Biomaterial–Related Cell Microenvironment in Tissue Engineering and Regenerative Medicine

作     者：Jingming Gao Xiaoye Yu Xinlei Wang Yingning He Jiandong Ding Jingming Gao;Xiaoye Yu;Xinlei Wang;Yingning He;Jiandong Ding

作者机构：State Key Laboratory of Molecular Engineering of PolymersDepartment of Macromolecular ScienceFudan UniversityShanghai 200438China 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2022年第8卷第6期

页      面：31-45页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：the financial support from the National Natural Science Foundation of China (21961160721 and 52130302) the National Key Research and Development Program of China(2016YFC1100300) 

主　　题：Tissue engineering Regenerative medicine Biomaterials Cell microenvironment Porous scaffold Surface patterning Cell-material interactions 

摘      要：An appropriate cell microenvironment is key to tissue engineering and regenerative medicine.Revealing the factors that influence the cell microenvironment is a fundamental research topic in the fields of cell biology,biomaterials,tissue engineering,and regenerative medicine.The cell microenvironment consists of not only its surrounding cells and soluble factors,but also its extracellular matrix(ECM)or nearby external biomaterials in tissue engineering and regeneration.This review focuses on six aspects of bioma-terial-related cell microenvironments:①chemical composition of materials,②material dimensions and architecture,③material-controlled cell geometry,④effects of material charges on cells,⑤matrix stiff-ness and biomechanical microenvironment,and⑥surface modification of materials.The present chal-lenges in tissue engineering are also mentioned,and eight perspectives are predicted.