlei Wang Tong Xu State Grid Economic and Technological Research Institute Co. LtdBeijing102209China State Grid Jiangxi Electric Power Research Institute State Grid Jiangxi Electric Power Co.LtdNanchangChina

As the proportion of electricity in final energy consumption gradually increases,CO_(2) emissions reduction actions in the power system will become the key to achieving China’s carbon-peak and carbon-neutrality goals.It is essential to analyse and quantify the driving forces of CO_(2) emissions from electricity generation in the fossil-rich area in China.This paper aims to identify the characteristics of CO_(2) emissions generated by electricity and provide a basis for formulating CO_(2)-reduction policies in power systems.First,we analyse the current state of CO_(2) emissions from electricity generation in Anhui Province that was dominated by fossil energy during the period 2010-19.Then,we apply the logarithmic mean Divisia index method to find the nature of the factors influencing the changes in CO_(2) emissions.Finally,we analyse the CO_(2)-reduction measures of each side of the source-network-load-storage of the power system in Anhui through a power-system carbon-reduction path analysis model proposed in this study and provide policy suggestions.The results showed the following.(i)CO_(2) emissions in Anhui Province continued to increase from 2010 to 2019 and the trend in the growth rate of CO_(2) emissions presented approximately a u-shaped curve.(ii)Economic activity has always been the dominant factor driving the growth of electricity CO_(2) emis-sions.The increase in the proportion of renewable energy in power generation,the improvement in thermal power-conversion efficiency and the decrease in the intensity of power consumption are the three major driving factors for the reduction in CO_(2) emissions from power generation in Anhui.(iii)The CO_(2)-reduction measures of the power system are provided in each link of the source-network-load-storage,such as developing the photovoltaic industry and building energy storage,upgrading and transforming coal-fired power stations,redu-cing the loss rate of transmission lines on the grid side and improving the efficiency of the utilization of electricity on the user s

关键词： CO_(2)emissions LMDI electricity generation carbon-reduction measures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2022年第6期8卷 31-45页

作者： Jingming Gao Xiaoye Yu Xinlei Wang Yingning He Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

An appropriate cell microenvironment is key to tissue engineering and regenerative medicine.Revealing the factors that influence the cell microenvironment is a fundamental research topic in the fields of cell biology,biomaterials,tissue engineering,and regenerative medicine.The cell microenvironment consists of not only its surrounding cells and soluble factors,but also its extracellular matrix(ECM)or nearby external biomaterials in tissue engineering and regeneration.This review focuses on six aspects of bioma-terial-related cell microenvironments:①chemical composition of materials,②material dimensions and architecture,③material-controlled cell geometry,④effects of material charges on cells,⑤matrix stiff-ness and biomechanical microenvironment,and⑥surface modification of materials.The present chal-lenges in tissue engineering are also mentioned,and eight perspectives are predicted.

关键词： Tissue engineering Regenerative medicine Biomaterials Cell microenvironment Porous scaffold Surface patterning Cell-material interactions

An expectation–maximization algorithm for estimating proportions of deletions among bacterial populations with application to study antibiotic resistance gene transfer in Enterococcus faecalis

在线全文

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2023年第1期5卷 28-43页

作者： Yu Zhang Cong Zhang Wenwen Huo Xinlei Wang Michael Zhang Kelli Palmer Min Chen School of Mathematical Sciences Ocean University of ChinaQingdao266000China Department of Mathematical Sciences University of Texas at DallasRichardsonTX75080USA Department of Biological Sciences University of Texas at DallasRichardsonTX75080USA Department of Statistical Science Southern Methodist UniversityDallasTX75205USA MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing100084China Department of Population and Data Sciences UT Southwestern Medical CenterDallasTX75390USA

The emergence of antibiotic resistance in bacteria limits the availability of antibiotic choices for treatment and infection control,thereby representing a major threat to human health.The de novo mutation of bacterial genomes is an essential mechanism by which bacteria acquire antibiotic resistance.Previously,deletion mutations within bacterial immune systems,ranging from dozens to thousands of base pairs(bps)in length,have been associated with the spread of antibiotic resistance.Most current methods for evaluating genomic structural variations(SVs)have concentrated on detecting them,rather than estimating the proportions of populations that carry distinct SVs.A better understanding of the distribution of mutations and subpopulations dynamics in bacterial populations is needed to appreciate antibiotic resistance evolution and movement of resistance genes through populations.Here,we propose a statistical model to estimate the proportions of genomic deletions in a mixed population based on Expectation–Maximization(EM)algorithms and next-generation sequencing(NGS)data.The method integrates both insert size and split-read mapping information to iteratively update estimated distributions.The proposed method was evaluated with three simulations that demonstrated the production of accurate estimations.The proposed method was then applied to investigate the horizontal transfers of antibiotic resistance genes in concert with changes in the CRISPR-Cas system of E.faecalis.

关键词： Bacterial genomes CRISPR-Cas system Antibiotic resistance EM algorithm Proportion estimation

Temporal–spatial distribution and diastereoisomer pattern of hexabromocyclododecane in the vicinity of a chemical plant

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2019年第8期31卷 203-212页

作者： Xinlei Wang Ruirui Sun Yuedong Chen Xu Zhang Zhaojie Cui School of Environmental Science and Engineering Shandong University Department of Plant and Microbial Biology University of Zurich

Hexabromocyclododecane(HBCD) is an effective brominated flame-retardant additive, which is mainly produced in the coastal area of China. This study collected soil samples from a HBCD production plant and its surrounding area in Weifang, Shandong Province, China, and analyzed the temporal–spatial distribution of HBCD and its diastereoisomers in soil. The analysis results showed that the concentration of HBCD in soil near the plant was much higher than normal values, with an annual average concentration reaching 5405 ng/g. Soils 1,2 and 4 km away from the plant were also analyzed, showing that the concentration of HBCD in soil decreased accordingly with the distance from the pollution sources. In order to investigate the effect of the season on HBCD content, the soil samples were collected in all four seasons of the year 2017–2018. According to variations in the wind direction, the concentration of HBCD in soil was also changed. The distribution trend showed that the concentration of HBCD in soil in the downwind direction of the prevailing wind was higher than that in the upwind direction. In addition, this work analyzed the distribution of HBCD in vertical soil sections. It was found that the concentration of HBCD decreased with depth in the soil vertical profile. Finally, the various diastereoisomer patterns in the soil compartments were examined, finding that α-HBCD and γ-HBCD were the predominant diastereoisomers in the soil of the study area.

关键词： Hexabromocyclododecane(HBCD) Temporal–spatial distribution Diastereoisomers Seasonal variation Soil

Promoting effect of FeOx addition on the mechanochemically prepared vanadium-based catalyst for real PCDD/Fs removal and mechanism insight

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 478-487页

作者： Minghui Tang Ling wang Hongxian Li xinlei Huang Cuicui Du Shengyong Lu State Key Laboratory for Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China

Industrial-use VOx-based catalysts usually have a higher active temperature window (>250-300℃),which becomes a“bottleneck”for the practical application of PCDD/Fs catalytic degradation technology.In this work,VO_(x)-FeO_(x)/TiO_(2) catalyst prepared via mechanochemically method was investigated for the catalytic removal of PCDD/Fs.The removal efficiency of 1,2-DCBz,pure PCDD/Fs gas generated in the lab,PCDD/Fs from actual fue gas,long-term were studied,and the degradation mechanism was explored using FTIR and TOFMS.The degradation efficiency of 1,2-DCBz and PCDD/Fs on VO_(x)-FeO_(x)/TiO_(2) were higher than that of VO_(x)/TiO_(2)catalyst,and the optimal FeOx addition ratio was 3 wt.%.The characterization results show that the addition of FeOx can effectively improve the pore structure,surface acidity,and VOx dispersion of the catalyst,thus contributing to increasing the V^(5+)content and surface-active oxygen,which is conducive to the improvement of adsorption and redox performance of the catalyst.Under the actual MSWI (municipal solid waste incineration)fue gas,the PCDD/Fs removal efficiency over VTi-3Fe-MC maintained long-term stability,higher than 85%for 240 min.This result was not significantly reduced compared with the data obtained in the laboratory.According to the analysis results of intermediate products by FTIR and GC-TOFMS,it can be inferred that the epoxidation fracture of benzene ring is the rate-limiting step of dioxin catalytic degradation reaction.This work gives an in-depth view into the PCDD/Fs removal over VO_(x)-FeO_(x)/TiO_(2) catalysts and could provide guidelines for the rational design of reliable catalysts for industrial applications.

关键词： PCDD/F removal MSWI fue gas VO_(x)-FeO_(x)/TiO_(2) Mechanochemical GC-TOFMS

Cross-Regional Analysis of New Energy Consumption Capacity

在线全文

学校读者我要写书评

暂无评论

Journal of Beijing Institute of Technology 2020年第1期29卷 38-44页

作者： Shiyi Ma Cong Duan Tong Xu Xinlei Wang Xueqin Tian Liang wang Beijing Huajian Power Design and Research Institute Beijing 102209China School of Automation Beijing Institute of TechnologyBeijing 100081China

An assessment of the new energy consumption capacity of the grid can help to improve new energy efficiency and its planning and development.The annual capacity of multi-regional new energy consumption is affected by the new energy installed capacity of each region,the output of thermal power units,the load size,and the exchange capacity between regional tie lines.In this paper,a real-time data processing method of a province is proposed,and a raw data processing method with dimensionality reduction equivalent is proposed.From the perspective of new installed capacity of new energy across regions,we obtain the assessment of the capacity of wind power photovoltaic bases in a given scenario,and propose new installed capacity for wind,light and energy storage power stations.

关键词： new energy consumption new energy assessment mixed integer programming production simulation

Transient Simulation and Optimization of Regional Integrated Energy System

在线全文

学校读者我要写书评

暂无评论

Energy Engineering 2022年第3期119卷 1031-1045页

作者： Xueqin Tian Mengran Cui Tong Xu Jinfei Sun Xinlei Wang Jiangxiang Guo De-Gejirifu Na wang State Grid Economic and Technological Research Institute Co. Ltd.Beijing102209China Qingdao University of Technology Qingdao266033China

A modeling method of regional integrated energy system based on bus method and transient simulation is proposed,and the system optimization is based on the dynamic balance of supply and demand in the whole year energy supply cycle.A CCHP systemof gas turbine coupled with ground source heat pump and electric refrigeration unit is constructed.The energy relationship of the systemis described by bus structure,and the transient calculationmodel is built on TRNSYS platform.The weighted sum of annual total cost saving rate,primary energy saving rate and environmental pollutant shadow cost saving rate is taken as the optimized objective function,and on the basis of annual dynamic balance,the Hooke-Jeeves algorithm is used for optimization of the system configuration.A complex commercial area in Beijing is taken as an example,and different weighting coefficients are set for optimization of the system configuration.The results show that,from the perspective of economy,environmental benefit and primary energy consumption,performance of the system increases and then decreases with rise of gas turbine power;under the simulated cooling/heating load,the maximum number of optimum configuration is seen in the combination of 35 kW gas turbine+723 kW GSHP and 1178 kW electric chiller;in comparison with traditional distributed system,the annual cost saving rate,primary energy saving rate and environmental pollutant shadow cost saving rate of the system are 29.4%,49.6%and 58.2%,respectively.

关键词： Integrated energy system transient simulation multi-objective optimization